Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/CSR_EARLY_UP.V1_UP
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314 genes differentially expressed following the CSR_EARLY_UP.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
ADRM1 adhesion regulating molecule 1
AMD1 adenosylmethionine decarboxylase 1
ATG101 autophagy related 101
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
BCAR1 breast cancer anti-estrogen resistance 1
BCAR3 breast cancer anti-estrogen resistance 3
BDKRB1 bradykinin receptor B1
BRPF1 bromodomain and PHD finger containing, 1
C21ORF91 chromosome 21 open reading frame 91
C8ORF76 chromosome 8 open reading frame 76
CBFB core-binding factor, beta subunit
CCDC59 coiled-coil domain containing 59
CD274 CD274 molecule
CD33 CD33 molecule
CHUK conserved helix-loop-helix ubiquitous kinase
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSRNP2 cysteine-serine-rich nuclear protein 2
CTPS1 CTP synthase 1
DCBLD1 discoidin, CUB and LCCL domain containing 1
DDIT4L DNA-damage-inducible transcript 4-like
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DHX33 DEAH (Asp-Glu-Ala-His) box polypeptide 33
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
DKC1 dyskeratosis congenita 1, dyskerin
DLX2 distal-less homeobox 2
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DOT1L DOT1-like histone H3K79 methyltransferase
DSP desmoplakin
EHD4 EH-domain containing 4
EIF4A1 eukaryotic translation initiation factor 4A1
EIF4A3 eukaryotic translation initiation factor 4A3
EIF4H eukaryotic translation initiation factor 4H
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ELL elongation factor RNA polymerase II
EMC6 ER membrane protein complex subunit 6
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM107B family with sequence similarity 107, member B
FAM180A family with sequence similarity 180, member A
FJX1 four jointed box 1 (Drosophila)
FOXD1 forkhead box D1
FRMD6 FERM domain containing 6
FZD8 frizzled class receptor 8
GABPB2 GA binding protein transcription factor, beta subunit 2
GAL galanin/GMAP prepropeptide
GATA2 GATA binding protein 2
GNL2 guanine nucleotide binding protein-like 2 (nucleolar)
GTPBP4 GTP binding protein 4
HBEGF heparin-binding EGF-like growth factor
HECTD2 HECT domain containing E3 ubiquitin protein ligase 2
HLX H2.0-like homeobox
HMGA1 high mobility group AT-hook 1
HPCAL1 hippocalcin-like 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IL11 interleukin 11
ILF2 interleukin enhancer binding factor 2
INHBA inhibin, beta A
IRAK1 interleukin-1 receptor-associated kinase 1
ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein-like 2
KIAA0020 KIAA0020
KLF10 Kruppel-like factor 10
KLF13 Kruppel-like factor 13
KPNA4 karyopherin alpha 4 (importin alpha 3)
LRRC8A leucine rich repeat containing 8 family, member A
MAP2K3 mitogen-activated protein kinase kinase 3
MAPRE1 microtubule-associated protein, RP/EB family, member 1
MESDC1 mesoderm development candidate 1
MNAT1 MNAT CDK-activating kinase assembly factor 1
MOB1B MOB kinase activator 1B
MRPS35 mitochondrial ribosomal protein S35
MSANTD3 Myb/SANT-like DNA-binding domain containing 3
MYO9B myosin IXB
NCL nucleolin
NET1 neuroepithelial cell transforming 1
NIFK nucleolar protein interacting with the FHA domain of MKI67
NIP7 NIP7, nucleolar pre-rRNA processing protein
NMD3 NMD3 ribosome export adaptor
NOP16 NOP16 nucleolar protein
NRBF2 nuclear receptor binding factor 2
NRIP1 nuclear receptor interacting protein 1
NSG1 neuron specific gene family member 1
NT5E 5'-nucleotidase, ecto (CD73)
NUP54 nucleoporin 54kDa
PANX1 pannexin 1
PAPD4 PAP associated domain containing 4
PAPD7 PAP associated domain containing 7
PCSK7 proprotein convertase subtilisin/kexin type 7
PDE4DIP phosphodiesterase 4D interacting protein
PHF20L1 PHD finger protein 20-like 1
PHLDB1 pleckstrin homology-like domain, family B, member 1
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2
PLAUR plasminogen activator, urokinase receptor
PLCH1 phospholipase C, eta 1
PNP purine nucleoside phosphorylase
