CUL4A Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description cullin 4A|CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009] (NCBI Entrez Gene Database, 8451)
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Genes

365 genes differentially expressed following the CUL4A gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 2.7319
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 2.7319
CCER2 coiled-coil glutamate-rich protein 2 2.7319
DUSP9 dual specificity phosphatase 9 2.7319
SCN10A sodium channel, voltage gated, type X alpha subunit 2.7319
OR51M1 olfactory receptor, family 51, subfamily M, member 1 2.7319
CLEC4D C-type lectin domain family 4, member D 2.7319
GPR85 G protein-coupled receptor 85 2.7319
USH1G Usher syndrome 1G (autosomal recessive) 2.7319
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.7319
FIBIN fin bud initiation factor homolog (zebrafish) 2.7319
PCDHGA3 protocadherin gamma subfamily A, 3 2.7319
C8ORF48 chromosome 8 open reading frame 48 2.7319
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit 2.7319
LOC107986837 uncharacterized LOC107986837 2.7319
MLIP muscular LMNA-interacting protein 2.7319
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 2.7319
CDH22 cadherin 22, type 2 2.7319
KLHL10 kelch-like family member 10 2.7319
PRRT1B proline rich transmembrane protein 1B 2.7319
ANKRD65 ankyrin repeat domain 65 2.7319
MEP1B meprin A, beta 2.7319
FGF21 fibroblast growth factor 21 2.72991
ELF5 E74-like factor 5 (ets domain transcription factor) 2.72991
MUC5B mucin 5B, oligomeric mucus/gel-forming 2.72991
PTH2 parathyroid hormone 2 2.72991
PAX3 paired box 3 2.72991
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 2.72991
UPB1 ureidopropionase, beta 2.72991
WDR87 WD repeat domain 87 2.72991
SLC26A9 solute carrier family 26 (anion exchanger), member 9 2.72991
SLC26A1 solute carrier family 26 (anion exchanger), member 1 2.72991
CD1C CD1c molecule 2.72991
PCDHB7 protocadherin beta 7 2.72991
SLC4A9 solute carrier family 4, sodium bicarbonate cotransporter, member 9 2.72991
PRSS41 protease, serine, 41 2.72991
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 2.72991
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 2.72991
ASB17 ankyrin repeat and SOCS box containing 17 2.72991
PRSS36 protease, serine, 36 2.72991
C8ORF74 chromosome 8 open reading frame 74 2.72991
PLK5 polo-like kinase 5 2.72991
TREML1 triggering receptor expressed on myeloid cells-like 1 2.72991
TRPC5OS TRPC5 opposite strand 2.72991
LGALS4 lectin, galactoside-binding, soluble, 4 2.72991
LGALS9 lectin, galactoside-binding, soluble, 9 2.72991
GRP gastrin-releasing peptide 2.72991
HMX2 H6 family homeobox 2 2.72991
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 2.72991
KRTAP5-8 keratin associated protein 5-8 2.72991
ERP44 endoplasmic reticulum protein 44 2.72991
TNS3 tensin 3 2.72991
NFAM1 NFAT activating protein with ITAM motif 1 2.72991
SLC30A2 solute carrier family 30 (zinc transporter), member 2 2.72991
HERPUD2 HERPUD family member 2 2.72991
TLX2 T-cell leukemia homeobox 2 2.72991
GRIA1 glutamate receptor, ionotropic, AMPA 1 2.72991
DIRAS2 DIRAS family, GTP-binding RAS-like 2 2.72991
CYLD cylindromatosis (turban tumor syndrome) 2.72991
SLC39A5 solute carrier family 39 (zinc transporter), member 5 2.72991
OTUD6A OTU deubiquitinase 6A 2.72991
C1ORF146 chromosome 1 open reading frame 146 2.72991
FSCN2 fascin actin-bundling protein 2, retinal 2.72991
EMCN endomucin 2.72991
CATSPERH catsper channel auxiliary subunit eta 2.72991
BET1L Bet1 golgi vesicular membrane trafficking protein-like 2.72991
GPX5 glutathione peroxidase 5 2.72991
SMPX small muscle protein, X-linked 2.72991
