| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | benzo[k]fluoranthene 100.99 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome) |
| Similar Terms | |
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164 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:P22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 4.18495 |
| E2F2 | E2F transcription factor 2 | 3.7953 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 3.465 |
| DCTN6 | dynactin 6 | 3.3652 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 3.218 |
| CSNK1A1 | casein kinase 1, alpha 1 | 2.9285 |
| HLA-DMB | major histocompatibility complex, class II, DM beta | 2.8119 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 2.7937 |
| LOC124906748 | beta-defensin 4A | 2.6457 |
| PUDP | pseudouridine 5'-phosphatase | 2.6041 |
| IL21 | interleukin 21 | 2.5776 |
| MAB21L4 | mab-21 like 4 | 2.5694 |
| FUBP3 | far upstream element (FUSE) binding protein 3 | 2.5542 |
| LRRC31 | leucine rich repeat containing 31 | 2.5423 |
| UBAP1 | ubiquitin associated protein 1 | 2.54035 |
| GSE1 | Gse1 coiled-coil protein | 2.4644 |
| LOC122539214 | Zinc finger protein LOC122539214 | 2.452 |
| CTSO | cathepsin O | 2.451 |
| ATP6V1B1 | ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 | 2.3951 |
| DAPK2 | death-associated protein kinase 2 | 2.38415 |
| SLC9A8 | solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 | 2.376 |
| FUT2 | fucosyltransferase 2 (secretor status included) | 2.36515 |
| PCBP4 | poly(rC) binding protein 4 | 2.3587 |
| CNKSR3 | CNKSR family member 3 | 2.3517 |
| ZNF587 | zinc finger protein 587 | 2.3465 |
| KRT75 | keratin 75, type II | 2.3254 |
| MTMR6 | myotubularin related protein 6 | 2.2942 |
| ZMYM2 | zinc finger, MYM-type 2 | 2.28513 |
| PTEN | phosphatase and tensin homolog | 2.27655 |
| OR7C2 | olfactory receptor, family 7, subfamily C, member 2 | 2.2736 |
| CELSR2 | cadherin, EGF LAG seven-pass G-type receptor 2 | 2.2644 |
| BCKDHA | branched chain keto acid dehydrogenase E1, alpha polypeptide | 2.2537 |
| ASPA | aspartoacylase | 2.2505 |
| PTBP2 | polypyrimidine tract binding protein 2 | 2.223 |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | 2.2159 |
| GJB1 | gap junction protein, beta 1, 32kDa | 2.2155 |
| PDE1A | phosphodiesterase 1A, calmodulin-dependent | 2.2148 |
| CD40LG | CD40 ligand | 2.2037 |
| RSPH10B2 | radial spoke head 10 homolog B2 (Chlamydomonas) | 2.1972 |
| HAL | histidine ammonia-lyase | 2.19615 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 | 2.19485 |
| LOC127933115 | uncharacterized LOC127933115 | 2.1918 |
| CCDC7 | coiled-coil domain containing 7 | 2.1909 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 2.18857 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 | 2.1792 |
| TMEM14B | transmembrane protein 14B | 2.1721 |
| TVP23B | trans-golgi network vesicle protein 23 homolog B (S. cerevisiae) | 2.1592 |
| MED24 | mediator complex subunit 24 | 2.158 |
| LDHC | lactate dehydrogenase C | 2.1547 |
| LXN | latexin | 2.1523 |
| CHUK | conserved helix-loop-helix ubiquitous kinase | 2.1482 |
| CALML4 | calmodulin-like 4 | 2.1446 |
| F2R | coagulation factor II (thrombin) receptor | 2.1343 |
| B3GAT1 | beta-1,3-glucuronyltransferase 1 | 2.1231 |
| PI3 | peptidase inhibitor 3, skin-derived | 2.1226 |
| CXXC4 | CXXC finger protein 4 | 2.1181 |
| PAM16 | presequence translocase-associated motor 16 homolog (S. cerevisiae) | 2.1137 |
| MREG | melanoregulin | 2.1135 |
| CDHR1 | cadherin-related family member 1 | 2.0953 |
| NME3 | NME/NM23 nucleoside diphosphate kinase 3 | 2.0808 |
| TMPRSS5 | transmembrane protease, serine 5 | 2.077 |
| RNF39 | ring finger protein 39 | 2.0756 |
| NKAIN1 | Na+/K+ transporting ATPase interacting 1 | 2.0712 |
| EREG | epiregulin | 2.07 |
| ZBTB35 | zinc finger and BTB domain containing 35 | 2.06535 |
| GSTA3 | glutathione S-transferase alpha 3 | 2.063 |
| MKS1 | Meckel syndrome, type 1 | 2.0606 |
| PLPPR1 | phospholipid phosphatase related 1 | 2.0601 |
| GRB14 | growth factor receptor-bound protein 14 | 2.0572 |
| IPO13 | importin 13 | 2.0567 |
| TRAPPC10 | trafficking protein particle complex 10 | 2.05365 |
| URM1 | ubiquitin related modifier 1 | 2.05 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 2.0444 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 2.0369 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | 2.0357 |
| FRMD4A | FERM domain containing 4A | 2.03365 |
| PBLD | phenazine biosynthesis-like protein domain containing | 2.033 |
| PARG | poly (ADP-ribose) glycohydrolase | 2.0271 |
| MUC1 | mucin 1, cell surface associated | 2.02703 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 2.02597 |
