CRCGN017_MCF10A.WT.HP_24H:P15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cyclophosphamide 11.26 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

288 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:P15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHMP6 charged multivesicular body protein 6 10.0
CCDC92 coiled-coil domain containing 92 9.8345
HBA1 hemoglobin, alpha 1 8.61887
HBB hemoglobin, beta 7.68617
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 7.49653
CNRIP1 cannabinoid receptor interacting protein 1 5.7982
COL11A1 collagen, type XI, alpha 1 5.11635
DHDDS dehydrodolichyl diphosphate synthase 4.93505
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 4.3709
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.3057
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 4.0563
MLYCD malonyl-CoA decarboxylase 3.9824
LEP leptin 3.9145
RDH5 retinol dehydrogenase 5 (11-cis/9-cis) 3.8856
STX12 syntaxin 12 3.8738
SESN1 sestrin 1 3.5047
ACOT2 acyl-CoA thioesterase 2 3.4505
CIDEC cell death-inducing DFFA-like effector c 3.4331
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 3.4082
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 3.40405
CRYAB crystallin, alpha B 3.3151
GSTZ1 glutathione S-transferase zeta 1 3.229
DCTN3 dynactin 3 (p22) 3.2109
CORO1C coronin, actin binding protein, 1C 3.2109
SAP30BP SAP30 binding protein 3.1908
SLC46A3 solute carrier family 46, member 3 3.1263
PRH1 proline-rich protein HaeIII subfamily 1 3.0727
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 3.0532
PRB3 proline-rich protein BstNI subfamily 3 3.0431
AOPEP aminopeptidase O (putative) 3.0151
TRNAU1AP tRNA selenocysteine 1 associated protein 1 2.9723
ANKRD46 ankyrin repeat domain 46 2.9437
PEF1 penta-EF-hand domain containing 1 2.9129
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 2.9114
DMBT1 deleted in malignant brain tumors 1 2.8943
NCK1 NCK adaptor protein 1 2.87685
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 2.8524
GLUL glutamate-ammonia ligase 2.85077
CA4 carbonic anhydrase IV 2.81885
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.8009
TUFT1 tuftelin 1 2.7679
ITGA7 integrin, alpha 7 2.76475
MAP3K6 mitogen-activated protein kinase kinase kinase 6 2.7589
POMT1 protein-O-mannosyltransferase 1 2.7345
TRIM22 tripartite motif containing 22 2.7216
CLU clusterin 2.71303
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 2.7087
SAMD14 sterile alpha motif domain containing 14 2.7048
NPIPB6 nuclear pore complex interacting protein family, member B6 2.7036
CZIB CXXC motif containing zinc binding protein 2.6995
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 2.6981
IFI27 interferon, alpha-inducible protein 27 2.6887
PXMP2 peroxisomal membrane protein 2, 22kDa 2.687
IFI44L interferon-induced protein 44-like 2.6449
ASL argininosuccinate lyase 2.6318
SFT2D2 SFT2 domain containing 2 2.6258
PGCKA1 PDCD10 and GCKIII kinases associated 1 2.622
SCD5 stearoyl-CoA desaturase 5 2.6141
ZFYVE21 zinc finger, FYVE domain containing 21 2.6085
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 2.6043
MPHOSPH8 M-phase phosphoprotein 8 2.5942
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase 2.5825
ADGRF1 adhesion G protein-coupled receptor F1 2.5795
SMR3B submaxillary gland androgen regulated protein 3B 2.57375
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 2.561
VAMP8 vesicle-associated membrane protein 8 2.5593
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.5574
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 2.5503
PPP1R8 protein phosphatase 1, regulatory subunit 8 2.5489
STBD1 starch binding domain 1 2.5402
COPZ2 coatomer protein complex, subunit zeta 2 2.5328
SLC31A2 solute carrier family 31 (copper transporter), member 2 2.5221
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.5131
HSPB2 heat shock 27kDa protein 2 2.5086
LPO lactoperoxidase 2.4941
GLDC glycine dehydrogenase (decarboxylating) 2.4913
HLA-DRB3 major histocompatibility complex, class II, DR beta 3 2.4692
LXN latexin 2.4689
GPS1 G protein pathway suppressor 1 2.4678
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7 2.46175
DCTN6 dynactin 6 2.4611
ACOX1 acyl-CoA oxidase 1, palmitoyl 2.4575
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 2.4553
MFAP5 microfibrillar associated protein 5 2.42647
PRB4 proline-rich protein BstNI subfamily 4 2.404
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 2.4009
IFI6 interferon, alpha-inducible protein 6 2.3939
ZNHIT3 zinc finger, HIT-type containing 3 2.3924
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 2.3923
PLAAT3 phospholipase A and acyltransferase 3 2.3887
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A 2.3883
CHRDL1 chordin-like 1 2.3855
CIDEA cell death-inducing DFFA-like effector a 2.3755
