CRX Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description cone-rod homeobox|The protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. This homeodomain protein is necessary for the maintenance of normal cone and rod function. Mutations in this gene are associated with photoreceptor degeneration, Leber congenital amaurosis type III and the autosomal dominant cone-rod dystrophy 2. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1406)
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Genes

291 genes differentially expressed following the CRX gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SMIM43 small integral membrane protein 43 2.66071
LHX2 LIM homeobox 2 2.66071
NT5C1B 5'-nucleotidase, cytosolic IB 2.66071
FAM187B family with sequence similarity 187, member B 2.66071
PRRX1 paired related homeobox 1 2.66071
IL31RA interleukin 31 receptor A 2.66071
COLEC10 collectin sub-family member 10 (C-type lectin) 2.66071
XKR3 XK, Kell blood group complex subunit-related family, member 3 2.66071
DLL4 delta-like 4 (Drosophila) 2.66071
RGPD3 RANBP2-like and GRIP domain containing 3 2.66071
LPA lipoprotein, Lp(a) 2.66071
WFDC8 WAP four-disulfide core domain 8 2.66071
ZC2HC1B zinc finger, C2HC-type containing 1B 2.66071
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 2.66071
H4C14 H4 clustered histone 14 2.66071
SPEM1 spermatid maturation 1 2.66071
ARR3 arrestin 3, retinal (X-arrestin) 2.66071
POF1B premature ovarian failure, 1B 2.66071
C9ORF152 chromosome 9 open reading frame 152 2.6155
PRDM7 PR domain containing 7 2.6155
FABP12 fatty acid binding protein 12 2.6155
ARL8A ADP-ribosylation factor-like 8A 2.6155
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 2.6155
TMEM71 transmembrane protein 71 2.6155
LRRC10B leucine rich repeat containing 10B 2.6155
LRRC73 leucine rich repeat containing 73 2.6155
LGSN lengsin, lens protein with glutamine synthetase domain 2.6155
MAGIX MAGI family member, X-linked 2.6155
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 2.6155
TMIGD1 transmembrane and immunoglobulin domain containing 1 2.6155
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 2.6155
FAM81B family with sequence similarity 81, member B 2.6155
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 2.6155
SMPX small muscle protein, X-linked 2.6155
RNASE9 ribonuclease, RNase A family, 9 (non-active) 2.6155
NR4A3 nuclear receptor subfamily 4, group A, member 3 2.6155
TTR transthyretin 2.6155
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 2.6155
SPACA5 sperm acrosome associated 5 2.6155
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 2.6155
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 2.6155
OR52E4 olfactory receptor, family 52, subfamily E, member 4 2.6155
LGALS2 lectin, galactoside-binding, soluble, 2 2.6155
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.6155
TAS1R1 taste receptor, type 1, member 1 2.6155
C3ORF80 chromosome 3 open reading frame 80 2.6155
SCG2 secretogranin II 2.6155
ZSCAN5B zinc finger and SCAN domain containing 5B 2.6155
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 2.6155
MAG myelin associated glycoprotein 2.6155
FOXL1 forkhead box L1 2.6155
SRSF8 serine/arginine-rich splicing factor 8 2.6155
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 2.6155
HBA2 hemoglobin, alpha 2 2.6155
OR2A1 olfactory receptor, family 2, subfamily A, member 1 2.6155
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 2.6155
RHOXF2 Rhox homeobox family, member 2 2.6155
PCDHB10 protocadherin beta 10 2.6155
OR7C1 olfactory receptor, family 7, subfamily C, member 1 2.6155
CLDN9 claudin 9 2.6155
ADHFE1 alcohol dehydrogenase, iron containing, 1 2.6155
TMEM176A transmembrane protein 176A 2.6155