| ERLIN2 | ER lipid raft associated 2 | 2.0205 |
| CYTIP | cytohesin 1 interacting protein | 2.0176 |
| SLC16A6 | solute carrier family 16, member 6 | 2.0148 |
| KRT1 | keratin 1, type II | 2.0145 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | 2.0113 |
| SHBG | sex hormone-binding globulin | 2.003 |
| USP6 | ubiquitin specific peptidase 6 | 2.0002 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DNM1L | dynamin 1-like | -10.0 |
| BAG3 | BCL2-associated athanogene 3 | -10.0 |
| YARS2 | tyrosyl-tRNA synthetase 2, mitochondrial | -8.8059 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | -7.56145 |
| ACAA1 | acetyl-CoA acyltransferase 1 | -5.0457 |
| CAPRIN2 | caprin family member 2 | -5.0298 |
| MED21 | mediator complex subunit 21 | -4.88425 |
| COPS7A | COP9 signalosome subunit 7A | -4.8789 |
| INTS13 | integrator complex subunit 13 | -4.0381 |
| THAP11 | THAP domain containing 11 | -3.801 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -3.32995 |
| IPO8 | importin 8 | -3.0782 |
| RESF1 | retroelement silencing factor 1 | -3.07 |
| MLF2 | myeloid leukemia factor 2 | -3.0457 |
| RNF34 | ring finger protein 34, E3 ubiquitin protein ligase | -3.0353 |
| UQCR10 | ubiquinol-cytochrome c reductase, complex III subunit X | -3.0042 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | -2.9942 |
| ERGIC2 | ERGIC and golgi 2 | -2.9188 |
| RPS5 | ribosomal protein S5 | -2.7832 |
| NOP2 | NOP2 nucleolar protein | -2.7521 |
| TSR2 | TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) | -2.7075 |
| ASCC2 | activating signal cointegrator 1 complex subunit 2 | -2.6541 |
| DDX47 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 | -2.6523 |
| SINHCAF | SIN3-HDAC complex associated factor | -2.6398 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -2.6132 |
| PPM1G | protein phosphatase, Mg2+/Mn2+ dependent, 1G | -2.5592 |
| ATP6V1E1 | ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 | -2.5364 |
| SNX7 | sorting nexin 7 | -2.5196 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -2.5058 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | -2.4887 |
| CEP83 | centrosomal protein 83kDa | -2.4773 |
| TOMM34 | translocase of outer mitochondrial membrane 34 | -2.4645 |
| WRAP73 | WD repeat containing, antisense to TP73 | -2.4179 |
| RPAP3 | RNA polymerase II associated protein 3 | -2.4005 |
| PLTP | phospholipid transfer protein | -2.3507 |
| PISD | phosphatidylserine decarboxylase | -2.3451 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | -2.3443 |
| PJA1 | praja ring finger 1, E3 ubiquitin protein ligase | -2.3399 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -2.3322 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | -2.2966 |
| CGB8 | chorionic gonadotropin, beta polypeptide 8 | -2.2928 |
| TULP3 | tubby like protein 3 | -2.2866 |
| ZNF384 | zinc finger protein 384 | -2.2754 |
| AMDHD2 | amidohydrolase domain containing 2 | -2.2542 |
| UXS1 | UDP-glucuronate decarboxylase 1 | -2.2329 |
| NUP43 | nucleoporin 43kDa | -2.2252 |
| CCDC91 | coiled-coil domain containing 91 | -2.1943 |
| PGM3 | phosphoglucomutase 3 | -2.18345 |
| GPHRA | golgi pH regulator A | -2.1793 |
| DDOST | dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) | -2.16965 |
| EFNA3 | ephrin-A3 | -2.1634 |
| RIOK2 | RIO kinase 2 | -2.1555 |
| NARS1 | asparaginyl-tRNA synthetase 1 | -2.1363 |
| TGFBR3 | transforming growth factor, beta receptor III | -2.1276 |
| PKP2 | plakophilin 2 | -2.12495 |
| SAE1 | SUMO1 activating enzyme subunit 1 | -2.1247 |
| BAHCC1 | BAH domain and coiled-coil containing 1 | -2.1032 |
| ZNF84 | zinc finger protein 84 | -2.1012 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | -2.0971 |
| PDCD5 | programmed cell death 5 | -2.0823 |
| GORASP1 | golgi reassembly stacking protein 1, 65kDa | -2.0801 |
| TWSG1 | twisted gastrulation BMP signaling modulator 1 | -2.0792 |
| DCP2 | decapping mRNA 2 | -2.0789 |
| LPCAT3 | lysophosphatidylcholine acyltransferase 3 | -2.074 |
| AKIP1 | A kinase (PRKA) interacting protein 1 | -2.0712 |
| RFXAP | regulatory factor X-associated protein | -2.0578 |
| SNX2 | sorting nexin 2 | -2.0563 |
| SRFBP1 | serum response factor binding protein 1 | -2.0555 |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | -2.0443 |
| SYNGR3 | synaptogyrin 3 | -2.0275 |
| ADGRA3 | adhesion G protein-coupled receptor A3 | -2.0156 |
| M6PR | mannose-6-phosphate receptor (cation dependent) | -2.0149 |
| WDR19 | WD repeat domain 19 | -2.0147 |
| LTA4H | leukotriene A4 hydrolase | -2.0114 |
| STK38L | serine/threonine kinase 38 like | -2.00635 |
| PCID2 | PCI domain containing 2 | -2.0049 |
| CMAS | cytidine monophosphate N-acetylneuraminic acid synthetase | -2.0032 |
