| Dataset | Guide to Pharmacology Protein Ligands of Receptors |
| Category | physical interactions |
| Type | ligand (protein) |
| Description | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)|This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014] (NCBI Entrez Gene Database, 2919) |
| External Link | http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2919 |
| Similar Terms | |
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2 receptors of the CXCL1 ligand (protein) from the curated Guide to Pharmacology Protein Ligands of Receptors dataset.
