CRCGN017_MCF10A.WT.HP_24H:P18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ifosfamide 11.24 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

332 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:P18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 5.0614
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.6158
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 4.2988
KDM5D lysine (K)-specific demethylase 5D 4.1627
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 3.70435
PDLIM1 PDZ and LIM domain 1 3.5401
NT5C2 5'-nucleotidase, cytosolic II 3.2489
TMEM14A transmembrane protein 14A 3.2054
DDR1 discoidin domain receptor tyrosine kinase 1 3.15512
EMC2 ER membrane protein complex subunit 2 2.9274
PROS1 protein S (alpha) 2.8977
IRAK4 interleukin-1 receptor-associated kinase 4 2.8022
IL36G interleukin 36, gamma 2.8019
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.7646
RMDN1 regulator of microtubule dynamics 1 2.696
SAMD9 sterile alpha motif domain containing 9 2.6704
CDK6 cyclin-dependent kinase 6 2.662
USP9Y ubiquitin specific peptidase 9, Y-linked 2.65155
TMEM135 transmembrane protein 135 2.6459
CGB8 chorionic gonadotropin, beta polypeptide 8 2.6153
SPAG5 sperm associated antigen 5 2.6112
IL1R2 interleukin 1 receptor, type II 2.60575
RNFT1-DT RNFT1 divergent transcript 2.564
KLK8 kallikrein-related peptidase 8 2.5382
AFTPH aftiphilin 2.5367
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2 2.5143
WDR43 WD repeat domain 43 2.5128
GPATCH2 G patch domain containing 2 2.4792
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.4673
COBL cordon-bleu WH2 repeat protein 2.4105
HSPA4L heat shock 70kDa protein 4-like 2.4042
HIBCH 3-hydroxyisobutyryl-CoA hydrolase 2.3872
IL13RA1 interleukin 13 receptor, alpha 1 2.33547
PMVK phosphomevalonate kinase 2.3276
MFN1 mitofusin 1 2.3115
TIMCC TIM double twin CX3C motif chaperone 2.3102
AP1M2 adaptor-related protein complex 1, mu 2 subunit 2.3095
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 2.3091
PON2 paraoxonase 2 2.30415
CENPM centromere protein M 2.2941
TMEM106C transmembrane protein 106C 2.289
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.2796
FGGY FGGY carbohydrate kinase domain containing 2.2796
WASHC4 WASH complex subunit 4 2.27863
VWF von Willebrand factor 2.2675
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 2.2401
EBI3 Epstein-Barr virus induced 3 2.2361
CYB5R1 cytochrome b5 reductase 1 2.2314
HIP1 huntingtin interacting protein 1 2.2311
FKBP9 FK506 binding protein 9, 63 kDa 2.2305
SLC38A6 solute carrier family 38, member 6 2.2242
SH3YL1 SH3 and SYLF domain containing 1 2.2154
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 2.2039
PDCD11 programmed cell death 11 2.19305
MCM9 minichromosome maintenance complex component 9 2.1844
HIKESHI heat shock protein nuclear import factor hikeshi 2.174
PLSCR3 phospholipid scramblase 3 2.17305
RBM47 RNA binding motif protein 47 2.1671
MYO18A myosin XVIIIA 2.1575
ARF5 ADP-ribosylation factor 5 2.1572
MPZL1 myelin protein zero-like 1 2.1533
S1PR4 sphingosine-1-phosphate receptor 4 2.1516
BTG1 B-cell translocation gene 1, anti-proliferative 2.13705
PEX2 peroxisomal biogenesis factor 2 2.1315
WDR83OS WD repeat domain 83 opposite strand 2.1315
KIF4A kinesin family member 4A 2.1178
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 2.1139
DNM2 dynamin 2 2.1083
UBR5 ubiquitin protein ligase E3 component n-recognin 5 2.09193
MAPK3 mitogen-activated protein kinase 3 2.0917
BST2 bone marrow stromal cell antigen 2 2.0757
FZD6 frizzled class receptor 6 2.0749
MYOF myoferlin 2.06273
EIF3G eukaryotic translation initiation factor 3, subunit G 2.0226
GLTP glycolipid transfer protein 2.0209
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae) 2.0193
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 2.0182
EPHB4 EPH receptor B4 2.0169
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 2.0156
STAT5A signal transducer and activator of transcription 5A 2.0103
TARBP2 TAR (HIV-1) RNA binding protein 2 2.0091
