| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | cAMP responsive element modulator|This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1390) |
| External Link | https://ncbi.nlm.nih.gov/gene/1390 |
| Similar Terms | |
| Downloads & Tools |
499 genes differentially expressed following the CREM gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.0185481 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0150641 |
| BEX1 | brain expressed, X-linked 1 | 0.0140224 |
| BRCA1 | breast cancer 1, early onset | 0.0114135 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.0113671 |
| NTS | neurotensin | 0.0108119 |
| FGFR3 | fibroblast growth factor receptor 3 | 0.0105976 |
| BMP4 | bone morphogenetic protein 4 | 0.0103958 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 0.0103401 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.00992171 |
| TNC | tenascin C | 0.00985051 |
| NRGN | neurogranin (protein kinase C substrate, RC3) | 0.0098238 |
| HBB | hemoglobin, beta | 0.00970301 |
| RNASE2 | ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) | 0.00953132 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | 0.0094879 |
| DCXR | dicarbonyl/L-xylulose reductase | 0.00946015 |
| PLK1 | polo-like kinase 1 | 0.0093187 |
| BIRC5 | baculoviral IAP repeat containing 5 | 0.00920326 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | 0.00906868 |
| DLK1 | delta-like 1 homolog (Drosophila) | 0.00896649 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.00896395 |
| DPYD | dihydropyrimidine dehydrogenase | 0.00888312 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | 0.00877908 |
| SV2A | synaptic vesicle glycoprotein 2A | 0.00877374 |
| FASN | fatty acid synthase | 0.00874165 |
| CPVL | carboxypeptidase, vitellogenic-like | 0.00867658 |
| DHCR24 | 24-dehydrocholesterol reductase | 0.00864908 |
| PCYOX1L | prenylcysteine oxidase 1 like | 0.00859695 |
| SPINK2 | serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) | 0.00858166 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.00856059 |
| PCP4 | Purkinje cell protein 4 | 0.00852124 |
| KIF20A | kinesin family member 20A | 0.00848568 |
| S100A8 | S100 calcium binding protein A8 | 0.00844204 |
| SDC2 | syndecan 2 | 0.00842083 |
| LYZ | lysozyme | 0.00836898 |
| PRKCA | protein kinase C, alpha | 0.00833227 |
| LBR | lamin B receptor | 0.00831332 |
| C7 | complement component 7 | 0.00821033 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.00818178 |
| NPY | neuropeptide Y | 0.0081626 |
| SRGN | serglycin | 0.00814539 |
| NUSAP1 | nucleolar and spindle associated protein 1 | 0.00814445 |
| HOPX | HOP homeobox | 0.00811908 |
| GSTM3 | glutathione S-transferase mu 3 (brain) | 0.00808223 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | 0.00804003 |
| RPA3 | replication protein A3, 14kDa | 0.0080281 |
| CCNB2 | cyclin B2 | 0.00791372 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | 0.00781459 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.00778244 |
| LTF | lactotransferrin | 0.00769073 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | 0.00768169 |
| LRRN3 | leucine rich repeat neuronal 3 | 0.00765847 |
| NEIL3 | nei endonuclease VIII-like 3 (E. coli) | 0.00764197 |
| GUCY2C | guanylate cyclase 2C | 0.00759064 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.00758497 |
| PF4 | platelet factor 4 | 0.00757515 |
| PKIA | protein kinase (cAMP-dependent, catalytic) inhibitor alpha | 0.00754544 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.00750016 |
| PRIM1 | primase, DNA, polypeptide 1 (49kDa) | 0.00747319 |
| PRKAR2B | protein kinase, cAMP-dependent, regulatory, type II, beta | 0.00747256 |
| SSX2IP | synovial sarcoma, X breakpoint 2 interacting protein | 0.00746655 |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | 0.0074455 |
| TMEM38B | transmembrane protein 38B | 0.00743681 |
| INSIG1 | insulin induced gene 1 | 0.0074175 |
| ZBTB18 | zinc finger and BTB domain containing 18 | 0.00739233 |
| ESPL1 | extra spindle pole bodies homolog 1 (S. cerevisiae) | 0.00736604 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | 0.00731159 |
