| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | cytotoxic T-lymphocyte-associated protein 4|This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1493) |
| External Link | https://ncbi.nlm.nih.gov/gene/1493 |
| Similar Terms | |
| Downloads & Tools |
498 genes differentially expressed following the CTLA4 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 0.0180757 |
| CA2 | carbonic anhydrase II | 0.0159175 |
| S100A7 | S100 calcium binding protein A7 | 0.0152487 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0145421 |
| KRT14 | keratin 14, type I | 0.0134525 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.0132282 |
| GCH1 | GTP cyclohydrolase 1 | 0.0119428 |
| CFB | complement factor B | 0.011261 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0112317 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | 0.0111397 |
| BST2 | bone marrow stromal cell antigen 2 | 0.0107458 |
| MT2A | metallothionein 2A | 0.0106111 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0104714 |
| COG7 | component of oligomeric golgi complex 7 | 0.0103457 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0103426 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0102481 |
| ABLIM1 | actin binding LIM protein 1 | 0.0101741 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | 0.0101032 |
| ZNF91 | zinc finger protein 91 | 0.009905 |
| PFKP | phosphofructokinase, platelet | 0.00973509 |
| TRIM22 | tripartite motif containing 22 | 0.00965009 |
| BMP4 | bone morphogenetic protein 4 | 0.00958003 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0095359 |
| CCNB1IP1 | cyclin B1 interacting protein 1, E3 ubiquitin protein ligase | 0.00951778 |
| LGALS2 | lectin, galactoside-binding, soluble, 2 | 0.00950747 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 0.00938528 |
| MT1HL1 | metallothionein 1H-like 1 | 0.00934075 |
| SP110 | SP110 nuclear body protein | 0.00932725 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.00929977 |
| EIF5A | eukaryotic translation initiation factor 5A | 0.00893545 |
| DDX58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | 0.00889833 |
| MT1E | metallothionein 1E | 0.00889568 |
| AK4 | adenylate kinase 4 | 0.00887775 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.00886408 |
| RNF167 | ring finger protein 167 | 0.00878448 |
| POLR2D | polymerase (RNA) II (DNA directed) polypeptide D | 0.0087396 |
| DEFB1 | defensin, beta 1 | 0.00862775 |
| SPRR1A | small proline-rich protein 1A | 0.00859229 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | 0.00843586 |
| LTB | lymphotoxin beta (TNF superfamily, member 3) | 0.00841429 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.00836916 |
| QRSL1 | glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 | 0.00833867 |
| LITAF | lipopolysaccharide-induced TNF factor | 0.00825904 |
| PDZK1IP1 | PDZK1 interacting protein 1 | 0.00819862 |
| SPRR2B | small proline-rich protein 2B | 0.00819204 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | 0.00807304 |
| AKIRIN1 | akirin 1 | 0.00804717 |
| CSTA | cystatin A (stefin A) | 0.00798173 |
| IL6ST | interleukin 6 signal transducer | 0.00798004 |
| SMAD3 | SMAD family member 3 | 0.00797588 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 0.00791939 |
| MT1X | metallothionein 1X | 0.00789143 |
| ALDH7A1 | aldehyde dehydrogenase 7 family, member A1 | 0.00785573 |
| PSMB8 | proteasome (prosome, macropain) subunit, beta type, 8 | 0.00785345 |
| ADM | adrenomedullin | 0.00778874 |
| TAP1 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 0.00770395 |
| MT1H | metallothionein 1H | 0.00764324 |
| RTP4 | receptor (chemosensory) transporter protein 4 | 0.00763165 |
| DEFB4A | defensin, beta 4A | 0.00760895 |
