CUL3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description cullin 3|This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012] (NCBI Entrez Gene Database, 8452)
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Genes

328 genes differentially expressed following the CUL3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
RS1 retinoschisin 1 2.4263
SLIRP SRA stem-loop interacting RNA binding protein 2.4263
OR10A4 olfactory receptor, family 10, subfamily A, member 4 2.4263
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 2.4263
CSTL1 cystatin-like 1 2.4263
OR2J3 olfactory receptor, family 2, subfamily J, member 3 2.4263
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 2.4263
OLIG3 oligodendrocyte transcription factor 3 2.4263
CEP295NL CEP295 N-terminal like 2.4263
RPL27A ribosomal protein L27a 2.4263
UGP2 UDP-glucose pyrophosphorylase 2 2.4263
DNASE1L3 deoxyribonuclease I-like 3 2.4263
HEATR9 HEAT repeat containing 9 2.4263
ISM2 isthmin 2 2.4263
BPIFA2 BPI fold containing family A, member 2 2.4263
KLF17 Kruppel-like factor 17 2.4263
TMPRSS11A transmembrane protease, serine 11A 2.4263
RASL10A RAS-like, family 10, member A 2.4263
ASB15 ankyrin repeat and SOCS box containing 15 2.4263
MEGF6 multiple EGF-like-domains 6 2.4263
AKAP14 A kinase (PRKA) anchor protein 14 2.4263
HPCAL4 hippocalcin like 4 2.4263
DIRAS2 DIRAS family, GTP-binding RAS-like 2 2.4263
ADAD1 adenosine deaminase domain containing 1 (testis-specific) 2.4263
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 2.4263
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 2.4263
STEAP4 STEAP family member 4 2.4263
SPAG8 sperm associated antigen 8 2.4263
SLC10A5 solute carrier family 10, member 5 2.4263
PCDHGA11 protocadherin gamma subfamily A, 11 2.4263
CD22 CD22 molecule 2.4263
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 2.4263
ANKRD30A ankyrin repeat domain 30A 2.4263
FAM240A family with sequence similarity 240 member A 2.4263
ATOH7 atonal homolog 7 (Drosophila) 2.4263
MMP20 matrix metallopeptidase 20 2.4263
GIMAP2 GTPase, IMAP family member 2 2.4263
ARSF arylsulfatase F 2.4263
GADL1 glutamate decarboxylase-like 1 2.4263
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 2.4263
ZNF556 zinc finger protein 556 2.4263
GNAT3 guanine nucleotide binding protein, alpha transducing 3 2.4263
TDRD6 tudor domain containing 6 2.4263
FSCN2 fascin actin-bundling protein 2, retinal 2.4263
KYNU kynureninase 2.4263
SPINT4 serine peptidase inhibitor, Kunitz type 4 2.4263
ACTL10 actin-like 10 2.4263
LY6S-AS1 LY6S antisense RNA 1 2.4263
H1-6 H1.6 linker histone, cluster member 2.4263
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 2.4263
GIPC3 GIPC PDZ domain containing family, member 3 2.4263
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 2.4263
PTH1R parathyroid hormone 1 receptor 2.4263
C3AR1 complement component 3a receptor 1 2.4263
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.4263
STX11 syntaxin 11 2.4263
FMO2 flavin containing monooxygenase 2 (non-functional) 2.4263
H3-3A H3.3 histone A 2.4263
CCN4 cellular communication network factor 4 2.4263
CLXN calaxin 2.4263
LIPT2-AS1 LIPT2 antisense RNA 1 2.4263
SPMIP3 sperm microtubule inner protein 3 2.4263
CCDC201 coiled-coil domain containing 201 2.4263
C1ORF202 chromosome 1 open reading frame 202 2.4263
CTXND1 cortexin domain containing 1 2.4263
RHEX regulator of hemoglobinization and erythroid cell expansion 2.4263
H3-7 H3.7 histone (putative) 2.4263
MUCL3 mucin like 3 2.4263
RTL5 retrotransposon Gag like 5 2.4263
C1QTNF9B C1q and tumor necrosis factor related protein 9B 2.4263
LMNTD1 lamin tail domain containing 1 2.4263
SASH3 SAM and SH3 domain containing 3 2.4263
BARX2 BARX homeobox 2 2.4263
C1QTNF1 C1q and tumor necrosis factor related protein 1 2.4263
KLRF2 killer cell lectin-like receptor subfamily F, member 2 2.4263
RNF113B ring finger protein 113B 2.4263
TLR8 toll-like receptor 8 2.4263
OVOL3 ovo-like zinc finger 3 2.4263
GGACT gamma-glutamylamine cyclotransferase 2.4263
CALCA calcitonin-related polypeptide alpha 2.4263
