CRCGN017_MCF10A.WT.HP_24H:P13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cyclophosphamide 101.35 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

246 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:P13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LOXL1 lysyl oxidase-like 1 10.0
AMDHD2 amidohydrolase domain containing 2 9.7781
TIMP2 TIMP metallopeptidase inhibitor 2 5.0084
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 4.2206
SPDEF SAM pointed domain containing ETS transcription factor 3.9496
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.7729
CSNK1A1 casein kinase 1, alpha 1 3.19993
ZMPSTE24 zinc metallopeptidase STE24 3.0471
FCHO1 FCH domain only 1 3.0343
UBE2J1 ubiquitin-conjugating enzyme E2, J1 2.92803
SPTBN2 spectrin, beta, non-erythrocytic 2 2.9029
TNP1 transition protein 1 (during histone to protamine replacement) 2.8912
ANTKMT adenine nucleotide translocase lysine methyltransferase 2.8489
PDGFRB platelet-derived growth factor receptor, beta polypeptide 2.7617
TIMP3 TIMP metallopeptidase inhibitor 3 2.75432
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 2.7262
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 2.6949
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 2.65825
ARFRP1 ADP-ribosylation factor related protein 1 2.6571
MATN4 matrilin 4 2.6551
SMIM44 small integral membrane protein 44 2.64255
COL10A1 collagen, type X, alpha 1 2.601
GJA8 gap junction protein, alpha 8, 50kDa 2.5846
MCUR1 mitochondrial calcium uniporter regulator 1 2.583
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 2.5738
CXCL14 chemokine (C-X-C motif) ligand 14 2.5251
KAT6B K(lysine) acetyltransferase 6B 2.50997
TOP6BL TOP6B like initiator of meiotic double strand breaks 2.506
POMC proopiomelanocortin 2.4876
CCDC85B coiled-coil domain containing 85B 2.4813
DEPDC5 DEP domain containing 5 2.4774
SORT1 sortilin 1 2.4638
CRYGC crystallin, gamma C 2.4595
MORN1 MORN repeat containing 1 2.4572
S100A14 S100 calcium binding protein A14 2.4509
KLK5 kallikrein-related peptidase 5 2.44
KRT16 keratin 16, type I 2.438
ABHD17B abhydrolase domain containing 17B 2.4367
TRAPPC6A trafficking protein particle complex 6A 2.4305
CRNKL1 crooked neck pre-mRNA splicing factor 1 2.4284
ACTN4 actinin, alpha 4 2.4259
AEBP1 AE binding protein 1 2.4106
ZNF205 zinc finger protein 205 2.4102
LAMA5 laminin, alpha 5 2.407
TBXAS1 thromboxane A synthase 1 (platelet) 2.4025
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 2.3947
ZNF706 zinc finger protein 706 2.3928
IFI27 interferon, alpha-inducible protein 27 2.3882
GPR27 G protein-coupled receptor 27 2.3837
CLCN1 chloride channel, voltage-sensitive 1 2.3756
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 2.3728
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 2.3462
CYB5RL cytochrome b5 reductase-like 2.3409
CD24 CD24 molecule 2.34028
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.3395
ZNF562 zinc finger protein 562 2.3363
TWSG1 twisted gastrulation BMP signaling modulator 1 2.3278
CCDC6 coiled-coil domain containing 6 2.3159
CRYGD crystallin, gamma D 2.31
IFNB1 interferon, beta 1, fibroblast 2.3094
TMEM230 transmembrane protein 230 2.3068
ARSD arylsulfatase D 2.29525
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 2.291
LAMP5 lysosomal-associated membrane protein family, member 5 2.2909
TRIM5 tripartite motif containing 5 2.2851
SYNGAP1 synaptic Ras GTPase activating protein 1 2.2803
RAB11FIP2 RAB11 family interacting protein 2 (class I) 2.27935
RAB3A RAB3A, member RAS oncogene family 2.2739
SAMD9 sterile alpha motif domain containing 9 2.2731
PCDHB3 protocadherin beta 3 2.2668
FAM114A2 family with sequence similarity 114, member A2 2.2613
OXT oxytocin/neurophysin I prepropeptide 2.2495
PANK3 pantothenate kinase 3 2.24535
DZANK1 double zinc ribbon and ankyrin repeat domains 1 2.2451
EFCAB14 EF-hand calcium binding domain 14 2.24095
AHDC1 AT hook, DNA binding motif, containing 1 2.2352
ZNF668 zinc finger protein 668 2.2274