TTC13 tetratricopeptide repeat domain 13 2.3743
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 2.36505
EPB41L4B erythrocyte membrane protein band 4.1 like 4B 2.357
RAP1B RAP1B, member of RAS oncogene family 2.3467
ZNF593 zinc finger protein 593 2.3449
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A 2.3273
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 2.3241
AGR2 anterior gradient 2 2.3167
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 2.3126
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3 2.3008
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 2.2949
ADIPOQ adiponectin, C1Q and collagen domain containing 2.2898
PINK1 PTEN induced putative kinase 1 2.2881
CCL8 chemokine (C-C motif) ligand 8 2.2862
MUC4 mucin 4, cell surface associated 2.28445
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 2.2826
FBLN2 fibulin 2 2.2771
STOML1 stomatin (EPB72)-like 1 2.27675
S100PBP S100P binding protein 2.2748
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 2.2691
COL5A3 collagen, type V, alpha 3 2.26845
CTSK cathepsin K 2.264
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 2.263
KLK1 kallikrein 1 2.2573
SNCG synuclein, gamma (breast cancer-specific protein 1) 2.2541
KCTD9 potassium channel tetramerization domain containing 9 2.2519
KCNIP2 Kv channel interacting protein 2 2.2497
PEX13 peroxisomal biogenesis factor 13 2.2423
SLC19A3 solute carrier family 19 (thiamine transporter), member 3 2.235
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 2.22325
PLIN1 perilipin 1 2.2191
MUC7 mucin 7, secreted 2.2161
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 2.2132
CASD1 CAS1 domain containing 1 2.2106
TPK1 thiamin pyrophosphokinase 1 2.2053
HTN3 histatin 3 2.198
ACACB acetyl-CoA carboxylase beta 2.19325
KLHL12 kelch-like family member 12 2.193
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 2.1927
GCSH glycine cleavage system protein H (aminomethyl carrier) 2.1897
ADAMDEC1 ADAM-like, decysin 1 2.1888
LOC107985101 uncharacterized LOC107985101 2.1851
NFU1 NFU1 iron-sulfur cluster scaffold 2.1742
SPRING1 SREBF pathway regulator in golgi 1 2.1699
VPS9D1 VPS9 domain containing 1 2.1689
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 2.1658
CLDN9 claudin 9 2.1572
PRB2 proline-rich protein BstNI subfamily 2 2.15043
RSRP1 arginine/serine-rich protein 1 2.14715
STAU2 staufen double-stranded RNA binding protein 2 2.1471
RBP4 retinol binding protein 4, plasma 2.1469
NAGK N-acetylglucosamine kinase 2.1438
IL11RA interleukin 11 receptor, alpha 2.1415
HBD hemoglobin, delta 2.1413
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 2.1394
TTC39A tetratricopeptide repeat domain 39A 2.13543
EDA2R ectodysplasin A2 receptor 2.1286
HSPB8 heat shock 22kDa protein 8 2.1226
ACO1 aconitase 1, soluble 2.1188
UBA7 ubiquitin-like modifier activating enzyme 7 2.11295
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 2.1127
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 2.1073
CDO1 cysteine dioxygenase type 1 2.1062
LYZ lysozyme 2.1025
IFNGR1 interferon gamma receptor 1 2.1012
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.08715
PEAK1 pseudopodium-enriched atypical kinase 1 2.0866
MUL1 mitochondrial E3 ubiquitin protein ligase 1 2.0848
HACD2 3-hydroxyacyl-CoA dehydratase 2 2.0831
RNF38 ring finger protein 38 2.0805
MACO1 macoilin 1 2.0801
NPPB natriuretic peptide B 2.0765
MUC13 mucin 13, cell surface associated 2.0759
CTNNBIP1 catenin, beta interacting protein 1 2.0731
SMAP1 small ArfGAP 1 2.073
DYNC2I1 dynein 2 intermediate chain 1 2.073
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 2.0704
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) 2.06575
COL5A2 collagen, type V, alpha 2 2.0649
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2.0629
PARP12 poly (ADP-ribose) polymerase family, member 12 2.0621
LOC100652777 group 10 secretory phospholipase A2-like 2.0612
DACT1 dishevelled-binding antagonist of beta-catenin 1 2.0609
MYO1B myosin IB 2.05897
STOM stomatin 2.0541
TMEM120B transmembrane protein 120B 2.053
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 2.0494
PDK2 pyruvate dehydrogenase kinase, isozyme 2 2.04135
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 2.0412
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 2.0373
EPYC epiphycan 2.0373
SUGCT succinyl-CoA:glutarate-CoA transferase 2.0343
ALDH4A1 aldehyde dehydrogenase 4 family, member A1 2.03385
FAM107A family with sequence similarity 107, member A 2.03295
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 2.0323
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F 2.0285
CLCA4 chloride channel accessory 4 2.0259
LIPE lipase, hormone-sensitive 2.01835
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 2.0129