VCX3B variable charge, X-linked 3B 2.4263
COX8C cytochrome c oxidase subunit VIIIC 2.4263
ACE2 angiotensin I converting enzyme 2 2.4263
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 2.4263
NHLH1 nescient helix loop helix 1 2.4263
CYC1 cytochrome c-1 2.4263
LY6H lymphocyte antigen 6 complex, locus H 2.4263
SMTNL1 smoothelin-like 1 2.4263
DTD1 D-tyrosyl-tRNA deacylase 1 2.4263
FAM228A family with sequence similarity 228, member A 2.4263
OR7D2 olfactory receptor, family 7, subfamily D, member 2 2.4263
MROH5 maestro heat-like repeat family member 5 2.4263
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 2.4263
ALOXE3 arachidonate lipoxygenase 3 2.4263
CLDN34 claudin 34 2.4263
FAIM2 Fas apoptotic inhibitory molecule 2 2.4263
HAMP hepcidin antimicrobial peptide 2.4263
GAB4 GRB2-associated binding protein family, member 4 2.4263
NOG noggin 2.4263
OSR1 odd-skipped related transciption factor 1 2.4263
CTXN2 cortexin 2 2.4263
GFI1B growth factor independent 1B transcription repressor 2.4263
C10ORF105 chromosome 10 open reading frame 105 2.4263
MAOA monoamine oxidase A 2.4263
LRRC4C leucine rich repeat containing 4C 2.4263
LRCOL1 leucine rich colipase-like 1 2.4263
MORC1 MORC family CW-type zinc finger 1 2.4263
PIH1D2 PIH1 domain containing 2 2.4263
CRYBA1 crystallin, beta A1 2.4263
CDC20B cell division cycle 20B 2.4263
RAD51AP2 RAD51 associated protein 2 2.4263
EHF ets homologous factor 2.4263
COX7B2 cytochrome c oxidase subunit VIIb2 2.4263
TRIM55 tripartite motif containing 55 2.4263
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 2.4263
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 2.4263
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 2.4263
SPATA3 spermatogenesis associated 3 2.4263
C11ORF16 chromosome 11 open reading frame 16 2.4263
CHI3L2 chitinase 3-like 2 2.4263
KLHL41 kelch-like family member 41 2.4263
GPR150 G protein-coupled receptor 150 2.4263
DGCR6 DiGeorge syndrome critical region gene 6 2.4263
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 2.4263
SYNE3 spectrin repeat containing, nuclear envelope family member 3 2.4263
OTC ornithine carbamoyltransferase 2.4263
TIPE2 TNF alpha induced protein 8 like 2 2.4263
KRT15 keratin 15, type I 2.4263
OR52N2 olfactory receptor, family 52, subfamily N, member 2 2.4263
FCAR Fc fragment of IgA receptor 2.4263
TIGD3 tigger transposable element derived 3 2.4263
PTCRA pre T-cell antigen receptor alpha 2.4263
C1ORF105 chromosome 1 open reading frame 105 2.4263
CCNI2 cyclin I family, member 2 2.4263
NYX nyctalopin 2.4263
ADRA1B adrenoceptor alpha 1B 2.4263
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) 2.4263
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 2.4263
PADI1 peptidyl arginine deiminase, type I 2.4263
ANGPTL5 angiopoietin-like 5 2.4263
TRHR thyrotropin-releasing hormone receptor 2.4263
AHSG alpha-2-HS-glycoprotein 2.4263
PFN2 profilin 2 2.4263
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 2.4263
OXER1 oxoeicosanoid (OXE) receptor 1 2.4263
ASCL5 achaete-scute family bHLH transcription factor 5 2.4263
LAT2 linker for activation of T cells family, member 2 2.4263
CD8B CD8b molecule 2.4263
ART1 ADP-ribosyltransferase 1 2.4263
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 2.4263
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.4263
PRTN3 proteinase 3 2.4263
TSPAN19 tetraspanin 19 2.4263
PHOX2A paired-like homeobox 2a 2.4263
WDFY4 WDFY family member 4 2.4263
IBSP integrin-binding sialoprotein 2.4263
ADGRF5 adhesion G protein-coupled receptor F5 2.4263
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2.4263
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa 2.4263
HIGD2B HIG1 hypoxia inducible domain family, member 2B 2.4263
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 2.4263
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 2.42018
ZBED3 zinc finger, BED-type containing 3 2.39493
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome 2.3741
H3C7 H3 clustered histone 7 2.36498
DDIT4L DNA-damage-inducible transcript 4-like 2.36498