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B 2.2273
SMAD6 SMAD family member 6 2.22585
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 2.2235
EPHX3 epoxide hydrolase 3 2.2231
PDCD1 programmed cell death 1 2.2213
GPBP1L1 GC-rich promoter binding protein 1-like 1 2.2209
TBL3 transducin (beta)-like 3 2.21845
SAMD14 sterile alpha motif domain containing 14 2.2056
ANO1 anoctamin 1, calcium activated chloride channel 2.2036
HOXA6 homeobox A6 2.2007
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase 2.1977
UNC93B1 unc-93 homolog B1 (C. elegans) 2.1931
ZNF195 zinc finger protein 195 2.1894
KRT15 keratin 15, type I 2.1863
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) 2.1839
PTP4A3 protein tyrosine phosphatase type IVA, member 3 2.183
LARP1 La ribonucleoprotein domain family, member 1 2.18227
SCGB2A2 secretoglobin, family 2A, member 2 2.1796
CSRNP3 cysteine-serine-rich nuclear protein 3 2.161
CBARP CACN subunit beta associated regulatory protein 2.1566
IFT140 intraflagellar transport 140 2.1562
SAP30L SAP30-like 2.1551
SNRPB2 small nuclear ribonucleoprotein polypeptide B 2.1398
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 2.1378
MUC5B mucin 5B, oligomeric mucus/gel-forming 2.137
NR2F1 nuclear receptor subfamily 2, group F, member 1 2.13
ZNF33B zinc finger protein 33B 2.1284
COMP cartilage oligomeric matrix protein 2.1283
INPP5J inositol polyphosphate-5-phosphatase J 2.1253
APOA4 apolipoprotein A-IV 2.1222
GGT5 gamma-glutamyltransferase 5 2.1185
CNPY4 canopy FGF signaling regulator 4 2.1168
THBS2 thrombospondin 2 2.1163
CPNE7 copine VII 2.1135
FAF2 Fas associated factor family member 2 2.11285
DOC2B double C2-like domains, beta 2.1123
ADRA2C adrenoceptor alpha 2C 2.1108
TMEM184C transmembrane protein 184C 2.1101
CCDC40 coiled-coil domain containing 40 2.1097
TMEM106B transmembrane protein 106B 2.109
ARMC9 armadillo repeat containing 9 2.10663
MLPH melanophilin 2.1047
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 2.1047
SNCG synuclein, gamma (breast cancer-specific protein 1) 2.1033
CXADR coxsackie virus and adenovirus receptor 2.1032
MKKS McKusick-Kaufman syndrome 2.1026
HOXC8 homeobox C8 2.1014
MTRF1 mitochondrial translational release factor 1 2.0998
DAAM1 dishevelled associated activator of morphogenesis 1 2.0994
EFHD1 EF-hand domain family, member D1 2.0977
CAAP1 caspase activity and apoptosis inhibitor 1 2.0878
MMP23B matrix metallopeptidase 23B 2.086
ZNF268 zinc finger protein 268 2.0854
KLK6 kallikrein-related peptidase 6 2.0833
CRYBB2 crystallin, beta B2 2.0822
UCKL1 uridine-cytidine kinase 1-like 1 2.0808
RRAGC Ras-related GTP binding C 2.0737
CEMP1 cementum protein 1 2.0736
SSPN sarcospan 2.0672
NMRK2 nicotinamide riboside kinase 2 2.0616
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 2.0591
RFTN1 raftlin, lipid raft linker 1 2.0576
ADM2 adrenomedullin 2 2.0537
ITFG1 integrin alpha FG-GAP repeat containing 1 2.0519
PCDHB12 protocadherin beta 12 2.0478
ZCCHC2 zinc finger, CCHC domain containing 2 2.0478
PCDHB13 protocadherin beta 13 2.0463
OSBPL7 oxysterol binding protein-like 7 2.04415
CRYBB1 crystallin, beta B1 2.0378
EHF ets homologous factor 2.0364
AIM2 absent in melanoma 2 2.0343
E4F1 E4F transcription factor 1 2.0343
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.0315
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 2.0245
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 2.0233
TJP3 tight junction protein 3 2.02035
DHRS11 dehydrogenase/reductase (SDR family) member 11 2.0178
ZXDC ZXD family zinc finger C 2.0173
MRPL34 mitochondrial ribosomal protein L34 2.0161
LRRC17 leucine rich repeat containing 17 2.0135
IFI44L interferon-induced protein 44-like 2.0092
RB1 retinoblastoma 1 2.0001

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -10.0
HAT1 histone acetyltransferase 1 -9.7515
UBE3C ubiquitin protein ligase E3C -9.2522
PLK1 polo-like kinase 1 -8.1031
SNCA synuclein, alpha (non A4 component of amyloid precursor) -7.4445
TLCD3A TLC domain containing 3A -5.0658