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 2.004

decreased expression

Symbol Name Standardized Value
NUP85 nucleoporin 85kDa -10.0
FASTKD5 FAST kinase domains 5 -10.0
GNAS GNAS complex locus -8.23611
SAP30BP SAP30 binding protein -5.7485
SMC1A structural maintenance of chromosomes 1A -5.5042
TLCD3A TLC domain containing 3A -5.2911
RPL38 ribosomal protein L38 -4.8446
MRPS7 mitochondrial ribosomal protein S7 -4.5437
KCTD2 potassium channel tetramerization domain containing 2 -4.4943
NELFCD negative elongation factor complex member C/D -4.0595
LZTS3 leucine zipper, putative tumor suppressor family member 3 -4.0447
SUMO4 small ubiquitin-like modifier 4 -4.0177
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -3.76555
UBA1 ubiquitin-like modifier activating enzyme 1 -3.6211
RPN2 ribophorin II -3.58143
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -3.5778
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -3.4932
THAP11 THAP domain containing 11 -3.4068
MRPL58 mitochondrial ribosomal protein L58 -3.3762
ATP5PD ATP synthase peripheral stalk subunit d -3.364
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.3587
HPS6 Hermansky-Pudlak syndrome 6 -3.3282
NOL4 nucleolar protein 4 -3.3091
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -3.29455
ATRN attractin -3.2821
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 -3.2587
CALM2 calmodulin 2 (phosphorylase kinase, delta) -3.2193
ATP5F1E ATP synthase F1 subunit epsilon -3.1847
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 -3.1741
CDR2L cerebellar degeneration-related protein 2-like -3.1536
SEPTIN6 septin 6 -3.1468
CASKIN2 CASK interacting protein 2 -3.10445
GRB2 growth factor receptor-bound protein 2 -3.0848
KDM5C lysine (K)-specific demethylase 5C -3.0813
SLC35G2 solute carrier family 35, member G2 -3.0784
ARSL arylsulfatase L -3.0755
UCKL1 uridine-cytidine kinase 1-like 1 -3.0626
MMP8 matrix metallopeptidase 8 -2.9899
PUDP pseudouridine 5'-phosphatase -2.97
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.95397
CKB creatine kinase, brain -2.9408
MAD2L1BP MAD2L1 binding protein -2.9227
LSAMP limbic system-associated membrane protein -2.901
FXYD1 FXYD domain containing ion transport regulator 1 -2.8771
TUBA1C tubulin, alpha 1c -2.85137
MARCO macrophage receptor with collagenous structure -2.8372
PCDH8 protocadherin 8 -2.8248
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 -2.7909
PHOSPHO2-KLHL23 PHOSPHO2-KLHL23 readthrough -2.7805
H3-3B H3.3 histone B -2.76225
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 -2.7597
HLA-A major histocompatibility complex, class I, A -2.75065
MEPE matrix extracellular phosphoglycoprotein -2.7462
LLGL2 lethal giant larvae homolog 2 (Drosophila) -2.74
UBE2O ubiquitin-conjugating enzyme E2O -2.6859
FAIM Fas apoptotic inhibitory molecule -2.66
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2 -2.6561
NPTX1 neuronal pentraxin I -2.6542
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like -2.6224
ZNF529 zinc finger protein 529 -2.6099
POPDC2 popeye domain containing 2 -2.6013
GSPT2 G1 to S phase transition 2 -2.591
TUBA1B tubulin, alpha 1b -2.584
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.57603
PCP4 Purkinje cell protein 4 -2.5716
BPHL biphenyl hydrolase-like (serine hydrolase) -2.5687
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 -2.5668
TMEM94 transmembrane protein 94 -2.5652
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 -2.5363
GCHFR GTP cyclohydrolase I feedback regulator -2.5294
KDM6A lysine (K)-specific demethylase 6A -2.5251
ZNF223 zinc finger protein 223 -2.5163
PYGO1 pygopus family PHD finger 1 -2.5132
HGS hepatocyte growth factor-regulated tyrosine kinase substrate -2.5091
GRN granulin -2.5074
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.50245
POTEF POTE ankyrin domain family, member F -2.50158
GDF15 growth differentiation factor 15 -2.4975
RBM42 RNA binding motif protein 42 -2.4755
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 -2.4724
DDX25 DEAD (Asp-Glu-Ala-Asp) box helicase 25 -2.4639
