CREM Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description cAMP responsive element modulator|This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1390)
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Genes

293 genes differentially expressed following the CREM gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
HIGD1C HIG1 hypoxia inducible domain family, member 1C 3.28156
SSTR3 somatostatin receptor 3 3.28156
ASB12 ankyrin repeat and SOCS box containing 12 3.28156
SIGLEC7 sialic acid binding Ig-like lectin 7 3.28156
OLIG1 oligodendrocyte transcription factor 1 3.28156
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 3.28156
PAX5 paired box 5 3.28156
OR2J2 olfactory receptor, family 2, subfamily J, member 2 3.28156
CXORF65 chromosome X open reading frame 65 3.28156
OSR2 odd-skipped related transciption factor 2 3.28156
NCF1 neutrophil cytosolic factor 1 3.28156
CELA3B chymotrypsin-like elastase family, member 3B 3.28156
ANKRD22 ankyrin repeat domain 22 3.28156
IGFL2 IGF-like family member 2 3.28156
CTRC chymotrypsin C (caldecrin) 3.28156
FAM180B family with sequence similarity 180, member B 3.28156
MAP3K7CL MAP3K7 C-terminal like 3.28156
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 3.28156
FCRL5 Fc receptor-like 5 3.28156
MYOM3 myomesin 3 3.28156
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 3.28156
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 3.28156
SNAI2 snail family zinc finger 2 3.28156
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 3.28156
IL23R interleukin 23 receptor 3.28156
RNASE9 ribonuclease, RNase A family, 9 (non-active) 3.28156
IL18R1 interleukin 18 receptor 1 3.28156
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 3.28156
CPLX4 complexin 4 3.28156
LGALS2 lectin, galactoside-binding, soluble, 2 3.28156
ATOH1 atonal homolog 1 (Drosophila) 3.28156
MMP20 matrix metallopeptidase 20 3.28156
PNMA5 paraneoplastic Ma antigen family member 5 3.28156
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 3.28156
OC90 otoconin 90 3.28156
CELA1 chymotrypsin-like elastase family, member 1 3.28156
PSCA prostate stem cell antigen 3.28156
NCKAP1L NCK-associated protein 1-like 3.28156
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 3.28156
CD6 CD6 molecule 3.28156
GJA3 gap junction protein, alpha 3, 46kDa 3.28156
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 3.28156
GPR33 G protein-coupled receptor 33 (gene/pseudogene) 3.28156
AVPR1A arginine vasopressin receptor 1A 3.28156
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 3.28156
STING1 stimulator of interferon response cGAMP interactor 1 3.28156
STYXL2 serine/threonine/tyrosine interacting like 2 3.28156
VSIR V-set immunoregulatory receptor 3.28156
H2AP H2A.P histone 3.28156
ODAPH odontogenesis associated phosphoprotein 3.28156
H1-8 H1.8 linker histone 3.28156
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 3.28156
CIMAP1B ciliary microtubule associated protein 1B 3.28156
CIMAP1C ciliary microtubule associated protein 1C 3.28156
EXOC1L exocyst complex component 1 like 3.28156
PRR20G proline rich 20G 3.28156
CIMIP2C ciliary microtubule inner protein 2C 3.28156
CIMIP2A ciliary microtubule inner protein 2A 3.28156
TMPRSS3 transmembrane protease, serine 3 3.28156
SAG S-antigen; retina and pineal gland (arrestin) 3.28156
ASB4 ankyrin repeat and SOCS box containing 4 3.28156
NRN1 neuritin 1 3.28156
OR2A1 olfactory receptor, family 2, subfamily A, member 1 3.28156
PCDHA2 protocadherin alpha 2 3.28156
TRIM60 tripartite motif containing 60 3.28156
CD48 CD48 molecule 3.28156
CATSPER1 cation channel, sperm associated 1 3.28156
SLC22A25 solute carrier family 22, member 25 3.28156
