CRCGN017_MCF10A.WT.HP_24H:P02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-naphthylamine 34.22 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:P02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SNAP25 synaptosomal-associated protein, 25kDa 5.12848
PPARG peroxisome proliferator-activated receptor gamma 4.62082
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 4.42264
STK10 serine/threonine kinase 10 4.24319
ACAA1 acetyl-CoA acyltransferase 1 3.56122
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 3.46851
CNRIP1 cannabinoid receptor interacting protein 1 3.28911
MAP7 microtubule-associated protein 7 2.70596
TOB1 transducer of ERBB2, 1 2.60305
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.59974
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.54922
TCF12 transcription factor 12 2.27072
COPS5 COP9 signalosome subunit 5 2.16597
SERTAD2 SERTA domain containing 2 2.07977
GTF2H5 general transcription factor IIH, polypeptide 5 2.0433
CRYM crystallin, mu 2.03128
ZCCHC2 zinc finger, CCHC domain containing 2 2.00935
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 2.00529

decreased expression

Symbol Name Standardized Value
CAB39 calcium binding protein 39 -5.08321
CDC25B cell division cycle 25B -5.02754
PGAM4 phosphoglycerate mutase family member 4 -4.93186
LDHD lactate dehydrogenase D -4.73394
GOLT1B golgi transport 1B -4.48847
TUBB6 tubulin, beta 6 class V -4.266
S100A8 S100 calcium binding protein A8 -4.21554
KIF20A kinesin family member 20A -4.00095
CLTB clathrin, light chain B -3.79797
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -3.35622
PPIC peptidylprolyl isomerase C (cyclophilin C) -3.32329
FKBP1C FK506 binding protein 1C -3.2365
KRT14 keratin 14, type I -3.15237
THAP11 THAP domain containing 11 -3.04314
SCYL3 SCY1-like 3 (S. cerevisiae) -2.8896
C1QBP complement component 1, q subcomponent binding protein -2.73454
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa -2.60823
ARID4B AT rich interactive domain 4B (RBP1-like) -2.5671
RAI14 retinoic acid induced 14 -2.5646
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.38987
MDFIC MyoD family inhibitor domain containing -2.34731
PFN1 profilin 1 -2.25864
PGK1 phosphoglycerate kinase 1 -2.14957
BCAP29 B-cell receptor-associated protein 29 -2.13258
ILK integrin-linked kinase -2.12053
NGRN neugrin, neurite outgrowth associated -2.08668
RNF208 ring finger protein 208 -2.0354
COQ8A coenzyme Q8A -2.02537
NCAPD2 non-SMC condensin I complex, subunit D2 -2.01714
DNASE1 deoxyribonuclease I -2.00835