TTR transthyretin 2.72991
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 2.72991
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 2.72991
OR7D2 olfactory receptor, family 7, subfamily D, member 2 2.72991
TMEM276-ZFTRAF1 TMEM276-ZFTRAF1 readthrough 2.72991
OSTN osteocrin 2.72991
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 2.72991
NECTIN4 nectin cell adhesion molecule 4 2.72991
MDFIC2 MyoD family inhibitor domain containing 2 2.72991
RHEX regulator of hemoglobinization and erythroid cell expansion 2.72991
CFAP92 cilia and flagella associated protein 92 (putative) 2.72991
GARIN4 golgi associated RAB2 interactor family member 4 2.72991
CBY2 chibby family member 2 2.72991
DIPK1C divergent protein kinase domain 1C 2.72991
ANGPTL8 angiopoietin like 8 2.72991
H3-5 H3.5 histone 2.72991
STING1 stimulator of interferon response cGAMP interactor 1 2.72991
HNF1A HNF1 homeobox A 2.72991
HNF1B HNF1 homeobox B 2.72991
DLK2 delta-like 2 homolog (Drosophila) 2.72991
CBLN3 cerebellin 3 precursor 2.72991
GOLGA6L2 golgin A6 family-like 2 2.72991
PCDHA3 protocadherin alpha 3 2.72991
TLR4 toll-like receptor 4 2.72991
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 2.72991
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 2.72991
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 2.72991
SBK3 SH3 domain binding kinase family, member 3 2.72991
GJA5 gap junction protein, alpha 5, 40kDa 2.72991
GRB7 growth factor receptor-bound protein 7 2.72991
MSX2 msh homeobox 2 2.72991
WNT9B wingless-type MMTV integration site family, member 9B 2.72991
UTS2 urotensin 2 2.72991
CCR3 chemokine (C-C motif) receptor 3 2.72991
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.72991
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 2.72991
BARHL1 BarH-like homeobox 1 2.72991
TPTE transmembrane phosphatase with tensin homology 2.72991
TLR8 toll-like receptor 8 2.72991
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 2.72991
COX4I2 cytochrome c oxidase subunit IV isoform 2 (lung) 2.72991
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 2.72991
TCF21 transcription factor 21 2.72991
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 2.72991
KLHL41 kelch-like family member 41 2.72991
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 2.72991
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 2.72991
MAB21L1 mab-21-like 1 (C. elegans) 2.72991
BCO1 beta-carotene oxygenase 1 2.72991
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 2.72991
LRRK2 leucine-rich repeat kinase 2 2.72991
EGR3 early growth response 3 2.72991
MPV17L MPV17 mitochondrial membrane protein-like 2.72991
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) 2.72991
SMYD1 SET and MYND domain containing 1 2.72991
KRT17 keratin 17, type I 2.72991
ERMN ermin, ERM-like protein 2.72991
TBPL2 TATA box binding protein like 2 2.72991
ENDOU endonuclease, polyU-specific 2.72991
FNDC5 fibronectin type III domain containing 5 2.72991
KCNK9 potassium channel, two pore domain subfamily K, member 9 2.72991
RGS11 regulator of G-protein signaling 11 2.72991
HCRT hypocretin (orexin) neuropeptide precursor 2.72991
TEX12 testis expressed 12 2.72991
TPPP3 tubulin polymerization-promoting protein family member 3 2.72991
PLCD4 phospholipase C, delta 4 2.72991
PSG3 pregnancy specific beta-1-glycoprotein 3 2.72991
QRFP pyroglutamylated RFamide peptide 2.72991
ADCY4 adenylate cyclase 4 2.72991
PCNP PEST proteolytic signal containing nuclear protein 2.72991
CXORF58 chromosome X open reading frame 58 2.72991
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.72991
FOXS1 forkhead box S1 2.72991
PHACTR3 phosphatase and actin regulator 3 2.72991
SLC38A8 solute carrier family 38, member 8 2.72991
NCOA2 nuclear receptor coactivator 2 2.72991
NT5DC4 5'-nucleotidase domain containing 4 2.72991
IL15RA interleukin 15 receptor, alpha 2.72991
ACSBG2 acyl-CoA synthetase bubblegum family member 2 2.72991
MORN5 MORN repeat containing 5 2.72991
FCRLB Fc receptor-like B 2.72991
SIGLEC15 sialic acid binding Ig-like lectin 15 2.72991
SYNGR4 synaptogyrin 4 2.72991
VAV1 vav 1 guanine nucleotide exchange factor 2.72991
SDS serine dehydratase 2.72991
DNAH10 dynein, axonemal, heavy chain 10 2.72991
PADI1 peptidyl arginine deiminase, type I 2.72991
DCST1 DC-STAMP domain containing 1 2.72991
NLRP3 NLR family, pyrin domain containing 3 2.72991
ITPKA inositol-trisphosphate 3-kinase A 2.72991
SPDEF SAM pointed domain containing ETS transcription factor 2.72991
OR14A2 olfactory receptor, family 14, subfamily A, member 2 2.72991
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 2.72991
AOC1 amine oxidase, copper containing 1 2.72991
CD22 CD22 molecule 2.72991
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 2.72991
IFITM10 interferon induced transmembrane protein 10 2.72991
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 2.72991
SLC34A3 solute carrier family 34 (type II sodium/phosphate cotransporter), member 3 2.72991
RNF224 ring finger protein 224 2.72991
LKAAEAR1 LKAAEAR motif containing 1 2.72991
MRGPRX3 MAS-related GPR, member X3 2.72991
XCR1 chemokine (C motif) receptor 1 2.72991
R3HDML R3H domain containing-like 2.72991
SLITRK6 SLIT and NTRK-like family, member 6 2.72991
SCN3A sodium channel, voltage gated, type III alpha subunit 2.72991
LAMP5 lysosomal-associated membrane protein family, member 5 2.72991
CD34 CD34 molecule 2.72991
DEFB134 defensin, beta 134 2.72991
AMIGO3 adhesion molecule with Ig-like domain 3 2.72991
SPDYE10 speedy/RINGO cell cycle regulator family member E10 2.66168
CIB1 calcium and integrin binding 1 (calmyrin) 2.65673
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 2.64301
COL9A2 collagen, type IX, alpha 2 2.64301
AXL AXL receptor tyrosine kinase 2.5651
PCF11 PCF11 cleavage and polyadenylation factor subunit 2.56352
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae) 2.55592
RASEF RAS and EF-hand domain containing 2.55416
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2.54967
ACAT2 acetyl-CoA acetyltransferase 2 2.52565
NPIPB5 nuclear pore complex interacting protein family, member B5 2.47356
POU6F2 POU class 6 homeobox 2 2.46547
NKIRAS1 NFKB inhibitor interacting Ras-like 1 2.46542
PTGIS prostaglandin I2 (prostacyclin) synthase 2.45871
ZNF146 zinc finger protein 146 2.45608
RSPRY1 ring finger and SPRY domain containing 1 2.42593
CRLS1 cardiolipin synthase 1 2.40734
HESX1 HESX homeobox 1 2.39961
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5 2.39127
PLPPR1 phospholipid phosphatase related 1 2.38022
BMP8A bone morphogenetic protein 8a 2.35593
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 2.34133
SPRYD4 SPRY domain containing 4 2.32339
HAX1 HCLS1 associated protein X-1 2.31523
KIF3A kinesin family member 3A 2.29512
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 2.29238
OPN3 opsin 3 2.28985
ADAM9 ADAM metallopeptidase domain 9 2.27238
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 2.27238
SLC71A2 solute carrier family 71 member 2 2.27238
TGDS TDP-glucose 4,6-dehydratase 2.26471
AHNAK AHNAK nucleoprotein 2.24553
ISCU iron-sulfur cluster assembly enzyme 2.21983
PLXNB2 plexin B2 2.21417
PWWP3B PWWP domain containing 3B 2.17852
ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 2.17842
FGD5 FYVE, RhoGEF and PH domain containing 5 2.17444
RBMXL1 RNA binding motif protein, X-linked-like 1 2.15924
NIFK nucleolar protein interacting with the FHA domain of MKI67 2.15924
CCDC8 coiled-coil domain containing 8 2.14383
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 2.14085
AIF1L allograft inflammatory factor 1-like 2.13748
CDH7 cadherin 7, type 2 2.13748
SYAP1 synapse associated protein 1 2.12285
ARFGAP2 ADP-ribosylation factor GTPase activating protein 2 2.11624
ARLN allregulin 2.1104
NUCLEOLIN nucleolin multifunctional protein 2.08991
UBAP1 ubiquitin associated protein 1 2.08318
MEA1 male-enhanced antigen 1 2.05387
WDR45B WD repeat domain 45B 2.03281
RIOX1 ribosomal oxygenase 1 2.02693
RPS10 ribosomal protein S10 2.02624
SMIM15 small integral membrane protein 15 2.0185
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 2.01737
ADORA2B adenosine A2b receptor 2.01104
HEMK1 HemK methyltransferase family member 1 2.00666
ZNF35 zinc finger protein 35 2.00511
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 2.00511
CADPS2 Ca++-dependent secretion activator 2 2.00511
FTSJ3 FtsJ homolog 3 (E. coli) 2.00206
CHTOP chromatin target of PRMT1 2.00082
NCOA4 nuclear receptor coactivator 4 2.00082
MFF mitochondrial fission factor 2.00082

decreased expression

Symbol Name Standardized Value
PSKH2 protein serine kinase H2 -2.7319
ACSM3 acyl-CoA synthetase medium-chain family member 3 -2.7319
CNTNAP4 contactin associated protein-like 4 -2.7319
KYNU kynureninase -2.7319
CLIC5 chloride intracellular channel 5 -2.7319
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -2.7319
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) -2.7319
FRMPD1 FERM and PDZ domain containing 1 -2.7319
PRRT4 proline-rich transmembrane protein 4 -2.72991
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa -2.72991
ZNF763 zinc finger protein 763 -2.72991
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 -2.72991
TENM2 teneurin transmembrane protein 2 -2.72991
NRGN neurogranin (protein kinase C substrate, RC3) -2.72991
SGMS2 sphingomyelin synthase 2 -2.72991
EXOC3L2 exocyst complex component 3-like 2 -2.72991
AHSG alpha-2-HS-glycoprotein -2.72991
TRAF3IP3 TRAF3 interacting protein 3 -2.72991
TEX36 testis expressed 36 -2.72991
MYO16 myosin XVI -2.72991
KLHL35 kelch-like family member 35 -2.72991
CHRD chordin -2.72991
IL11RA interleukin 11 receptor, alpha -2.72991
GFRA3 GDNF family receptor alpha 3 -2.72991
PON1 paraoxonase 1 -2.72991
FOXA2 forkhead box A2 -2.72991
SH2D7 SH2 domain containing 7 -2.72991
OR8D4 olfactory receptor, family 8, subfamily D, member 4 -2.72991
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7 -2.72991
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2 -2.72991
TNC tenascin C -2.72991
OPRL1 opiate receptor-like 1 -2.72991
REN renin -2.72991
SPDYE6 speedy/RINGO cell cycle regulator family member E6 -2.72991
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 -2.72991
F2 coagulation factor II (thrombin) -2.72991
AVP arginine vasopressin -2.72991
TACR2 tachykinin receptor 2 -2.72991
CECR2 cat eye syndrome chromosome region, candidate 2 -2.72991
FOXN3 forkhead box N3 -2.72991
UBXN10 UBX domain protein 10 -2.72991
GBP4 guanylate binding protein 4 -2.72991
TPSB2 tryptase beta 2 (gene/pseudogene) -2.72991
H2AC8 H2A clustered histone 8 -2.72991
ODAD1 outer dynein arm docking complex subunit 1 -2.72991
FAM193A family with sequence similarity 193, member A -2.72991
RBM20 RNA binding motif protein 20 -2.72991
TEKT2 tektin 2 (testicular) -2.72991
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 -2.72991
LRRC36 leucine rich repeat containing 36 -2.72991
GOLGA8B golgin A8 family, member B -2.72991