GDF10 growth differentiation factor 10 3.28156
BARX2 BARX homeobox 2 3.28156
PGLYRP2 peptidoglycan recognition protein 2 3.28156
PLEK2 pleckstrin 2 3.28156
GPR88 G protein-coupled receptor 88 3.28156
GATA6 GATA binding protein 6 3.28156
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 3.28156
MAGIX MAGI family member, X-linked 3.28156
GRAP GRB2-related adaptor protein 3.28156
SRPK3 SRSF protein kinase 3 3.28156
OR56B2 olfactory receptor family 56 subfamily B member 2 3.28156
KLF4 Kruppel-like factor 4 (gut) 3.28156
SMYD1 SET and MYND domain containing 1 3.28156
CIDEA cell death-inducing DFFA-like effector a 3.28156
IL12A interleukin 12A 3.28156
FIGLA folliculogenesis specific basic helix-loop-helix 3.28156
SLFN12L schlafen family member 12-like 3.28156
TRIM22 tripartite motif containing 22 3.28156
GPR119 G protein-coupled receptor 119 3.28156
MUC15 mucin 15, cell surface associated 3.28156
ALOX5AP arachidonate 5-lipoxygenase-activating protein 3.28156
PRPH peripherin 3.28156
LPAR5 lysophosphatidic acid receptor 5 3.28156
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 3.28156
ESAM endothelial cell adhesion molecule 3.28156
WFDC6 WAP four-disulfide core domain 6 3.28156
DGCR6 DiGeorge syndrome critical region gene 6 3.28156
CERKL ceramide kinase-like 3.28156
C18ORF63 chromosome 18 open reading frame 63 3.28156
AKNAD1 AKNA domain containing 1 3.28156
OR56A4 olfactory receptor, family 56, subfamily A, member 4 3.28156
NOG noggin 3.28156
KLHL41 kelch-like family member 41 3.28156
MEFV Mediterranean fever 3.28156
CLIC3 chloride intracellular channel 3 3.28156
TREH trehalase (brush-border membrane glycoprotein) 3.28156
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 3.28156
CGB7 chorionic gonadotropin, beta polypeptide 7 3.28156
PLGLB2 plasminogen-like B2 3.28156
TPPP2 tubulin polymerization-promoting protein family member 2 3.28156
LST1 leukocyte specific transcript 1 3.28156
ART1 ADP-ribosyltransferase 1 3.28156
TEX38 testis expressed 38 3.28156
IFNE interferon, epsilon 3.28156
STRC stereocilin 3.28156
ANGPTL3 angiopoietin-like 3 3.28156
AREG amphiregulin 3.28156
WNK4 WNK lysine deficient protein kinase 4 3.28156
MNX1 motor neuron and pancreas homeobox 1 3.28156
PLA2G1B phospholipase A2, group IB (pancreas) 3.28156
NPC1L1 NPC1-like 1 3.28156
GJC2 gap junction protein, gamma 2, 47kDa 3.28156
TTC24 tetratricopeptide repeat domain 24 3.28156
CTSW cathepsin W 3.28156
CLCA1 chloride channel accessory 1 3.28156
MT1M metallothionein 1M 3.28156
GSTA1 glutathione S-transferase alpha 1 3.28156
CETP cholesteryl ester transfer protein, plasma 3.28156
DCN decorin 3.28156
GRAP2 GRB2-related adaptor protein 2 3.28156
NKX6-1 NK6 homeobox 1 3.28156
ABLIM3 actin binding LIM protein family, member 3 3.28156
KRT39 keratin 39, type I 3.28156
CD22 CD22 molecule 3.28156
OR2A5 olfactory receptor, family 2, subfamily A, member 5 3.22733
SHOX short stature homeobox 3.22733
ZNF281 zinc finger protein 281 3.0158
SCX scleraxis basic helix-loop-helix transcription factor 2.86729
CDKL4 cyclin-dependent kinase-like 4 2.72825
TERF2IP telomeric repeat binding factor 2, interacting protein 2.71579
RBPMS RNA binding protein with multiple splicing 2.60479
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7 2.55656
ZNF135 zinc finger protein 135 2.52105
SCD stearoyl-CoA desaturase (delta-9-desaturase) 2.48243
ZFP36L1 ZFP36 ring finger protein-like 1 2.41443
DNAH11 dynein, axonemal, heavy chain 11 2.40878
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.39688
DPRX divergent-paired related homeobox 2.39688
PEMT phosphatidylethanolamine N-methyltransferase 2.39688
WBP2NL WBP2 N-terminal like 2.37907
