Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/CSR_LATE_UP.V1_UP
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337 genes differentially expressed following the CSR_LATE_UP.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
ACTL6A actin-like 6A
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
ALKBH7 alkB, alkylation repair homolog 7 (E. coli)
ANKRD32 ankyrin repeat domain 32
ANLN anillin, actin binding protein
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ASB6 ankyrin repeat and SOCS box containing 6
BEX1 brain expressed, X-linked 1
BIRC5 baculoviral IAP repeat containing 5
C19ORF48 chromosome 19 open reading frame 48
CASP2 caspase 2, apoptosis-related cysteine peptidase
CBFB core-binding factor, beta subunit
CCDC34 coiled-coil domain containing 34
CCND3 cyclin D3
CCT6P3 chaperonin containing TCP1, subunit 6 (zeta) pseudogene 3
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA8 cell division cycle associated 8
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDK5 cyclin-dependent kinase 5
CHEK2 checkpoint kinase 2
CIAPIN1 cytokine induced apoptosis inhibitor 1
CKAP2 cytoskeleton associated protein 2
CLSPN claspin
CMC2 C-x(9)-C motif containing 2
COPS3 COP9 signalosome subunit 3
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTPS1 CTP synthase 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL6 chemokine (C-X-C motif) ligand 6
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCBLD1 discoidin, CUB and LCCL domain containing 1
DCTPP1 dCTP pyrophosphatase 1
DIAPH3 diaphanous-related formin 3
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DTYMK deoxythymidylate kinase (thymidylate kinase)
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1
EIF3B eukaryotic translation initiation factor 3, subunit B
EIF5A eukaryotic translation initiation factor 5A
EML1 echinoderm microtubule associated protein like 1
EXOSC9 exosome component 9
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM216A family with sequence similarity 216, member A
FAM83D family with sequence similarity 83, member D
FANCA Fanconi anemia, complementation group A
FARSA phenylalanyl-tRNA synthetase, alpha subunit
FARSB phenylalanyl-tRNA synthetase, beta subunit
FEN1 flap structure-specific endonuclease 1
FKBP1A FK506 binding protein 1A, 12kDa
FOXM1 forkhead box M1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GMNN geminin, DNA replication inhibitor
GREM2 gremlin 2, DAN family BMP antagonist
GTF3C6 general transcription factor IIIC, polypeptide 6, alpha 35kDa
GYS1 glycogen synthase 1 (muscle)
HAT1 histone acetyltransferase 1
HAUS2 HAUS augmin-like complex, subunit 2
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HIP1 huntingtin interacting protein 1
HMGB1 high mobility group box 1
HN1 hematological and neurological expressed 1
HYPK huntingtin interacting protein K
IGFBP3 insulin-like growth factor binding protein 3
IL7R interleukin 7 receptor
ILF2 interleukin enhancer binding factor 2
IMP4 IMP4, U3 small nucleolar ribonucleoprotein
ITGA6 integrin, alpha 6
KATNAL1 katanin p60 subunit A-like 1
KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4
KIF1BP KIF1 binding protein
KIF22 kinesin family member 22
KISS1 KiSS-1 metastasis-suppressor
KRT18 keratin 18, type I
KRT25 keratin 25, type I
LMNB2 lamin B2
LTBP2 latent transforming growth factor beta binding protein 2
LYAR Ly1 antibody reactive
MAPRE1 microtubule-associated protein, RP/EB family, member 1
MAZ MYC-associated zinc finger protein (purine-binding transcription factor)
MBL2 mannose-binding lectin (protein C) 2, soluble
MCM3 minichromosome maintenance complex component 3
MET MET proto-oncogene, receptor tyrosine kinase
MMP3 matrix metallopeptidase 3
MRAS muscle RAS oncogene homolog
MT1B metallothionein 1B
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1L metallothionein 1L (gene/pseudogene)
MT1X metallothionein 1X
MT2A metallothionein 2A
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYH1 myosin, heavy chain 1, skeletal muscle, adult
MZT1 mitotic spindle organizing protein 1
NDC1 NDC1 transmembrane nucleoporin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NKX2-1 NK2 homeobox 1
NMB neuromedin B
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae)
