CRK Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description v-crk avian sarcoma virus CT10 oncogene homolog|This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1398)
External Link http://www.ncbi.nlm.nih.gov/gene/1398
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372 interacting proteins for CRK from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AAK1 AP2 associated kinase 1
ABAT 4-aminobutyrate aminotransferase
ABI1 abl-interactor 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACTB actin, beta
AFF2 AF4/FMR2 family, member 2
AGO1 argonaute RISC catalytic component 1
AGO2 argonaute RISC catalytic component 2
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
AIRE autoimmune regulator
AKAP2 A kinase (PRKA) anchor protein 2
AKAP6 A kinase (PRKA) anchor protein 6
ANGPT1 angiopoietin 1
ANGPT4 angiopoietin 4
ANKRD28 ankyrin repeat domain 28
AP1B1 adaptor-related protein complex 1, beta 1 subunit
AP2A1 adaptor-related protein complex 2, alpha 1 subunit
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AP2M1 adaptor-related protein complex 2, mu 1 subunit
AP2S1 adaptor-related protein complex 2, sigma 1 subunit
APOL5 apolipoprotein L, 5
AR androgen receptor
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARHGAP17 Rho GTPase activating protein 17
ARHGAP32 Rho GTPase activating protein 32
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
ATXN1 ataxin 1
AVIL advillin
BAG3 BCL2-associated athanogene 3
BCAR1 breast cancer anti-estrogen resistance 1
BCR breakpoint cluster region
BDNF brain-derived neurotrophic factor
BLNK B-cell linker
BMP2K BMP2 inducible kinase
BMX BMX non-receptor tyrosine kinase
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRD4 bromodomain containing 4
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C20ORF57 chromosome 20 open reading frame 57
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CASS4 Cas scaffolding protein family member 4
CAST calpastatin
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBLC Cbl proto-oncogene C, E3 ubiquitin protein ligase
CD2AP CD2-associated protein
CD93 CD93 molecule
CDC42 cell division cycle 42
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CNTFR ciliary neurotrophic factor receptor
CNTNAP1 contactin associated protein 1
CORO1C coronin, actin binding protein, 1C
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSK c-src tyrosine kinase
CSMD2 CUB and Sushi multiple domains 2
CTTN cortactin
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila)
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DKKL1 dickkopf-like 1
DLGAP1 discs, large (Drosophila) homolog-associated protein 1
DLGAP2 discs, large (Drosophila) homolog-associated protein 2
DLGAP3 discs, large (Drosophila) homolog-associated protein 3
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DLX4 distal-less homeobox 4
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNM2 dynamin 2
DOCK1 dedicator of cytokinesis 1
DOCK3 dedicator of cytokinesis 3
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DOK4 docking protein 4
DPPA4 developmental pluripotency associated 4
DSC1 desmocollin 1
DTX1 deltex 1, E3 ubiquitin ligase
EDC4 enhancer of mRNA decapping 4
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EFNB1 ephrin-B1
EFNB2 ephrin-B2
EFNB3 ephrin-B3
EFS embryonal Fyn-associated substrate
EGFR epidermal growth factor receptor
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPHA3 EPH receptor A3
EPHB1 EPH receptor B1
EPHB2 EPH receptor B2
EPHB3 EPH receptor B3
EPHB6 EPH receptor B6
EPS15 epidermal growth factor receptor pathway substrate 15
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
EXTL3 exostosin-like glycosyltransferase 3
F2RL2 coagulation factor II (thrombin) receptor-like 2
FANCA Fanconi anemia, complementation group A
FASLG Fas ligand (TNF superfamily, member 6)
FASTK Fas-activated serine/threonine kinase
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FCHO2 FCH domain only 2
FER fer (fps/fes related) tyrosine kinase
FGF1 fibroblast growth factor 1 (acidic)
FGFR1 fibroblast growth factor receptor 1
FLNA filamin A, alpha
FLNB filamin B, beta
FLNC filamin C, gamma
FLT1 fms-related tyrosine kinase 1
FRS2 fibroblast growth factor receptor substrate 2
FUBP1 far upstream element (FUSE) binding protein 1
FYB FYN binding protein
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB1 GRB2-associated binding protein 1
GAB2 GRB2-associated binding protein 2
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GCFC2 GC-rich sequence DNA-binding factor 2
GDNF glial cell derived neurotrophic factor
GFRA1 GDNF family receptor alpha 1
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3
GHR growth hormone receptor
GLTSCR1 glioma tumor suppressor candidate region gene 1
GP9 glycoprotein IX (platelet)
GRAP2 GRB2-related adaptor protein 2
GRB2 growth factor receptor-bound protein 2
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D
GRIP2 glutamate receptor interacting protein 2
HEXA hexosaminidase A (alpha polypeptide)
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-B major histocompatibility complex, class I, B
HNRNPR heterogeneous nuclear ribonucleoprotein R
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1B heat shock 70kDa protein 1B
HSPA1L heat shock 70kDa protein 1-like
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPB1 heat shock 27kDa protein 1
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
INPPL1 inositol polyphosphate phosphatase-like 1
INSR insulin receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
ITGAV integrin, alpha V
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB5 integrin, beta 5
KCNIP3 Kv channel interacting protein 3, calsenilin
KDR kinase insert domain receptor
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIDINS220 kinase D-interacting substrate, 220kDa
KIF22 kinesin family member 22
