CXCL12 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description chemokine (C-X-C motif) ligand 12|This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014] (NCBI Entrez Gene Database, 6387)
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Genes

279 genes differentially expressed following the CXCL12 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TGM3 transglutaminase 3 2.90531
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 2.90531
GUCY2F guanylate cyclase 2F, retinal 2.90531
GSG1 germ cell associated 1 2.90531
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2.90531
ADGB androglobin 2.90531
OTUD6A OTU deubiquitinase 6A 2.90531
RFPL2 ret finger protein-like 2 2.90531
TRIM73 tripartite motif containing 73 2.90531
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.90531
TUBB1 tubulin, beta 1 class VI 2.90531
OLFM4 olfactomedin 4 2.90531
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 2.90531
WNT16 wingless-type MMTV integration site family, member 16 2.90531
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 2.90531
NOD2 nucleotide-binding oligomerization domain containing 2 2.90531
PCDHGB3 protocadherin gamma subfamily B, 3 2.90531
UBA7 ubiquitin-like modifier activating enzyme 7 2.90531
PARP10 poly (ADP-ribose) polymerase family, member 10 2.90531
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 2.90531
PADI6 peptidyl arginine deiminase, type VI 2.90531
PPP1R3C protein phosphatase 1, regulatory subunit 3C 2.90531
ADAM20 ADAM metallopeptidase domain 20 2.90531
MLN motilin 2.90531
KIF12 kinesin family member 12 2.90531
C5ORF46 chromosome 5 open reading frame 46 2.90531
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 2.90531
OR6B1 olfactory receptor, family 6, subfamily B, member 1 2.90531
CD38 CD38 molecule 2.90531
DSPP dentin sialophosphoprotein 2.90531
FGF6 fibroblast growth factor 6 2.90531
PLCZ1 phospholipase C, zeta 1 2.90531
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 2.90531
TMPRSS3 transmembrane protease, serine 3 2.90531
PRDM13 PR domain containing 13 2.90531
PROC protein C (inactivator of coagulation factors Va and VIIIa) 2.90531
PGBDF plakoglobin binding and degradation factor 2.90531
PCDHB4 protocadherin beta 4 2.90531
PCDHB12 protocadherin beta 12 2.90531
LTBP2 latent transforming growth factor beta binding protein 2 2.90531
CCDC17 coiled-coil domain containing 17 2.90531
CLDN2 claudin 2 2.90531
MSX1 msh homeobox 1 2.90531
CATSPERQ catsper channel auxiliary subunit theta 2.90531
TMEM17 transmembrane protein 17 2.90531
OR2A12 olfactory receptor, family 2, subfamily A, member 12 2.90531
IL6 interleukin 6 2.90531
TLR7 toll-like receptor 7 2.90531
SLAMF9 SLAM family member 9 2.90531
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 2.90531
KLRF1 killer cell lectin-like receptor subfamily F, member 1 2.90531
KCNT1 potassium channel, sodium activated subfamily T, member 1 2.90531
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 2.90531
MTMR11 myotubularin related protein 11 2.90531
NPIPB7 nuclear pore complex interacting protein family, member B7 2.90531
COX8C cytochrome c oxidase subunit VIIIC 2.90531
PVRIG poliovirus receptor related immunoglobulin domain containing 2.90531
PDIA2 protein disulfide isomerase family A, member 2 2.90531
PRICKLE4 prickle homolog 4 (Drosophila) 2.90531
TSPAN8 tetraspanin 8 2.90531
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 2.90531
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 2.90531
GATA4 GATA binding protein 4 2.90531
