CTNNB1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description catenin (cadherin-associated protein), beta 1, 88kDa|The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Oct 2009] (NCBI Entrez Gene Database, 1499)
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Genes

360 genes differentially expressed following the CTNNB1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
IZUMO3 IZUMO family member 3 2.84713
ADAMTSL5 ADAMTS-like 5 2.84713
NLRP10 NLR family, pyrin domain containing 10 2.84713
MROH2B maestro heat-like repeat family member 2B 2.84713
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.84713
TMEM82 transmembrane protein 82 2.84713
MLNR motilin receptor 2.84713
GNRHR gonadotropin-releasing hormone receptor 2.84713
IL2RG interleukin 2 receptor, gamma 2.84713
ATOH8 atonal homolog 8 (Drosophila) 2.84713
ATOH1 atonal homolog 1 (Drosophila) 2.84713
GIMAP1 GTPase, IMAP family member 1 2.84713
PLXNB3 plexin B3 2.84713
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 2.84713
GNLY granulysin 2.84713
IL22RA2 interleukin 22 receptor, alpha 2 2.84713
SPINK4 serine peptidase inhibitor, Kazal type 4 2.84713
PRICKLE4 prickle homolog 4 (Drosophila) 2.84713
ZNF662 zinc finger protein 662 2.84713
TCHH trichohyalin 2.84713
SKOR2 SKI family transcriptional corepressor 2 2.84713
RSPO1 R-spondin 1 2.84713
NUGGC nuclear GTPase, germinal center associated 2.84713
VCX variable charge, X-linked 2.84713
CRYAA crystallin, alpha A 2.84713
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.84713
MROH2A maestro heat-like repeat family member 2A 2.84713
AOC1 amine oxidase, copper containing 1 2.84713
ANGPTL6 angiopoietin-like 6 2.84713
KCTD7 potassium channel tetramerization domain containing 7 2.84713
SDSL serine dehydratase-like 2.84713
TGM1 transglutaminase 1 2.84713
TEX35 testis expressed 35 2.84713
SLC51B solute carrier family 51, beta subunit 2.84713
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 2.84713
IRX1 iroquois homeobox 1 2.84713
SESN2 sestrin 2 2.84713
STK31 serine/threonine kinase 31 2.84713
MYL4 myosin, light chain 4, alkali; atrial, embryonic 2.84713
THEMIS thymocyte selection associated 2.84713
SLC10A5 solute carrier family 10, member 5 2.84713
RNASE6 ribonuclease, RNase A family, k6 2.84713
GFAP glial fibrillary acidic protein 2.84713
RBP4 retinol binding protein 4, plasma 2.84713
WFDC11 WAP four-disulfide core domain 11 2.84713
CD22 CD22 molecule 2.84713
PITX3 paired-like homeodomain 3 2.84713
CHAD chondroadherin 2.84713
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 2.84713
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 2.84713
TMEM40 transmembrane protein 40 2.84713
OR2F2 olfactory receptor, family 2, subfamily F, member 2 2.84713
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 2.84713
PARVG parvin, gamma 2.84713
KL klotho 2.84713
PRDM7 PR domain containing 7 2.84713
SAA2 serum amyloid A2 2.84713
CELA2A chymotrypsin-like elastase family, member 2A 2.84713
CCR7 chemokine (C-C motif) receptor 7 2.84713
MYZAP myocardial zonula adherens protein 2.84713
FMO2 flavin containing monooxygenase 2 (non-functional) 2.84713
SPMIP10 sperm microtubule inner protein 10 2.84713
EXOC1L exocyst complex component 1 like 2.84713
FAM240A family with sequence similarity 240 member A 2.84713
NOTCH2NLB notch 2 N-terminal like B 2.84713
PRRT1B proline rich transmembrane protein 1B 2.84713
CBLIF cobalamin binding intrinsic factor 2.84713
PHF24 PHD finger protein 24 2.84713
CES4A carboxylesterase 4A 2.84713
MYO5B myosin VB 2.84713
VGLL2 vestigial-like family member 2 2.84713
LECT2 leukocyte cell-derived chemotaxin 2 2.84713
