CREBBP Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description CREB binding protein|This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009] (NCBI Entrez Gene Database, 1387)
External Link http://www.ncbi.nlm.nih.gov/gene/1387
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Genes

440 interacting proteins for CREBBP from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ACVR1 activin A receptor, type I
AIRE autoimmune regulator
AKAP11 A kinase (PRKA) anchor protein 11
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALX1 ALX homeobox 1
ANAPC2 anaphase promoting complex subunit 2
ANAPC5 anaphase promoting complex subunit 5
ANAPC7 anaphase promoting complex subunit 7
AP1B1 adaptor-related protein complex 1, beta 1 subunit
APC adenomatous polyposis coli
AR androgen receptor
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATAD3B ATPase family, AAA domain containing 3B
ATF1 activating transcription factor 1
ATF2 activating transcription factor 2
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATG3 autophagy related 3
ATXN3 ataxin 3
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
BMI1 BMI1 proto-oncogene, polycomb ring finger
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BRCA1 breast cancer 1, early onset
CALCOCO1 calcium binding and coiled-coil domain 1
CAMK4 calcium/calmodulin-dependent protein kinase IV
CARM1 coactivator-associated arginine methyltransferase 1
CCDC8 coiled-coil domain containing 8
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CCNC cyclin C
CCND1 cyclin D1
CCNE1 cyclin E1
CCNE2 cyclin E2
CCNJ cyclin J
CDC16 cell division cycle 16
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDC27 cell division cycle 27
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK13 cyclin-dependent kinase 13
CDK2 cyclin-dependent kinase 2
CDK3 cyclin-dependent kinase 3
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDK7 cyclin-dependent kinase 7
CDK8 cyclin-dependent kinase 8
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDT1 chromatin licensing and DNA replication factor 1
CDX2 caudal type homeobox 2
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CENPJ centromere protein J
CHUK conserved helix-loop-helix ubiquitous kinase
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CITED4 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CNOT3 CCR4-NOT transcription complex, subunit 3
CNTN2 contactin 2 (axonal)
COPS2 COP9 signalosome subunit 2
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa
CREB1 cAMP responsive element binding protein 1
CREM cAMP responsive element modulator
CRTC2 CREB regulated transcription coactivator 2
CRX cone-rod homeobox
CSK c-src tyrosine kinase
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTBP1 C-terminal binding protein 1
CTBP2 C-terminal binding protein 2
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUX1 cut-like homeobox 1
DACH1 dachshund family transcription factor 1
DAXX death-domain associated protein
DCAF7 DDB1 and CUL4 associated factor 7
DCP1A decapping mRNA 1A
DDB1 damage-specific DNA binding protein 1, 127kDa
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DEK DEK proto-oncogene
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DYNLL1 dynein, light chain, LC8-type 1
DYNLL2 dynein, light chain, LC8-type 2
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
E2F1 E2F transcription factor 1
E2F3 E2F transcription factor 3
E2F5 E2F transcription factor 5, p130-binding
EBF1 early B-cell factor 1
EGR1 early growth response 1
EID1 EP300 interacting inhibitor of differentiation 1
EID3 EP300 interacting inhibitor of differentiation 3
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
ELAVL1 ELAV like RNA binding protein 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ELK1 ELK1, member of ETS oncogene family
ENAH enabled homolog (Drosophila)
EP300 E1A binding protein p300
EP400 E1A binding protein p400
EPAS1 endothelial PAS domain protein 1
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EWSR1 EWS RNA-binding protein 1
FAM117A family with sequence similarity 117, member A
FAM117B family with sequence similarity 117, member B
FAM53C family with sequence similarity 53, member C
FGFR1 fibroblast growth factor receptor 1
FHL2 four and a half LIM domains 2
FNTA farnesyltransferase, CAAX box, alpha
FNTB farnesyltransferase, CAAX box, beta
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXH1 forkhead box H1
FOXK1 forkhead box K1
FOXM1 forkhead box M1
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FOXO4 forkhead box O4
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GAK cyclin G associated kinase
GATA1 GATA binding protein 1 (globin transcription factor 1)
GATA2 GATA binding protein 2
GCM1 glial cells missing homolog 1 (Drosophila)