STKLD1 serine/threonine kinase-like domain containing 1 2.90531
COL20A1 collagen, type XX, alpha 1 2.90531
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 2.90531
HRH1 histamine receptor H1 2.90531
LEKR1 leucine, glutamate and lysine rich 1 2.90531
PLVAP plasmalemma vesicle associated protein 2.90531
OVGP1 oviductal glycoprotein 1, 120kDa 2.90531
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 2.90531
DLK2 delta-like 2 homolog (Drosophila) 2.90531
PRG4 proteoglycan 4 2.90531
PGA5 pepsinogen 5, group I (pepsinogen A) 2.90531
ADGRG3 adhesion G protein-coupled receptor G3 2.90531
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.90531
ARL13A ADP-ribosylation factor-like 13A 2.90531
SPEF1 sperm flagellar 1 2.90531
ACOT12 acyl-CoA thioesterase 12 2.90531
FYB2 FYN binding protein 2 2.90531
MUCL3 mucin like 3 2.90531
PCDH12 protocadherin 12 2.90531
SEC14L6 SEC14-like 6 (S. cerevisiae) 2.90531
IL1B interleukin 1, beta 2.90531
PCDHGA4 protocadherin gamma subfamily A, 4 2.90531
DRD4 dopamine receptor D4 2.90531
EMP1 epithelial membrane protein 1 2.90531
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 2.90531
MAB21L3 mab-21-like 3 (C. elegans) 2.90531
CD248 CD248 molecule, endosialin 2.90531
APOC2 apolipoprotein C-II 2.90531
SH2D4B SH2 domain containing 4B 2.90531
ANKRD53 ankyrin repeat domain 53 2.90531
TPPP2 tubulin polymerization-promoting protein family member 2 2.90531
SCNN1B sodium channel, non voltage gated 1 beta subunit 2.90531
UPK1B uroplakin 1B 2.90531
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 2.90531
NPY2R neuropeptide Y receptor Y2 2.90531
SCPPPQ1 secretory calcium-binding phosphoprotein proline-glutamine rich 1 2.90531
FBXO15 F-box protein 15 2.90531
LRRN4 leucine rich repeat neuronal 4 2.90531
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 2.90531
NMBR neuromedin B receptor 2.90531
NYX nyctalopin 2.90531
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.90531
FLRT3 fibronectin leucine rich transmembrane protein 3 2.90531
QRFP pyroglutamylated RFamide peptide 2.90531
ADGRD1 adhesion G protein-coupled receptor D1 2.90531
TMEM31 transmembrane protein 31 2.90531
NR5A1 nuclear receptor subfamily 5, group A, member 1 2.90531
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 2.90531
STPG3 sperm-tail PG-rich repeat containing 3 2.90531
TMEM225B transmembrane protein 225B 2.90531
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 2.90531
NGFR nerve growth factor receptor 2.90531
KPNA7 karyopherin alpha 7 (importin alpha 8) 2.90531
HSPB2 heat shock 27kDa protein 2 2.90531
YIPF7 Yip1 domain family, member 7 2.90531
DMTN dematin actin binding protein 2.90531
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 2.90531
C9ORF50 chromosome 9 open reading frame 50 2.90531
POU3F4 POU class 3 homeobox 4 2.90531
PSORS1C2 psoriasis susceptibility 1 candidate 2 2.90531
VTCN1 V-set domain containing T cell activation inhibitor 1 2.90531
PNLIPRP2 pancreatic lipase-related protein 2 2.90531
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 2.90531
TMEM86A transmembrane protein 86A 2.90531
ZBED6 zinc finger, BED-type containing 6 2.90531
DMRTC1 DMRT-like family C1 2.90531
PCDHGA9 protocadherin gamma subfamily A, 9 2.90531
TIGIT T cell immunoreceptor with Ig and ITIM domains 2.90531
DACT3 dishevelled-binding antagonist of beta-catenin 3 2.90531
KLF2 Kruppel-like factor 2 2.90531
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.90531
TIGD3 tigger transposable element derived 3 2.90531