| FAIM | Fas apoptotic inhibitory molecule | 0.00759384 |
| FLT3 | fms-related tyrosine kinase 3 | 0.00759137 |
| SPRR3 | small proline-rich protein 3 | 0.00758135 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 0.00754581 |
| MT1F | metallothionein 1F | 0.00754235 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | 0.00747101 |
| LEPROT | leptin receptor overlapping transcript | 0.0074654 |
| ASH2L | ash2 (absent, small, or homeotic)-like (Drosophila) | 0.00745367 |
| RMND1 | required for meiotic nuclear division 1 homolog (S. cerevisiae) | 0.00744424 |
| SPRR1B | small proline-rich protein 1B | 0.00738978 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | 0.00737142 |
| KRT17 | keratin 17, type I | 0.00735049 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.00727657 |
| IRF7 | interferon regulatory factor 7 | 0.00727598 |
| PXDN | peroxidasin | 0.00725611 |
| MYO1C | myosin IC | 0.00725026 |
| KLF6 | Kruppel-like factor 6 | 0.00724453 |
| TUBB2A | tubulin, beta 2A class IIa | 0.00723268 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 0.00721039 |
| PRSS8 | protease, serine, 8 | 0.00719982 |
| COL9A3 | collagen, type IX, alpha 3 | 0.00719889 |
| SELL | selectin L | 0.00718509 |
| CRABP1 | cellular retinoic acid binding protein 1 | 0.00718147 |
| CD200 | CD200 molecule | 0.00716164 |
| SP100 | SP100 nuclear antigen | 0.00715692 |
| POLDIP2 | polymerase (DNA-directed), delta interacting protein 2 | 0.00713119 |
| GAB2 | GRB2-associated binding protein 2 | 0.00709928 |
| MPHOSPH8 | M-phase phosphoprotein 8 | 0.00705945 |
| MT1G | metallothionein 1G | 0.0070315 |
| KLK7 | kallikrein-related peptidase 7 | 0.00698495 |
| GATC | glutamyl-tRNA(Gln) amidotransferase, subunit C | 0.00697706 |
| MVP | major vault protein | 0.00696872 |
| CCNC | cyclin C | 0.00696066 |
| NSA2 | NSA2 ribosome biogenesis homolog (S. cerevisiae) | 0.00696058 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.00695857 |
| PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 | 0.00688477 |
| ECHDC3 | enoyl CoA hydratase domain containing 3 | 0.00688356 |
| RRAGC | Ras-related GTP binding C | 0.00687207 |
| GBP1 | guanylate binding protein 1, interferon-inducible | 0.00686304 |
| RAB29 | RAB29, member RAS oncogene family | 0.00683614 |
| HSPA8 | heat shock 70kDa protein 8 | 0.00682069 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.00680364 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.00677647 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.0067721 |
| VSNL1 | visinin-like 1 | 0.00676699 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.00674539 |
| PLPBP | pyridoxal phosphate binding protein | 0.0067126 |
| BIK | BCL2-interacting killer (apoptosis-inducing) | 0.00667885 |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa | 0.00665276 |
| BFAR | bifunctional apoptosis regulator | 0.00665001 |
| HPD | 4-hydroxyphenylpyruvate dioxygenase | 0.00662766 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.00658792 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.00657261 |
| PTHLH | parathyroid hormone-like hormone | 0.00657 |
| ATF3 | activating transcription factor 3 | 0.0065698 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 0.00656638 |
| KLF9 | Kruppel-like factor 9 | 0.00655995 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.00652399 |
| NVL | nuclear VCP-like | 0.00650376 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.00648751 |
| SHTN1 | shootin 1 | 0.00648712 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.00643634 |
| EFHD1 | EF-hand domain family, member D1 | 0.00641049 |
| CRABP2 | cellular retinoic acid binding protein 2 | 0.00640248 |
| KLK5 | kallikrein-related peptidase 5 | 0.00639876 |