C1QL3 complement component 1, q subcomponent-like 3 2.84713
ELAVL4 ELAV like neuron-specific RNA binding protein 4 2.84713
ACTRT1 actin-related protein T1 2.84713
FRMD7 FERM domain containing 7 2.84713
FPR3 formyl peptide receptor 3 2.84713
SYCP2 synaptonemal complex protein 2 2.84713
GJA3 gap junction protein, alpha 3, 46kDa 2.84713
FOXQ1 forkhead box Q1 2.84713
ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 2.84713
EQTN equatorin, sperm acrosome associated 2.84713
VTN vitronectin 2.84713
LOC124906892 uncharacterized LOC124906892 2.84713
PCDHA6 protocadherin alpha 6 2.84713
TBX3 T-box 3 2.84713
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 2.84713
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7 2.84713
UROC1 urocanate hydratase 1 2.84713
CD79A CD79a molecule, immunoglobulin-associated alpha 2.84713
OR8D1 olfactory receptor, family 8, subfamily D, member 1 2.84713
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 2.84713
CLDN9 claudin 9 2.84713
ARL5C ADP-ribosylation factor-like 5C 2.84713
PRB4 proline-rich protein BstNI subfamily 4 2.84713
CPXCR1 CPX chromosome region, candidate 1 2.84713
TMEM86B transmembrane protein 86B 2.84713
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) 2.84713
WFDC5 WAP four-disulfide core domain 5 2.84713
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.84713
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 2.84713
CDH19 cadherin 19, type 2 2.84713
CLEC4C C-type lectin domain family 4, member C 2.84713
FIBIN fin bud initiation factor homolog (zebrafish) 2.84713
TTC9C tetratricopeptide repeat domain 9C 2.84713
C2CD4D C2 calcium-dependent domain containing 4D 2.84713
WNT7B wingless-type MMTV integration site family, member 7B 2.84713
OR52N2 olfactory receptor, family 52, subfamily N, member 2 2.84713
KLF1 Kruppel-like factor 1 (erythroid) 2.84713
OR56A1 olfactory receptor, family 56, subfamily A, member 1 2.84713
RGCC regulator of cell cycle 2.84713
CALM2 calmodulin 2 (phosphorylase kinase, delta) 2.84713
CERKL ceramide kinase-like 2.84713
OR52N4 olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene) 2.84713
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) 2.84713
AQP8 aquaporin 8 2.84713
CRYBB2 crystallin, beta B2 2.84713
OR52N5 olfactory receptor, family 52, subfamily N, member 5 2.84713
WNT7A wingless-type MMTV integration site family, member 7A 2.84713
AGXT2 alanine--glyoxylate aminotransferase 2 2.84713
LYPD5 LY6/PLAUR domain containing 5 2.84713
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 2.84713
TMPPE transmembrane protein with metallophosphoesterase domain 2.84713
MYADML2 myeloid-associated differentiation marker-like 2 2.84713
EFCAB11 EF-hand calcium binding domain 11 2.84713
C11ORF42 chromosome 11 open reading frame 42 2.84713
PCDHAC2 protocadherin alpha subfamily C, 2 2.84713
IL27 interleukin 27 2.84713
LRRN4 leucine rich repeat neuronal 4 2.84713
CD28 CD28 molecule 2.84713
SOSTDC1 sclerostin domain containing 1 2.84713
MUC19 mucin 19, oligomeric 2.84713
LRRK2 leucine-rich repeat kinase 2 2.84713
C8ORF89 chromosome 8 open reading frame 89 2.84713
COL6A5 collagen, type VI, alpha 5 2.84713
TEX12 testis expressed 12 2.84713
PRR30 proline rich 30 2.84713
CTXN2 cortexin 2 2.84713
NR5A1 nuclear receptor subfamily 5, group A, member 1 2.84713
LYZ lysozyme 2.84713
TEX26 testis expressed 26 2.84713
ABHD1 abhydrolase domain containing 1 2.84713
DYTN dystrotelin 2.84713
SMIM22 small integral membrane protein 22 2.84713
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 2.84713
SLITRK1 SLIT and NTRK-like family, member 1 2.84713