DGCR6 DiGeorge syndrome critical region gene 6 2.90531
CXCR2 chemokine (C-X-C motif) receptor 2 2.90531
CXCR4 chemokine (C-X-C motif) receptor 4 2.90531
GARIN6 golgi associated RAB2 interactor family member 6 2.90531
H2BC3 H2B clustered histone 3 2.90531
PCARE photoreceptor cilium actin regulator 2.90531
ZNF541 zinc finger protein 541 2.90531
EDN1 endothelin 1 2.90531
C1QTNF12 C1q and TNF related 12 2.90531
H3-5 H3.5 histone 2.90531
AKR1B15 aldo-keto reductase family 1, member B15 2.90531
CCL25 chemokine (C-C motif) ligand 25 2.90531
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 2.90531
ST18 suppression of tumorigenicity 18, zinc finger 2.90531
LRRC19 leucine rich repeat containing 19 2.7789
TGOLN2 trans-golgi network protein 2 2.77285
MYLK myosin light chain kinase 2.73644
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 2.67056
ZNF334 zinc finger protein 334 2.65412
ZSCAN31 zinc finger and SCAN domain containing 31 2.64229
MPHOSPH8 M-phase phosphoprotein 8 2.64229
SORBS3 sorbin and SH3 domain containing 3 2.62327
BTN2A2 butyrophilin, subfamily 2, member A2 2.57137
TP53BP2 tumor protein p53 binding protein 2 2.5151
CEP250 centrosomal protein 250kDa 2.48704
CISD1 CDGSH iron sulfur domain 1 2.48704
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 2.44972
CDCA7 cell division cycle associated 7 2.44957
GEMIN2 gem (nuclear organelle) associated protein 2 2.41392
CCDC200 coiled-coil domain containing 200 2.4086
RTL4 retrotransposon Gag like 4 2.39972
ERAS ES cell expressed Ras 2.39251
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 2.35475
SARNP SAP domain containing ribonucleoprotein 2.3108
WFDC3 WAP four-disulfide core domain 3 2.30296
NRBF2 nuclear receptor binding factor 2 2.27738
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 2.26072
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 2.24007
MATN2 matrilin 2 2.18136
CEP95 centrosomal protein 95kDa 2.1031
CPNE1 copine I 2.10174
SLC39A13 solute carrier family 39 (zinc transporter), member 13 2.10159
GOLPH3L golgi phosphoprotein 3-like 2.09535
SRA1 steroid receptor RNA activator 1 2.08312
FGF14 fibroblast growth factor 14 2.07211
YEATS2 YEATS domain containing 2 2.06602
LIPA lipase A, lysosomal acid, cholesterol esterase 2.00147

decreased expression

Symbol Name Standardized Value
LRRTM3 leucine rich repeat transmembrane neuronal 3 -2.90531
ZNF287 zinc finger protein 287 -2.90531
KLC3 kinesin light chain 3 -2.90531
RFX4 regulatory factor X, 4 (influences HLA class II expression) -2.90531
YY2 YY2 transcription factor -2.90531
ECE2 endothelin converting enzyme 2 -2.90531
PPP4R2 protein phosphatase 4, regulatory subunit 2 -2.90531
PAQR9 progestin and adipoQ receptor family member IX -2.90531
JMJD4 jumonji domain containing 4 -2.90531
ZFTRAF1 zinc finger TRAF-type containing 1 -2.90531
FOXI3 forkhead box I3 -2.90531
PIGT phosphatidylinositol glycan anchor biosynthesis, class T -2.81871
NOTCH2NLA notch 2 N-terminal like A -2.78758
JAG2 jagged 2 -2.78758
KICS2 KICSTOR subunit 2 -2.74617
COL15A1 collagen, type XV, alpha 1 -2.64229
REM2 RAS (RAD and GEM)-like GTP binding 2 -2.64229
NGEF neuronal guanine nucleotide exchange factor -2.64229
CFAP100 cilia and flagella associated protein 100 -2.64229
KIF19 kinesin family member 19 -2.64229
TEKTIP1 tektin bundle interacting protein 1 -2.64229
SGMS2 sphingomyelin synthase 2 -2.64229
TNS2 tensin 2 -2.64229
ODAD4 outer dynein arm docking complex subunit 4 -2.64229
C16ORF86 chromosome 16 open reading frame 86 -2.64229