| TSPAN3 | tetraspanin 3 | 0.00638402 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.00637435 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0063556 |
| CAPG | capping protein (actin filament), gelsolin-like | 0.00633611 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.00631933 |
| CARHSP1 | calcium regulated heat stable protein 1, 24kDa | 0.00631856 |
| REEP5 | receptor accessory protein 5 | 0.00630466 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.00626453 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 0.00626136 |
| PEBP1 | phosphatidylethanolamine binding protein 1 | 0.00625577 |
| CTTN | cortactin | 0.00618911 |
| CXCL11 | chemokine (C-X-C motif) ligand 11 | 0.00618679 |
| IRF9 | interferon regulatory factor 9 | 0.00617605 |
| IRF1 | interferon regulatory factor 1 | 0.00617569 |
| SP140L | SP140 nuclear body protein-like | 0.00615826 |
| BCL11A | B-cell CLL/lymphoma 11A (zinc finger protein) | 0.00613592 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.00613461 |
| CDC42 | cell division cycle 42 | 0.00612098 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | 0.00611291 |
| KLK6 | kallikrein-related peptidase 6 | 0.00610177 |
| PNO1 | partner of NOB1 homolog (S. cerevisiae) | 0.00609818 |
| IER3 | immediate early response 3 | 0.0060699 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | 0.00606388 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.00604369 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.00603217 |
| MCM2 | minichromosome maintenance complex component 2 | 0.00601418 |
| GAL | galanin/GMAP prepropeptide | 0.00601362 |
| GRAMD2B | GRAM domain containing 2B | 0.00600523 |
| LOX | lysyl oxidase | 0.0060033 |
| RPP40 | ribonuclease P/MRP 40kDa subunit | 0.00599599 |
| IFI44L | interferon-induced protein 44-like | 0.00597833 |
| PHF11 | PHD finger protein 11 | 0.00597101 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.00595938 |
| KRT81 | keratin 81, type II | 0.00594096 |
| GPC3 | glypican 3 | 0.00593981 |
| KCNJ16 | potassium channel, inwardly rectifying subfamily J, member 16 | 0.00592328 |
| DENND5A | DENN/MADD domain containing 5A | 0.00592325 |
| RND1 | Rho family GTPase 1 | 0.00591042 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.00590777 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.00587893 |
| RHCG | Rh family, C glycoprotein | 0.00586956 |
| HMOX2 | heme oxygenase 2 | 0.00586201 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.00585464 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.00583764 |
| TICAM1 | toll-like receptor adaptor molecule 1 | 0.00583491 |
| HLA-B | major histocompatibility complex, class I, B | 0.00578773 |
| OAT | ornithine aminotransferase | 0.00578244 |
| APEX1 | APEX nuclease (multifunctional DNA repair enzyme) 1 | 0.00577865 |
| ZC3H12A | zinc finger CCCH-type containing 12A | 0.00573312 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.00572461 |
| PPA1 | pyrophosphatase (inorganic) 1 | 0.00572348 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.00572285 |
| MXI1 | MAX interactor 1, dimerization protein | 0.00571126 |
| LYRM4 | LYR motif containing 4 | 0.0057088 |
| DSP | desmoplakin | 0.00570226 |
| CLNS1A | chloride channel, nucleotide-sensitive, 1A | 0.00569514 |
| AIM2 | absent in melanoma 2 | 0.00569413 |
| MX1 | MX dynamin-like GTPase 1 | 0.00568577 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.0056745 |
| AUTS2 | autism susceptibility candidate 2 | 0.00566306 |
| IER2 | immediate early response 2 | 0.00565718 |
| SRPX2 | sushi-repeat containing protein, X-linked 2 | 0.00565031 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.005634 |