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
POM121 POM121 transmembrane nucleoporin
PPIF peptidylprolyl isomerase F
PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PXN paxillin
REPS2 RALBP1 associated Eps domain containing 2
REST RE1-silencing transcription factor
RFK riboflavin kinase
RGMB repulsive guidance molecule family member b
RIPK2 receptor-interacting serine-threonine kinase 2
RNPS1 RNA binding protein S1, serine-rich domain
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
SCHIP1 schwannomin interacting protein 1
SEC24A SEC24 family member A
SHB Src homology 2 domain containing adaptor protein B
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SMAD7 SMAD family member 7
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMIM13 small integral membrane protein 13
SMTN smoothelin
SNAI1 snail family zinc finger 1
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SREK1IP1 SREK1-interacting protein 1
SRP72 signal recognition particle 72kDa
SRSF3 serine/arginine-rich splicing factor 3
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
STC1 stanniocalcin 1
TBX2 T-box 2
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
TCEB3 transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)
TDG thymine-DNA glycosylase
TFG TRK-fused gene
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TIMM23 translocase of inner mitochondrial membrane 23 homolog (yeast)
TMEM2 transmembrane protein 2
TMEM200A transmembrane protein 200A
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOP1 topoisomerase (DNA) I
TRMT10C tRNA methyltransferase 10 homolog C (S. cerevisiae)
TRNP1 TMF1-regulated nuclear protein 1
TXNDC12 thioredoxin domain containing 12 (endoplasmic reticulum)
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2N ubiquitin-conjugating enzyme E2N
UFM1 ubiquitin-fold modifier 1
UGDH UDP-glucose 6-dehydrogenase
USP12 ubiquitin specific peptidase 12
USP36 ubiquitin specific peptidase 36
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VGLL4 vestigial-like family member 4
VTA1 vesicle (multivesicular body) trafficking 1
YOD1 YOD1 deubiquitinase
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
ZBTB12 zinc finger and BTB domain containing 12
ZBTB2 zinc finger and BTB domain containing 2
ZNF324 zinc finger protein 324
ZNF697 zinc finger protein 697
ZNF800 zinc finger protein 800
ZPBP zona pellucida binding protein

decreased expression

Symbol Name
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10
ACBD4 acyl-CoA binding domain containing 4
ACCS 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)
ACYP1 acylphosphatase 1, erythrocyte (common) type
ADM adrenomedullin
AKIP1 A kinase (PRKA) interacting protein 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1L2 aldehyde dehydrogenase 1 family, member L2
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
AMT aminomethyltransferase
ANKRD33B ankyrin repeat domain 33B
ANKZF1 ankyrin repeat and zinc finger domain containing 1
AP4S1 adaptor-related protein complex 4, sigma 1 subunit
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARL4D ADP-ribosylation factor-like 4D
ARRDC3 arrestin domain containing 3
ARRDC4 arrestin domain containing 4
ASPA aspartoacylase
ATF7IP activating transcription factor 7 interacting protein
ATP11A ATPase, class VI, type 11A
BBC3 BCL2 binding component 3
BRD8 bromodomain containing 8
C14ORF132 chromosome 14 open reading frame 132
C2CD5 C2 calcium-dependent domain containing 5
CC2D1A coiled-coil and C2 domain containing 1A
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDRT4 CMT1A duplicated region transcript 4
CIRBP cold inducible RNA binding protein
CKB creatine kinase, brain
COL1A1 collagen, type I, alpha 1
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DAAM2 dishevelled associated activator of morphogenesis 2
DCP1B decapping mRNA 1B
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DHRS3 dehydrogenase/reductase (SDR family) member 3
DXO decapping exoribonuclease
EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3
ELMOD2 ELMO/CED-12 domain containing 2
