CRCGN017_MCF10A.WT.HP_24H:P14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cyclophosphamide 33.78 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

114 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:P14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
VAV3 vav 3 guanine nucleotide exchange factor 4.8478
RNF167 ring finger protein 167 4.5912
TXNL4B thioredoxin-like 4B 4.2343
NVL nuclear VCP-like 4.0795
CERK ceramide kinase 4.0642
LSR lipolysis stimulated lipoprotein receptor 3.6939
TPD52L2 tumor protein D52-like 2 3.4599
BPHL biphenyl hydrolase-like (serine hydrolase) 3.3226
DEGS1 delta(4)-desaturase, sphingolipid 1 3.3066
AHNAK2 AHNAK nucleoprotein 2 3.0544
LORICRIN loricrin cornified envelope precursor protein 2.9089
CCDC85B coiled-coil domain containing 85B 2.8631
VASH2 vasohibin 2 2.6806
KRT2 keratin 2, type II 2.6538
RPP38 ribonuclease P/MRP 38kDa subunit 2.6332
ZFP36 ZFP36 ring finger protein 2.5981
SOSTDC1 sclerostin domain containing 1 2.5932
GAS2 growth arrest-specific 2 2.5181
MYLIP myosin regulatory light chain interacting protein 2.451
AOPEP aminopeptidase O (putative) 2.4196
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A 2.3373
ZNF250 zinc finger protein 250 2.3256
RHEX regulator of hemoglobinization and erythroid cell expansion 2.30935
ASPA aspartoacylase 2.2942
FLG filaggrin 2.2664
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1 2.2659
TACC2 transforming, acidic coiled-coil containing protein 2 2.25795
ZNF248 zinc finger protein 248 2.2542
MTTP microsomal triglyceride transfer protein 2.2471
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 2.247
RAB8B RAB8B, member RAS oncogene family 2.2427
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.2378
ASTE1 asteroid homolog 1 (Drosophila) 2.2338
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 2.23
KRT1 keratin 1, type II 2.2265
EIF2D eukaryotic translation initiation factor 2D 2.2256
PDHB pyruvate dehydrogenase (lipoamide) beta 2.2191
TMEM80 transmembrane protein 80 2.2147
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 2.2089
PLAG1 pleiomorphic adenoma gene 1 2.2053
EFNA1 ephrin-A1 2.1604
THEMIS2 thymocyte selection associated family member 2 2.1587
RCOR3 REST corepressor 3 2.1582
RETREG1 reticulophagy regulator 1 2.14665
ZSCAN26 zinc finger and SCAN domain containing 26 2.1454
SCNN1B sodium channel, non voltage gated 1 beta subunit 2.1438
BAG1 BCL2-associated athanogene 2.13585
MUC1 mucin 1, cell surface associated 2.1316
CCDC51 coiled-coil domain containing 51 2.1168
EMX2 empty spiracles homeobox 2 2.1155
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 2.1127
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 2.1079
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase 2.1066
BCL6 B-cell CLL/lymphoma 6 2.10515
MTMR11 myotubularin related protein 11 2.0955
JUP junction plakoglobin 2.0913
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein 2.0808
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 2.0783
MRPL15 mitochondrial ribosomal protein L15 2.0779
TRNAU1AP tRNA selenocysteine 1 associated protein 1 2.0756
TNS2 tensin 2 2.0679
CLPTM1 cleft lip and palate associated transmembrane protein 1 2.0434
PHACTR4 phosphatase and actin regulator 4 2.0178
BAALC brain and acute leukemia, cytoplasmic 2.0118
CTSA cathepsin A 2.0086
RDH5 retinol dehydrogenase 5 (11-cis/9-cis) 2.0054
EHD3 EH-domain containing 3 2.0048
COQ9 coenzyme Q9 2.0046
MREG melanoregulin 2.0024
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 2.0003

decreased expression

Symbol Name Standardized Value
KIF14 kinesin family member 14 -10.0
CANT1 calcium activated nucleotidase 1 -5.8519
THAP11 THAP domain containing 11 -3.8963
CHIC2 cysteine-rich hydrophobic domain 2 -3.0213
TM9SF2 transmembrane 9 superfamily member 2 -2.8958
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.7966
PRSS58 protease, serine, 58 -2.7737
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 -2.708
PRSS2 protease, serine, 2 (trypsin 2) -2.69685
KIF18A kinesin family member 18A -2.6467
MIS18BP1 MIS18 binding protein 1 -2.6086
SETD1B SET domain containing 1B -2.6013
RPS5 ribosomal protein S5 -2.5853
MACROH2A2 macroH2A.2 histone -2.4869
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) -2.4816
SPPL2A signal peptide peptidase like 2A -2.3914
NPY neuropeptide Y -2.3843
PSAT1 phosphoserine aminotransferase 1 -2.3619
TMOD3 tropomodulin 3 (ubiquitous) -2.3604
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.3486
AKT1 v-akt murine thymoma viral oncogene homolog 1 -2.3186
STIL SCL/TAL1 interrupting locus -2.3133
CEP170 centrosomal protein 170kDa -2.3122
SNX10 sorting nexin 10 -2.3092
RIOX1 ribosomal oxygenase 1 -2.2173
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -2.21
NTM neurotrimin -2.198
CTSZ cathepsin Z -2.1806
TTK TTK protein kinase -2.1725
SUCO SUN domain containing ossification factor -2.1304
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 -2.12405
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.1171
CDC73 cell division cycle 73 -2.0797
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.0776
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -2.0776
FBXO7 F-box protein 7 -2.0701
CDC45 cell division cycle 45 -2.0615
RPRD1A regulation of nuclear pre-mRNA domain containing 1A -2.0594
RNPS1 RNA binding protein S1, serine-rich domain -2.0509
ANKRD10 ankyrin repeat domain 10 -2.0425
KIF23 kinesin family member 23 -2.0407
CYTH3 cytohesin 3 -2.02
HOMER1 homer scaffolding protein 1 -2.014
SSH1 slingshot protein phosphatase 1 -2.00275