PHOX2A paired-like homeobox 2a 2.84713
SLITRK6 SLIT and NTRK-like family, member 6 2.84713
ZMYND12 zinc finger, MYND-type containing 12 2.84713
NPAS4 neuronal PAS domain protein 4 2.84713
IL12B interleukin 12B 2.84713
SHOX short stature homeobox 2.84713
SCN3A sodium channel, voltage gated, type III alpha subunit 2.84713
EPX eosinophil peroxidase 2.84713
CCL27 chemokine (C-C motif) ligand 27 2.84713
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.84713
CALML6 calmodulin-like 6 2.84713
LST1 leukocyte specific transcript 1 2.84713
POTEF POTE ankyrin domain family, member F 2.84713
MORC1 MORC family CW-type zinc finger 1 2.84713
KCNK9 potassium channel, two pore domain subfamily K, member 9 2.84713
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 2.84713
BAG2 BCL2-associated athanogene 2 2.84713
EREG epiregulin 2.84713
RHAG Rh-associated glycoprotein 2.84713
VTCN1 V-set domain containing T cell activation inhibitor 1 2.84713
RGS11 regulator of G-protein signaling 11 2.84713
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 2.84713
EBF2 early B-cell factor 2 2.84713
GP1BB glycoprotein Ib (platelet), beta polypeptide 2.84713
PATE2 prostate and testis expressed 2 2.84713
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa 2.79282
NPIPB11 nuclear pore complex interacting protein family, member B11 2.74199
ZSCAN22 zinc finger and SCAN domain containing 22 2.74083
FMO1 flavin containing monooxygenase 1 2.74083
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.56557
IDNK idnK, gluconokinase homolog (E. coli) 2.56557
CRPPA CDP-L-ribitol pyrophosphorylase A 2.56495
NCOA1 nuclear receptor coactivator 1 2.56483
TMEM35B transmembrane protein 35B 2.53708
PTGIS prostaglandin I2 (prostacyclin) synthase 2.47169
SV2B synaptic vesicle glycoprotein 2B 2.43729
TIMMDC1 translocase of inner mitochondrial membrane domain containing 1 2.39992
TMEM132D transmembrane protein 132D 2.39695
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 2.39695
NFIA nuclear factor I/A 2.38728
PGA5 pepsinogen 5, group I (pepsinogen A) 2.34536
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1 2.34536
TOGARAM2 TOG array regulator of axonemal microtubules 2 2.34536
RBM44 RNA binding motif protein 44 2.34536
KANK3 KN motif and ankyrin repeat domains 3 2.33855
TKFC triokinase/FMN cyclase 2.32132
YPEL5 yippee-like 5 (Drosophila) 2.31311
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 2.30919
IZUMO4 IZUMO family member 4 2.30699
TCEAL7 transcription elongation factor A (SII)-like 7 2.29496
KIAA1755 KIAA1755 2.28691
CMC4 C-x(9)-C motif containing 4 2.28286
QTRT2 queuine tRNA-ribosyltransferase accessory subunit 2 2.27051
ERG28 ergosterol biosynthesis 28 homolog 2.25611
TIMP4 TIMP metallopeptidase inhibitor 4 2.24443
SLIT1 slit homolog 1 (Drosophila) 2.24443
IST1 increased sodium tolerance 1 homolog (yeast) 2.23698
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 2.21973
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 2.21714
SYT9 synaptotagmin IX 2.21714
PRR15 proline rich 15 2.2052
SOX2 SRY (sex determining region Y)-box 2 2.20223
CD300LF CD300 molecule-like family member f 2.19892
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 2.19435
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 2.19326
PDK3 pyruvate dehydrogenase kinase, isozyme 3 2.17787
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 2.16481
SDR39U1 short chain dehydrogenase/reductase family 39U, member 1 2.16481
MXI1 MAX interactor 1, dimerization protein 2.1591
LPCAT4 lysophosphatidylcholine acyltransferase 4 2.1591
PRDX2 peroxiredoxin 2 2.13663