| ELP3 | elongator acetyltransferase complex subunit 3 | 0.00563226 |
| B2M | beta-2-microglobulin | 0.00562001 |
| SELE | selectin E | 0.00559186 |
| TAF10 | TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa | 0.00558769 |
| CX3CL1 | chemokine (C-X3-C motif) ligand 1 | 0.00558164 |
| CTSS | cathepsin S | 0.00557522 |
| HSD11B2 | hydroxysteroid (11-beta) dehydrogenase 2 | 0.00556184 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | 0.00553795 |
| ANXA2 | annexin A2 | 0.00553265 |
| ZYX | zyxin | 0.00553061 |
| FOXC1 | forkhead box C1 | 0.00552869 |
| USP18 | ubiquitin specific peptidase 18 | 0.00552406 |
| KLK10 | kallikrein-related peptidase 10 | 0.00552149 |
| GTF2H1 | general transcription factor IIH, polypeptide 1, 62kDa | 0.00551354 |
| IFIT5 | interferon-induced protein with tetratricopeptide repeats 5 | 0.00550271 |
| EREG | epiregulin | 0.00550213 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.00548158 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 0.00548132 |
| SET | SET nuclear proto-oncogene | 0.00546582 |
| ELOVL1 | ELOVL fatty acid elongase 1 | 0.00546104 |
| ERGIC2 | ERGIC and golgi 2 | 0.00545224 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.00544976 |
| IL36G | interleukin 36, gamma | 0.00544786 |
| RIDA | reactive intermediate imine deaminase A homolog | 0.00544396 |
| NFATC2IP | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein | 0.00544047 |
| DARS1 | aspartyl-tRNA synthetase 1 | 0.00543315 |
| COL9A2 | collagen, type IX, alpha 2 | 0.00543238 |
| EAF2 | ELL associated factor 2 | 0.00543128 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | 0.00542874 |
| S100A2 | S100 calcium binding protein A2 | 0.00540452 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.00540213 |
| RBM34 | RNA binding motif protein 34 | 0.00539183 |
| CNN2 | calponin 2 | 0.00539017 |
| ICAM3 | intercellular adhesion molecule 3 | 0.00537261 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.00536929 |
| CYP26A1 | cytochrome P450, family 26, subfamily A, polypeptide 1 | 0.00536802 |
| CALB1 | calbindin 1, 28kDa | 0.00533895 |
| ANG | angiogenin, ribonuclease, RNase A family, 5 | 0.00533677 |
| PI3 | peptidase inhibitor 3, skin-derived | 0.00533631 |
| FGF13 | fibroblast growth factor 13 | 0.00532061 |
| WASHC4 | WASH complex subunit 4 | 0.00531169 |
| BMERB1 | bMERB domain containing 1 | 0.00530614 |
| GZMK | granzyme K (granzyme 3; tryptase II) | 0.00530279 |
| USP15 | ubiquitin specific peptidase 15 | 0.00530181 |
| C12ORF43 | chromosome 12 open reading frame 43 | 0.00530153 |
| NAGPA | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase | 0.0053014 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0052989 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | 0.00529778 |
| RIPOR2 | RHO family interacting cell polarization regulator 2 | 0.0052872 |
| PIGP | phosphatidylinositol glycan anchor biosynthesis, class P | 0.00526913 |
| JPT2 | Jupiter microtubule associated homolog 2 | 0.0052638 |
| CBFB | core-binding factor, beta subunit | 0.00525025 |
| BHMT2 | betaine--homocysteine S-methyltransferase 2 | 0.00524896 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | 0.00524227 |
| STC2 | stanniocalcin 2 | 0.0052387 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.00523718 |
| CCL17 | chemokine (C-C motif) ligand 17 | 0.00522986 |
| RNASET2 | ribonuclease T2 | 0.00522469 |
| ZNF430 | zinc finger protein 430 | 0.00522253 |
| SSR3 | signal sequence receptor, gamma (translocon-associated protein gamma) | 0.00521429 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 0.00519399 |
| FN1 | fibronectin 1 | 0.00518854 |