C1ORF146 chromosome 1 open reading frame 146 2.6155
OOSP1 oocyte secreted protein 1, pseudogene 2.6155
SASH3 SAM and SH3 domain containing 3 2.6155
SLC39A2 solute carrier family 39 (zinc transporter), member 2 2.6155
TCAF2 TRPM8 channel-associated factor 2 2.6155
PTH2 parathyroid hormone 2 2.6155
GJB4 gap junction protein, beta 4, 30.3kDa 2.6155
C1QTNF8 C1q and tumor necrosis factor related protein 8 2.6155
AFM afamin 2.6155
KLRF1 killer cell lectin-like receptor subfamily F, member 1 2.6155
SSTR1 somatostatin receptor 1 2.6155
ELOVL3 ELOVL fatty acid elongase 3 2.6155
SLC22A25 solute carrier family 22, member 25 2.6155
DNASE1L2 deoxyribonuclease I-like 2 2.6155
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 2.6155
MAGEB1 melanoma antigen family B1 2.6155
NPY2R neuropeptide Y receptor Y2 2.6155
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 2.6155
ASTL astacin-like metallo-endopeptidase (M12 family) 2.6155
C20ORF144 chromosome 20 open reading frame 144 2.6155
PLA1A phospholipase A1 member A 2.6155
THBD thrombomodulin 2.6155
AKR1C8 aldo-keto reductase family 1 member C8 2.6155
DNTT DNA nucleotidylexotransferase 2.6155
IFITM5 interferon induced transmembrane protein 5 2.6155
WNT7A wingless-type MMTV integration site family, member 7A 2.6155
PKDREJ polycystin (PKD) family receptor for egg jelly 2.6155
HAVCR1 hepatitis A virus cellular receptor 1 2.6155
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 2.6155
SEPTIN12 septin 12 2.6155
H2AC1 H2A clustered histone 1 2.6155
ACP4 acid phosphatase 4 2.6155
PTPN20 protein tyrosine phosphatase, non-receptor type 20 2.6155
SFTA2 surfactant associated 2 2.6155
PPP1R27 protein phosphatase 1, regulatory subunit 27 2.6155
SMIM45 small integral membrane protein 45 2.6155
C20ORF204 chromosome 20 open reading frame 204 2.6155
IL26 interleukin 26 2.6155
PLA2G2C phospholipase A2, group IIC 2.6155
POU4F1 POU class 4 homeobox 1 2.6155
CLEC1B C-type lectin domain family 1, member B 2.6155
CSF1R colony stimulating factor 1 receptor 2.6155
TMEM238L transmembrane protein 238 like 2.6155
RGS4 regulator of G-protein signaling 4 2.6155
OTOP3 otopetrin 3 2.6155
CRHBP corticotropin releasing hormone binding protein 2.6155
CFB complement factor B 2.6155
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 2.6155
CPSF4L cleavage and polyadenylation specific factor 4-like 2.6155
VXN vexin 2.6155
DEFB118 defensin, beta 118 2.6155
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 2.6155
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 2.6155
FAM25G family with sequence similarity 25, member G 2.6155
C5AR2 complement component 5a receptor 2 2.6155
SP100 SP100 nuclear antigen 2.6155
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.6155
TYROBP TYRO protein tyrosine kinase binding protein 2.6155
LRRC74B leucine rich repeat containing 74B 2.6155
ITPKA inositol-trisphosphate 3-kinase A 2.6155
TMEM156 transmembrane protein 156 2.6155
ALLC allantoicase 2.6155
A1CF APOBEC1 complementation factor 2.6155
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) 2.6155
YIPF7 Yip1 domain family, member 7 2.6155
PADI3 peptidyl arginine deiminase, type III 2.6155
CRYBB3 crystallin, beta B3 2.6155
CCDC187 coiled-coil domain containing 187 2.6155
UBQLNL ubiquilin-like 2.6155
CLDN34 claudin 34 2.6155
EXTL2 exostosin-like glycosyltransferase 2 2.6155
EDN2 endothelin 2 2.6155
DIPK2B divergent protein kinase domain 2B 2.6155
RTL9 retrotransposon Gag like 9 2.6155
CCN6 cellular communication network factor 6 2.6155
LRCOL1 leucine rich colipase-like 1 2.6155
ERVW-1 endogenous retrovirus group W, member 1 2.6155
OR10H5 olfactory receptor, family 10, subfamily H, member 5 2.6155
DMTN dematin actin binding protein 2.6155
SLC25A53 solute carrier family 25, member 53 2.5902