WDR72 WD repeat domain 72 2.13631
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa 2.12399
ANLN anillin, actin binding protein 2.11537
TM6SF1 transmembrane 6 superfamily member 1 2.11308
RNPEP arginyl aminopeptidase (aminopeptidase B) 2.10498
SIK3 SIK family kinase 3 2.09835
RHOT1 ras homolog family member T1 2.09485
TPD52L1 tumor protein D52-like 1 2.09013
GYPC glycophorin C (Gerbich blood group) 2.08081
SFRP1 secreted frizzled-related protein 1 2.08002
RHOB ras homolog family member B 2.07929
ASF1A anti-silencing function 1A histone chaperone 2.04539
CFL1 cofilin 1 (non-muscle) 2.03703
KPNA1 karyopherin alpha 1 (importin alpha 5) 2.03426
RXFP1 relaxin/insulin-like family peptide receptor 1 2.01467
BBX bobby sox homolog (Drosophila) 2.01467
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 2.00261

decreased expression

Symbol Name Standardized Value
SFTPD surfactant protein D -2.84713
LDHC lactate dehydrogenase C -2.84713
PLXNA3 plexin A3 -2.84713
PDIA2 protein disulfide isomerase family A, member 2 -2.84713
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) -2.84713
SPINK1 serine peptidase inhibitor, Kazal type 1 -2.84713
ALOX15 arachidonate 15-lipoxygenase -2.84713
SNAI3 snail family zinc finger 3 -2.84713
ZBTB16 zinc finger and BTB domain containing 16 -2.84713
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 -2.84713
CD79B CD79b molecule, immunoglobulin-associated beta -2.84713
RNF212B ring finger protein 212B -2.84713
FAM186B family with sequence similarity 186, member B -2.84713
CLCNKA chloride channel, voltage-sensitive Ka -2.84713
ZNF879 zinc finger protein 879 -2.84713
SPHK1 sphingosine kinase 1 -2.84713
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C -2.84713
IRS1 insulin receptor substrate 1 -2.84713
CA1 carbonic anhydrase I -2.84713
C2ORF80 chromosome 2 open reading frame 80 -2.84713
NAGS N-acetylglutamate synthase -2.84713
SLCO1B1 solute carrier organic anion transporter family, member 1B1 -2.84713
FAM90A1 family with sequence similarity 90, member A1 -2.84713
BHLHE40 basic helix-loop-helix family, member e40 -2.84713
YY2 YY2 transcription factor -2.84713
DCDC2 doublecortin domain containing 2 -2.84713
STOML1 stomatin (EPB72)-like 1 -2.84713
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 -2.84713
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 -2.84713
BCAT1 branched chain amino-acid transaminase 1, cytosolic -2.84713
C6ORF118 chromosome 6 open reading frame 118 -2.84713
DRP2 dystrophin related protein 2 -2.84713
C17ORF114 chromosome 17 open reading frame 114 -2.84713
SIAH3 siah E3 ubiquitin protein ligase family member 3 -2.84713
PNMA8B PNMA family member 8B -2.84713
ODAD1 outer dynein arm docking complex subunit 1 -2.84713
SPEF2 sperm flagellar 2 -2.84713
CCN3 cellular communication network factor 3 -2.84713
ITGB7 integrin, beta 7 -2.84713
LSMEM1 leucine-rich single-pass membrane protein 1 -2.84713
H2BC17 H2B clustered histone 17 -2.84713
TEX46 testis expressed 46 -2.84713
SLC38A8 solute carrier family 38, member 8 -2.84713
KLHL10 kelch-like family member 10 -2.84713
CCDC196 coiled-coil domain containing 196 -2.84713
TRPC7 transient receptor potential cation channel, subfamily C, member 7 -2.84713
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -2.84713
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 -2.84713
GDF6 growth differentiation factor 6 -2.84713
ASIC4 acid sensing (proton gated) ion channel family member 4 -2.84713
PCDHGB2 protocadherin gamma subfamily B, 2 -2.84713
PDCL2 phosducin-like 2 -2.84713
CCDC152 coiled-coil domain containing 152 -2.84713