RFX5 regulatory factor X, 5 (influences HLA class II expression) 2.3747
TPRG1 tumor protein p63 regulated 1 2.32649
MYSM1 Myb-like, SWIRM and MPN domains 1 2.32649
C17ORF99 chromosome 17 open reading frame 99 2.31289
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 2.29365
AGFG1 ArfGAP with FG repeats 1 2.26112
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2.25696
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 2.25163
LRRC41 leucine rich repeat containing 41 2.25075
ADGRG6 adhesion G protein-coupled receptor G6 2.25075
PLET1 placenta expressed transcript 1 2.24929
FOXN4 forkhead box N4 2.24929
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 2.24929
ARL5C ADP-ribosylation factor-like 5C 2.24929
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.24929
PRDM6 PR domain containing 6 2.24929
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) 2.24929
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 2.2374
TSPYL2 TSPY-like 2 2.2374
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.2237
NUDCD3 NudC domain containing 3 2.21943
PCSK6 proprotein convertase subtilisin/kexin type 6 2.21943
BAIAP2L1 BAI1-associated protein 2-like 1 2.1863
ATOH7 atonal homolog 7 (Drosophila) 2.17316
SIK3 SIK family kinase 3 2.16814
ZHX3 zinc fingers and homeoboxes 3 2.16814
CLEC2L C-type lectin domain family 2, member L 2.16388
TFB1M transcription factor B1, mitochondrial 2.1597
ZNF580 zinc finger protein 580 2.13458
PCDH10 protocadherin 10 2.11603
MTERF4 mitochondrial transcription termination factor 4 2.10454
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.08854
C1ORF87 chromosome 1 open reading frame 87 2.07587
RAP1GAP RAP1 GTPase activating protein 2.07365
DCP1A decapping mRNA 1A 2.07151
AKAP6 A kinase (PRKA) anchor protein 6 2.06854
SP8 Sp8 transcription factor 2.04851
CSNK1G1 casein kinase 1, gamma 1 2.04851
FAM20A family with sequence similarity 20, member A 2.04375
ADCY8 adenylate cyclase 8 (brain) 2.04375
WAPL WAPL cohesin release factor 2.04375
KRABD4 KRAB domain containing 4 2.04375
DIXDC1 DIX domain containing 1 2.03872
PDLIM5 PDZ and LIM domain 5 2.03743
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 2.03743
LIPT2 lipoyl(octanoyl) transferase 2 (putative) 2.02812
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 2.02028
BTK Bruton agammaglobulinemia tyrosine kinase 2.00299

decreased expression

Symbol Name Standardized Value
PNMA6F PNMA family member 6F -3.28156
DQX1 DEAQ box RNA-dependent ATPase 1 -3.28156
SLC51B solute carrier family 51, beta subunit -3.28156
TMPRSS15 transmembrane protease, serine 15 -3.28156
ZNF404 zinc finger protein 404 -3.28156
OXER1 oxoeicosanoid (OXE) receptor 1 -3.28156
VPREB3 pre-B lymphocyte 3 -3.28156
EXOC3 exocyst complex component 3 -3.28156
ZNF575 zinc finger protein 575 -3.28156
ACVRL1 activin A receptor type II-like 1 -3.28156
SLC25A45 solute carrier family 25, member 45 -3.28156
PDYN prodynorphin -3.28156
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) -3.28156
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 -3.28156
SPATA31G1 SPATA31 subfamily G member 1 -3.28156
HHEX hematopoietically expressed homeobox -3.28156
ACTL10 actin-like 10 -3.28156
LOC124902436 talanin -3.28156
BTNL2 butyrophilin-like 2 -3.28156
SPATA9 spermatogenesis associated 9 -3.28156
SPEF2 sperm flagellar 2 -3.28156
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B -3.28156
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) -3.28156
FNDC1 fibronectin type III domain containing 1 -3.28156
KCTD12 potassium channel tetramerization domain containing 12 -3.28156
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 -3.28156
C1ORF105 chromosome 1 open reading frame 105 -3.28156