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KMT2B lysine (K)-specific methyltransferase 2B
KRT1 keratin 1, type II
KRT10 keratin 10, type I
KRT12 keratin 12, type I
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT19 keratin 19, type I
KRT2 keratin 2, type II
KRT24 keratin 24, type I
KRT3 keratin 3, type II
KRT33A keratin 33A, type I
KRT36 keratin 36, type I
KRT4 keratin 4, type II
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KRT73 keratin 73, type II
KRT76 keratin 76, type II
KRT77 keratin 77, type II
KRT78 keratin 78, type II
KRT79 keratin 79, type II
KRT8 keratin 8, type II
KRT9 keratin 9, type I
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LIG3 ligase III, DNA, ATP-dependent
LMNA lamin A/C
LYZ lysozyme
MAP2K4 mitogen-activated protein kinase kinase 4
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK4 mitogen-activated protein kinase 4
MAPK8 mitogen-activated protein kinase 8
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta)
MEPE matrix extracellular phosphoglycoprotein
MET MET proto-oncogene, receptor tyrosine kinase
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MYO18B myosin XVIIIB
MYO1C myosin IC
MYO1D myosin ID
NANS N-acetylneuraminic acid synthase
NCK1 NCK adaptor protein 1
NCK2 NCK adaptor protein 2
NCKIPSD NCK interacting protein with SH3 domain
NECAP1 NECAP endocytosis associated 1
NECAP2 NECAP endocytosis associated 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFASC neurofascin
NGF nerve growth factor (beta polypeptide)
NKX2-1 NK2 homeobox 1
NR5A1 nuclear receptor subfamily 5, group A, member 1
NRF1 nuclear respiratory factor 1
NTF3 neurotrophin 3
NTF4 neurotrophin 4
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
NXPH3 neurexophilin 3
OGN osteoglycin
OPTC opticin
PAX7 paired box 7
PCDHA1 protocadherin alpha 1
PCDHA10 protocadherin alpha 10
PCDHA11 protocadherin alpha 11
PCDHA12 protocadherin alpha 12
PCDHA2 protocadherin alpha 2
PCDHA3 protocadherin alpha 3
PCDHA5 protocadherin alpha 5
PCDHA6 protocadherin alpha 6
PCDHA7 protocadherin alpha 7
PCDHA8 protocadherin alpha 8
PCDHA9 protocadherin alpha 9
PDGFB platelet-derived growth factor beta polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDIA2 protein disulfide isomerase family A, member 2
PHACTR2 phosphatase and actin regulator 2
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLCG1 phospholipase C, gamma 1
PLSCR1 phospholipid scramblase 1
PNMA2 paraneoplastic Ma antigen 2
POT1 protection of telomeres 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1R9B protein phosphatase 1, regulatory subunit 9B
PRICKLE3 prickle homolog 3 (Drosophila)
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKCG protein kinase C, gamma
PRKCH protein kinase C, eta
PRKCQ protein kinase C, theta
PRX periaxin
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
PXN paxillin
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAG1 recombination activating gene 1
RAP1A RAP1A, member of RAS oncogene family
RAP1B RAP1B, member of RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RAP2A RAP2A, member of RAS oncogene family
RAP2B RAP2B, member of RAS oncogene family
RAP2C RAP2C, member of RAS oncogene family
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
REPS1 RALBP1 associated Eps domain containing 1
RET ret proto-oncogene
RGS20 regulator of G-protein signaling 20
RGS7 regulator of G-protein signaling 7
RHOA ras homolog family member A
RHOB ras homolog family member B
RHOC ras homolog family member C
RHOQ ras homolog family member Q
RIN3 Ras and Rab interactor 3
RNGTT RNA guanylyltransferase and 5'-phosphatase
RPL23 ribosomal protein L23
RPP38 ribonuclease P/MRP 38kDa subunit
RPS19 ribosomal protein S19
RPS25 ribosomal protein S25
RPS3 ribosomal protein S3
RPS5 ribosomal protein S5
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RRAS related RAS viral (r-ras) oncogene homolog
SEC16A SEC16 homolog A (S. cerevisiae)
SEMG1 semenogelin I
SEMG2 semenogelin II
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFN stratifin
SH3BP1 SH3-domain binding protein 1
SH3KBP1 SH3-domain kinase binding protein 1
SHANK2 SH3 and multiple ankyrin repeat domains 2
SHANK3 SH3 and multiple ankyrin repeat domains 3
SHB Src homology 2 domain containing adaptor protein B
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SNX17 sorting nexin 17
SNX3 sorting nexin 3
SNX7 sorting nexin 7
SOCS1 suppressor of cytokine signaling 1
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
SP1 Sp1 transcription factor
SPEN spen family transcriptional repressor
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRR2A small proline-rich protein 2A
SPTA1 spectrin, alpha, erythrocytic 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRCIN1 SRC kinase signaling inhibitor 1
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STON2 stonin 2
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
SYN1 synapsin I
TAL1 T-cell acute lymphocytic leukemia 1
TEK TEK tyrosine kinase, endothelial
TERF2IP telomeric repeat binding factor 2, interacting protein
TGOLN2 trans-golgi network protein 2
THOC2 THO complex 2
TNK2 tyrosine kinase, non-receptor, 2
TP53BP2 tumor protein p53 binding protein 2
TPX2 TPX2, microtubule-associated
TRAF2 TNF receptor-associated factor 2
TRIM21 tripartite motif containing 21
TRIM39 tripartite motif containing 39
TTBK2 tau tubulin kinase 2
TUBA1A tubulin, alpha 1a
TUBB tubulin, beta class I
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
UBASH3A ubiquitin associated and SH3 domain containing A
UBASH3B ubiquitin associated and SH3 domain containing B
UBC ubiquitin C
USP9X ubiquitin specific peptidase 9, X-linked
USP9Y ubiquitin specific peptidase 9, Y-linked
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
WASF1 WAS protein family, member 1
WASL Wiskott-Aldrich syndrome-like
WEE1 WEE1 G2 checkpoint kinase
XPO1 exportin 1
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa