CUL7 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description cullin 7|The protein encoded by this gene is a component of an E3 ubiquitin-protein ligase complex. The encoded protein interacts with TP53, CUL9, and FBXW8 proteins. Defects in this gene are a cause of 3M syndrome type 1 (3M1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009] (NCBI Entrez Gene Database, 9820)
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Genes

280 genes differentially expressed following the CUL7 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
GUCA1C guanylate cyclase activator 1C 2.44457
FABP1 fatty acid binding protein 1, liver 2.44457
DPEP2 dipeptidase 2 2.44457
CNTNAP4 contactin associated protein-like 4 2.44457
MYBPC1 myosin binding protein C, slow type 2.44457
SSMEM1 serine-rich single-pass membrane protein 1 2.44457
OPRL1 opiate receptor-like 1 2.44457
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 2.44457
GIMAP2 GTPase, IMAP family member 2 2.44457
SCGB3A1 secretoglobin, family 3A, member 1 2.44457
PLIN1 perilipin 1 2.44457
BTN1A1 butyrophilin, subfamily 1, member A1 2.44457
MEP1A meprin A, alpha (PABA peptide hydrolase) 2.44457
FAM187B family with sequence similarity 187, member B 2.44457
FOLR1 folate receptor 1 (adult) 2.44457
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 2.44457
CD5 CD5 molecule 2.44457
ZACN zinc activated ligand-gated ion channel 2.44457
GPR52 G protein-coupled receptor 52 2.44457
SLC46A2 solute carrier family 46, member 2 2.44457
SP7 Sp7 transcription factor 2.44457
SGK3 serum/glucocorticoid regulated kinase family, member 3 2.44457
CRYGC crystallin, gamma C 2.44457
BHMT2 betaine--homocysteine S-methyltransferase 2 2.44457
ARHGAP36 Rho GTPase activating protein 36 2.44457
MRPL27 mitochondrial ribosomal protein L27 2.44457
ETV2 ets variant 2 2.44457
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 2.44457
FGF7 fibroblast growth factor 7 2.44457
PCDHGA11 protocadherin gamma subfamily A, 11 2.44457
TREML1 triggering receptor expressed on myeloid cells-like 1 2.44457
SHE Src homology 2 domain containing E 2.44457
AURKAIP1 aurora kinase A interacting protein 1 2.44457
THRSP thyroid hormone responsive 2.44457
RPL3L ribosomal protein L3-like 2.44457
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 2.44457
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 2.44457
CPB1 carboxypeptidase B1 (tissue) 2.44457
CLEC5A C-type lectin domain family 5, member A 2.44457
ACVRL1 activin A receptor type II-like 1 2.44457
OCSTAMP osteoclast stimulatory transmembrane protein 2.44457
RBP4 retinol binding protein 4, plasma 2.44457
ACKR5 atypical chemokine receptor 5 2.44457
NCBP3 nuclear cap binding subunit 3 2.44457
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 2.44457
CD300LF CD300 molecule-like family member f 2.44457
PNLIPRP2 pancreatic lipase-related protein 2 2.44457
RD3 retinal degeneration 3 2.44457
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 2.44457
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 2.44457
OR1C1 olfactory receptor, family 1, subfamily C, member 1 2.44457
SLURP2 secreted LY6/PLAUR domain containing 2 2.44457
MSANTD5 Myb/SANT DNA binding domain containing 5 2.44457
CALHM5 calcium homeostasis modulator family member 5 2.44457
FAM240C family with sequence similarity 240 member C 2.44457
EXOC1L exocyst complex component 1 like 2.44457
LINC02268 long intergenic non-protein coding RNA 2268 2.44457
C1ORF232 chromosome 1 open reading frame 230 2.44457
TMA7B translation machinery associated 7 homolog B 2.44457
SPEM2 SPEM family member 2 2.44457
CCDC190 coiled-coil domain containing 190 2.44457
CCDC187 coiled-coil domain containing 187 2.44457
FCMR Fc fragment of IgM receptor 2.44457
GATA2 GATA binding protein 2 2.44457
SCRT2 scratch family zinc finger 2 2.44457
CLIP4 CAP-GLY domain containing linker protein family, member 4 2.44457
ZBTB16 zinc finger and BTB domain containing 16 2.44457
IRF5 interferon regulatory factor 5 2.44457
UBAP1 ubiquitin associated protein 1 2.44457
OASL 2'-5'-oligoadenylate synthetase-like 2.44457
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.44457
LIPJ lipase, family member J 2.44457
C1ORF162 chromosome 1 open reading frame 162 2.44457
ADGRG1 adhesion G protein-coupled receptor G1 2.44457
MYH13 myosin, heavy chain 13, skeletal muscle 2.44457
LTK leukocyte receptor tyrosine kinase 2.44457
PCDHGC4 protocadherin gamma subfamily C, 4 2.44457
NPIPB8 nuclear pore complex interacting protein family, member B8 2.44457
GPR85 G protein-coupled receptor 85 2.44457
C6 complement component 6 2.44457
EXOC3L4 exocyst complex component 3-like 4 2.44457
KLRF1 killer cell lectin-like receptor subfamily F, member 1 2.44457
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.44457
GRXCR1 glutaredoxin, cysteine rich 1 2.44457
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 2.44457
HHATL hedgehog acyltransferase-like 2.44457
DEFB107B defensin, beta 107B 2.44457
S100Z S100 calcium binding protein Z 2.44457
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 2.44457
CDHR5 cadherin-related family member 5 2.44457
TBC1D10A TBC1 domain family, member 10A 2.44457
TBC1D10C TBC1 domain family, member 10C 2.44457
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 2.44457
WFDC5 WAP four-disulfide core domain 5 2.44457
AQP7 aquaporin 7 2.44457
AQP8 aquaporin 8 2.44457
UBFD1 ubiquitin family domain containing 1 2.44457
ZNF132 zinc finger protein 132 2.44457
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 2.44457
C18ORF63 chromosome 18 open reading frame 63 2.44457
LCNL1 lipocalin-like 1 2.44457
LCT lactase 2.44457
KLHL1 kelch-like family member 1 2.44457
THTPA thiamine triphosphatase 2.44457
POM121 POM121 transmembrane nucleoporin 2.44457
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 2.44457
AKNAD1 AKNA domain containing 1 2.44457
C8A complement component 8, alpha polypeptide 2.44457
TAAR1 trace amine associated receptor 1 2.44457
LY96 lymphocyte antigen 96 2.44457
AMN amnion associated transmembrane protein 2.44457
CTSS cathepsin S 2.44457
BCL2L15 BCL2-like 15 2.44457
GOLGA8J golgin A8 family, member J 2.44457
ALPP alkaline phosphatase, placental 2.44457
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.44457
EGR3 early growth response 3 2.44457
FBXO47 F-box protein 47 2.44457
HKDC1 hexokinase domain containing 1 2.44457
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 2.44457
CLEC4D C-type lectin domain family 4, member D 2.44457
MAB21L1 mab-21-like 1 (C. elegans) 2.44457
CCDC27 coiled-coil domain containing 27 2.44457
CCL17 chemokine (C-C motif) ligand 17 2.44457
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 2.44457
HELT helt bHLH transcription factor 2.44457
HRCT1 histidine rich carboxyl terminus 1 2.44457
BCL2A1 BCL2-related protein A1 2.44457
TMEM52B transmembrane protein 52B 2.44457
CHAT choline O-acetyltransferase 2.44457
TRPM8 transient receptor potential cation channel, subfamily M, member 8 2.44457
CLCNKB chloride channel, voltage-sensitive Kb 2.44457
CCDC166 coiled-coil domain containing 166 2.44457
THEM5 thioesterase superfamily member 5 2.44457
SLC34A3 solute carrier family 34 (type II sodium/phosphate cotransporter), member 3 2.44457
TEX36 testis expressed 36 2.44457
OR10G3 olfactory receptor, family 10, subfamily G, member 3 2.44457
ADAM29 ADAM metallopeptidase domain 29 2.44457
SSX3 synovial sarcoma, X breakpoint 3 2.44457
SSX1 synovial sarcoma, X breakpoint 1 2.44457
OXER1 oxoeicosanoid (OXE) receptor 1 2.44457
MYOZ2 myozenin 2 2.44457
NLRP9 NLR family, pyrin domain containing 9 2.44457
CD22 CD22 molecule 2.44457
NEUROD1 neuronal differentiation 1 2.44457
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 2.44457
POTEI POTE ankyrin domain family, member I 2.44457
C9ORF50 chromosome 9 open reading frame 50 2.44457
PRSS54 protease, serine, 54 2.44457
C9ORF57 chromosome 9 open reading frame 57 2.44457
PCDHGB5 protocadherin gamma subfamily B, 5 2.44457
CPZ carboxypeptidase Z 2.44457
OARD1 O-acyl-ADP-ribose deacylase 1 2.44457
LRRC32 leucine rich repeat containing 32 2.44457
SUN3 Sad1 and UNC84 domain containing 3 2.44457
POU3F3 POU class 3 homeobox 3 2.44457
MBOAT4 membrane bound O-acyltransferase domain containing 4 2.44457
PRR15L proline rich 15-like 2.44457
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 2.40344
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 2.33766
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 2.33766
CD48 CD48 molecule 2.31428
OSR2 odd-skipped related transciption factor 2 2.31428
RDH10 retinol dehydrogenase 10 (all-trans) 2.31267
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 2.26437
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) 2.2582
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase 2.25328
MEIG1 meiosis/spermiogenesis associated 1 2.22964
PCDHGA7 protocadherin gamma subfamily A, 7 2.22964
CFAP206 cilia and flagella associated protein 206 2.22964
PTPN12 protein tyrosine phosphatase, non-receptor type 12 2.21741
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa 2.21149
ZP3 zona pellucida glycoprotein 3 (sperm receptor) 2.21149
ZFTA zinc finger translocation associated 2.18768
SNAI1 snail family zinc finger 1 2.18646
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 2.16334
DZANK1 double zinc ribbon and ankyrin repeat domains 1 2.15438
CNBP CCHC-type zinc finger, nucleic acid binding protein 2.13743
SMG9 SMG9 nonsense mediated mRNA decay factor 2.13743
RHOXF1 Rhox homeobox family, member 1 2.12028
TLX2 T-cell leukemia homeobox 2 2.11257
RHOF ras homolog family member F (in filopodia) 2.07902
YLPM1 YLP motif containing 1 2.0719
MPG N-methylpurine-DNA glycosylase 2.06915
MAPK7 mitogen-activated protein kinase 7 2.03905
TNS2 tensin 2 2.01877
MTX3 metaxin 3 2.01877
AAMP angio-associated, migratory cell protein 2.01585

decreased expression

Symbol Name Standardized Value
H2BC8 H2B clustered histone 8 -2.44457
DSC2 desmocollin 2 -2.44457
CCDC167 coiled-coil domain containing 167 -2.44457
F2RL2 coagulation factor II (thrombin) receptor-like 2 -2.44457
TMEM61 transmembrane protein 61 -2.44457
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 -2.44457
AMIGO1 adhesion molecule with Ig-like domain 1 -2.44457
PCGF5 polycomb group ring finger 5 -2.44457
BMX BMX non-receptor tyrosine kinase -2.44457
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -2.44457
BDNF brain-derived neurotrophic factor -2.44457
GALM galactose mutarotase (aldose 1-epimerase) -2.44457
NLRP7 NLR family, pyrin domain containing 7 -2.44457
TLCD2 TLC domain containing 2 -2.44457
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 -2.44457
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 -2.44457