GLCCI1 glucocorticoid induced 1
GLI3 GLI family zinc finger 3
GMEB1 glucocorticoid modulatory element binding protein 1
GMEB2 glucocorticoid modulatory element binding protein 2
GMNN geminin, DNA replication inhibitor
GOLGA2 golgin A2
GRIP1 glutamate receptor interacting protein 1
GTF2B general transcription factor IIB
H3F3A H3 histone, family 3A
HBP1 HMG-box transcription factor 1
HCK HCK proto-oncogene, Src family tyrosine kinase
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC3 histone deacetylase 3
HES6 hes family bHLH transcription factor 6
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIPK2 homeodomain interacting protein kinase 2
HIST1H1E histone cluster 1, H1e
HIST1H2BA histone cluster 1, H2ba
HIST1H2BB histone cluster 1, H2bb
HIST1H2BD histone cluster 1, H2bd
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BJ histone cluster 1, H2bj
HIST1H2BK histone cluster 1, H2bk
HIST1H2BL histone cluster 1, H2bl
HIST1H2BM histone cluster 1, H2bm
HIST1H2BN histone cluster 1, H2bn
HIST1H2BO histone cluster 1, H2bo
HIST1H3B histone cluster 1, H3b
HIST1H4F histone cluster 1, H4f
HIST2H2BE histone cluster 2, H2be
HIST2H2BF histone cluster 2, H2bf
HIST2H3A histone cluster 2, H3a
HIST3H2BB histone cluster 3, H2bb
HIST3H3 histone cluster 3, H3
HLF hepatic leukemia factor
HMGA1 high mobility group AT-hook 1
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HNF1A HNF1 homeobox A
HNF1B HNF1 homeobox B
HNF4A hepatocyte nuclear factor 4, alpha
HOXA10 homeobox A10
HOXA11 homeobox A11
HOXA9 homeobox A9
HOXB1 homeobox B1
HOXB2 homeobox B2
HOXB3 homeobox B3
HOXB4 homeobox B4
HOXB6 homeobox B6
HOXB7 homeobox B7
HOXB9 homeobox B9
HOXD10 homeobox D10
HOXD12 homeobox D12
HOXD13 homeobox D13
HOXD4 homeobox D4
HSF1 heat shock transcription factor 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1B heat shock 70kDa protein 1B
HSPA1L heat shock 70kDa protein 1-like
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
HTT huntingtin
IFNAR2 interferon (alpha, beta and omega) receptor 2
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ING1 inhibitor of growth family, member 1
IRF1 interferon regulatory factor 1
IRF3 interferon regulatory factor 3
IRF5 interferon regulatory factor 5
IRF7 interferon regulatory factor 7
IRF9 interferon regulatory factor 9
ITPK1 inositol-tetrakisphosphate 1-kinase
JDP2 Jun dimerization protein 2
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KAT2A K(lysine) acetyltransferase 2A
KAT2B K(lysine) acetyltransferase 2B
KAT5 K(lysine) acetyltransferase 5
KAT6A K(lysine) acetyltransferase 6A
KAT8 K(lysine) acetyltransferase 8
KDM3B lysine (K)-specific demethylase 3B
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIAA0232 KIAA0232
KLF1 Kruppel-like factor 1 (erythroid)
KLF13 Kruppel-like factor 13
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF8 Kruppel-like factor 8
KMT2A lysine (K)-specific methyltransferase 2A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KPNA6 karyopherin alpha 6 (importin alpha 7)
LDLR low density lipoprotein receptor
LIG4 ligase IV, DNA, ATP-dependent
LYN LYN proto-oncogene, Src family tyrosine kinase
LZTS2 leucine zipper, putative tumor suppressor 2
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K
MAML1 mastermind-like 1 (Drosophila)
MAML2 mastermind-like 2 (Drosophila)
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK10 mitogen-activated protein kinase 10
MAPK14 mitogen-activated protein kinase 14
MAPK15 mitogen-activated protein kinase 15
MAVS mitochondrial antiviral signaling protein
MBD2 methyl-CpG binding domain protein 2
MDC1 mediator of DNA-damage checkpoint 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MECOM MDS1 and EVI1 complex locus
MED1 mediator complex subunit 1
MED15 mediator complex subunit 15
MED21 mediator complex subunit 21
MED24 mediator complex subunit 24
MED25 mediator complex subunit 25
MED6 mediator complex subunit 6
MEIS1 Meis homeobox 1
MGMT O-6-methylguanine-DNA methyltransferase
MIER1 mesoderm induction early response 1, transcriptional regulator
MKNK1 MAP kinase interacting serine/threonine kinase 1
MNAT1 MNAT CDK-activating kinase assembly factor 1
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MSL3 male-specific lethal 3 homolog (Drosophila)
MSX1 msh homeobox 1
MTDH metadherin
MTF1 metal-regulatory transcription factor 1
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH9 myosin, heavy chain 9, non-muscle
MYOD1 myogenic differentiation 1
N4BP2 NEDD4 binding protein 2
NAP1L1 nucleosome assembly protein 1-like 1
NCOA1 nuclear receptor coactivator 1
NCOA2 nuclear receptor coactivator 2
NCOA3 nuclear receptor coactivator 3
NCOA6 nuclear receptor coactivator 6
NCOR1 nuclear receptor corepressor 1
NCOR2 nuclear receptor corepressor 2
NEUROG1 neurogenin 1