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 2.01245
GUCA2A guanylate cyclase activator 2A (guanylin) 2.0121
JAG1 jagged 1 2.0098
GYG2 glycogenin 2 2.0087
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 2.00405

decreased expression

Symbol Name Standardized Value
ADI1 acireductone dioxygenase 1 -10.0
HMG20B high mobility group 20B -10.0
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -8.1891
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -4.6223
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.6828
RPS5 ribosomal protein S5 -3.5573
MFSD12 major facilitator superfamily domain containing 12 -3.5061
PRSS21 protease, serine, 21 (testisin) -3.2744
SGK1 serum/glucocorticoid regulated kinase 1 -3.1478
MYDGF myeloid-derived growth factor -3.1387
GDF15 growth differentiation factor 15 -3.0353
PRAME preferentially expressed antigen in melanoma -3.0301
THAP11 THAP domain containing 11 -2.9466
SPATA5L1 spermatogenesis associated 5-like 1 -2.838
DAZAP1 DAZ associated protein 1 -2.7638
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.7453
THOP1 thimet oligopeptidase 1 -2.7074
SCGB2A2 secretoglobin, family 2A, member 2 -2.6999
DONSON downstream neighbor of SON -2.6932
MTO1 mitochondrial tRNA translation optimization 1 -2.67065
UBE2M ubiquitin-conjugating enzyme E2M -2.6413
PLAT plasminogen activator, tissue -2.6396
ALOX15 arachidonate 15-lipoxygenase -2.6352
AMPD2 adenosine monophosphate deaminase 2 -2.5713
RPF1 ribosome production factor 1 homolog (S. cerevisiae) -2.5674
RFC2 replication factor C (activator 1) 2, 40kDa -2.5665
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -2.5635
KLK11 kallikrein-related peptidase 11 -2.5492
MAGEA2B melanoma antigen family A2B -2.5255
FOXL2 forkhead box L2 -2.4842
MANEA mannosidase, endo-alpha -2.4741
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 -2.45132
HLA-G major histocompatibility complex, class I, G -2.44233
PLPP2 phospholipid phosphatase 2 -2.4381
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) -2.4376
GYPC glycophorin C (Gerbich blood group) -2.4182
MOGAT1 monoacylglycerol O-acyltransferase 1 -2.3717
HPCAL1 hippocalcin-like 1 -2.36715
SBNO2 strawberry notch homolog 2 (Drosophila) -2.3671
TCEAL9 transcription elongation factor A like 9 -2.3634
TIPIN TIMELESS interacting protein -2.3593
EEF2 eukaryotic translation elongation factor 2 -2.3587
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) -2.3558
PRR7 proline rich 7 (synaptic) -2.35
MAGEA12 melanoma antigen family A12 -2.3442
WNT5A wingless-type MMTV integration site family, member 5A -2.3109
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.30963
HOXB5 homeobox B5 -2.27455
CD81 CD81 molecule -2.2703
LOC100533997 MAGEA10-MAGEA5 readthrough -2.2646
NEIL1 nei endonuclease VIII-like 1 (E. coli) -2.2576
GREB1L growth regulation by estrogen in breast cancer-like -2.2485
SMN2 survival of motor neuron 2, centromeric -2.2335
TOMM34 translocase of outer mitochondrial membrane 34 -2.2287
CBX4 chromobox homolog 4 -2.2233
DOHH deoxyhypusine hydroxylase/monooxygenase -2.2207
CLNS1A chloride channel, nucleotide-sensitive, 1A -2.2187
IRAK1 interleukin-1 receptor-associated kinase 1 -2.2119
INTS8 integrator complex subunit 8 -2.2108
MAGEA1 melanoma antigen family A1 -2.1969
TFF3 trefoil factor 3 (intestinal) -2.1927
TPST1 tyrosylprotein sulfotransferase 1 -2.1905
NR2F1 nuclear receptor subfamily 2, group F, member 1 -2.1888
SH2B3 SH2B adaptor protein 3 -2.1843
GALE UDP-galactose-4-epimerase -2.1769
SORD sorbitol dehydrogenase -2.1762
CFAP298 cilia and flagella associated protein 298 -2.1732
MAP2K2 mitogen-activated protein kinase kinase 2 -2.1726
BCHE butyrylcholinesterase -2.1699
REL v-rel avian reticuloendotheliosis viral oncogene homolog -2.1608
SCGB1D2 secretoglobin, family 1D, member 2 -2.1605
CDC6 cell division cycle 6 -2.15805
DUSP4 dual specificity phosphatase 4 -2.15015
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.1496
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -2.14
MYG1 MYG1 exonuclease -2.1364
INTS14 integrator complex subunit 14 -2.1189
PNKP polynucleotide kinase 3'-phosphatase -2.1159
NES nestin -2.1015
ZNF592 zinc finger protein 592 -2.096
MSMO1 methylsterol monooxygenase 1 -2.0936
DLK1 delta-like 1 homolog (Drosophila) -2.0901
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 -2.0877
RPAP3 RNA polymerase II associated protein 3 -2.0865
MFAP1 microfibrillar-associated protein 1 -2.0714
EIF4H eukaryotic translation initiation factor 4H -2.0542
PPP1R15A protein phosphatase 1, regulatory subunit 15A -2.0496
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C -2.0472
RRP1B ribosomal RNA processing 1B -2.0237
SNRPC small nuclear ribonucleoprotein polypeptide C -2.0153
ABHD17A abhydrolase domain containing 17A -2.004