SLC35D3 solute carrier family 35, member D3 -2.44457
WDR17 WD repeat domain 17 -2.44457
HLA-DMB major histocompatibility complex, class II, DM beta -2.44457
OPTN optineurin -2.44457
TMEM255A transmembrane protein 255A -2.44457
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 -2.44457
EBPL emopamil binding protein-like -2.44457
PAK1IP1 PAK1 interacting protein 1 -2.44457
FAM234A family with sequence similarity 234 member A -2.40727
H3-7 H3.7 histone (putative) -2.33766
IL37 interleukin 37 -2.33766
STYXL2 serine/threonine/tyrosine interacting like 2 -2.33766
OSGIN1 oxidative stress induced growth inhibitor 1 -2.33766
ODAPH odontogenesis associated phosphoprotein -2.33766
DLL4 delta-like 4 (Drosophila) -2.33766
SOWAHB sosondowah ankyrin repeat domain family member B -2.33766
AANAT aralkylamine N-acetyltransferase -2.33766
CD68 CD68 molecule -2.33766
TMPRSS6 transmembrane protease, serine 6 -2.33766
PCP4L1 Purkinje cell protein 4 like 1 -2.33766
PDILT protein disulfide isomerase-like, testis expressed -2.33766
OR2B6 olfactory receptor, family 2, subfamily B, member 6 -2.33766
EIF3CL eukaryotic translation initiation factor 3, subunit C-like -2.33766
GFI1B growth factor independent 1B transcription repressor -2.33766
NOG noggin -2.33766
DES desmin -2.33766
RASGEF1A RasGEF domain family, member 1A -2.33766
TMPPE transmembrane protein with metallophosphoesterase domain -2.33766
PRH1 proline-rich protein HaeIII subfamily 1 -2.33766
EVI2A ecotropic viral integration site 2A -2.33766
THBD thrombomodulin -2.33766
ZNF114 zinc finger protein 114 -2.33766
PHF2 PHD finger protein 2 -2.33184
CUL7 cullin 7 -2.30287
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 -2.30092
CRYGD crystallin, gamma D -2.28408
RNF150 ring finger protein 150 -2.25076
LAMC1 laminin, gamma 1 (formerly LAMB2) -2.22964
CPNE9 copine family member IX -2.18646
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -2.17294
RGS5 regulator of G-protein signaling 5 -2.17212
CXCL12 chemokine (C-X-C motif) ligand 12 -2.16224
BMPER BMP binding endothelial regulator -2.16224
CCDC18 coiled-coil domain containing 18 -2.15656
ACTRT3 actin-related protein T3 -2.14838
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae) -2.13743
SEC14L4 SEC14-like 4 (S. cerevisiae) -2.13743
CHML choroideremia-like (Rab escort protein 2) -2.13743
TMOD1 tropomodulin 1 -2.13743
JMJD1C jumonji domain containing 1C -2.13743
ATF1 activating transcription factor 1 -2.13743
UBQLN1 ubiquilin 1 -2.13532
TOB2 transducer of ERBB2, 2 -2.07902
ARMCX1 armadillo repeat containing, X-linked 1 -2.07839
LONP1 lon peptidase 1, mitochondrial -2.0693
ACER2 alkaline ceramidase 2 -2.06396
FAM120C family with sequence similarity 120C -2.06096
CSRNP1 cysteine-serine-rich nuclear protein 1 -2.04629
IL18BP interleukin 18 binding protein -2.03933
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 -2.03905
PALS2 protein associated with LIN7 2, MAGUK p55 family member -2.03554
CMTR2 cap methyltransferase 2 -2.03554
SPC24 SPC24, NDC80 kinetochore complex component -2.03224
AQP11 aquaporin 11 -2.03224
MECP2 methyl CpG binding protein 2 -2.02857
MMP3 matrix metallopeptidase 3 -2.02798
RHOD ras homolog family member D -2.02418
TLR5 toll-like receptor 5 -2.02006
QPCT glutaminyl-peptide cyclotransferase -2.01877
PLN phospholamban -2.01877
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) -2.01877
PXDC1 PX domain containing 1 -2.01659
SLC9D1 solute carrier family 9 member D1 -2.00597
CNKSR3 CNKSR family member 3 -2.00487
ABI2 abl-interactor 2 -2.00212
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -2.00109