NSG1 neuron specific gene family member 1
NUDC nudC nuclear distribution protein
NUDCD1 NudC domain containing 1
NUF2 NUF2, NDC80 kinetochore complex component
NUP88 nucleoporin 88kDa
PA2G4 proliferation-associated 2G4, 38kDa
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP11 poly (ADP-ribose) polymerase family, member 11
PBK PDZ binding kinase
PDCL3 phosducin-like 3
PDLIM5 PDZ and LIM domain 5
PGM2 phosphoglucomutase 2
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPP5C protein phosphatase 5, catalytic subunit
PREB prolactin regulatory element binding
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRMT5 protein arginine methyltransferase 5
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
RAD18 RAD18 E3 ubiquitin protein ligase
RPF2 ribosome production factor 2 homolog (S. cerevisiae)
RRM2 ribonucleotide reductase M2
S1PR1 sphingosine-1-phosphate receptor 1
SAMD11 sterile alpha motif domain containing 11
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7
SHCBP1 SHC SH2-domain binding protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
SMS spermine synthase
SNORD22 small nucleolar RNA, C/D box 22
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
SRM spermidine synthase
SSTR1 somatostatin receptor 1
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
STRA13 stimulated by retinoic acid 13
TAGLN3 transgelin 3
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
TCF19 transcription factor 19
TEX30 testis expressed 30
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM130 transmembrane protein 130
TOMM34 translocase of outer mitochondrial membrane 34
TPM2 tropomyosin 2 (beta)
TRIP13 thyroid hormone receptor interactor 13
TRNP1 TMF1-regulated nuclear protein 1
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TRPC4 transient receptor potential cation channel, subfamily C, member 4
TSPAN13 tetraspanin 13
TUBA3C tubulin, alpha 3c
TUBA4A tubulin, alpha 4a
TUBG1 tubulin, gamma 1
UBE2C ubiquitin-conjugating enzyme E2C
UHRF1 ubiquitin-like with PHD and ring finger domains 1
UMPS uridine monophosphate synthetase
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
VEGFC vascular endothelial growth factor C
WSB2 WD repeat and SOCS box containing 2
YEATS4 YEATS domain containing 4
YIPF3 Yip1 domain family, member 3
ZNF367 zinc finger protein 367
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein

decreased expression

Symbol Name
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6
ACCS 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)
ACVRL1 activin A receptor type II-like 1
ADAM17 ADAM metallopeptidase domain 17
ADGRB2 adhesion G protein-coupled receptor B2
ADORA2B adenosine A2b receptor
ALPI alkaline phosphatase, intestinal
ANGPTL2 angiopoietin-like 2
ANKRD29 ankyrin repeat domain 29
ANKRD33B ankyrin repeat domain 33B
APOL3 apolipoprotein L, 3
ASS1 argininosuccinate synthase 1
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BCL10 B-cell CLL/lymphoma 10
BTBD19 BTB (POZ) domain containing 19
BTG2 BTG family, member 2
C10ORF54 chromosome 10 open reading frame 54
C14ORF1 chromosome 14 open reading frame 1
C1ORF115 chromosome 1 open reading frame 115
C1ORF52 chromosome 1 open reading frame 52
C2ORF27A chromosome 2 open reading frame 27A
C6ORF1 chromosome 6 open reading frame 1
CALD1 caldesmon 1
CCL11 chemokine (C-C motif) ligand 11
CCL2 chemokine (C-C motif) ligand 2
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
CFH complement factor H
CHL1 cell adhesion molecule L1-like
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLEC3B C-type lectin domain family 3, member B
CMBL carboxymethylenebutenolidase homolog (Pseudomonas)
COL8A2 collagen, type VIII, alpha 2
CTSF cathepsin F
DAAM2 dishevelled associated activator of morphogenesis 2
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
DENND2A DENN/MADD domain containing 2A
DHCR7 7-dehydrocholesterol reductase
DKK2 dickkopf WNT signaling pathway inhibitor 2
DPP4 dipeptidyl-peptidase 4
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP4 dual specificity phosphatase 4
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
EBP emopamil binding protein (sterol isomerase)
ECH1 enoyl CoA hydratase 1, peroxisomal
ELOVL6 ELOVL fatty acid elongase 6