HDLBP high density lipoprotein binding protein -2.72991
KLK7 kallikrein-related peptidase 7 -2.72991
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 -2.72991
C4ORF50 chromosome 4 open reading frame 50 -2.72991
MYH2 myosin, heavy chain 2, skeletal muscle, adult -2.72991
PHF21B PHD finger protein 21B -2.72991
HEATR6 HEAT repeat containing 6 -2.71084
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) -2.71084
MPZL2 myelin protein zero-like 2 -2.65491
TMT1B thiol methyltransferase 1B -2.65491
NOP53 NOP53 ribosome biogenesis factor -2.63815
MYO15A myosin XVA -2.60699
LRP4 low density lipoprotein receptor-related protein 4 -2.57938
KCTD6 potassium channel tetramerization domain containing 6 -2.56352
TIAM2 T-cell lymphoma invasion and metastasis 2 -2.55416
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3 -2.54967
NRXN3 neurexin 3 -2.54692
NRXN1 neurexin 1 -2.5414
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) -2.48046
C12ORF75 chromosome 12 open reading frame 75 -2.46542
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A -2.45154
PCDHA6 protocadherin alpha 6 -2.45154
CCDC117 coiled-coil domain containing 117 -2.45154
ZNF28 zinc finger protein 28 -2.43083
ARFRP1 ADP-ribosylation factor related protein 1 -2.37594
ABHD14A abhydrolase domain containing 14A -2.35711
ZNF667 zinc finger protein 667 -2.34195
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -2.32537
TRPV2 transient receptor potential cation channel, subfamily V, member 2 -2.31779
SCARF1 scavenger receptor class F, member 1 -2.31779
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) -2.30183
ARSL arylsulfatase L -2.29238
ZBTB3 zinc finger and BTB domain containing 3 -2.29005
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 -2.27513
UPP1 uridine phosphorylase 1 -2.27238
ATF3 activating transcription factor 3 -2.27238
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -2.25092
STK33 serine/threonine kinase 33 -2.22664
TMEM181 transmembrane protein 181 -2.22528
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -2.21118
NPB neuropeptide B -2.18395
USP50 ubiquitin specific peptidase 50 -2.18395
STAT5A signal transducer and activator of transcription 5A -2.18395
ERICH1 glutamate-rich 1 -2.17278
TMEM41A transmembrane protein 41A -2.16674
ZNF26 zinc finger protein 26 -2.16114
NUP210L nucleoporin 210kDa-like -2.15924
RASAL1 RAS protein activator like 1 (GAP1 like) -2.15193
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -2.14603
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -2.13831
H1-3 H1.3 linker histone, cluster member -2.12449
RPS19BP1 ribosomal protein S19 binding protein 1 -2.12074
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.10561
GRIA3 glutamate receptor, ionotropic, AMPA 3 -2.101
MAVS mitochondrial antiviral signaling protein -2.09764
TSR3 TSR3, 20S rRNA accumulation, homolog (S. cerevisiae) -2.09312
RAB11A RAB11A, member RAS oncogene family -2.09312
EPHB1 EPH receptor B1 -2.06952
MARCHF6 membrane associated ring-CH-type finger 6 -2.06481
CUX1 cut-like homeobox 1 -2.04578
GID4 GID complex subunit 4 -2.04206
SIAE sialic acid acetylesterase -2.02711
CDK5RAP1 CDK5 regulatory subunit associated protein 1 -2.02693
NEMP2 nuclear envelope integral membrane protein 2 -2.02643
MYO6 myosin VI -2.02624
ZNF552 zinc finger protein 552 -2.02395
ZHX2 zinc fingers and homeoboxes 2 -2.01737
MBTD1 mbt domain containing 1 -2.01737
RRP1 ribosomal RNA processing 1 -2.01737
SLC35E2B solute carrier family 35, member E2B -2.01737
SMOC2 SPARC related modular calcium binding 2 -2.00511
SCARA3 scavenger receptor class A, member 3 -2.00348
FXYD7 FXYD domain containing ion transport regulator 7 -2.00082