CDCA4 cell division cycle associated 4 2.55923
C11ORF86 chromosome 11 open reading frame 86 2.5587
WDR76 WD repeat domain 76 2.51809
GPS1 G protein pathway suppressor 1 2.5178
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific 2.49525
SLCO1B1 solute carrier organic anion transporter family, member 1B1 2.46539
TINCR tissue differentiation-inducing non-protein coding RNA 2.45497
RUBCN rubicon autophagy regulator 2.42014
ADAM15 ADAM metallopeptidase domain 15 2.41154
TUBA3D tubulin, alpha 3d 2.40704
PRSS21 protease, serine, 21 (testisin) 2.40704
AGK acylglycerol kinase 2.37534
TMEM200A transmembrane protein 200A 2.37403
COPB1 coatomer protein complex, subunit beta 1 2.33584
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 2.33584
FMO2 flavin containing monooxygenase 2 (non-functional) 2.33479
TDRD6 tudor domain containing 6 2.33479
COL4A6 collagen, type IV, alpha 6 2.2993
TMTC1 transmembrane and tetratricopeptide repeat containing 1 2.29907
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase 2.29907
RGMA repulsive guidance molecule family member a 2.29907
DTNA dystrobrevin, alpha 2.29907
ECH1 enoyl CoA hydratase 1, peroxisomal 2.2447
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 2.2447
LRRC32 leucine rich repeat containing 32 2.2447
LEPROTL1 leptin receptor overlapping transcript-like 1 2.23126
KIAA1586 KIAA1586 2.22588
RPL37A ribosomal protein L37a 2.18625
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 2.18625
NUDCD2 NudC domain containing 2 2.18273
PARP14 poly (ADP-ribose) polymerase family, member 14 2.18252
PGCKA1 PDCD10 and GCKIII kinases associated 1 2.17836
NANS N-acetylneuraminic acid synthase 2.17806
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 2.17806
MIX23 mitochondrial matrix import factor 23 2.1721
DCK deoxycytidine kinase 2.17045
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa 2.17045
THBS4 thrombospondin 4 2.15117
GCFC2 GC-rich sequence DNA-binding factor 2 2.12781
ARL14EP ADP-ribosylation factor-like 14 effector protein 2.12164
EBPL emopamil binding protein-like 2.11028
HAUS7 HAUS augmin-like complex, subunit 7 2.10739
SPATA20 spermatogenesis associated 20 2.10642
ESRP2 epithelial splicing regulatory protein 2 2.10482
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) 2.08202
MAMDC2 MAM domain containing 2 2.07791
DLC1 DLC1 Rho GTPase activating protein 2.07414
CASP9 caspase 9, apoptosis-related cysteine peptidase 2.07374
MEDAG mesenteric estrogen-dependent adipogenesis 2.07345
RHEBL1 Ras homolog enriched in brain like 1 2.07321
ZNF223 zinc finger protein 223 2.07041
PVALB parvalbumin 2.06662
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 2.06447
F8A1 coagulation factor VIII-associated 1 2.05667
TMC2 transmembrane channel-like 2 2.03892
NRK Nik related kinase 2.03557
LAPTM4A lysosomal protein transmembrane 4 alpha 2.02371
ZBTB35 zinc finger and BTB domain containing 35 2.01945
HOMER1 homer scaffolding protein 1 2.01829
RSPH9 radial spoke head 9 homolog (Chlamydomonas) 2.0115
RNF220 ring finger protein 220 2.00103
UNC5CL unc-5 homolog C (C. elegans)-like 2.00103

decreased expression

Symbol Name Standardized Value
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) -2.66071
SCT secretin -2.66071
VSTM4 V-set and transmembrane domain containing 4 -2.66071
C11ORF96 chromosome 11 open reading frame 96 -2.64009
DIO1 deiodinase, iodothyronine, type I -2.64009
TRAM1L1 translocation associated membrane protein 1-like 1 -2.64009
SLC22A14 solute carrier family 22, member 14 -2.64009
ZNF843 zinc finger protein 843 -2.64009
C1ORF202 chromosome 1 open reading frame 202 -2.64009
PTPN23 protein tyrosine phosphatase, non-receptor type 23 -2.6155
SLC7A14 solute carrier family 7, member 14 -2.6155