| HCP5 | HLA complex P5 (non-protein coding) | 0.00518121 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AGR2 | anterior gradient 2 | -0.0166571 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0166304 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | -0.0155209 |
| OLFM4 | olfactomedin 4 | -0.0128692 |
| ALOX5 | arachidonate 5-lipoxygenase | -0.0126188 |
| COPS7A | COP9 signalosome subunit 7A | -0.012485 |
| TFF3 | trefoil factor 3 (intestinal) | -0.0121458 |
| DES | desmin | -0.0119017 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0116435 |
| CD163 | CD163 molecule | -0.0114198 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0111115 |
| STAB1 | stabilin 1 | -0.0110056 |
| S100P | S100 calcium binding protein P | -0.0109834 |
| VSIG4 | V-set and immunoglobulin domain containing 4 | -0.010495 |
| PCP4 | Purkinje cell protein 4 | -0.0102078 |
| ZBTB18 | zinc finger and BTB domain containing 18 | -0.00994906 |
| BCHE | butyrylcholinesterase | -0.00994634 |
| SAMSN1 | SAM domain, SH3 domain and nuclear localization signals 1 | -0.00993104 |
| FBXO11 | F-box protein 11 | -0.00990035 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.00981423 |
| DLK1 | delta-like 1 homolog (Drosophila) | -0.00979138 |
| C1QB | complement component 1, q subcomponent, B chain | -0.00975855 |
| TPSAB1 | tryptase alpha/beta 1 | -0.00973732 |
| COLEC12 | collectin sub-family member 12 | -0.00969729 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | -0.00967328 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | -0.00967179 |
| LTF | lactotransferrin | -0.00957379 |
| PID1 | phosphotyrosine interaction domain containing 1 | -0.00948035 |
| TXNIP | thioredoxin interacting protein | -0.00942263 |
| GOLM1 | golgi membrane protein 1 | -0.00941857 |
| TSPAN7 | tetraspanin 7 | -0.00929981 |
| C8ORF4 | chromosome 8 open reading frame 4 | -0.00920929 |
| APOD | apolipoprotein D | -0.00917795 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.00915409 |
| GRIA2 | glutamate receptor, ionotropic, AMPA 2 | -0.00914426 |
| SRPX | sushi-repeat containing protein, X-linked | -0.00913298 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | -0.00905155 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.00883835 |
| PTCH1 | patched 1 | -0.00883773 |
| MLPH | melanophilin | -0.0088062 |
| MAGED1 | melanoma antigen family D1 | -0.00874981 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) | -0.00870561 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.00865769 |
| CD14 | CD14 molecule | -0.00865217 |
| COL6A2 | collagen, type VI, alpha 2 | -0.00853313 |
| GALC | galactosylceramidase | -0.00843701 |
| CD320 | CD320 molecule | -0.00842794 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | -0.00839473 |
| PLTP | phospholipid transfer protein | -0.00835728 |
| KCND3 | potassium channel, voltage gated Shal related subfamily D, member 3 | -0.00828667 |
| PFKM | phosphofructokinase, muscle | -0.00826819 |
| SCAF4 | SR-related CTD-associated factor 4 | -0.0081442 |
| PKIA | protein kinase (cAMP-dependent, catalytic) inhibitor alpha | -0.00809354 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | -0.00808188 |
| FBLN1 | fibulin 1 | -0.00807651 |
| DMD | dystrophin | -0.00805643 |
| SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase | -0.00805459 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.00802248 |
| CCR1 | chemokine (C-C motif) receptor 1 | -0.00801551 |
| FCGR2B | Fc fragment of IgG, low affinity IIb, receptor (CD32) | -0.00800935 |
| MYOT | myotilin | -0.00794289 |
| KANK2 | KN motif and ankyrin repeat domains 2 | -0.00789321 |
| MAOA | monoamine oxidase A | -0.00786527 |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | -0.0078446 |
| BRCA1 | breast cancer 1, early onset | -0.00780692 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0078003 |