DCLK3 doublecortin-like kinase 3 2.35475
TRIL TLR4 interactor with leucine-rich repeats 2.35475
LDHA lactate dehydrogenase A 2.32394
LHX6 LIM homeobox 6 2.31156
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 2.30629
ZNF292 zinc finger protein 292 2.30629
H4C5 H4 clustered histone 5 2.30276
RPS9 ribosomal protein S9 2.29535
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 2.29535
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 2.29383
AKIRIN1 akirin 1 2.29383
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent) 2.29383
MRPL22 mitochondrial ribosomal protein L22 2.29383
CSNK2B casein kinase 2, beta polypeptide 2.29383
ATG4A autophagy related 4A, cysteine peptidase 2.27429
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 2.26335
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 2.26054
NAV3 neuron navigator 3 2.25968
WFDC2 WAP four-disulfide core domain 2 2.21306
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) 2.20765
MTA1 metastasis associated 1 2.20128
MET MET proto-oncogene, receptor tyrosine kinase 2.19996
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like 2.19338
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 2.19311
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) 2.19212
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) 2.17758
ARHGAP24 Rho GTPase activating protein 24 2.17463
HUS1 HUS1 checkpoint homolog (S. pombe) 2.16579
WAPL WAPL cohesin release factor 2.15394
SNX21 sorting nexin family member 21 2.14241
PTH2R parathyroid hormone 2 receptor 2.1404
CCDC88C coiled-coil domain containing 88C 2.1404
CACFD1 calcium channel flower domain containing 1 2.13881
PLA2G12A phospholipase A2, group XIIA 2.1343
ALDOA aldolase A, fructose-bisphosphate 2.11304
CLUH clustered mitochondria (cluA/CLU1) homolog 2.09031
PICK1 protein interacting with PRKCA 1 2.0792
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 2.07826
AVPI1 arginine vasopressin-induced 1 2.07467
ZNF595 zinc finger protein 595 2.0691
MRPS30 mitochondrial ribosomal protein S30 2.0589
HMGN3 high mobility group nucleosomal binding domain 3 2.05243
ORAI2 ORAI calcium release-activated calcium modulator 2 2.04836
P3H2 prolyl 3-hydroxylase 2 2.02903
TM2D3 TM2 domain containing 3 2.01733
CCDC157 coiled-coil domain containing 157 2.01571
CTTN cortactin 2.01174
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 2.01174
MIGA1 mitoguardin 1 2.01063
ZNF525 zinc finger protein 525 2.00993
BTBD6 BTB (POZ) domain containing 6 2.00435

decreased expression

Symbol Name Standardized Value
NAP1L5 nucleosome assembly protein 1-like 5 -2.4263
TNS1 tensin 1 -2.4263
MOB3B MOB kinase activator 3B -2.4263
CLDND2 claudin domain containing 2 -2.4263
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma -2.4263
NBPF10 neuroblastoma breakpoint family, member 10 -2.4263
ZRANB3 zinc finger, RAN-binding domain containing 3 -2.4263
CDHR1 cadherin-related family member 1 -2.4263
MAP3K6 mitogen-activated protein kinase kinase kinase 6 -2.4263
SACK1A scaffolding CK1 anchoring protein A -2.4263
SRRM5 serine/arginine repetitive matrix 5 -2.4263
ISG20 interferon stimulated exonuclease gene 20kDa -2.4263
BANK1 B-cell scaffold protein with ankyrin repeats 1 -2.4263
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 -2.4263
STAC3 SH3 and cysteine rich domain 3 -2.4263
MTPN myotrophin -2.4263
BEAN1 brain expressed, associated with NEDD4, 1 -2.4263
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme -2.4263
MAGEH1 melanoma antigen family H1 -2.4263
TCEAL7 transcription elongation factor A (SII)-like 7 -2.4263
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D -2.4263
SLIT2 slit homolog 2 (Drosophila) -2.4263
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) -2.41966
STKLD1 serine/threonine kinase-like domain containing 1 -2.41117
ATP5MK ATP synthase membrane subunit k -2.40431
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa -2.40193
ZMIZ2 zinc finger, MIZ-type containing 2 -2.36902
SLC35B3 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3 -2.36902
