CRX_DN.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/CRX_DN.V1_UP
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Genes

269 genes differentially expressed following the CRX_DN.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4
AGR2 anterior gradient 2
ALPK2 alpha-kinase 2
ALPL alkaline phosphatase, liver/bone/kidney
ANKRD33 ankyrin repeat domain 33
AQP1 aquaporin 1 (Colton blood group)
ARG2 arginase 2
ARHGAP10 Rho GTPase activating protein 10
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BATF2 basic leucine zipper transcription factor, ATF-like 2
BCAR3 breast cancer anti-estrogen resistance 3
BMP15 bone morphogenetic protein 15
BST1 bone marrow stromal cell antigen 1
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C14ORF37 chromosome 14 open reading frame 37
C16ORF74 chromosome 16 open reading frame 74
CABP4 calcium binding protein 4
CCDC107 coiled-coil domain containing 107
CCDC64 coiled-coil domain containing 64
CDR2 cerebellar degeneration-related protein 2, 62kDa
CKMT1A creatine kinase, mitochondrial 1A
CLDN7 claudin 7
COL19A1 collagen, type XIX, alpha 1
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
DDHD1 DDHD domain containing 1
DHH desert hedgehog
DOCK8 dedicator of cytokinesis 8
DOHH deoxyhypusine hydroxylase/monooxygenase
DPF3 D4, zinc and double PHD fingers, family 3
DUSP14 dual specificity phosphatase 14
ESRRB estrogen-related receptor beta
FAAH fatty acid amide hydrolase
FAIM Fas apoptotic inhibitory molecule
FAM107B family with sequence similarity 107, member B
FAM161A family with sequence similarity 161, member A
GAS7 growth arrest-specific 7
GCKR glucokinase (hexokinase 4) regulator
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
GPSM2 G-protein signaling modulator 2
GPSM3 G-protein signaling modulator 3
GRK1 G protein-coupled receptor kinase 1
GRTP1 growth hormone regulated TBC protein 1
GUCA1B guanylate cyclase activator 1B (retina)
GZMM granzyme M (lymphocyte met-ase 1)
HCLS1 hematopoietic cell-specific Lyn substrate 1
HSPA1A heat shock 70kDa protein 1A
HSPA1B heat shock 70kDa protein 1B
IER3 immediate early response 3
INSL5 insulin-like 5
JAG1 jagged 1
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14
KLKB1 kallikrein B, plasma (Fletcher factor) 1
KRT18 keratin 18, type I
LLGL2 lethal giant larvae homolog 2 (Drosophila)
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MDM1 Mdm1 nuclear protein homolog (mouse)
MEF2C myocyte enhancer factor 2C
MMP23B matrix metallopeptidase 23B
MYLK myosin light chain kinase
MYRF myelin regulatory factor
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NRM nurim (nuclear envelope membrane protein)
NXNL1 nucleoredoxin-like 1
NXNL2 nucleoredoxin-like 2
ONECUT1 one cut homeobox 1
OPN1MW opsin 1 (cone pigments), medium-wave-sensitive
OPN1SW opsin 1 (cone pigments), short-wave-sensitive
OSGEP O-sialoglycoprotein endopeptidase
PACRG PARK2 co-regulated
PAQR4 progestin and adipoQ receptor family member IV
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha
PDE6H phosphodiesterase 6H, cGMP-specific, cone, gamma
PDIA5 protein disulfide isomerase family A, member 5
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PLA2R1 phospholipase A2 receptor 1, 180kDa
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPAP2C phosphatidic acid phosphatase type 2C
PPP1R42 protein phosphatase 1, regulatory subunit 42
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme
PRPH2 peripherin 2 (retinal degeneration, slow)
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1
RAD51 RAD51 recombinase
RANGRF RAN guanine nucleotide release factor
RCVRN recoverin
RDH12 retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
RDH5 retinol dehydrogenase 5 (11-cis/9-cis)
REEP6 receptor accessory protein 6
RGR retinal G protein coupled receptor
RHPN1 rhophilin, Rho GTPase binding protein 1
RNF123 ring finger protein 123
RNF207 ring finger protein 207
RPE65 retinal pigment epithelium-specific protein 65kDa
RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1
RS1 retinoschisin 1
RTBDN retbindin
SELENBP1 selenium binding protein 1
SERINC4 serine incorporator 4
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SH2D1A SH2 domain containing 1A
SH3YL1 SH3 and SYLF domain containing 1
SLC17A1 solute carrier family 17 (organic anion transporter), member 1
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
SNTA1 syntrophin, alpha 1
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
SNTG2 syntrophin, gamma 2
SP6 Sp6 transcription factor
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
STK17B serine/threonine kinase 17b
STK35 serine/threonine kinase 35
STRA6 stimulated by retinoic acid 6
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
SYNPO2 synaptopodin 2
TAOK3 TAO kinase 3
TCP11 t-complex 11, testis-specific
TMEM218 transmembrane protein 218
TMEM229B transmembrane protein 229B
TMEM27 transmembrane protein 27
TMEM35 transmembrane protein 35
TMLHE trimethyllysine hydroxylase, epsilon
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRAFD1 TRAF-type zinc finger domain containing 1
TTC39C tetratricopeptide repeat domain 39C
UBTD1 ubiquitin domain containing 1
UBXN11 UBX domain protein 11
VTN vitronectin
WDR31 WD repeat domain 31
WDR78 WD repeat domain 78
WISP1 WNT1 inducible signaling pathway protein 1
XIST X inactive specific transcript (non-protein coding)
ZDHHC12 zinc finger, DHHC-type containing 12
ZFP57 ZFP57 zinc finger protein