EPB41L4A-AS1 EPB41L4A antisense RNA 1
EPHB6 EPH receptor B6
EPSTI1 epithelial stromal interaction 1 (breast)
ERMP1 endoplasmic reticulum metallopeptidase 1
EXOC6 exocyst complex component 6
F8 coagulation factor VIII, procoagulant component
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM131C family with sequence similarity 131, member C
FAM213A family with sequence similarity 213, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FDXR ferredoxin reductase
FGGY FGGY carbohydrate kinase domain containing
FIBIN fin bud initiation factor homolog (zebrafish)
FTH1 ferritin, heavy polypeptide 1
GAS1 growth arrest-specific 1
GAS6 growth arrest-specific 6
GFRA1 GDNF family receptor alpha 1
GJD3 gap junction protein, delta 3, 31.9kDa
GLI3 GLI family zinc finger 3
GLT8D2 glycosyltransferase 8 domain containing 2
GSN gelsolin
GYPC glycophorin C (Gerbich blood group)
HHEX hematopoietically expressed homeobox
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGDCC4 immunoglobulin superfamily, DCC subclass, member 4
IL1B interleukin 1, beta
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
ITGB8 integrin, beta 8
KIAA0930 KIAA0930
KIAA1147 KIAA1147
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLHL29 kelch-like family member 29
L1CAM L1 cell adhesion molecule
LDLR low density lipoprotein receptor
LOC100287704 uncharacterized LOC100287704
LOC653602 uncharacterized LOC653602
LONRF1 LON peptidase N-terminal domain and ring finger 1
LPAR3 lysophosphatidic acid receptor 3
LPIN1 lipin 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAMDC2 MAM domain containing 2
MAMLD1 mastermind-like domain containing 1
MAN1A1 mannosidase, alpha, class 1A, member 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
MME membrane metallo-endopeptidase
MOB3C MOB kinase activator 3C
MRGPRF MAS-related GPR, member F
MSMO1 methylsterol monooxygenase 1
MVD mevalonate (diphospho) decarboxylase
MXD4 MAX dimerization protein 4
NBEA neurobeachin
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NOV nephroblastoma overexpressed
NTN4 netrin 4
NYNRIN NYN domain and retroviral integrase containing
OAF OAF homolog (Drosophila)
OLFML2A olfactomedin-like 2A
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PAMR1 peptidase domain containing associated with muscle regeneration 1
PDE5A phosphodiesterase 5A, cGMP-specific
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PGF placental growth factor
PLBD2 phospholipase B domain containing 2
PLCD1 phospholipase C, delta 1
PLEKHG4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4
POR P450 (cytochrome) oxidoreductase
PRKCI protein kinase C, iota
PRKG1 protein kinase, cGMP-dependent, type I
PRRT2 proline-rich transmembrane protein 2
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PYROXD2 pyridine nucleotide-disulphide oxidoreductase domain 2
QPRT quinolinate phosphoribosyltransferase
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RCAN2 regulator of calcineurin 2
RNLS renalase, FAD-dependent amine oxidase
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
SAMD5 sterile alpha motif domain containing 5
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCML1 sex comb on midleg-like 1 (Drosophila)
SDPR serum deprivation response
SFTPB surfactant protein B
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1
SLC22A18 solute carrier family 22, member 18
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
SNX18 sorting nexin 18
SOD2 superoxide dismutase 2, mitochondrial
STARD4 StAR-related lipid transfer (START) domain containing 4
SUMF1 sulfatase modifying factor 1
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
TBC1D2B TBC1 domain family, member 2B
TCEAL7 transcription elongation factor A (SII)-like 7
TM7SF2 transmembrane 7 superfamily member 2
TMEM119 transmembrane protein 119
TMEM258 transmembrane protein 258
TNXB tenascin XB
TOX thymocyte selection-associated high mobility group box
TP53INP1 tumor protein p53 inducible nuclear protein 1
TRERF1 transcriptional regulating factor 1
TRIM22 tripartite motif containing 22
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TSPAN9 tetraspanin 9
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VAMP5 vesicle-associated membrane protein 5
XAF1 XIAP associated factor 1