CRCGN017_MCF10A.WT.HP_24H:P21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-(2-bromo-2-ethylbutanoyl)urea 11.02 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

73 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:P21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GARRE1 granule associated Rac and RHOG effector 1 6.915
PPP1R13B protein phosphatase 1, regulatory subunit 13B 6.7291
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 6.1133
ADRB2 adrenoceptor beta 2, surface 5.5406
UGDH UDP-glucose 6-dehydrogenase 4.8937
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 3.611
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa 2.888
THAP10 THAP domain containing 10 2.6785
HBB hemoglobin, beta 2.6003
DSCC1 DNA replication and sister chromatid cohesion 1 2.5452
LIN7B lin-7 homolog B (C. elegans) 2.5108
UPK3B uroplakin 3B 2.481
MYNN myoneurin 2.4005
COQ8A coenzyme Q8A 2.3408
PTK6 protein tyrosine kinase 6 2.3127
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1 2.2903
TGM3 transglutaminase 3 2.2847
H2AZ2 H2A.Z variant histone 2 2.27763
IPCEF1 interaction protein for cytohesin exchange factors 1 2.2538
CCP110 centriolar coiled coil protein 110kDa 2.2535
LOC128966597 MAL-like protein 2.243
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 2.2248
TENT5C terminal nucleotidyltransferase 5C 2.2063
ZNF14 zinc finger protein 14 2.2017
PEX13 peroxisomal biogenesis factor 13 2.1861
ZNF248 zinc finger protein 248 2.1732
VCPKMT valosin containing protein lysine (K) methyltransferase 2.1593
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2 2.138
CD226 CD226 molecule 2.1355
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 2.1156
BAHCC1 BAH domain and coiled-coil containing 1 2.1096
UBQLN2 ubiquilin 2 2.0908
BANK1 B-cell scaffold protein with ankyrin repeats 1 2.0901
TGM1 transglutaminase 1 2.0797
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.0747
HOXD1 homeobox D1 2.0659
EVPL envoplakin 2.0611
RECK reversion-inducing-cysteine-rich protein with kazal motifs 2.0573
SFTPD surfactant protein D 2.0556
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa 2.0329
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 2.0271
CXCR2 chemokine (C-X-C motif) receptor 2 2.0199
KLK13 kallikrein-related peptidase 13 2.01045
BDKRB1 bradykinin receptor B1 2.0058

decreased expression

Symbol Name Standardized Value
COG2 component of oligomeric golgi complex 2 -10.0
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -4.69615
AURKA aurora kinase A -4.0097
SNX7 sorting nexin 7 -2.8042
NCAPD2 non-SMC condensin I complex, subunit D2 -2.7539
BASP1 brain abundant, membrane attached signal protein 1 -2.7408
SEC16A SEC16 homolog A (S. cerevisiae) -2.5237
CBX6 chromobox homolog 6 -2.51825
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 -2.45983
TOMM34 translocase of outer mitochondrial membrane 34 -2.3933
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 -2.3159
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) -2.2937
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.2934
SLIT2 slit homolog 2 (Drosophila) -2.1782
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -2.1567
GMIP GEM interacting protein -2.1489
SF3B2 splicing factor 3b, subunit 2, 145kDa -2.127
HSPA1A heat shock 70kDa protein 1A -2.1245
CDK5RAP1 CDK5 regulatory subunit associated protein 1 -2.1237
MTMR11 myotubularin related protein 11 -2.11
KTN1 kinectin 1 (kinesin receptor) -2.1084
ADGRE5 adhesion G protein-coupled receptor E5 -2.0998
BCAR3 breast cancer anti-estrogen resistance 3 -2.0963
FTSJ3 FtsJ homolog 3 (E. coli) -2.0476
FSTL3 follistatin-like 3 (secreted glycoprotein) -2.0291
MTX1 metaxin 1 -2.0215
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 -2.0193
MAN2A1 mannosidase, alpha, class 2A, member 1 -2.0189
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -2.0005