| DHFR | dihydrofolate reductase | 0.00728588 |
| NPTX1 | neuronal pentraxin I | 0.00727651 |
| CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha | 0.00725425 |
| HBD | hemoglobin, delta | 0.00724292 |
| C12ORF29 | chromosome 12 open reading frame 29 | 0.00720873 |
| PDP1 | pyruvate dehyrogenase phosphatase catalytic subunit 1 | 0.00720081 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.00718938 |
| MGAM | maltase-glucoamylase | 0.00716765 |
| DEFA4 | defensin, alpha 4, corticostatin | 0.00716103 |
| B3GNT1 | 0.00716074 | |
| TSPAN5 | tetraspanin 5 | 0.00714286 |
| IDH2 | isocitrate dehydrogenase 2 (NADP+), mitochondrial | 0.00714285 |
| UNC119B | unc-119 homolog B (C. elegans) | 0.00713643 |
| S100A9 | S100 calcium binding protein A9 | 0.00712611 |
| SLC3A1 | solute carrier family 3 (amino acid transporter heavy chain), member 1 | 0.00711289 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.00701728 |
| LMNB2 | lamin B2 | 0.00695951 |
| CLC | Charcot-Leyden crystal galectin | 0.00695712 |
| KIF18B | kinesin family member 18B | 0.00695361 |
| VSNL1 | visinin-like 1 | 0.00690766 |
| NRN1 | neuritin 1 | 0.00690728 |
| FADS1 | fatty acid desaturase 1 | 0.00690483 |
| CCNF | cyclin F | 0.00689951 |
| MRTFB | myocardin related transcription factor B | 0.00689464 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.00686679 |
| HLTF | helicase-like transcription factor | 0.006864 |
| MSMO1 | methylsterol monooxygenase 1 | 0.00686027 |
| CDC7 | cell division cycle 7 | 0.00684785 |
| FXYD2 | FXYD domain containing ion transport regulator 2 | 0.0068097 |
| OIP5 | Opa interacting protein 5 | 0.00679819 |
| CHST2 | carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 | 0.00678692 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | 0.00675352 |
| CDK1 | cyclin-dependent kinase 1 | 0.00674571 |
| CCNA2 | cyclin A2 | 0.00667744 |
| SLC2A4RG | SLC2A4 regulator | 0.00665891 |
| DHCR7 | 7-dehydrocholesterol reductase | 0.00665539 |
| PLPP3 | phospholipid phosphatase 3 | 0.00663652 |
| DLEU1 | deleted in lymphocytic leukemia 1 (non-protein coding) | 0.00662764 |
| ALDOC | aldolase C, fructose-bisphosphate | 0.00661791 |
| EPHX2 | epoxide hydrolase 2, cytoplasmic | 0.00659207 |
| TECR | trans-2,3-enoyl-CoA reductase | 0.00655981 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.00650264 |
| RNASE3 | ribonuclease, RNase A family, 3 | 0.00650151 |
| MLEC | malectin | 0.00649274 |
| NUDT11 | nudix (nucleoside diphosphate linked moiety X)-type motif 11 | 0.0064631 |
| TMX1 | thioredoxin-related transmembrane protein 1 | 0.00643346 |
| FBXO5 | F-box protein 5 | 0.00641777 |
| MT3 | metallothionein 3 | 0.00641403 |
| SELL | selectin L | 0.00641368 |
| ICMT | isoprenylcysteine carboxyl methyltransferase | 0.00639846 |
| TROAP | trophinin associated protein | 0.00639407 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.00638856 |
| COLEC11 | collectin sub-family member 11 | 0.00638038 |
| ATXN10 | ataxin 10 | 0.00637595 |
| COL1A2 | collagen, type I, alpha 2 | 0.00637311 |
| KIF11 | kinesin family member 11 | 0.00634281 |
| PIMREG | PICALM interacting mitotic regulator | 0.00633716 |
| CTSK | cathepsin K | 0.00633571 |
| FABP6 | fatty acid binding protein 6, ileal | 0.00633446 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.00633062 |
| CRYM | crystallin, mu | 0.00632571 |
| ACAT2 | acetyl-CoA acetyltransferase 2 | 0.00631824 |
| CETN2 | centrin, EF-hand protein, 2 | 0.00631732 |
| NCAPD3 | non-SMC condensin II complex, subunit D3 | 0.00629987 |
| PDE8B | phosphodiesterase 8B | 0.00629854 |
| WNT5A | wingless-type MMTV integration site family, member 5A | 0.00629785 |
| WDR61 | WD repeat domain 61 | 0.00628226 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.00628127 |
| KIF15 | kinesin family member 15 | 0.00627524 |
| MFF | mitochondrial fission factor | 0.00626189 |
| BGN | biglycan | 0.00624579 |
| C3ORF14 | chromosome 3 open reading frame 14 | 0.00623378 |
| ASF1B | anti-silencing function 1B histone chaperone | 0.00623126 |
| TMX4 | thioredoxin-related transmembrane protein 4 | 0.00621664 |
| SPTSSA | serine palmitoyltransferase, small subunit A | 0.00620373 |
