CRCGN017_MCF10A.WT.HP_24H:P16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ifosfamide 101.19 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

154 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:P16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
WFS1 Wolfram syndrome 1 (wolframin) 9.0545
POLR1D polymerase (RNA) I polypeptide D, 16kDa 4.60737
ANO10 anoctamin 10 4.3936
MPC2 mitochondrial pyruvate carrier 2 4.2452
NOTCH1 notch 1 4.2083
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 3.9362
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.5709
GSTZ1 glutathione S-transferase zeta 1 3.3682
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.2103
LOC122526780 uncharacterized LOC122526780 3.2099
S100A14 S100 calcium binding protein A14 3.0704
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.0025
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.8045
RASL11B RAS-like, family 11, member B 2.7873
CLCNKB chloride channel, voltage-sensitive Kb 2.7536
STARD5 StAR-related lipid transfer (START) domain containing 5 2.7478
PRR15L proline rich 15-like 2.7275
SUGCT succinyl-CoA:glutarate-CoA transferase 2.6803
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 2.6751
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1 2.6089
TNFAIP8L2-SCNM1 TNFAIP8L2-SCNM1 readthrough 2.6086
EFNA1 ephrin-A1 2.562
EFNA4 ephrin-A4 2.558
ZXDC ZXD family zinc finger C 2.5502
SCTR secretin receptor 2.5331
COL11A1 collagen, type XI, alpha 1 2.4963
STK16 serine/threonine kinase 16 2.4488
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 2.437
COL17A1 collagen, type XVII, alpha 1 2.4364
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 2.4303
NCOA3 nuclear receptor coactivator 3 2.37023
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 2.3275
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 2.2969
HTD2 hydroxyacyl-thioester dehydratase type 2 2.2897
WDR73 WD repeat domain 73 2.2814
SLC38A12 solute carrier family 38 member 12 2.2772
PMVK phosphomevalonate kinase 2.2668
TMEM265 transmembrane protein 265 2.26
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa 2.2553
CHD8 chromodomain helicase DNA binding protein 8 2.2473
NOP14 NOP14 nucleolar protein 2.2263
STK38 serine/threonine kinase 38 2.2234
CIAO3 cytosolic iron-sulfur assembly component 3 2.2119
TGDS TDP-glucose 4,6-dehydratase 2.1952
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 2.1887
DHCR24 24-dehydrocholesterol reductase 2.1817
ADGRG1 adhesion G protein-coupled receptor G1 2.17975
LYPD3 LY6/PLAUR domain containing 3 2.1724
CRABP1 cellular retinoic acid binding protein 1 2.1665
MARCO macrophage receptor with collagenous structure 2.1593
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 2.1558
EMP2 epithelial membrane protein 2 2.1546
GRHPR glyoxylate reductase/hydroxypyruvate reductase 2.15113
BCAP31 B-cell receptor-associated protein 31 2.1442
TMEM51 transmembrane protein 51 2.1402
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 2.1277
TRAPPC6A trafficking protein particle complex 6A 2.1269
WNT4 wingless-type MMTV integration site family, member 4 2.1048
SPI1 Spi-1 proto-oncogene 2.1004
DKK3 dickkopf WNT signaling pathway inhibitor 3 2.0877
GHR growth hormone receptor 2.0835
ANXA8L1 annexin A8-like 1 2.0819
HLA-DMB major histocompatibility complex, class II, DM beta 2.0808
HGFAC HGF activator 2.0803
AGRN agrin 2.06853
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 2.0676
CD2AP CD2-associated protein 2.055
TEAD3 TEA domain family member 3 2.0481
MISP mitotic spindle positioning 2.0472
AAMP angio-associated, migratory cell protein 2.0451
COL7A1 collagen, type VII, alpha 1 2.04475
FTSJ3 FtsJ homolog 3 (E. coli) 2.0445
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 2.0436
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 2.04117
DLK2 delta-like 2 homolog (Drosophila) 2.038
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 2.0281
MUC1 mucin 1, cell surface associated 2.02223
PFKM phosphofructokinase, muscle 2.0171
SLC4A2 solute carrier family 4 (anion exchanger), member 2 2.0164
MTMR4 myotubularin related protein 4 2.0102
CCDC51 coiled-coil domain containing 51 2.0035
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 2.0011

decreased expression

Symbol Name Standardized Value
NPDC1 neural proliferation, differentiation and control, 1 -10.0
LYPLA1 lysophospholipase I -7.1834
FABP5 fatty acid binding protein 5 (psoriasis-associated) -5.6792
MRPL12 mitochondrial ribosomal protein L12 -3.9645
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.4559
CDC20 cell division cycle 20 -3.0109
FAIM Fas apoptotic inhibitory molecule -3.0021
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor -2.959
GALE UDP-galactose-4-epimerase -2.8912
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.8674
RPS5 ribosomal protein S5 -2.8481
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.7371
SLC35G2 solute carrier family 35, member G2 -2.7176
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.6971
THAP11 THAP domain containing 11 -2.6959
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa -2.6178
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 -2.5944
PRKDC protein kinase, DNA-activated, catalytic polypeptide -2.5612
SOCS6 suppressor of cytokine signaling 6 -2.55745
KIFBP kinesin family binding protein -2.5454
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.5399
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -2.5152
NBAS neuroblastoma amplified sequence -2.5152
MRPL15 mitochondrial ribosomal protein L15 -2.5148
MLEC malectin -2.5019
RRAGA Ras-related GTP binding A -2.4952
NUP88 nucleoporin 88kDa -2.4635
TOMM34 translocase of outer mitochondrial membrane 34 -2.4531
CD40LG CD40 ligand -2.4513
CEP170 centrosomal protein 170kDa -2.42665
STX1A syntaxin 1A (brain) -2.4234
LYPLA1-TCEA1 LYPLA1-TCEA1 readthrough -2.3938
TTC19 tetratricopeptide repeat domain 19 -2.3454
FBXO7 F-box protein 7 -2.338
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 -2.337
ATMIN ATM interactor -2.322
PCBP1 poly(rC) binding protein 1 -2.3167
PRKACB protein kinase, cAMP-dependent, catalytic, beta -2.2925
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 -2.2888
PTER phosphotriesterase related -2.2873
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 -2.2801
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 -2.2779
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 -2.2645
SNX7 sorting nexin 7 -2.2576
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -2.24265
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.2326
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -2.2256
RDX radixin -2.2095
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -2.204
SRPX sushi-repeat containing protein, X-linked -2.2026
RSU1 Ras suppressor protein 1 -2.1951
CASC3 cancer susceptibility candidate 3 -2.1941
HACD1 3-hydroxyacyl-CoA dehydratase 1 -2.1832
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) -2.15645
TMEM185B transmembrane protein 185B -2.1561
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) -2.1398
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha -2.13665
GSK3B glycogen synthase kinase 3 beta -2.1174
VANGL1 VANGL planar cell polarity protein 1 -2.101
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -2.0933
PPID peptidylprolyl isomerase D -2.08965
RPP25 ribonuclease P/MRP 25kDa subunit -2.081
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -2.0724
ZNF106 zinc finger protein 106 -2.0634
CTR9 CTR9, Paf1/RNA polymerase II complex component -2.0615
SELENOF selenoprotein F -2.0572
HLTF helicase-like transcription factor -2.0271
BCL7B B-cell CLL/lymphoma 7B -2.0266
PLS1 plastin 1 -2.0255
MCM3 minichromosome maintenance complex component 3 -2.0086
HLA-C major histocompatibility complex, class I, C -2.00583
KCTD12 potassium channel tetramerization domain containing 12 -2.00495