CUL4B Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description cullin 4B|This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8450)
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Genes

370 genes differentially expressed following the CUL4B gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SIX1 SIX homeobox 1 4.45047
HES3 hes family bHLH transcription factor 3 4.45047
CASP4 caspase 4, apoptosis-related cysteine peptidase 4.45047
RRAD Ras-related associated with diabetes 4.45047
IQCJ IQ motif containing J 4.45047
PAX9 paired box 9 4.45047
SIGLEC6 sialic acid binding Ig-like lectin 6 4.45047
RSPO2 R-spondin 2 4.45047
ADAD2 adenosine deaminase domain containing 2 4.45047
KCNRG potassium channel regulator 4.45047
TRIM74 tripartite motif containing 74 4.45047
SPRR1B small proline-rich protein 1B 4.45047
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 4.45047
OR2A42 olfactory receptor, family 2, subfamily A, member 42 4.45047
NXPH4 neurexophilin 4 4.45047
LAPTM5 lysosomal protein transmembrane 5 4.45047
ELF4 E74-like factor 4 (ets domain transcription factor) 4.45047
AGTR1 angiotensin II receptor, type 1 4.45047
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 4.45047
RASL10A RAS-like, family 10, member A 4.45047
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 4.45047
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 4.45047
COLEC10 collectin sub-family member 10 (C-type lectin) 4.45047
LRRTM2 leucine rich repeat transmembrane neuronal 2 4.45047
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 4.45047
PRELP proline/arginine-rich end leucine-rich repeat protein 4.45047
ADAMTSL5 ADAMTS-like 5 4.45047
C1ORF141 chromosome 1 open reading frame 141 4.45047
HMX1 H6 family homeobox 1 4.45047
ETV2 ets variant 2 4.45047
OIT3 oncoprotein induced transcript 3 4.45047
EVPL envoplakin 4.45047
TECTB tectorin beta 4.45047
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 4.45047
PRSS22 protease, serine, 22 4.45047
R3HDML R3H domain containing-like 4.45047
AMPD1 adenosine monophosphate deaminase 1 4.45047
GHRH growth hormone releasing hormone 4.45047
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 4.45047
KISS1R KISS1 receptor 4.45047
RNF133 ring finger protein 133 4.45047
MRC1 mannose receptor, C type 1 4.45047
GMFG glia maturation factor, gamma 4.45047
TMEM71 transmembrane protein 71 4.45047
CRX cone-rod homeobox 4.45047
OCSTAMP osteoclast stimulatory transmembrane protein 4.45047
SHE Src homology 2 domain containing E 4.45047
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 4.45047
CRYGC crystallin, gamma C 4.45047
VSX1 visual system homeobox 1 4.45047
TAS2R19 taste receptor, type 2, member 19 4.45047
CORO6 coronin 6 4.45047
MYO1A myosin IA 4.45047
MMP10 matrix metallopeptidase 10 4.45047
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 4.45047
AVPR1A arginine vasopressin receptor 1A 4.45047
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 4.45047
ALX4 ALX homeobox 4 4.45047
DUSP8 dual specificity phosphatase 8 4.45047
KRT86 keratin 86, type II 4.45047
SPRR2A small proline-rich protein 2A 4.45047
FIMP1 fertilization-influencing membrane protein 1 4.45047
FMOD fibromodulin 4.45047
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 4.45047
IGSF22 immunoglobulin superfamily, member 22 4.45047
GCSAM germinal center-associated, signaling and motility 4.45047
ARX aristaless related homeobox 4.45047
ERVW-1 endogenous retrovirus group W, member 1 4.45047
CPHXL2 cytoplasmic polyadenylated homeobox like 2 4.45047
TEX53 testis expressed 53 4.45047
H2BK1 H2B.K variant histone 1 4.45047
ACP7 acid phosphatase 7, tartrate resistant (putative) 4.45047
MINDY4B MINDY family member 4B 4.45047
EZHIP EZH inhibitory protein 4.45047
MEIOSIN meiosis initiator 4.45047
SPACDR sperm acrosome developmental regulator 4.45047
CABCOCO1 ciliary associated calcium binding coiled-coil 1 4.45047
MINAR2 membrane integral NOTCH2 associated receptor 2 4.45047
SPACA9 sperm acrosome associated 9 4.45047
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 4.45047
REP15 RAB15 effector protein 4.45047
GATA3 GATA binding protein 3 4.45047
SH3TC2 SH3 domain and tetratricopeptide repeats 2 4.45047
SCRT1 scratch family zinc finger 1 4.45047
TMEM235 transmembrane protein 235 4.45047
CD79A CD79a molecule, immunoglobulin-associated alpha 4.45047
CCDC17 coiled-coil domain containing 17 4.45047
KLHL33 kelch-like family member 33 4.45047
PCDHA5 protocadherin alpha 5 4.45047
SLFN14 schlafen family member 14 4.45047
IL12RB1 interleukin 12 receptor, beta 1 4.45047
TBX22 T-box 22 4.45047
HNF4A hepatocyte nuclear factor 4, alpha 4.45047
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 4.45047
C1QL2 complement component 1, q subcomponent-like 2 4.45047
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 4.45047
GATA2 GATA binding protein 2 4.45047
TUBA4B tubulin, alpha 4b 4.45047
LRRC71 leucine rich repeat containing 71 4.45047
FAM131C family with sequence similarity 131, member C 4.45047
OPN5 opsin 5 4.45047
PTH parathyroid hormone 4.45047
BLNK B-cell linker 4.45047
BARX2 BARX homeobox 2 4.45047
S100G S100 calcium binding protein G 4.45047
CCR9 chemokine (C-C motif) receptor 9 4.45047
NPFF neuropeptide FF-amide peptide precursor 4.45047
LOX lysyl oxidase 4.45047
VMAC vimentin-type intermediate filament associated coiled-coil protein 4.45047
TMEM132E transmembrane protein 132E 4.45047
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 4.45047
KRTAP5-10 keratin associated protein 5-10 4.45047
SIAH3 siah E3 ubiquitin protein ligase family member 3 4.45047
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 4.45047
EXTL1 exostosin-like glycosyltransferase 1 4.45047
POF1B premature ovarian failure, 1B 4.45047
ZCCHC12 zinc finger, CCHC domain containing 12 4.45047
SAMD5 sterile alpha motif domain containing 5 4.45047
PALMD palmdelphin 4.45047
EBF2 early B-cell factor 2 4.45047
KRT14 keratin 14, type I 4.45047
KRT17 keratin 17, type I 4.45047
NLRP14 NLR family, pyrin domain containing 14 4.45047
DYTN dystrotelin 4.45047
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 4.45047
A3GALT2 alpha 1,3-galactosyltransferase 2 4.45047
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 4.45047
UTS2R urotensin 2 receptor 4.45047
SV2B synaptic vesicle glycoprotein 2B 4.45047
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B 4.45047
DQX1 DEAQ box RNA-dependent ATPase 1 4.45047
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene) 4.45047
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 4.45047
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 4.45047
VWA3B von Willebrand factor A domain containing 3B 4.45047
CBX8 chromobox homolog 8 4.45047
MUC17 mucin 17, cell surface associated 4.45047
EMP1 epithelial membrane protein 1 4.45047
ODF4 outer dense fiber of sperm tails 4 4.45047
ARG1 arginase 1 4.45047
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 4.45047
VWA7 von Willebrand factor A domain containing 7 4.45047
CLRN2 clarin 2 4.45047
CPSF4L cleavage and polyadenylation specific factor 4-like 4.45047
ANKRD63 ankyrin repeat domain 63 4.45047
SMIM23 small integral membrane protein 23 4.45047
KLF4 Kruppel-like factor 4 (gut) 4.45047
RNASE11 ribonuclease, RNase A family, 11 (non-active) 4.45047
ISL1 ISL LIM homeobox 1 4.45047
ISL2 ISL LIM homeobox 2 4.45047
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 4.45047
IL9R interleukin 9 receptor 4.45047
ANGPTL5 angiopoietin-like 5 4.45047
CASQ2 calsequestrin 2 (cardiac muscle) 4.45047
GPR150 G protein-coupled receptor 150 4.45047
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 4.45047
TSPAN19 tetraspanin 19 4.45047
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 4.45047
RTN4RL1 reticulon 4 receptor-like 1 4.45047
PRAP1 proline-rich acidic protein 1 4.45047
CD86 CD86 molecule 4.45047
TICAM1 toll-like receptor adaptor molecule 1 4.45047
TMEM86A transmembrane protein 86A 4.45047
LY6G5C lymphocyte antigen 6 complex, locus G5C 4.45047
SEZ6L seizure related 6 homolog (mouse)-like 4.45047
MZB1 marginal zone B and B1 cell-specific protein 4.45047
DRC7 dynein regulatory complex subunit 7 4.45047
IFITM10 interferon induced transmembrane protein 10 4.45047
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 4.45047
TGM6 transglutaminase 6 4.45047
TTC24 tetratricopeptide repeat domain 24 4.45047
IFNE interferon, epsilon 4.45047
TEX38 testis expressed 38 4.45047
APOL3 apolipoprotein L, 3 4.45047
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 4.45047
PTGDR prostaglandin D2 receptor (DP) 4.45047
F13B coagulation factor XIII, B polypeptide 4.45047
NT5C1A 5'-nucleotidase, cytosolic IA 4.45047
CDH17 cadherin 17, LI cadherin (liver-intestine) 4.45047
ZNF750 zinc finger protein 750 4.45047
IDI2 isopentenyl-diphosphate delta isomerase 2 4.45047
ACSM1 acyl-CoA synthetase medium-chain family member 1 4.45047
SLFN12L schlafen family member 12-like 4.45047
ZGLP1 zinc finger, GATA-like protein 1 4.45047
AICDA activation-induced cytidine deaminase 4.45047
LY96 lymphocyte antigen 96 4.45047
C9ORF57 chromosome 9 open reading frame 57 4.45047
CSF1R colony stimulating factor 1 receptor 4.45047
CD28 CD28 molecule 4.45047
QRFP pyroglutamylated RFamide peptide 4.45047
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 4.45047
MC5R melanocortin 5 receptor 4.45047
NCF2 neutrophil cytosolic factor 2 4.36653
LOC122539214 Zinc finger protein LOC122539214 4.36653
ZNF595 zinc finger protein 595 3.84854
EEIG2 EEIG family member 2 3.47889
CDK20 cyclin-dependent kinase 20 3.40648
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 3.40648
SLC24A5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 3.40648
SF3A2 splicing factor 3a, subunit 2, 66kDa 3.14738
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 3.12671
SMKR1 small lysine-rich protein 1 3.1248
RIMKLB ribosomal modification protein rimK-like family member B 3.08172
TACC3 transforming, acidic coiled-coil containing protein 3 2.86742
TAFAZZIN tafazzin, phospholipid-lysophospholipid transacylase 2.86284
TMEM164 transmembrane protein 164 2.80998
KMT5A lysine methyltransferase 5A 2.80268
GABPA GA binding protein transcription factor, alpha subunit 60kDa 2.73494
FAM193B family with sequence similarity 193, member B 2.7025
RBSN rabenosyn, RAB effector 2.70136
TRMT10C tRNA methyltransferase 10 homolog C (S. cerevisiae) 2.68996
KLHL20 kelch-like family member 20 2.647
OSBP oxysterol binding protein 2.49414
ARFGEF3 ARFGEF family member 3 2.48418
LYN LYN proto-oncogene, Src family tyrosine kinase 2.47484
SLC35D3 solute carrier family 35, member D3 2.473
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 2.473
DISP2 dispatched homolog 2 (Drosophila) 2.473
SVBP small vasohibin binding protein 2.473
ARRDC4 arrestin domain containing 4 2.46181
FZD7 frizzled class receptor 7 2.45897
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 2.44554
CA9 carbonic anhydrase IX 2.44075
HMGA2 high mobility group AT-hook 2 2.41762
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) 2.41726
GALNT17 polypeptide N-acetylgalactosaminyltransferase 17 2.41065
RFK riboflavin kinase 2.36381
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 2.36225
DYNLRB1 dynein, light chain, roadblock-type 1 2.35237
TBC1D14 TBC1 domain family, member 14 2.34753
CRYGS crystallin, gamma S 2.34642
NKD2 naked cuticle homolog 2 (Drosophila) 2.34642
DLD dihydrolipoamide dehydrogenase 2.33606
NCOA3 nuclear receptor coactivator 3 2.33116
EPHA10 EPH receptor A10 2.32651
CCDC124 coiled-coil domain containing 124 2.32009
GSDMD gasdermin D 2.31298
ZNF780B zinc finger protein 780B 2.26271
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.25785
EIF2D eukaryotic translation initiation factor 2D 2.24962
COL4A2 collagen, type IV, alpha 2 2.24711
PER1 period circadian clock 1 2.24543
CRY2 cryptochrome circadian clock 2 2.22503
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 2.22327
CSMD1 CUB and Sushi multiple domains 1 2.21506
ZFP2 ZFP2 zinc finger protein 2.17732
ZNF320 zinc finger protein 320 2.16452
DTNBP1 dystrobrevin binding protein 1 2.14962
PCED1B PC-esterase domain containing 1B 2.12406
MIER1 mesoderm induction early response 1, transcriptional regulator 2.12406
YPEL1 yippee-like 1 (Drosophila) 2.12368
IFT20 intraflagellar transport 20 2.11152
KALRN kalirin, RhoGEF kinase 2.11152
STIM2 stromal interaction molecule 2 2.09432
ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 2.08443
HIPK1 homeodomain interacting protein kinase 1 2.07966
ZNF624 zinc finger protein 624 2.07626
PGF placental growth factor 2.07626
LRRC3B leucine rich repeat containing 3B 2.07
GEMIN5 gem (nuclear organelle) associated protein 5 2.06247
WDPCP WD repeat containing planar cell polarity effector 2.04025
HECTD2 HECT domain containing E3 ubiquitin protein ligase 2 2.02762

decreased expression

Symbol Name Standardized Value
SATL1 spermidine/spermine N1-acetyl transferase-like 1 -4.45047
PANO1 proapoptotic nucleolar protein 1 -4.36653
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 -4.36653
TMEM184A transmembrane protein 184A -4.36653
NRG2 neuregulin 2 -4.36653
ADAM21 ADAM metallopeptidase domain 21 -4.36653
ADRA1A adrenoceptor alpha 1A -4.36653
IL12A interleukin 12A -4.36653
TUBA8 tubulin, alpha 8 -4.36653
DNAH10 dynein, axonemal, heavy chain 10 -4.36653
SLC39A12 solute carrier family 39 (zinc transporter), member 12 -4.36653
WNT3A wingless-type MMTV integration site family, member 3A -4.36653
TRPV6 transient receptor potential cation channel, subfamily V, member 6 -4.36653
ITPRID1 ITPR interacting domain containing 1 -4.36653
NIBAN3 niban apoptosis regulator 3 -4.36653
SMTNL2 smoothelin-like 2 -4.36653
POU2F3 POU class 2 homeobox 3 -4.36653
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G -4.36653
LGALS7B lectin, galactoside-binding, soluble, 7B -4.36653
SLC26A7 solute carrier family 26 (anion exchanger), member 7 -4.36653
ZEB2 zinc finger E-box binding homeobox 2 -4.36653
ARHGAP30 Rho GTPase activating protein 30 -4.36653
CHCT1 CHD1 helical C-terminal domain containing 1 -4.36653
RASL11A RAS-like, family 11, member A -4.36653
TDRD12 tudor domain containing 12 -4.36653
EXD1 exonuclease 3'-5' domain containing 1 -4.36653
MIEF2 mitochondrial elongation factor 2 -4.36653
PCDHGA1 protocadherin gamma subfamily A, 1 -4.36653
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 -4.36653
TMEM200B transmembrane protein 200B -4.36653
DCDC2B doublecortin domain containing 2B -4.36653
PAH phenylalanine hydroxylase -4.36653
