CRCGN017_MCF10A.WT.HP_24H:P01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-naphthylamine 102.67 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

49 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:P01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.07368
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.50046
SPAG4 sperm associated antigen 4 3.18512
COMP cartilage oligomeric matrix protein 2.98015
KIF5C kinesin family member 5C 2.66818
PECR peroxisomal trans-2-enoyl-CoA reductase 2.53569
PRR7 proline rich 7 (synaptic) 2.52647
TBPL1 TBP-like 1 2.50382
PPCS phosphopantothenoylcysteine synthetase 2.42742
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.4162
KDM5A lysine (K)-specific demethylase 5A 2.38545
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.35247
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.31144
FXYD7 FXYD domain containing ion transport regulator 7 2.21948
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.17299
XAB2 XPA binding protein 2 2.15649
TBX2 T-box 2 2.12167
KANSL1 KAT8 regulatory NSL complex subunit 1 2.1197
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 2.11512
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 2.05786
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.05766
GLRX2 glutaredoxin 2 2.02459
ZMAT5 zinc finger, matrin-type 5 2.02446
TNFAIP8L2-SCNM1 TNFAIP8L2-SCNM1 readthrough 2.02428
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.02272

decreased expression

Symbol Name Standardized Value
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -6.4406
MAPK13 mitogen-activated protein kinase 13 -3.8558
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -3.8153
LAP3 leucine aminopeptidase 3 -3.6636
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -3.42439
ANXA2 annexin A2 -3.40476
HSPA8 heat shock 70kDa protein 8 -3.3626
CTSL cathepsin L -3.10253
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.59868
MLEC malectin -2.54074
CARMIL1 capping protein regulator and myosin 1 linker 1 -2.41382
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.3234
KCTD20 potassium channel tetramerization domain containing 20 -2.30768
KRT14 keratin 14, type I -2.28109
NNT nicotinamide nucleotide transhydrogenase -2.17781
TRAPPC3 trafficking protein particle complex 3 -2.12735
CREB1 cAMP responsive element binding protein 1 -2.1227
MT2A metallothionein 2A -2.11018
CLTC clathrin, heavy chain (Hc) -2.10632
MAP7 microtubule-associated protein 7 -2.08296
ODAM odontogenic, ameloblast asssociated -2.07849
SYPL1 synaptophysin-like 1 -2.03958
CASC3 cancer susceptibility candidate 3 -2.01995
CAPRIN1 cell cycle associated protein 1 -2.00262