FHIP2B FHF complex subunit HOOK interacting protein 2B -2.64229
DNAAF19 dynein axonemal assembly factor 19 -2.64229
C1QTNF1 C1q and tumor necrosis factor related protein 1 -2.64229
SH3TC2 SH3 domain and tetratricopeptide repeats 2 -2.64229
ZBTB12 zinc finger and BTB domain containing 12 -2.64229
ELFN1 extracellular leucine-rich repeat and fibronectin type III domain containing 1 -2.64229
SOX7 SRY (sex determining region Y)-box 7 -2.64229
PROKR1 prokineticin receptor 1 -2.64229
HYKK hydroxylysine kinase -2.64229
LOC124906010 uncharacterized LOC124906010 -2.64229
DCAF12L1 DDB1 and CUL4 associated factor 12-like 1 -2.64229
NT5C1B 5'-nucleotidase, cytosolic IB -2.64229
GPR62 G protein-coupled receptor 62 -2.64229
COL17A1 collagen, type XVII, alpha 1 -2.64229
APOB apolipoprotein B -2.64229
LYG1 lysozyme G-like 1 -2.64229
SLC9B1 solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 -2.64229
MYO3B myosin IIIB -2.64229
DCAF12L2 DDB1 and CUL4 associated factor 12-like 2 -2.64229
PTGDS prostaglandin D2 synthase 21kDa (brain) -2.64229
ZNF547 zinc finger protein 547 -2.64229
IL11 interleukin 11 -2.64229
TBC1D28 TBC1 domain family, member 28 -2.64229
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 -2.64229
CLIC2 chloride intracellular channel 2 -2.64229
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 -2.61679
AMOT angiomotin -2.6142
SUN1 Sad1 and UNC84 domain containing 1 -2.58877
MSN moesin -2.58173
FOXM1 forkhead box M1 -2.5454
CCDC184 coiled-coil domain containing 184 -2.53308
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 -2.53308
DCAF13 DDB1 and CUL4 associated factor 13 -2.53308
ANG angiogenin, ribonuclease, RNase A family, 5 -2.53308
CFAP44 cilia and flagella associated protein 44 -2.53308
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) -2.53308
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 -2.4945
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 -2.47614
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated -2.47018
C3ORF70 chromosome 3 open reading frame 70 -2.45191
VIL1 villin 1 -2.42742
ZNF284 zinc finger protein 284 -2.42742
ANKRD40 ankyrin repeat domain 40 -2.39972
ERI1 exoribonuclease 1 -2.39972
NBEAL1 neurobeachin-like 1 -2.33085
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.32074
RXYLT1 ribitol xylosyltransferase 1 -2.32006
TSPO translocator protein (18kDa) -2.31038
PROX1 prospero homeobox 1 -2.30869
A4GALT alpha 1,4-galactosyltransferase -2.28043
N4BP2 NEDD4 binding protein 2 -2.27772
CARD11 caspase recruitment domain family, member 11 -2.27738
SEH1L SEH1-like (S. cerevisiae) -2.27735
EVC Ellis van Creveld protein -2.26396
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 -2.26072
TMEM116 transmembrane protein 116 -2.25229
CLDN20 claudin 20 -2.19044
ATF7IP activating transcription factor 7 interacting protein -2.1777
PRH1 proline-rich protein HaeIII subfamily 1 -2.166
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -2.14476
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -2.112
NT5C 5', 3'-nucleotidase, cytosolic -2.10374
MAP1A microtubule-associated protein 1A -2.10174
RNF6 ring finger protein (C3H2C3 type) 6 -2.10174
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -2.08312
TMEM245 transmembrane protein 245 -2.08271
HUS1 HUS1 checkpoint homolog (S. pombe) -2.06929
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 -2.06096
SARDH sarcosine dehydrogenase -2.04374
OTOG otogelin -2.02556
MAN2A2 mannosidase, alpha, class 2A, member 2 -2.02556
STYK1 serine/threonine/tyrosine kinase 1 -2.02556