decreased expression

Symbol Name
ACBD6 acyl-CoA binding domain containing 6
ACSS1 acyl-CoA synthetase short-chain family member 1
ANXA2 annexin A2
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BCL3 B-cell CLL/lymphoma 3
C1QC complement component 1, q subcomponent, C chain
C1QTNF6 C1q and tumor necrosis factor related protein 6
CADPS2 Ca++-dependent secretion activator 2
CALCA calcitonin-related polypeptide alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAPN12 calpain 12
CCKBR cholecystokinin B receptor
CD44 CD44 molecule (Indian blood group)
CDH20 cadherin 20, type 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal)
CLRN3 clarin 3
COL16A1 collagen, type XVI, alpha 1
COL4A2 collagen, type IV, alpha 2
CRYBG3 beta-gamma crystallin domain containing 3
CSN3 casein kappa
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL13 chemokine (C-X-C motif) ligand 13
DCAF4 DDB1 and CUL4 associated factor 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHX32 DEAH (Asp-Glu-Ala-His) box polypeptide 32
DUSP16 dual specificity phosphatase 16
EFNA1 ephrin-A1
EGR1 early growth response 1
EYA1 EYA transcriptional coactivator and phosphatase 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FKBP5 FK506 binding protein 5
FMN1 formin 1
FMO3 flavin containing monooxygenase 3
FOXD1 forkhead box D1
FRMD6 FERM domain containing 6
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
GDAP1L1 ganglioside induced differentiation associated protein 1-like 1
GFAP glial fibrillary acidic protein
GHRH growth hormone releasing hormone
GLIPR2 GLI pathogenesis-related 2
GLYCAM1 glycosylation dependent cell adhesion molecule 1 (pseudogene)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GULOP gulonolactone (L-) oxidase, pseudogene
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HNF1A HNF1 homeobox A
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
INHBB inhibin, beta B
INSM1 insulinoma-associated 1
INSM2 insulinoma-associated 2
IRF5 interferon regulatory factor 5
JAM3 junctional adhesion molecule 3
JUNB jun B proto-oncogene
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLF10 Kruppel-like factor 10
KSR1 kinase suppressor of ras 1
LAD1 ladinin 1
LDB1 LIM domain binding 1
LECT1 leukocyte cell derived chemotaxin 1
LIN28A lin-28 homolog A (C. elegans)
LIX1 Lix1 homolog (chicken)
LRRC4 leucine rich repeat containing 4
LXN latexin
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MFSD4 major facilitator superfamily domain containing 4
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MYOCD myocardin
MYOZ1 myozenin 1
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NUPR1 nuclear protein, transcriptional regulator, 1
OSMR oncostatin M receptor
PCOLCE procollagen C-endopeptidase enhancer
PCSK2 proprotein convertase subtilisin/kexin type 2
PHOSPHO1 phosphatase, orphan 1
PHOX2B paired-like homeobox 2b
PLAT plasminogen activator, tissue
PLEC plectin
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A
PRDM1 PR domain containing 1, with ZNF domain
PTER phosphotriesterase related
PYCR1 pyrroline-5-carboxylate reductase 1
RAI14 retinoic acid induced 14
RBP4 retinol binding protein 4, plasma
RGL3 ral guanine nucleotide dissociation stimulator-like 3
RNASE4 ribonuclease, RNase A family, 4
RXRG retinoid X receptor, gamma
S100A16 S100 calcium binding protein A16
S100A6 S100 calcium binding protein A6
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA5B sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SH3BP4 SH3-domain binding protein 4
SKAP2 src kinase associated phosphoprotein 2
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SLC26A4 solute carrier family 26 (anion exchanger), member 4
SMOC2 SPARC related modular calcium binding 2
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SOCS3 suppressor of cytokine signaling 3
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome)
SPSB2 splA/ryanodine receptor domain and SOCS box containing 2
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3
STEAP4 STEAP family member 4
TAGLN2 transgelin 2
TCTE3 t-complex-associated-testis-expressed 3
TECTA tectorin alpha
TGM2 transglutaminase 2
TIMP1 TIMP metallopeptidase inhibitor 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMEM176A transmembrane protein 176A
TMOD1 tropomodulin 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNNC2 troponin C type 2 (fast)
TRIM13 tripartite motif containing 13
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TUBB6 tubulin, beta 6 class V
WWC1 WW and C2 domain containing 1
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF474 zinc finger protein 474