CTSB Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description cathepsin B|The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1508)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/MORF_CTSB
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Genes

190 co-expressed genes for CTSB from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ADAM20 ADAM metallopeptidase domain 20
ADAMTSL3 ADAMTS-like 3
ADRB1 adrenoceptor beta 1
AKAP3 A kinase (PRKA) anchor protein 3
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
ANXA10 annexin A10
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ATF2 activating transcription factor 2
ATF6B activating transcription factor 6 beta
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
ATP4B ATPase, H+/K+ exchanging, beta polypeptide
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2
ATXN3 ataxin 3
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
BRD4 bromodomain containing 4
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
CA3 carbonic anhydrase III
CADM4 cell adhesion molecule 4
CALN1 calneuron 1
CAMK4 calcium/calmodulin-dependent protein kinase IV
CAMTA1 calmodulin binding transcription activator 1
CBLN1 cerebellin 1 precursor
CCR3 chemokine (C-C motif) receptor 3
CDC73 cell division cycle 73
CDH8 cadherin 8, type 2
CDKL5 cyclin-dependent kinase-like 5
CDR1 cerebellar degeneration-related protein 1, 34kDa
CEP162 centrosomal protein 162kDa
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal)
CLCN3 chloride channel, voltage-sensitive 3
COL19A1 collagen, type XIX, alpha 1
COL8A1 collagen, type VIII, alpha 1
CPB2 carboxypeptidase B2 (plasma)
CRHR1 corticotropin releasing hormone receptor 1
CTSB cathepsin B
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DAZL deleted in azoospermia-like
DGCR9 DiGeorge syndrome critical region gene 9 (non-protein coding)
DMD dystrophin
DMPK dystrophia myotonica-protein kinase
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22
DRD1 dopamine receptor D1
EDIL3 EGF-like repeats and discoidin I-like domains 3
EDN3 endothelin 3
EXOC4 exocyst complex component 4
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM153B family with sequence similarity 153, member B
FAM63B family with sequence similarity 63, member B
FGA fibrinogen alpha chain
FLJ16124
FOSL1 FOS-like antigen 1
FSHR follicle stimulating hormone receptor
FZD5 frizzled class receptor 5
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GCM1 glial cells missing homolog 1 (Drosophila)
GHRHR growth hormone releasing hormone receptor
GJB5 gap junction protein, beta 5, 31.1kDa
GLRA3 glycine receptor, alpha 3
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GPR1 G protein-coupled receptor 1
GPR15 G protein-coupled receptor 15
GPR171 G protein-coupled receptor 171
GPR18 G protein-coupled receptor 18
GPR19 G protein-coupled receptor 19
GRIK1 glutamate receptor, ionotropic, kainate 1
HCG8 HLA complex group 8
HCRTR2 hypocretin (orexin) receptor 2
HNF1A HNF1 homeobox A
HOXB7 homeobox B7
HOXC11 homeobox C11
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IFNA1 interferon, alpha 1
IFNA10 interferon, alpha 10
IFNA14 interferon, alpha 14
IFNA2 interferon, alpha 2
IFNW1 interferon, omega 1
IL4 interleukin 4
IL7 interleukin 7
IPO9 importin 9
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JADE3 jade family PHD finger 3
JRKL JRK-like
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KLRC4 killer cell lectin-like receptor subfamily C, member 4
KPNA1 karyopherin alpha 1 (importin alpha 5)
KRT2 keratin 2, type II
KRT34 keratin 34, type I
LDB3 LIM domain binding 3
LECT2 leukocyte cell-derived chemotaxin 2
LGI1 leucine-rich, glioma inactivated 1
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
LPAR4 lysophosphatidic acid receptor 4