ELMOD3 ELMO/CED-12 domain containing 3
ERAP2 endoplasmic reticulum aminopeptidase 2
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FAM46C family with sequence similarity 46, member C
FAM63A family with sequence similarity 63, member A
FBN1 fibrillin 1
FBXO25 F-box protein 25
FBXO38 F-box protein 38
FUS FUS RNA binding protein
FUT10 fucosyltransferase 10 (alpha (1,3) fucosyltransferase)
FZD2 frizzled class receptor 2
GDF5 growth differentiation factor 5
GFRA1 GDNF family receptor alpha 1
GLG1 golgi glycoprotein 1
GRHL1 grainyhead-like 1 (Drosophila)
GSDMB gasdermin B
GTPBP8 GTP-binding protein 8 (putative)
HBP1 HMG-box transcription factor 1
HEBP2 heme binding protein 2
HOXA10 homeobox A10
HSPG2 heparan sulfate proteoglycan 2
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IGLL1 immunoglobulin lambda-like polypeptide 1
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1
ING4 inhibitor of growth family, member 4
IP6K2 inositol hexakisphosphate kinase 2
KBTBD6 kelch repeat and BTB (POZ) domain containing 6
KIAA0319L KIAA0319-like
KIAA1147 KIAA1147
LDB1 LIM domain binding 1
LOC100132062 uncharacterized LOC100132062
LOC653602 uncharacterized LOC653602
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3
LRRK2 leucine-rich repeat kinase 2
LTN1 listerin E3 ubiquitin protein ligase 1
LURAP1L leucine rich adaptor protein 1-like
MAB21L1 mab-21-like 1 (C. elegans)
MOSPD2 motile sperm domain containing 2
MPPE1 metallophosphoesterase 1
MRI1 methylthioribose-1-phosphate isomerase 1
MSRB1 methionine sulfoxide reductase B1
NATD1 N-acetyltransferase domain containing 1
NBPF3 neuroblastoma breakpoint family, member 3
NDNF neuron-derived neurotrophic factor
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NMT2 N-myristoyltransferase 2
NPHP3 nephronophthisis 3 (adolescent)
NR1H3 nuclear receptor subfamily 1, group H, member 3
NSUN5P2 NOP2/Sun domain family, member 5 pseudogene 2
NYNRIN NYN domain and retroviral integrase containing
OTUD1 OTU deubiquitinase 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAPLN papilin, proteoglycan-like sulfated glycoprotein
PDE5A phosphodiesterase 5A, cGMP-specific
PEX6 peroxisomal biogenesis factor 6
PHIP pleckstrin homology domain interacting protein
PLCD1 phospholipase C, delta 1
PMS2P1 postmeiotic segregation increased 2 pseudogene 1
POLL polymerase (DNA directed), lambda
PPIEL peptidylprolyl isomerase E-like pseudogene
PRRT2 proline-rich transmembrane protein 2
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
RABGAP1 RAB GTPase activating protein 1
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
RNF20 ring finger protein 20, E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SAG S-antigen; retina and pineal gland (arrestin)
SDPR serum deprivation response
SIX1 SIX homeobox 1
SIX5 SIX homeobox 5
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC25A46 solute carrier family 25, member 46
SLC7A14 solute carrier family 7, member 14
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SNPH syntaphilin
SPG11 spastic paraplegia 11 (autosomal recessive)
STAT2 signal transducer and activator of transcription 2, 113kDa
STC2 stanniocalcin 2
STOX1 storkhead box 1
STX16 syntaxin 16
SULF1 sulfatase 1
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TCAIM T cell activation inhibitor, mitochondrial
TDRD6 tudor domain containing 6
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TRIM56 tripartite motif containing 56
TRIM69 tripartite motif containing 69
TXNIP thioredoxin interacting protein
UBN2 ubinuclein 2
UFSP2 UFM1-specific peptidase 2
USP33 ubiquitin specific peptidase 33
WEE1 WEE1 G2 checkpoint kinase
XAF1 XIAP associated factor 1
YEATS2 YEATS domain containing 2
YPEL2 yippee-like 2 (Drosophila)
ZFP64 ZFP64 zinc finger protein
ZFYVE1 zinc finger, FYVE domain containing 1
ZNF226 zinc finger protein 226
ZNF302 zinc finger protein 302
ZNF337 zinc finger protein 337
ZNF33A zinc finger protein 33A
ZNF37BP zinc finger protein 37B, pseudogene
ZNF467 zinc finger protein 467
ZNF500 zinc finger protein 500
ZNF585B zinc finger protein 585B