CXCL12 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description chemokine (C-X-C motif) ligand 12|This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014] (NCBI Entrez Gene Database, 6387)
External Link http://www.ncbi.nlm.nih.gov/gene/6387
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Genes

44 interacting proteins for CXCL12 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ADRBK1 adrenergic, beta, receptor kinase 1
ADRBK2 adrenergic, beta, receptor kinase 2
ARR3 arrestin 3, retinal (X-arrestin)
ARRB2 arrestin, beta 2
BCAR1 breast cancer anti-estrogen resistance 1
CCR10 chemokine (C-C motif) receptor 10
CCR4 chemokine (C-C motif) receptor 4
CD4 CD4 molecule
CDC42 cell division cycle 42
CTSG cathepsin G
CXCR4 chemokine (C-X-C motif) receptor 4
DAZAP2 DAZ associated protein 2
DNM1 dynamin 1
DPP4 dipeptidyl-peptidase 4
DPP8 dipeptidyl-peptidase 8
ELANE elastase, neutrophil expressed
FN1 fibronectin 1
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNG2 guanine nucleotide binding protein (G protein), gamma 2
GRK6 G protein-coupled receptor kinase 6
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
ITCH itchy E3 ubiquitin protein ligase
LCK LCK proto-oncogene, Src family tyrosine kinase
MMP2 matrix metallopeptidase 2
PF4 platelet factor 4
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6
PTK2 protein tyrosine kinase 2
PXN paxillin
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RALB v-ral simian leukemia viral oncogene homolog B
SSH1 slingshot protein phosphatase 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
VCAN versican