SUMO2 small ubiquitin-like modifier 2 -2.46157
KLHL11 kelch-like family member 11 -2.4581
NTM neurotrimin -2.4455
LDHA lactate dehydrogenase A -2.43
TDRD1 tudor domain containing 1 -2.4193
DUS1L dihydrouridine synthase 1-like (S. cerevisiae) -2.4186
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) -2.4177
SRPRA SRP receptor subunit alpha -2.41245
CEMIP cell migration inducing protein, hyaluronan binding -2.4014
ACTR5 ARP5 actin-related protein 5 homolog (yeast) -2.3937
HELZ helicase with zinc finger -2.3898
ALOX5 arachidonate 5-lipoxygenase -2.38843
FEN1 flap structure-specific endonuclease 1 -2.38705
ACTL6B actin-like 6B -2.37505
H1-0 H1.0 linker histone -2.3742
SEPTIN9 septin 9 -2.36893
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -2.3514
KLHL3 kelch-like family member 3 -2.3491
ADRA2A adrenoceptor alpha 2A -2.3452
ZNF286A zinc finger protein 286A -2.3441
PDE1A phosphodiesterase 1A, calmodulin-dependent -2.3411
LRP5 low density lipoprotein receptor-related protein 5 -2.3331
MXRA7 matrix-remodelling associated 7 -2.3289
PDE3B phosphodiesterase 3B, cGMP-inhibited -2.32803
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 -2.3244
CPAMD8 C3 and PZP-like, alpha-2-macroglobulin domain containing 8 -2.3231
REG3A regenerating islet-derived 3 alpha -2.3191
GPR19 G protein-coupled receptor 19 -2.3173
UBA2 ubiquitin-like modifier activating enzyme 2 -2.3164
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 -2.3154
RPL3 ribosomal protein L3 -2.31302
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) -2.3028
CNTNAP1 contactin associated protein 1 -2.296
TUBA1A tubulin, alpha 1a -2.28218
SLC38A12 solute carrier family 38 member 12 -2.2787
WDR45B WD repeat domain 45B -2.2691
SKI SKI proto-oncogene -2.266
FAM131A family with sequence similarity 131, member A -2.2647
PRR16 proline rich 16 -2.2597
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 -2.2559
ACSL6 acyl-CoA synthetase long-chain family member 6 -2.25145
LECT2 leukocyte cell-derived chemotaxin 2 -2.2363
ZNF780A zinc finger protein 780A -2.2358
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z -2.2329
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -2.2319
SRD5A3 steroid 5 alpha-reductase 3 -2.2315
USP9X ubiquitin specific peptidase 9, X-linked -2.2303
SMAD9 SMAD family member 9 -2.227
SCMH1 sex comb on midleg homolog 1 (Drosophila) -2.2212
OLFM4 olfactomedin 4 -2.2208
HACD1 3-hydroxyacyl-CoA dehydratase 1 -2.2107
ZNF254 zinc finger protein 254 -2.2066
PTMA prothymosin, alpha -2.2033
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 -2.2031
RCAN3 RCAN family member 3 -2.2003
BEAN1 brain expressed, associated with NEDD4, 1 -2.1965
ACTG1 actin gamma 1 -2.18745
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 -2.1851
YBX1 Y box binding protein 1 -2.1846
PZP pregnancy-zone protein -2.1813
ZMYM6 zinc finger, MYM-type 6 -2.1788
ADAM7 ADAM metallopeptidase domain 7 -2.17485
ZNF287 zinc finger protein 287 -2.1735
CORO2B coronin, actin binding protein, 2B -2.1711
DEFA6 defensin, alpha 6, Paneth cell-specific -2.1701
HEXB hexosaminidase B (beta polypeptide) -2.17
FXYD7 FXYD domain containing ion transport regulator 7 -2.1684
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) -2.167
ZNF536 zinc finger protein 536 -2.1647
BCORL1 BCL6 corepressor-like 1 -2.1587
DRD1 dopamine receptor D1 -2.1572
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -2.1548
TBC1D16 TBC1 domain family, member 16 -2.1532
RAMP1 receptor (G protein-coupled) activity modifying protein 1 -2.1529
VWA1 von Willebrand factor A domain containing 1 -2.15
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C) -2.14955
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -2.1487
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked -2.14504
SV2B synaptic vesicle glycoprotein 2B -2.1435
MYH15 myosin, heavy chain 15 -2.1424
CASQ2 calsequestrin 2 (cardiac muscle) -2.1416
MFAP4 microfibrillar-associated protein 4 -2.1407
PNPLA4 patatin-like phospholipase domain containing 4 -2.1371
VAX2 ventral anterior homeobox 2 -2.1363