| SYNM | synemin, intermediate filament protein | -0.00777533 |
| MYH11 | myosin, heavy chain 11, smooth muscle | -0.00775839 |
| METRN | meteorin, glial cell differentiation regulator | -0.00773172 |
| TYROBP | TYRO protein tyrosine kinase binding protein | -0.00771598 |
| FCGR3B | Fc fragment of IgG, low affinity IIIb, receptor (CD16b) | -0.00768985 |
| DPM3 | dolichyl-phosphate mannosyltransferase polypeptide 3 | -0.00761457 |
| VPS13A | vacuolar protein sorting 13 homolog A (S. cerevisiae) | -0.00757786 |
| DMXL2 | Dmx-like 2 | -0.00747145 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | -0.00747069 |
| KLHL41 | kelch-like family member 41 | -0.00744703 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0074395 |
| WDR7 | WD repeat domain 7 | -0.00741987 |
| C4BPA | complement component 4 binding protein, alpha | -0.00735469 |
| AGTR1 | angiotensin II receptor, type 1 | -0.00731584 |
| PDLIM3 | PDZ and LIM domain 3 | -0.0073119 |
| NPTX2 | neuronal pentraxin II | -0.00730807 |
| SUB1 | SUB1 homolog (S. cerevisiae) | -0.007308 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.00730014 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.00728749 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.00727315 |
| FCGBP | Fc fragment of IgG binding protein | -0.00724205 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | -0.00723448 |
| NEK2 | NIMA-related kinase 2 | -0.00722456 |
| GAS1 | growth arrest-specific 1 | -0.00722158 |
| KRT19 | keratin 19, type I | -0.00722143 |
| HMGB1 | high mobility group box 1 | -0.0071768 |
| PDLIM5 | PDZ and LIM domain 5 | -0.00717484 |
| CAMP | cathelicidin antimicrobial peptide | -0.00716674 |
| CCP110 | centriolar coiled coil protein 110kDa | -0.00713004 |
| CRISP3 | cysteine-rich secretory protein 3 | -0.00712693 |
| FOXM1 | forkhead box M1 | -0.00712675 |
| MYL2 | myosin, light chain 2, regulatory, cardiac, slow | -0.0070905 |
| COL6A3 | collagen, type VI, alpha 3 | -0.00708153 |
| TNNI2 | troponin I type 2 (skeletal, fast) | -0.00704561 |
| ATP8A1 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 | -0.00703532 |
| PPA2 | pyrophosphatase (inorganic) 2 | -0.0070315 |
| TSPAN12 | tetraspanin 12 | -0.00696397 |
| SFTPA2 | surfactant protein A2 | -0.00694895 |
| TOB1 | transducer of ERBB2, 1 | -0.00694253 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | -0.0069375 |
| TARDBP | TAR DNA binding protein | -0.00693211 |
| BHLHE41 | basic helix-loop-helix family, member e41 | -0.00692508 |
| PDZRN3 | PDZ domain containing ring finger 3 | -0.0069238 |
| DPYD | dihydropyrimidine dehydrogenase | -0.00691333 |
| LYVE1 | lymphatic vessel endothelial hyaluronan receptor 1 | -0.00690036 |
| TTN | titin | -0.00689365 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.00682645 |
| RTN3 | reticulon 3 | -0.00680433 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.00679691 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.00676051 |
| SIK1 | salt-inducible kinase 1 | -0.00674254 |
| C1QA | complement component 1, q subcomponent, A chain | -0.00673371 |
| VAMP1 | vesicle-associated membrane protein 1 (synaptobrevin 1) | -0.00672721 |
| RAMP1 | receptor (G protein-coupled) activity modifying protein 1 | -0.00670736 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.00666455 |
| FCGR2A | Fc fragment of IgG, low affinity IIa, receptor (CD32) | -0.00666121 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 | -0.00665593 |
| CCL2 | chemokine (C-C motif) ligand 2 | -0.00664892 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.00661779 |
| KDM5D | lysine (K)-specific demethylase 5D | -0.00661663 |