| RACGAP1 | Rac GTPase activating protein 1 | 0.0062013 |
| LMNB1 | lamin B1 | 0.00617415 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 0.00616422 |
| RTN3 | reticulon 3 | 0.00614751 |
| PGD | phosphogluconate dehydrogenase | 0.00614701 |
| AP3M2 | adaptor-related protein complex 3, mu 2 subunit | 0.00613892 |
| EXTL2 | exostosin-like glycosyltransferase 2 | 0.00613701 |
| LSM2 | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.00613147 |
| TRMT5 | tRNA methyltransferase 5 | 0.00612945 |
| NMU | neuromedin U | 0.00612475 |
| PARP16 | poly (ADP-ribose) polymerase family, member 16 | 0.00612453 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.00611466 |
| FOXM1 | forkhead box M1 | 0.00609803 |
| LAPTM4B | lysosomal protein transmembrane 4 beta | 0.00609608 |
| CNN3 | calponin 3, acidic | 0.0060949 |
| PRKD3 | protein kinase D3 | 0.00609266 |
| PRKACB | protein kinase, cAMP-dependent, catalytic, beta | 0.00609055 |
| ADO | 2-aminoethanethiol (cysteamine) dioxygenase | 0.00607764 |
| PPA2 | pyrophosphatase (inorganic) 2 | 0.00607053 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 0.00606739 |
| HOXC6 | homeobox C6 | 0.00606705 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.00605612 |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) | 0.00604375 |
| NCAM1 | neural cell adhesion molecule 1 | 0.00604338 |
| CD2 | CD2 molecule | 0.00603231 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.00602341 |
| SRP9 | signal recognition particle 9kDa | 0.00602026 |
| RAPSN | receptor-associated protein of the synapse | 0.00599275 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.00598288 |
| TM7SF2 | transmembrane 7 superfamily member 2 | 0.00598021 |
| SLC25A1 | solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 | 0.00596148 |
| ITGA8 | integrin, alpha 8 | 0.00595561 |
| TMSB15A | thymosin beta 15a | 0.00594983 |
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | 0.00594441 |
| SELENOF | selenoprotein F | 0.00593486 |
| DNASE1L3 | deoxyribonuclease I-like 3 | 0.00592808 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.00592038 |
| AMD1 | adenosylmethionine decarboxylase 1 | 0.00591245 |
| APBA2 | amyloid beta (A4) precursor protein-binding, family A, member 2 | 0.0058928 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0058905 |
| CYP26A1 | cytochrome P450, family 26, subfamily A, polypeptide 1 | 0.00588383 |
| LSM6 | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.00588093 |
| DEK | DEK proto-oncogene | 0.00587674 |
| CDCA4 | cell division cycle associated 4 | 0.00586919 |
| TMPO | thymopoietin | 0.0058656 |
| CRIP2 | cysteine-rich protein 2 | 0.00586109 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | 0.0058399 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | 0.00583258 |
| CHI3L2 | chitinase 3-like 2 | 0.00582416 |
| GET1 | guided entry of tail-anchored proteins factor 1 | 0.00581905 |
| ZMYM3 | zinc finger, MYM-type 3 | 0.00581588 |
| APMAP | adipocyte plasma membrane associated protein | 0.00580172 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.00579671 |
| PSIP1 | PC4 and SFRS1 interacting protein 1 | 0.00579192 |
| ANGPT1 | angiopoietin 1 | 0.00578548 |
| PURA | purine-rich element binding protein A | 0.00578351 |
| ABHD10 | abhydrolase domain containing 10 | 0.00577141 |
| NME4 | NME/NM23 nucleoside diphosphate kinase 4 | 0.00574309 |
| NEK2 | NIMA-related kinase 2 | 0.00573957 |
| CD300A | CD300a molecule | 0.00573253 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.00572549 |
| RSAD1 | radical S-adenosyl methionine domain containing 1 | 0.00572437 |
| BPI | bactericidal/permeability-increasing protein | 0.00571676 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | 0.00571111 |
| TMEM168 | transmembrane protein 168 | 0.00569742 |
| CTSG | cathepsin G | 0.00569305 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | 0.00568524 |
| SLC19A1 | solute carrier family 19 (folate transporter), member 1 | 0.00568033 |
| EPHA4 | EPH receptor A4 | 0.0056523 |
| VBP1 | von Hippel-Lindau binding protein 1 | 0.00564151 |
| CRELD2 | cysteine-rich with EGF-like domains 2 | 0.00560582 |