NEUROD2 neuronal differentiation 2 -2.1353
ITGB6 integrin, beta 6 -2.1335
ZXDB zinc finger, X-linked, duplicated B -2.1316
TBC1D19 TBC1 domain family, member 19 -2.1315
CNKSR2 connector enhancer of kinase suppressor of Ras 2 -2.1262
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 -2.12477
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -2.1236
CDK16 cyclin-dependent kinase 16 -2.11607
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -2.1144
ADORA2B adenosine A2b receptor -2.114
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -2.1133
LGI1 leucine-rich, glioma inactivated 1 -2.1124
RNF43 ring finger protein 43 -2.1122
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H -2.1111
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -2.1038
ITPKA inositol-trisphosphate 3-kinase A -2.1023
RIPPLY3 ripply transcriptional repressor 3 -2.1005
NEUROD6 neuronal differentiation 6 -2.0965
EGFL6 EGF-like-domain, multiple 6 -2.096
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 -2.0937
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 -2.08835
ZSCAN2 zinc finger and SCAN domain containing 2 -2.0869
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 -2.08275
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -2.082
BPI bactericidal/permeability-increasing protein -2.0815
GREM2 gremlin 2, DAN family BMP antagonist -2.0801
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -2.0781
STUM stum, mechanosensory transduction mediator homolog -2.0764
NTSR2 neurotensin receptor 2 -2.0758
TMEM51 transmembrane protein 51 -2.0751
MRNIP MRN complex interacting protein -2.0749
ETV3 ets variant 3 -2.0726
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -2.0716
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 -2.0666
PRUNE2 prune homolog 2 (Drosophila) -2.0654
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 -2.06407
EDDM3B epididymal protein 3B -2.0639
HMGN2 high mobility group nucleosomal binding domain 2 -2.0625
SC5D sterol-C5-desaturase -2.06065
ARMC7 armadillo repeat containing 7 -2.0603
CTSK cathepsin K -2.0587
CTXND1 cortexin domain containing 1 -2.0582
LIPG lipase, endothelial -2.0582
RNF113A ring finger protein 113A -2.0579
EPHA5 EPH receptor A5 -2.0559
EIF1 eukaryotic translation initiation factor 1 -2.05462
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -2.0545
TACR2 tachykinin receptor 2 -2.0544
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 -2.0521
MAPK8 mitogen-activated protein kinase 8 -2.052
CDH20 cadherin 20, type 2 -2.0497
NPY5R neuropeptide Y receptor Y5 -2.0471
ENTREP2 endosomal transmembrane epsin interactor 2 -2.0446
RHCE Rh blood group, CcEe antigens -2.04297
MAP2K1 mitogen-activated protein kinase kinase 1 -2.0423
SH2B3 SH2B adaptor protein 3 -2.0408
NELL1 NEL-like 1 (chicken) -2.0401
CCDC181 coiled-coil domain containing 181 -2.04
TBR1 T-box, brain, 1 -2.0395
PYHIN1 pyrin and HIN domain family, member 1 -2.0363
IL2 interleukin 2 -2.0359
SLITRK3 SLIT and NTRK-like family, member 3 -2.0339
PARD6B par-6 family cell polarity regulator beta -2.03295
IL5 interleukin 5 -2.0324
UBC ubiquitin C -2.0315
SV2C synaptic vesicle glycoprotein 2C -2.0306
PANK2 pantothenate kinase 2 -2.0295
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 -2.0285
ANKMY2 ankyrin repeat and MYND domain containing 2 -2.0284
STMN3 stathmin-like 3 -2.0281
NCAM2 neural cell adhesion molecule 2 -2.0252
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -2.025
CCN5 cellular communication network factor 5 -2.0227
GPATCH1 G patch domain containing 1 -2.0166
SLBP stem-loop binding protein -2.0163
GPR22 G protein-coupled receptor 22 -2.0151
GDF10 growth differentiation factor 10 -2.0108
WBP2 WW domain binding protein 2 -2.0104
CAMK4 calcium/calmodulin-dependent protein kinase IV -2.0093
DEFA5 defensin, alpha 5, Paneth cell-specific -2.0072
ADRB1 adrenoceptor beta 1 -2.0057
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -2.00377
PLN phospholamban -2.00363
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) -2.00107
TIMP1 TIMP metallopeptidase inhibitor 1 -2.0007