| ALOX5AP | arachidonate 5-lipoxygenase-activating protein | -0.00660295 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.00660159 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | -0.00659793 |
| C5AR1 | complement component 5a receptor 1 | -0.00658765 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | -0.0065762 |
| PRUNE2 | prune homolog 2 (Drosophila) | -0.00657358 |
| KIAA0232 | KIAA0232 | -0.00657345 |
| C1R | complement component 1, r subcomponent | -0.00657296 |
| MARCO | macrophage receptor with collagenous structure | -0.00656972 |
| MBOAT7 | membrane bound O-acyltransferase domain containing 7 | -0.0065529 |
| DPT | dermatopontin | -0.00654561 |
| FCER1G | Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide | -0.00654387 |
| SPON2 | spondin 2, extracellular matrix protein | -0.00645217 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.00638918 |
| KIF18B | kinesin family member 18B | -0.00638761 |
| PPM1B | protein phosphatase, Mg2+/Mn2+ dependent, 1B | -0.00638362 |
| RPA1 | replication protein A1, 70kDa | -0.00633404 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.00633305 |
| KCNK3 | potassium channel, two pore domain subfamily K, member 3 | -0.00633272 |
| YKT6 | YKT6 v-SNARE homolog (S. cerevisiae) | -0.0062902 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.00628319 |
| MYH2 | myosin, heavy chain 2, skeletal muscle, adult | -0.00628189 |
| LEF1 | lymphoid enhancer-binding factor 1 | -0.00626001 |
| NLGN4X | neuroligin 4, X-linked | -0.0062453 |
| F13A1 | coagulation factor XIII, A1 polypeptide | -0.0062436 |
| IFT74 | intraflagellar transport 74 | -0.00621146 |
| A2M | alpha-2-macroglobulin | -0.00620822 |
| GGA1 | golgi-associated, gamma adaptin ear containing, ARF binding protein 1 | -0.00618045 |
| FEN1 | flap structure-specific endonuclease 1 | -0.00617385 |
| SPRY1 | sprouty homolog 1, antagonist of FGF signaling (Drosophila) | -0.00617327 |
| SKIV2L | superkiller viralicidic activity 2-like (S. cerevisiae) | -0.00617133 |
| SFTPB | surfactant protein B | -0.00613425 |
| DEFA5 | defensin, alpha 5, Paneth cell-specific | -0.00612336 |
| MYBPC1 | myosin binding protein C, slow type | -0.00611793 |
| TMEM164 | transmembrane protein 164 | -0.00609728 |
| RAD51AP1 | RAD51 associated protein 1 | -0.00608558 |
| HMGB3 | high mobility group box 3 | -0.0060829 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.00608281 |
| GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | -0.00607857 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.00606045 |
| TMX4 | thioredoxin-related transmembrane protein 4 | -0.0060404 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.00603914 |
| INSIG1 | insulin induced gene 1 | -0.006033 |
| KIF20A | kinesin family member 20A | -0.00603192 |
| HNRNPH2 | heterogeneous nuclear ribonucleoprotein H2 (H') | -0.0060309 |
| FGFR3 | fibroblast growth factor receptor 3 | -0.00601067 |
| CKM | creatine kinase, muscle | -0.00600867 |
| RCBTB2 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 | -0.00599476 |
| ENPP4 | ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) | -0.00597939 |
| LPCAT1 | lysophosphatidylcholine acyltransferase 1 | -0.00597656 |
| CDC25B | cell division cycle 25B | -0.0059751 |
| NDUFA5 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 | -0.00597422 |
| MAGEA3 | melanoma antigen family A3 | -0.00597318 |
| CCNB2 | cyclin B2 | -0.0059576 |
| RXRA | retinoid X receptor, alpha | -0.00594629 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.00594536 |
| HMGB2 | high mobility group box 2 | -0.0059418 |
| MICALL2 | MICAL-like 2 | -0.00593864 |
| COL1A2 | collagen, type I, alpha 2 | -0.00593006 |
| SMC1A | structural maintenance of chromosomes 1A | -0.00591338 |
| ADCY2 | adenylate cyclase 2 (brain) | -0.00591327 |