LPPR4 lipid phosphate phosphatase-related protein type 4
LRP4 low density lipoprotein receptor-related protein 4
LRP6 low density lipoprotein receptor-related protein 6
MAGEA8 melanoma antigen family A8
MAGEA9 melanoma antigen family A9
MAP2 microtubule-associated protein 2
MAP2K7 mitogen-activated protein kinase kinase 7
MC5R melanocortin 5 receptor
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MPZL1 myelin protein zero-like 1
MYH2 myosin, heavy chain 2, skeletal muscle, adult
MYT1 myelin transcription factor 1
NEB nebulin
NHEJ1 nonhomologous end-joining factor 1
NPAS2 neuronal PAS domain protein 2
NPFF neuropeptide FF-amide peptide precursor
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR3C2 nuclear receptor subfamily 3, group C, member 2
NTNG2 netrin G2
OR2B6 olfactory receptor, family 2, subfamily B, member 6
OR7A5 olfactory receptor, family 7, subfamily A, member 5
OTC ornithine carbamoyltransferase
P2RY10 purinergic receptor P2Y, G-protein coupled, 10
PART1 prostate androgen-regulated transcript 1 (non-protein coding)
PAX6 paired box 6
PCDHB17P protocadherin beta 17 pseudogene
PCM1 pericentriolar material 1
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha
PDE6H phosphodiesterase 6H, cGMP-specific, cone, gamma
PHF10 PHD finger protein 10
PHOX2B paired-like homeobox 2b
PLXNA3 plexin A3
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E
PRKCA protein kinase C, alpha
PRPS1L1 phosphoribosyl pyrophosphate synthetase 1-like 1
PSD pleckstrin and Sec7 domain containing
PSG1 pregnancy specific beta-1-glycoprotein 1
PTPN20 protein tyrosine phosphatase, non-receptor type 20
PTPRR protein tyrosine phosphatase, receptor type, R
PVR poliovirus receptor
RAD51D RAD51 paralog D
RB1CC1 RB1-inducible coiled-coil 1
RBBP7 retinoblastoma binding protein 7
REPS2 RALBP1 associated Eps domain containing 2
RNF24 ring finger protein 24
RORB RAR-related orphan receptor B
RREB1 ras responsive element binding protein 1
RSC1A1 regulatory solute carrier protein, family 1, member 1
RXRG retinoid X receptor, gamma
RYR3 ryanodine receptor 3
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
SIX6 SIX homeobox 6
SLC14A2 solute carrier family 14 (urea transporter), member 2
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC17A1 solute carrier family 17 (organic anion transporter), member 1
SLC17A3 solute carrier family 17 (organic anion transporter), member 3
SLC46A3 solute carrier family 46, member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SMYD3 SET and MYND domain containing 3
SOCS6 suppressor of cytokine signaling 6
SOX11 SRY (sex determining region Y)-box 11
SPA17 sperm autoantigenic protein 17
SPAG11B sperm associated antigen 11B
SPRR2C small proline-rich protein 2C (pseudogene)
SRPK3 SRSF protein kinase 3
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
STAC SH3 and cysteine rich domain
SULT4A1 sulfotransferase family 4A, member 1
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
T T, brachyury homolog (mouse)
TACC2 transforming, acidic coiled-coil containing protein 2
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TBX19 T-box 19
TENM4 teneurin transmembrane protein 4
TLL1 tolloid-like 1
TNIK TRAF2 and NCK interacting kinase
TNK1 tyrosine kinase, non-receptor, 1
TRIO trio Rho guanine nucleotide exchange factor
TSHB thyroid stimulating hormone, beta
TTTY1 testis-specific transcript, Y-linked 1 (non-protein coding)
UBE4B ubiquitination factor E4B
USP46 ubiquitin specific peptidase 46
WISP3 WNT1 inducible signaling pathway protein 3
ZBTB14 zinc finger and BTB domain containing 14
ZBTB40 zinc finger and BTB domain containing 40
ZNF132 zinc finger protein 132
ZNF157 zinc finger protein 157
ZNF202 zinc finger protein 202
ZSCAN26 zinc finger and SCAN domain containing 26