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NFE2 nuclear factor, erythroid 2
NFE2L2 nuclear factor, erythroid 2-like 2
NFIA nuclear factor I/A
NFIC nuclear factor I/C (CCAAT-binding transcription factor)
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFYB nuclear transcription factor Y, beta
NKX2-1 NK2 homeobox 1
NLK nemo-like kinase
NMI N-myc (and STAT) interactor
NOTCH1 notch 1
NPAS2 neuronal PAS domain protein 2
NPAT nuclear protein, ataxia-telangiectasia locus
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR5A1 nuclear receptor subfamily 5, group A, member 1
NUP98 nucleoporin 98kDa
ONECUT1 one cut homeobox 1
PAPOLA poly(A) polymerase alpha
PARP1 poly (ADP-ribose) polymerase 1
PAX5 paired box 5
PBX1 pre-B-cell leukemia homeobox 1
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PELP1 proline, glutamate and leucine rich protein 1
PHOX2A paired-like homeobox 2a
PIAS1 protein inhibitor of activated STAT, 1
PIAS3 protein inhibitor of activated STAT, 3
PLAGL1 pleiomorphic adenoma gene-like 1
PML promyelocytic leukemia
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
POT1 protection of telomeres 1
POU1F1 POU class 1 homeobox 1
POU2F3 POU class 2 homeobox 3
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP1R3F protein phosphatase 1, regulatory subunit 3F
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKCD protein kinase C, delta
PRLR prolactin receptor
PROX1 prospero homeobox 1
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PTGES3 prostaglandin E synthase 3 (cytosolic)
PTMA prothymosin, alpha
PTMS parathymosin
PTOV1 prostate tumor overexpressed 1
PYGO2 pygopus family PHD finger 2
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAD23A RAD23 homolog A (S. cerevisiae)
RARA retinoic acid receptor, alpha
RB1 retinoblastoma 1
RBBP4 retinoblastoma binding protein 4
RBBP7 retinoblastoma binding protein 7
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RBL1 retinoblastoma-like 1
RBL2 retinoblastoma-like 2
RECQL RecQ helicase-like
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RNF169 ring finger protein 169
RPA2 replication protein A2, 32kDa
RPS27A ribosomal protein S27a
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RUNX1 runt-related transcription factor 1
RUNX2 runt-related transcription factor 2
RUVBL1 RuvB-like AAA ATPase 1
RXRA retinoid X receptor, alpha
RXRG retinoid X receptor, gamma
SERTAD1 SERTA domain containing 1
SERTAD2 SERTA domain containing 2
SERTAD3 SERTA domain containing 3
SETD1A SET domain containing 1A
SH3GL1 SH3-domain GRB2-like 1
SIPA1L1 signal-induced proliferation-associated 1 like 1
SIPA1L2 signal-induced proliferation-associated 1 like 2
SIPA1L3 signal-induced proliferation-associated 1 like 3
SIRT1 sirtuin 1
SKI SKI proto-oncogene
SKP1 S-phase kinase-associated protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
SND1 staphylococcal nuclease and tudor domain containing 1
SNIP1 Smad nuclear interacting protein 1
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SP1 Sp1 transcription factor
SP3 Sp3 transcription factor
SPI1 Spi-1 proto-oncogene
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRCAP Snf2-related CREBBP activator protein
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
SRF serum response factor (c-fos serum response element-binding transcription factor)
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC2 transforming, acidic coiled-coil containing protein 2
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TBK1 TANK-binding kinase 1
TBP TATA box binding protein
TBX21 T-box 21
TCF12 transcription factor 12
TCF3 transcription factor 3
TCOF1 Treacher Collins-Franceschetti syndrome 1
TDG thymine-DNA glycosylase
TECR trans-2,3-enoyl-CoA reductase
TFF1 trefoil factor 1
TGS1 trimethylguanosine synthase 1
THRA thyroid hormone receptor, alpha
TLR2 toll-like receptor 2
TP53 tumor protein p53
TP53RK TP53 regulating kinase
TP73 tumor protein p73
TRERF1 transcriptional regulating factor 1
TRIM21 tripartite motif containing 21
TRIM28 tripartite motif containing 28
TRIP10 thyroid hormone receptor interactor 10
TRIP4 thyroid hormone receptor interactor 4
TROAP trophinin associated protein
UBC ubiquitin C
UBTF upstream binding transcription factor, RNA polymerase I
USP11 ubiquitin specific peptidase 11
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WDR5 WD repeat domain 5
WDR6 WD repeat domain 6
WRB tryptophan rich basic protein
WRN Werner syndrome, RecQ helicase-like
WT1 Wilms tumor 1
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YY1 YY1 transcription factor
ZBTB17 zinc finger and BTB domain containing 17
ZBTB2 zinc finger and BTB domain containing 2
ZCCHC12 zinc finger, CCHC domain containing 12
ZNF516 zinc finger protein 516
ZNF639 zinc finger protein 639