| USP32P2 | ubiquitin specific peptidase 32 pseudogene 2 | -0.00590201 |
| ZNF329 | zinc finger protein 329 | -0.00589004 |
| ACSL1 | acyl-CoA synthetase long-chain family member 1 | -0.00588563 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.00587284 |
| ATP5ME | ATP synthase membrane subunit e | -0.00586358 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | -0.00583903 |
| NECTIN3 | nectin cell adhesion molecule 3 | -0.00583416 |
| TNNT3 | troponin T type 3 (skeletal, fast) | -0.00583274 |
| MEF2C | myocyte enhancer factor 2C | -0.00582139 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | -0.00581261 |
| C14ORF132 | chromosome 14 open reading frame 132 | -0.00580673 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.00578814 |
| FHOD3 | formin homology 2 domain containing 3 | -0.00577335 |
| PLA2G7 | phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) | -0.0057696 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.00576498 |
| DEFA4 | defensin, alpha 4, corticostatin | -0.00574402 |
| ACTC1 | actin, alpha, cardiac muscle 1 | -0.005721 |
| TPM3 | tropomyosin 3 | -0.00571919 |
| ZNF331 | zinc finger protein 331 | -0.00571076 |
| MYL1 | myosin, light chain 1, alkali; skeletal, fast | -0.00569976 |
| NPL | N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) | -0.00569342 |
| RTN2 | reticulon 2 | -0.00568346 |
| CIT | citron rho-interacting serine/threonine kinase | -0.00567943 |
| ZNF432 | zinc finger protein 432 | -0.00567332 |
| TMSB15A | thymosin beta 15a | -0.00566343 |
| DPY19L1 | dpy-19-like 1 (C. elegans) | -0.00565668 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | -0.0056548 |
| HDC | histidine decarboxylase | -0.00564089 |
| LRIG1 | leucine-rich repeats and immunoglobulin-like domains 1 | -0.00563152 |
| SLN | sarcolipin | -0.00561397 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | -0.00561123 |
| REEP1 | receptor accessory protein 1 | -0.00560917 |
| CD209 | CD209 molecule | -0.0056052 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | -0.00559826 |
| ACTA1 | actin, alpha 1, skeletal muscle | -0.00558876 |
| EPHX1 | epoxide hydrolase 1, microsomal (xenobiotic) | -0.00558539 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0055716 |
| IFT81 | intraflagellar transport 81 | -0.00557117 |
| SDC3 | syndecan 3 | -0.00555949 |
| MANSC1 | MANSC domain containing 1 | -0.00554614 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.00552442 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | -0.00552437 |
| EFHD2 | EF-hand domain family, member D2 | -0.0055198 |
| PPP1R9A | protein phosphatase 1, regulatory subunit 9A | -0.00551844 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.00551461 |
| CYP4F3 | cytochrome P450, family 4, subfamily F, polypeptide 3 | -0.00550966 |
| RAD21 | RAD21 homolog (S. pombe) | -0.00550737 |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | -0.00550608 |
| H2AX | H2A.X variant histone | -0.00550566 |
| CRISPLD2 | cysteine-rich secretory protein LCCL domain containing 2 | -0.00550419 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.00550322 |
| SEC16A | SEC16 homolog A (S. cerevisiae) | -0.00549452 |
| MB | myoglobin | -0.00549029 |
| POLD2 | polymerase (DNA directed), delta 2, accessory subunit | -0.00547793 |
| COL21A1 | collagen, type XXI, alpha 1 | -0.00547704 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.00547403 |
| GPM6A | glycoprotein M6A | -0.00547325 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | -0.0054674 |
| ICMT | isoprenylcysteine carboxyl methyltransferase | -0.00546571 |
| ATP1A2 | ATPase, Na+/K+ transporting, alpha 2 polypeptide | -0.00545901 |
| YBX3 | Y box binding protein 3 | -0.00544542 |
