CSF1R Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description colony stimulating factor 1 receptor|The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013] (NCBI Entrez Gene Database, 1436)
External Link http://www.ncbi.nlm.nih.gov/gene/1436
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Genes

30 interacting proteins for CSF1R from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CSF1 colony stimulating factor 1 (macrophage)
FYN FYN proto-oncogene, Src family tyrosine kinase
GRAP2 GRB2-related adaptor protein 2
GRB2 growth factor receptor-bound protein 2
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
IL34 interleukin 34
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
INPPL1 inositol polyphosphate phosphatase-like 1
ITGAV integrin, alpha V
LYN LYN proto-oncogene, Src family tyrosine kinase
PAN2 PAN2 poly(A) specific ribonuclease subunit
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PKM pyruvate kinase, muscle
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN2 protein tyrosine phosphatase, non-receptor type 2
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RUNX1 runt-related transcription factor 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SOCS1 suppressor of cytokine signaling 1
SOCS3 suppressor of cytokine signaling 3
SOS1 son of sevenless homolog 1 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAP2 signal transducing adaptor family member 2
THOC5 THO complex 5
UBC ubiquitin C
VAV3 vav 3 guanine nucleotide exchange factor
YES1 YES proto-oncogene 1, Src family tyrosine kinase