PANK4 pantothenate kinase 4 -4.23073
ADNP2 ADNP homeobox 2 -3.78891
TAGLN2 transgelin 2 -3.60872
JAKMIP2 janus kinase and microtubule interacting protein 2 -3.53416
GINS3 GINS complex subunit 3 (Psf3 homolog) -3.32735
RPS15A ribosomal protein S15a -3.32658
TTYH3 tweety family member 3 -3.2242
SPC25 SPC25, NDC80 kinetochore complex component -3.21079
FAM184B family with sequence similarity 184, member B -3.20079
ATRX alpha thalassemia/mental retardation syndrome X-linked -3.14738
HHAT hedgehog acyltransferase -3.09245
WBP1L WW domain binding protein 1-like -3.04756
RLIG1 RNA 5'-phosphate and 3'-OH ligase 1 -2.86925
C1QL1 complement component 1, q subcomponent-like 1 -2.84632
DAPK3 death-associated protein kinase 3 -2.80998
GTPBP2 GTP binding protein 2 -2.80946
ZNF124 zinc finger protein 124 -2.78933
TOP2B topoisomerase (DNA) II beta 180kDa -2.65656
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.5872
SUMO3 small ubiquitin-like modifier 3 -2.54781
GPATCH11 G patch domain containing 11 -2.53148
FOXK1 forkhead box K1 -2.48577
PDE10A phosphodiesterase 10A -2.45521
TMEM35A transmembrane protein 35A -2.44075
SYT4 synaptotagmin IV -2.44075
SIAE sialic acid acetylesterase -2.44075
PLXDC1 plexin domain containing 1 -2.44075
MINDY1 MINDY lysine 48 deubiquitinase 1 -2.44075
GLRA1 glycine receptor, alpha 1 -2.41726
GPR82 G protein-coupled receptor 82 -2.41726
PCDHB15 protocadherin beta 15 -2.41726
TM4SF18 transmembrane 4 L six family member 18 -2.41726
SPATA18 spermatogenesis associated 18 -2.41726
ATP5MF ATP synthase membrane subunit f -2.406
PPP2R2B protein phosphatase 2, regulatory subunit B, beta -2.3929
GTPBP6 GTP binding protein 6 (putative) -2.36381
ALOX12 arachidonate 12-lipoxygenase -2.34642
BTBD18 BTB (POZ) domain containing 18 -2.34642
C12ORF60 chromosome 12 open reading frame 60 -2.34642
TBC1D10A TBC1 domain family, member 10A -2.31298
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide -2.30777
H2AC21 H2A clustered histone 21 -2.30777
DENND6B DENN/MADD domain containing 6B -2.30777
POLD2 polymerase (DNA directed), delta 2, accessory subunit -2.27543
CD63 CD63 molecule -2.27199
COL16A1 collagen, type XVI, alpha 1 -2.24543
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -2.24543
IRF9 interferon regulatory factor 9 -2.24543
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha -2.24543
BTN3A2 butyrophilin, subfamily 3, member A2 -2.24543
MBD1 methyl-CpG binding domain protein 1 -2.24371
ZNF721 zinc finger protein 721 -2.24233
NOTCH3 notch 3 -2.22845
ZC3H6 zinc finger CCCH-type containing 6 -2.21677
NQO2 NAD(P)H dehydrogenase, quinone 2 -2.21506
MIB1 mindbomb E3 ubiquitin protein ligase 1 -2.18425
COL14A1 collagen, type XIV, alpha 1 -2.18425
RNPS1 RNA binding protein S1, serine-rich domain -2.17994
ARF1 ADP-ribosylation factor 1 -2.1791
MGME1 mitochondrial genome maintenance exonuclease 1 -2.17283
ZNF101 zinc finger protein 101 -2.12129
MPC2 mitochondrial pyruvate carrier 2 -2.11542
MACIR macrophage immunometabolism regulator -2.11152
C2ORF76 chromosome 2 open reading frame 76 -2.11152
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 -2.11152
TARDBP TAR DNA binding protein -2.10416
SHISAL2B shisa like 2B -2.101
ABRACL ABRA C-terminal like -2.09778
BRI3 brain protein I3 -2.09432
NAGA N-acetylgalactosaminidase, alpha- -2.08452
ANKRD16 ankyrin repeat domain 16 -2.0702
C8ORF76 chromosome 8 open reading frame 76 -2.06247
PIGL phosphatidylinositol glycan anchor biosynthesis, class L -2.0485
TIMP1 TIMP metallopeptidase inhibitor 1 -2.03617
TDRD7 tudor domain containing 7 -2.02077
UBA6 ubiquitin-like modifier activating enzyme 6 -2.01256