TDRD10 tudor domain containing 10 -3.28156
PARP4 poly (ADP-ribose) polymerase family, member 4 -3.24579
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) -3.23252
IL15RA interleukin 15 receptor, alpha -3.2225
IFI27L2 interferon, alpha-inducible protein 27-like 2 -3.01102
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.9908
ADSL adenylosuccinate lyase -2.92727
TPR translocated promoter region, nuclear basket protein -2.84637
ELFN1 extracellular leucine-rich repeat and fibronectin type III domain containing 1 -2.78075
MED4 mediator complex subunit 4 -2.77271
RHOF ras homolog family member F (in filopodia) -2.67945
ZNF561 zinc finger protein 561 -2.62352
VAMP5 vesicle-associated membrane protein 5 -2.46157
FUNDC1 FUN14 domain containing 1 -2.46157
NBEA neurobeachin -2.44939
KEL Kell blood group, metallo-endopeptidase -2.44259
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 -2.40711
CANT1 calcium activated nucleotidase 1 -2.39688
EGFL7 EGF-like-domain, multiple 7 -2.3895
CD300A CD300a molecule -2.32649
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) -2.32649
DUOX1 dual oxidase 1 -2.32054
INSM1 insulinoma-associated 1 -2.28653
RPP21 ribonuclease P/MRP 21kDa subunit -2.28653
ZNF892 zinc finger protein 892 -2.28653
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) -2.28653
SREK1IP1 SREK1-interacting protein 1 -2.28637
TCFL5 transcription factor-like 5 (basic helix-loop-helix) -2.27854
ZMAT1 zinc finger, matrin-type 1 -2.26567
SWT1 SWT1 RNA endoribonuclease homolog (S. cerevisiae) -2.26567
RHEB Ras homolog enriched in brain -2.26567
FRMD1 FERM domain containing 1 -2.25316
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 -2.25133
APELA apelin receptor early endogenous ligand -2.24929
C11ORF42 chromosome 11 open reading frame 42 -2.24319
CARD14 caspase recruitment domain family, member 14 -2.24319
CCDC170 coiled-coil domain containing 170 -2.24319
TRPA1 transient receptor potential cation channel, subfamily A, member 1 -2.24319
ZWILCH zwilch kinetochore protein -2.2374
RASGEF1A RasGEF domain family, member 1A -2.23451
WDR62 WD repeat domain 62 -2.2237
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta -2.22153
UBLCP1 ubiquitin-like domain containing CTD phosphatase 1 -2.21943
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -2.21939
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -2.20286
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa -2.19404
HMGN3 high mobility group nucleosomal binding domain 3 -2.16814
SCRG1 stimulator of chondrogenesis 1 -2.1597
NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) -2.12352
PFN1 profilin 1 -2.1232
ITSN2 intersectin 2 -2.10454
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) -2.07587
GIGYF2 GRB10 interacting GYF protein 2 -2.07194
RPL36 ribosomal protein L36 -2.06854
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) -2.04851
CCDC85B coiled-coil domain containing 85B -2.04851
LATS2 large tumor suppressor kinase 2 -2.04375
PLCXD2 phosphatidylinositol-specific phospholipase C, X domain containing 2 -2.0431
NOB1 NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) -2.03872
SS18 synovial sarcoma translocation, chromosome 18 -2.03835
EXOG endo/exonuclease (5'-3'), endonuclease G-like -2.03743
ZNF408 zinc finger protein 408 -2.03743
AQP11 aquaporin 11 -2.0324
KHDC1 KH homology domain containing 1 -2.02848
VCF1 VCP nuclear cofactor family member 1 -2.02848
GEN1 GEN1 Holliday junction 5' flap endonuclease -2.02028
SFR1 SWI5-dependent recombination repair 1 -2.0163
ZNF292 zinc finger protein 292 -2.01399
TBC1D24 TBC1 domain family, member 24 -2.01399
ELAVL2 ELAV like neuron-specific RNA binding protein 2 -2.01251