SPTLC3 serine palmitoyltransferase, long chain base subunit 3 -2.36498
ADNP activity-dependent neuroprotector homeobox -2.33395
LINC02762 long intergenic non-protein coding RNA 2762 -2.29535
PELI3 pellino E3 ubiquitin protein ligase family member 3 -2.29535
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -2.29383
ZSCAN22 zinc finger and SCAN domain containing 22 -2.29383
PRR22 proline rich 22 -2.29383
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 -2.29383
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 -2.29383
TNC tenascin C -2.29383
C1ORF146 chromosome 1 open reading frame 146 -2.29383
SH2D6 SH2 domain containing 6 -2.29383
FNDC11 fibronectin type III domain containing 11 -2.29383
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 -2.29383
EPOP elongin BC and polycomb repressive complex 2 associated protein -2.29383
MTSS2 MTSS I-BAR domain containing 2 -2.29383
RAD9B RAD9 homolog B (S. pombe) -2.29383
CD70 CD70 molecule -2.29383
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L -2.29383
PLB1 phospholipase B1 -2.29383
DNAI2 dynein, axonemal, intermediate chain 2 -2.29383
USH1G Usher syndrome 1G (autosomal recessive) -2.29383
SMIM36 small integral membrane protein 36 -2.29383
CEP104 centrosomal protein 104kDa -2.29383
TMPRSS11E transmembrane protease, serine 11E -2.29383
SH3TC2 SH3 domain and tetratricopeptide repeats 2 -2.29383
IQCN IQ motif containing N -2.29383
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 -2.29383
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) -2.29383
PHOSPHO1 phosphatase, orphan 1 -2.29383
SMKR1 small lysine-rich protein 1 -2.29383
TNN tenascin N -2.29383
PLD6 phospholipase D family, member 6 -2.29383
TMEM61 transmembrane protein 61 -2.29383
SMIM17 small integral membrane protein 17 -2.29383
RELN reelin -2.29383
COL17A1 collagen, type XVII, alpha 1 -2.29383
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 -2.29383
MUC19 mucin 19, oligomeric -2.29383
PDXK pyridoxal (pyridoxine, vitamin B6) kinase -2.29383
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 -2.29383
VWA3A von Willebrand factor A domain containing 3A -2.29383
ESPNL espin-like -2.29383
NFE2 nuclear factor, erythroid 2 -2.29383
ACAN aggrecan -2.29383
RBP2 retinol binding protein 2, cellular -2.29383
DHRS2 dehydrogenase/reductase (SDR family) member 2 -2.29383
NELL1 NEL-like 1 (chicken) -2.29383
USP31 ubiquitin specific peptidase 31 -2.29282
ZNF267 zinc finger protein 267 -2.27429
H3C2 H3 clustered histone 2 -2.27365
MZT2A mitotic spindle organizing protein 2A -2.26329
ARMH1 armadillo like helical domain containing 1 -2.21188
COMMD10 COMM domain containing 10 -2.21188
IL10RB interleukin 10 receptor, beta -2.21031
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -2.20765
USP24 ubiquitin specific peptidase 24 -2.20512
ANKAR ankyrin and armadillo repeat containing -2.19338
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) -2.1921
TRIM5 tripartite motif containing 5 -2.19022
RADIL Ras association and DIL domains -2.17758
ANKRD13C ankyrin repeat domain 13C -2.16398
MXD3 MAX dimerization protein 3 -2.14965
CDC26 cell division cycle 26 -2.14965
SLC35A5 solute carrier family 35, member A5 -2.14881
GLRB glycine receptor, beta -2.14551
DCLRE1B DNA cross-link repair 1B -2.14241
SOGA3 SOGA family member 3 -2.14241
PBX1 pre-B-cell leukemia homeobox 1 -2.14241
CD164L2 CD164 sialomucin-like 2 -2.13328
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 -2.11936
TRIM58 tripartite motif containing 58 -2.11304
CAPN3 calpain 3, (p94) -2.11304
CUL3 cullin 3 -2.11304
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 -2.10481
EIF4A2 eukaryotic translation initiation factor 4A2 -2.09031
MEX3A mex-3 RNA binding family member A -2.0742
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -2.05746
ZBTB7B zinc finger and BTB domain containing 7B -2.05243
PHIP pleckstrin homology domain interacting protein -2.0371
AFF4 AF4/FMR2 family, member 4 -2.02867
OPHN1 oligophrenin 1 -2.01174
ADGRA3 adhesion G protein-coupled receptor A3 -2.00577