NGRN neugrin, neurite outgrowth associated -4.4409
ACAA1 acetyl-CoA acyltransferase 1 -4.42905
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.2199
BASP1 brain abundant, membrane attached signal protein 1 -4.0101
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.8882
SORBS3 sorbin and SH3 domain containing 3 -3.55435
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) -3.2928
PFN1 profilin 1 -3.1674
RRAGA Ras-related GTP binding A -3.1416
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator -3.053
ALAS2 5'-aminolevulinate synthase 2 -2.9587
FAIM Fas apoptotic inhibitory molecule -2.8869
DMTN dematin actin binding protein -2.8698
EPB42 erythrocyte membrane protein band 4.2 -2.7791
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing -2.7647
NCAPG2 non-SMC condensin II complex, subunit G2 -2.737
RFC2 replication factor C (activator 1) 2, 40kDa -2.7357
GALE UDP-galactose-4-epimerase -2.6265
CYFIP1 cytoplasmic FMR1 interacting protein 1 -2.6245
CRTC3 CREB regulated transcription coactivator 3 -2.6183
UBE2S ubiquitin-conjugating enzyme E2S -2.6008
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.5844
CCL20 chemokine (C-C motif) ligand 20 -2.541
TMCC2 transmembrane and coiled-coil domain family 2 -2.5383
FNDC4 fibronectin type III domain containing 4 -2.5334
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -2.4891
PSRC1 proline/serine-rich coiled-coil 1 -2.4825
DVL3 dishevelled segment polarity protein 3 -2.4523
SLC35G2 solute carrier family 35, member G2 -2.4286
ATG7 autophagy related 7 -2.4165
ITGAV integrin, alpha V -2.4127
ANKRD10 ankyrin repeat domain 10 -2.3799
EN2 engrailed homeobox 2 -2.3775
DES desmin -2.3447
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -2.3395
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) -2.338
SARAF store-operated calcium entry-associated regulatory factor -2.3024
ACKR1 atypical chemokine receptor 1 (Duffy blood group) -2.3006
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.2866
RPS5 ribosomal protein S5 -2.2698
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 -2.26465
NISCH nischarin -2.2621
PGC progastricsin (pepsinogen C) -2.2593
BPGM 2,3-bisphosphoglycerate mutase -2.2335
CENPA centromere protein A -2.23235
RNFT1-DT RNFT1 divergent transcript -2.2269
DDB2 damage-specific DNA binding protein 2, 48kDa -2.2264
ST18 suppression of tumorigenicity 18, zinc finger -2.226
MEMO1 mediator of cell motility 1 -2.2245
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 -2.2157
EFHD2 EF-hand domain family, member D2 -2.2106
PARP1 poly (ADP-ribose) polymerase 1 -2.2062
EXOSC10 exosome component 10 -2.1996
ENO3 enolase 3 (beta, muscle) -2.199
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated -2.1955
HBG1 hemoglobin, gamma A -2.19453
SHPK sedoheptulokinase -2.1855
SYNM synemin, intermediate filament protein -2.1853
PROM1 prominin 1 -2.1467
TRIM58 tripartite motif containing 58 -2.1417
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) -2.13655
MARS1 methionyl-tRNA synthetase 1 -2.11937
ITK IL2-inducible T-cell kinase -2.1085
SMTN smoothelin -2.09305
CNIH1 cornichon family AMPA receptor auxiliary protein 1 -2.0813
RIPOR1 RHO family interacting cell polarization regulator 1 -2.0548
AHSP alpha hemoglobin stabilizing protein -2.0512
FAM168B family with sequence similarity 168, member B -2.0429
CIB1 calcium and integrin binding 1 (calmyrin) -2.0426
H2AX H2A.X variant histone -2.0382
HYAL2 hyaluronoglucosaminidase 2 -2.0339
PTPN20 protein tyrosine phosphatase, non-receptor type 20 -2.0333
UNC13D unc-13 homolog D (C. elegans) -2.0306
PYGL phosphorylase, glycogen, liver -2.0273
MARCHF8 membrane associated ring-CH-type finger 8 -2.0176
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa -2.0173
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit -2.0126
FUCA1 fucosidase, alpha-L- 1, tissue -2.0104
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) -2.008
SNX7 sorting nexin 7 -2.0022
SPAG1 sperm associated antigen 1 -2.001