| ALDH6A1 | aldehyde dehydrogenase 6 family, member A1 | 0.00559938 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.00559094 |
| MDC1 | mediator of DNA-damage checkpoint 1 | 0.0055829 |
| KLHDC3 | kelch domain containing 3 | 0.0055802 |
| KCNN2 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 | 0.00557738 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.00556419 |
| NDUFB5 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa | 0.00556218 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.00556088 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.00554549 |
| SPC25 | SPC25, NDC80 kinetochore complex component | 0.00552855 |
| YKT6 | YKT6 v-SNARE homolog (S. cerevisiae) | 0.0055233 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | 0.00551688 |
| DUT | deoxyuridine triphosphatase | 0.00551319 |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | 0.00551164 |
| PIP4K2B | phosphatidylinositol-5-phosphate 4-kinase, type II, beta | 0.00550921 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | 0.0055037 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | 0.00550126 |
| GLB1L2 | galactosidase, beta 1-like 2 | 0.00549592 |
| GPM6A | glycoprotein M6A | 0.00549398 |
| HDDC2 | HD domain containing 2 | 0.00549173 |
| ARG2 | arginase 2 | 0.00548244 |
| PGM1 | phosphoglucomutase 1 | 0.00548138 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | 0.0054707 |
| AKAP7 | A kinase (PRKA) anchor protein 7 | 0.00546734 |
| RANBP1 | RAN binding protein 1 | 0.00546146 |
| TMEM106B | transmembrane protein 106B | 0.00546145 |
| VIM | vimentin | 0.00545489 |
| ZNF274 | zinc finger protein 274 | 0.00544863 |
| PCDH9 | protocadherin 9 | 0.00544304 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.00543731 |
| E2F8 | E2F transcription factor 8 | 0.00541638 |
| FSD1 | fibronectin type III and SPRY domain containing 1 | 0.0054139 |
| C21ORF33 | chromosome 21 open reading frame 33 | 0.00540352 |
| SFTPA2 | surfactant protein A2 | 0.00540331 |
| THYN1 | thymocyte nuclear protein 1 | 0.00539544 |
| PRUNE2 | prune homolog 2 (Drosophila) | 0.00539257 |
| ZNF175 | zinc finger protein 175 | 0.00538258 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IFI27 | interferon, alpha-inducible protein 27 | -0.0254845 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | -0.0173512 |
| MX1 | MX dynamin-like GTPase 1 | -0.0171366 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0168074 |
| HSPA1A | heat shock 70kDa protein 1A | -0.015703 |
| IFI44L | interferon-induced protein 44-like | -0.0152407 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | -0.0149362 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.0148508 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -0.0144174 |
| IL32 | interleukin 32 | -0.0140309 |
| HMOX1 | heme oxygenase 1 | -0.0136691 |
| BTG2 | BTG family, member 2 | -0.0131194 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.0130305 |
| KLF6 | Kruppel-like factor 6 | -0.0130132 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | -0.012893 |
| KRT14 | keratin 14, type I | -0.0124653 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0124594 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | -0.012263 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0121348 |
| ANO1 | anoctamin 1, calcium activated chloride channel | -0.0120656 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | -0.0119035 |
| IER5 | immediate early response 5 | -0.0116923 |
| CFB | complement factor B | -0.0115812 |
| ALDH7A1 | aldehyde dehydrogenase 7 family, member A1 | -0.0115668 |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa | -0.0115444 |
| CARD10 | caspase recruitment domain family, member 10 | -0.0114835 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0114045 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0113781 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | -0.0113069 |
| MVP | major vault protein | -0.0111322 |
| ASS1 | argininosuccinate synthase 1 | -0.0110697 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | -0.0109989 |