MROH5 maestro heat-like repeat family member 5 -2.84713
TSPAN8 tetraspanin 8 -2.84713
C2CD4B C2 calcium-dependent domain containing 4B -2.84713
GPR12 G protein-coupled receptor 12 -2.84713
GIPR gastric inhibitory polypeptide receptor -2.84713
KRT86 keratin 86, type II -2.84713
CALHM3 calcium homeostasis modulator 3 -2.84713
MINDY4B MINDY family member 4B -2.84713
ZSCAN31 zinc finger and SCAN domain containing 31 -2.83093
TTLL4 tubulin tyrosine ligase-like family member 4 -2.82682
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 -2.74199
SPDYE17 speedy/RINGO cell cycle regulator family member E17 -2.74199
IQUB IQ motif and ubiquitin domain containing -2.74199
RBP5 retinol binding protein 5, cellular -2.74199
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -2.71578
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 -2.70681
NR4A1 nuclear receptor subfamily 4, group A, member 1 -2.69171
EIF6 eukaryotic translation initiation factor 6 -2.59609
TTC39B tetratricopeptide repeat domain 39B -2.56557
JDP2 Jun dimerization protein 2 -2.54823
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) -2.51578
SASS6 spindle assembly 6 homolog (C. elegans) -2.46709
EHD3 EH-domain containing 3 -2.45561
ZNF33A zinc finger protein 33A -2.44459
COG5 component of oligomeric golgi complex 5 -2.43629
ZNF496 zinc finger protein 496 -2.40977
AK8 adenylate kinase 8 -2.40771
SLMAP sarcolemma associated protein -2.38355
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF -2.38236
ATF7 activating transcription factor 7 -2.3465
ULK3 unc-51 like kinase 3 -2.31511
RAD54B RAD54 homolog B (S. cerevisiae) -2.28691
KAT6A K(lysine) acetyltransferase 6A -2.26952
CEMIP2 cell migration inducing hyaluronidase 2 -2.26872
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -2.25511
BTF3 basic transcription factor 3 -2.24501
TTC19 tetratricopeptide repeat domain 19 -2.2415
TRIM59 tripartite motif containing 59 -2.23629
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa -2.21973
GPX3 glutathione peroxidase 3 -2.20877
GLT8D2 glycosyltransferase 8 domain containing 2 -2.20093
ZNF470 zinc finger protein 470 -2.19768
DLEC1 deleted in lung and esophageal cancer 1 -2.19768
CDNF cerebral dopamine neurotrophic factor -2.18151
PLAUR plasminogen activator, urokinase receptor -2.1793
SHROOM1 shroom family member 1 -2.17787
TMEM37 transmembrane protein 37 -2.16481
CST6 cystatin E/M -2.16481
ZNF696 zinc finger protein 696 -2.16481
F10 coagulation factor X -2.16481
CYTIP cytohesin 1 interacting protein -2.16481
TMEM175 transmembrane protein 175 -2.16481
CRTAC1 cartilage acidic protein 1 -2.16481
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 -2.1591
JUNB jun B proto-oncogene -2.15552
ZNF638 zinc finger protein 638 -2.15552
DEAF1 DEAF1 transcription factor -2.15499
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 -2.15466
PAXBP1 PAX3 and PAX7 binding protein 1 -2.14957
LAGE3 L antigen family, member 3 -2.14554
GDI2 GDP dissociation inhibitor 2 -2.14286
CTR9 CTR9, Paf1/RNA polymerase II complex component -2.1391
KCTD5 potassium channel tetramerization domain containing 5 -2.11308
NUP42 nucleoporin 42 -2.11046
TTLL1 tubulin tyrosine ligase-like family member 1 -2.09786
SPC24 SPC24, NDC80 kinetochore complex component -2.08002
MAP3K3 mitogen-activated protein kinase kinase kinase 3 -2.07856
SLC67A2 solute carrier family 67 member 2 -2.05508
H4C5 H4 clustered histone 5 -2.05019
CDK5RAP2 CDK5 regulatory subunit associated protein 2 -2.02612
AKR1C1 aldo-keto reductase family 1, member C1 -2.02612
ARRDC4 arrestin domain containing 4 -2.01467
IL10RB interleukin 10 receptor, beta -2.00955