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 -2.6155
ALKAL1 ALK and LTK ligand 1 -2.6155
PIGB phosphatidylinositol glycan anchor biosynthesis, class B -2.6155
RBM26 RNA binding motif protein 26 -2.6155
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1 -2.6155
PRCD progressive rod-cone degeneration -2.61077
CDK5RAP2 CDK5 regulatory subunit associated protein 2 -2.56358
LDHC lactate dehydrogenase C -2.53183
ASPA aspartoacylase -2.53183
CCDC9B coiled-coil domain containing 9B -2.53183
C1ORF141 chromosome 1 open reading frame 141 -2.53183
GADL1 glutamate decarboxylase-like 1 -2.53183
THRSP thyroid hormone responsive -2.53183
ADGB androglobin -2.53183
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) -2.53183
IZUMO4 IZUMO family member 4 -2.53183
GJB5 gap junction protein, beta 5, 31.1kDa -2.53183
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 -2.53183
WFDC1 WAP four-disulfide core domain 1 -2.53183
HPX hemopexin -2.53183
PCDHGA3 protocadherin gamma subfamily A, 3 -2.53183
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B -2.53183
EPPK1 epiplakin 1 -2.50769
LNPK lunapark, ER junction formation factor -2.50369
ASF1A anti-silencing function 1A histone chaperone -2.49358
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 -2.45815
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -2.44867
CHAD chondroadherin -2.44867
TRIP4 thyroid hormone receptor interactor 4 -2.44867
ANGPTL4 angiopoietin-like 4 -2.44867
KLK8 kallikrein-related peptidase 8 -2.44867
SPATC1 spermatogenesis and centriole associated 1 -2.44867
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 -2.44867
METTL2A methyltransferase like 2A -2.445
ISG20 interferon stimulated exonuclease gene 20kDa -2.4379
NFRKB nuclear factor related to kappaB binding protein -2.41572
TSPAN15 tetraspanin 15 -2.40714
GARIN5A golgi associated RAB2 interactor 5A -2.39624
FAR2 fatty acyl CoA reductase 2 -2.33243
CCDC172 coiled-coil domain containing 172 -2.29535
RBM25 RNA binding motif protein 25 -2.28474
STN1 STN1 subunit of CST complex -2.28416
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing -2.28416
FBXO16 F-box protein 16 -2.28154
ZNF266 zinc finger protein 266 -2.25766
MTFMT mitochondrial methionyl-tRNA formyltransferase -2.2447
FAM78A family with sequence similarity 78, member A -2.20634
ZNF317 zinc finger protein 317 -2.19365
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 -2.18625
ZNRF3 zinc and ring finger 3 -2.17806
AMMECR1L AMMECR1-like -2.17806
BIRC5 baculoviral IAP repeat containing 5 -2.17665
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -2.17381
IGSF23 immunoglobulin superfamily, member 23 -2.14454
CTSO cathepsin O -2.14454
ACAN aggrecan -2.14454
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 -2.14454
FANCD2 Fanconi anemia, complementation group D2 -2.11746
TMEM128 transmembrane protein 128 -2.10482
IGF2R insulin-like growth factor 2 receptor -2.10482
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) -2.10482
SPTSSA serine palmitoyltransferase, small subunit A -2.09071
SYCE3 synaptonemal complex central element protein 3 -2.07345
FAM209B family with sequence similarity 209, member B -2.07345
ACTL6A actin-like 6A -2.06517
CNTN2 contactin 2 (axonal) -2.06447
ZNF575 zinc finger protein 575 -2.06447
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 -2.06447
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta -2.06191
JPH2 junctophilin 2 -2.05303
TRPC3 transient receptor potential cation channel, subfamily C, member 3 -2.05303
TMEM106C transmembrane protein 106C -2.04797
PUSL1 pseudouridylate synthase-like 1 -2.04374
CCDC136 coiled-coil domain containing 136 -2.03582
NSL1 NSL1, MIS12 kinetochore complex component -2.02529
SUMF1 sulfatase modifying factor 1 -2.02102