| SIK1 | salt-inducible kinase 1 | -0.0109215 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0107754 |
| LAMC2 | laminin, gamma 2 | -0.0107586 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0106514 |
| MCL1 | myeloid cell leukemia 1 | -0.0105907 |
| PLK2 | polo-like kinase 2 | -0.0105515 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | -0.0104791 |
| PARP12 | poly (ADP-ribose) polymerase family, member 12 | -0.0103623 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.010334 |
| EIF5 | eukaryotic translation initiation factor 5 | -0.0103179 |
| KRT17 | keratin 17, type I | -0.0102608 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | -0.0102499 |
| TRIM22 | tripartite motif containing 22 | -0.0101601 |
| RRAD | Ras-related associated with diabetes | -0.0101055 |
| MFAP5 | microfibrillar associated protein 5 | -0.0100429 |
| GAS6 | growth arrest-specific 6 | -0.00998675 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.00974497 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.00973487 |
| LAMB3 | laminin, beta 3 | -0.00970879 |
| IRF7 | interferon regulatory factor 7 | -0.00957036 |
| STK10 | serine/threonine kinase 10 | -0.00955842 |
| SHTN1 | shootin 1 | -0.00954968 |
| IRF9 | interferon regulatory factor 9 | -0.00952555 |
| HSPB8 | heat shock 22kDa protein 8 | -0.00947641 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.00929333 |
| ANXA3 | annexin A3 | -0.00920808 |
| IFI44 | interferon-induced protein 44 | -0.00920211 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | -0.00918806 |
| HSPA2 | heat shock 70kDa protein 2 | -0.00915468 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | -0.00913491 |
| MT1E | metallothionein 1E | -0.00912749 |
| IRS2 | insulin receptor substrate 2 | -0.0091232 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.00907927 |
| YBX3 | Y box binding protein 3 | -0.00905721 |
| CRYAB | crystallin, alpha B | -0.00903546 |
| XAF1 | XIAP associated factor 1 | -0.00902709 |
| EGFL6 | EGF-like-domain, multiple 6 | -0.0089952 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.00895448 |
| MIR22HG | MIR22 host gene | -0.00894768 |
| ZNF91 | zinc finger protein 91 | -0.00893916 |
| IL1A | interleukin 1, alpha | -0.00892896 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.00891176 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.00890137 |
| CCN2 | cellular communication network factor 2 | -0.00882329 |
| KLF4 | Kruppel-like factor 4 (gut) | -0.00874843 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.00874439 |
| KLK10 | kallikrein-related peptidase 10 | -0.00868471 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | -0.00865234 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.00861684 |
| XIC | X chromosome inactivation center | -0.00858263 |
| DDX58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | -0.00854384 |
| SFRP4 | secreted frizzled-related protein 4 | -0.00852383 |
| CPM | carboxypeptidase M | -0.00849646 |
| GAB2 | GRB2-associated binding protein 2 | -0.00848208 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | -0.00837177 |
| ZBED2 | zinc finger, BED-type containing 2 | -0.00836013 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.00833146 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | -0.00826866 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -0.00826444 |
| INHBA | inhibin, beta A | -0.00821625 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.00821348 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | -0.00820165 |
| OSR2 | odd-skipped related transciption factor 2 | -0.00819458 |
| FKBP11 | FK506 binding protein 11, 19 kDa | -0.00816645 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.0081542 |
| KLHL41 | kelch-like family member 41 | -0.00810138 |
| DSP | desmoplakin | -0.00796512 |
| PKP2 | plakophilin 2 | -0.00794905 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.00794036 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | -0.0078641 |
| SLPI | secretory leukocyte peptidase inhibitor | -0.0078635 |
| MYOF | myoferlin | -0.00777886 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.00776295 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | -0.00775859 |
| CXCL11 | chemokine (C-X-C motif) ligand 11 | -0.00775857 |
| TAP1 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | -0.00773567 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | -0.00772703 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0077203 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.00771223 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -0.00769807 |
| MYO1B | myosin IB | -0.00769079 |
| SP110 | SP110 nuclear body protein | -0.00768739 |
| ACKR3 | atypical chemokine receptor 3 | -0.00767145 |
| PLAAT3 | phospholipase A and acyltransferase 3 | -0.00766164 |
| SLC39A6 | solute carrier family 39 (zinc transporter), member 6 | -0.00764686 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | -0.00763818 |
| FHL2 | four and a half LIM domains 2 | -0.00761083 |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 | -0.00760852 |
| RGCC | regulator of cell cycle | -0.00760096 |
| IGF1R | insulin-like growth factor 1 receptor | -0.00759851 |
| RABAC1 | Rab acceptor 1 (prenylated) | -0.00759809 |
| FOSL2 | FOS-like antigen 2 | -0.00758408 |
| ZMAT3 | zinc finger, matrin-type 3 | -0.00758373 |
| CAVIN3 | caveolae associated protein 3 | -0.00755444 |
| STK26 | serine/threonine protein kinase 26 | -0.00755221 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.00753853 |
| SOWAHC | sosondowah ankyrin repeat domain family member C | -0.00753687 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0075285 |
| PHLDA2 | pleckstrin homology-like domain, family A, member 2 | -0.00751745 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.00747479 |
| COL16A1 | collagen, type XVI, alpha 1 | -0.00745623 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.00745131 |
| MAP7D1 | MAP7 domain containing 1 | -0.00743675 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.00743058 |
| FXYD3 | FXYD domain containing ion transport regulator 3 | -0.00741756 |
| CRABP2 | cellular retinoic acid binding protein 2 | -0.00739086 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.00738663 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.00736929 |
| BIK | BCL2-interacting killer (apoptosis-inducing) | -0.00736452 |
| GATA6 | GATA binding protein 6 | -0.00735767 |
| ZNF706 | zinc finger protein 706 | -0.00733694 |
| PHF11 | PHD finger protein 11 | -0.00732505 |
| PRSS23 | protease, serine, 23 | -0.00732105 |
| KLK11 | kallikrein-related peptidase 11 | -0.00730487 |
| KRT23 | keratin 23, type I | -0.00729142 |
| RRAGC | Ras-related GTP binding C | -0.0072801 |
| OGA | O-GlcNAcase | -0.00723845 |
| OPTN | optineurin | -0.00722347 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.00721572 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.00720977 |
| POLDIP2 | polymerase (DNA-directed), delta interacting protein 2 | -0.00718305 |
| RFTN1 | raftlin, lipid raft linker 1 | -0.00718182 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 | -0.00718179 |
| AREG | amphiregulin | -0.0071783 |
| POU2AF1 | POU class 2 associating factor 1 | -0.00717278 |
| OLFML2A | olfactomedin-like 2A | -0.00713123 |
| TRIP6 | thyroid hormone receptor interactor 6 | -0.00712832 |
| TIGAR | TP53 induced glycolysis regulatory phosphatase | -0.00710854 |
| EFNA1 | ephrin-A1 | -0.00710258 |
| ATF3 | activating transcription factor 3 | -0.00708945 |
| MICAL1 | microtubule associated monooxygenase, calponin and LIM domain containing 1 | -0.00706566 |
| RYBP | RING1 and YY1 binding protein | -0.00706441 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.00705775 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.00705769 |
| DUSP4 | dual specificity phosphatase 4 | -0.00704669 |
| CYB5R2 | cytochrome b5 reductase 2 | -0.0070402 |
| PYCARD | PYD and CARD domain containing | -0.00703376 |
| KLHL24 | kelch-like family member 24 | -0.00703356 |
| TYMP | thymidine phosphorylase | -0.00701059 |
| AK1 | adenylate kinase 1 | -0.00700727 |
| PERP | PERP, TP53 apoptosis effector | -0.00700251 |
| MXRA5 | matrix-remodelling associated 5 | -0.00699145 |
| BMP2 | bone morphogenetic protein 2 | -0.00698878 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | -0.00698118 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.00697077 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | -0.00695237 |
| ZFAND5 | zinc finger, AN1-type domain 5 | -0.00693861 |
| CCNG2 | cyclin G2 | -0.00693537 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -0.00691379 |
| VPREB1 | pre-B lymphocyte 1 | -0.00690874 |
| WDR45 | WD repeat domain 45 | -0.00689404 |
| JUNB | jun B proto-oncogene | -0.0068831 |
| ZNF165 | zinc finger protein 165 | -0.00686747 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | -0.00684303 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | -0.00683911 |
| EMP1 | epithelial membrane protein 1 | -0.00682189 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.00681314 |
| CD14 | CD14 molecule | -0.00680128 |
| SNAI2 | snail family zinc finger 2 | -0.00679743 |
| RNF103 | ring finger protein 103 | -0.00676029 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.00675905 |
| LAMA3 | laminin, alpha 3 | -0.00675209 |
| IL18 | interleukin 18 | -0.00674455 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.00673765 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.00671101 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | -0.00670152 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | -0.0066859 |
| MYO1E | myosin IE | -0.00668082 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.00667416 |
| MT1X | metallothionein 1X | -0.00667192 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | -0.00666894 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.00666154 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.00662625 |
| FBN2 | fibrillin 2 | -0.00662088 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.00660775 |
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 | -0.0065965 |
| MYO1D | myosin ID | -0.00656332 |
| TTN | titin | -0.00653978 |
| IL6 | interleukin 6 | -0.00653034 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 | -0.00652016 |
| SERPING1 | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | -0.00650415 |
| NEU1 | sialidase 1 (lysosomal sialidase) | -0.00649509 |
| HIST1H2BD | histone cluster 1, H2bd | -0.00648502 |
| SLC31A2 | solute carrier family 31 (copper transporter), member 2 | -0.00647983 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.00641533 |
| IGF2R | insulin-like growth factor 2 receptor | -0.00640392 |
| LGALS4 | lectin, galactoside-binding, soluble, 4 | -0.00638526 |
| KLK5 | kallikrein-related peptidase 5 | -0.00637705 |
| TMEM176B | transmembrane protein 176B | -0.00637003 |
| HSPA4L | heat shock 70kDa protein 4-like | -0.0063655 |
| MMP10 | matrix metallopeptidase 10 | -0.00634625 |
| KRT7 | keratin 7, type II | -0.00632951 |
| PTGES | prostaglandin E synthase | -0.00630989 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.00628596 |
| TMPRSS4 | transmembrane protease, serine 4 | -0.00627874 |
| AHNAK | AHNAK nucleoprotein | -0.0062616 |
| RAB9A | RAB9A, member RAS oncogene family | -0.00625592 |
| KIAA0040 | KIAA0040 | -0.00625189 |
| SWAP70 | SWAP switching B-cell complex 70kDa subunit | -0.00624196 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | -0.00619746 |
| C3 | complement component 3 | -0.00618564 |
| ZNF394 | zinc finger protein 394 | -0.00616459 |
| DSG2 | desmoglein 2 | -0.00614612 |
| MPDZ | multiple PDZ domain protein | -0.00614266 |
| IST1 | increased sodium tolerance 1 homolog (yeast) | -0.00614232 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.00614219 |
| SLC38A1 | solute carrier family 38, member 1 | -0.00613815 |
| GALNT6 | polypeptide N-acetylgalactosaminyltransferase 6 | -0.00613737 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | -0.00613078 |
| TSC22D2 | TSC22 domain family, member 2 | -0.00612704 |
| HECA | headcase homolog (Drosophila) | -0.00612158 |
| SQSTM1 | sequestosome 1 | -0.00611749 |
| HBP1 | HMG-box transcription factor 1 | -0.00611222 |
| TSPAN1 | tetraspanin 1 | -0.00610752 |
| CD163 | CD163 molecule | -0.00610392 |
| CAPN3 | calpain 3, (p94) | -0.00608422 |
| RARRES2 | retinoic acid receptor responder (tazarotene induced) 2 | -0.00607214 |
