CXCL5 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description chemokine (C-X-C motif) ligand 5|This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in cancer cell proliferation, migration, and invasion. [provided by RefSeq, May 2013] (NCBI Entrez Gene Database, 6374)
Similar Terms
Downloads & Tools

Genes

342 genes differentially expressed following the CXCL5 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FGF21 fibroblast growth factor 21 3.68224
MYBPC3 myosin binding protein C, cardiac 3.68224
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 3.68224
DSG3 desmoglein 3 3.68224
PDE7B phosphodiesterase 7B 3.68224
OLIG2 oligodendrocyte lineage transcription factor 2 3.68224
SSMEM1 serine-rich single-pass membrane protein 1 3.68224
SCNN1G sodium channel, non voltage gated 1 gamma subunit 3.68224
RFPL3 ret finger protein-like 3 3.68224
GNAT3 guanine nucleotide binding protein, alpha transducing 3 3.68224
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 3.68224
DDN dendrin 3.68224
SCGN secretagogin, EF-hand calcium binding protein 3.68224
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 3.68224
SACK1A scaffolding CK1 anchoring protein A 3.68224
IZUMO3 IZUMO family member 3 3.68224
CELF3 CUGBP, Elav-like family member 3 3.68224
AKR1C2 aldo-keto reductase family 1, member C2 3.68224
TRIM15 tripartite motif containing 15 3.68224
SYBU syntabulin (syntaxin-interacting) 3.68224
RIMBP2 RIMS binding protein 2 3.68224
C9ORF152 chromosome 9 open reading frame 152 3.68224
TMEM71 transmembrane protein 71 3.68224
TMEM217 transmembrane protein 217 3.68224
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 3.68224
ETV2 ets variant 2 3.68224
NPR3 natriuretic peptide receptor 3 3.68224
ANXA2R annexin A2 receptor 3.68224
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 3.68224
SPINT4 serine peptidase inhibitor, Kunitz type 4 3.68224
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 3.68224
ASCL2 achaete-scute family bHLH transcription factor 2 3.68224
GPR179 G protein-coupled receptor 179 3.68224
TMC2 transmembrane channel-like 2 3.68224
LGALS2 lectin, galactoside-binding, soluble, 2 3.68224
CD69 CD69 molecule 3.68224
FABP12 fatty acid binding protein 12 3.68224
GMNC geminin coiled-coil domain containing 3.68224
NPIPA8 nuclear pore complex interacting protein family, member A8 3.68224
MISP mitotic spindle positioning 3.68224
TREML1 triggering receptor expressed on myeloid cells-like 1 3.68224
ATOH7 atonal homolog 7 (Drosophila) 3.68224
PRDM12 PR domain containing 12 3.68224
LGALS4 lectin, galactoside-binding, soluble, 4 3.68224
CDCP2 CUB domain containing protein 2 3.68224
CLEC12A C-type lectin domain family 12, member A 3.68224
H4C14 H4 clustered histone 14 3.68224
HAO2 hydroxyacid oxidase 2 (long chain) 3.68224
CD300LF CD300 molecule-like family member f 3.68224
SPRR2F small proline-rich protein 2F 3.68224
PKD2L1 polycystic kidney disease 2-like 1 3.68224
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 3.68224
LY6K lymphocyte antigen 6 complex, locus K 3.68224
ZNF705D zinc finger protein 705D 3.68224
PARVG parvin, gamma 3.68224
CSAG3 CSAG family, member 3 3.68224
CES4A carboxylesterase 4A 3.68224
SPATS1 spermatogenesis associated, serine-rich 1 3.68224
DUSP29 dual specificity phosphatase 29 3.68224
ERFE erythroferrone 3.68224
VXN vexin 3.68224
CIROP ciliated left-right organizer metallopeptidase 3.68224
RTL5 retrotransposon Gag like 5 3.68224
MINAR2 membrane integral NOTCH2 associated receptor 2 3.68224
PLAAT2 phospholipase A and acyltransferase 2 3.68224
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 3.68224
ERVW-1 endogenous retrovirus group W, member 1 3.68224
SYT15 synaptotagmin XV 3.68224
PNPLA1 patatin-like phospholipase domain containing 1 3.68224
ARMC12 armadillo repeat containing 12 3.68224
TM6SF2 transmembrane 6 superfamily member 2 3.68224
ATP13A5 ATPase type 13A5 3.68224
GRXCR1 glutaredoxin, cysteine rich 1 3.68224
TBX20 T-box 20 3.68224
CFHR3 complement factor H-related 3 3.68224
GJA9 gap junction protein, alpha 9, 59kDa 3.68224
HLX H2.0-like homeobox 3.68224
HRH1 histamine receptor H1 3.68224
INHBB inhibin, beta B 3.68224
PCDHA3 protocadherin alpha 3 3.68224
LGALS7B lectin, galactoside-binding, soluble, 7B 3.68224
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 3.68224
CDSN corneodesmosin 3.68224
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 3.68224
MYH13 myosin, heavy chain 13, skeletal muscle 3.68224
ULBP1 UL16 binding protein 1 3.68224
NR1I3 nuclear receptor subfamily 1, group I, member 3 3.68224
CBLN2 cerebellin 2 precursor 3.68224
DAO D-amino-acid oxidase 3.68224
PTGDR2 prostaglandin D2 receptor 2 3.68224
LRRD1 leucine-rich repeats and death domain containing 1 3.68224
SPATA4 spermatogenesis associated 4 3.68224
OR3A3 olfactory receptor, family 3, subfamily A, member 3 3.68224
C8ORF89 chromosome 8 open reading frame 89 3.68224
KLK15 kallikrein-related peptidase 15 3.68224
FBXO40 F-box protein 40 3.68224
FSHR follicle stimulating hormone receptor 3.68224
HSPB9 heat shock protein, alpha-crystallin-related, B9 3.68224
SAMD5 sterile alpha motif domain containing 5 3.68224
ANKRD62 ankyrin repeat domain 62 3.68224
PRSS55 protease, serine, 55 3.68224
AGR2 anterior gradient 2 3.68224
ACSM1 acyl-CoA synthetase medium-chain family member 1 3.68224
CHIT1 chitinase 1 (chitotriosidase) 3.68224
GLRB glycine receptor, beta 3.68224
LRRC3 leucine rich repeat containing 3 3.68224
MBOAT4 membrane bound O-acyltransferase domain containing 4 3.68224
F2RL3 coagulation factor II (thrombin) receptor-like 3 3.68224
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 3.68224
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 3.68224
C11ORF16 chromosome 11 open reading frame 16 3.68224
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 3.68224
C3ORF18 chromosome 3 open reading frame 18 3.68224
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 3.68224
CLRN1 clarin 1 3.68224
POF1B premature ovarian failure, 1B 3.68224
CERKL ceramide kinase-like 3.68224
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 3.68224
IGFBP7 insulin-like growth factor binding protein 7 3.68224
RGCC regulator of cell cycle 3.68224
HRCT1 histidine rich carboxyl terminus 1 3.68224
THBD thrombomodulin 3.68224
PRRT1B proline rich transmembrane protein 1B 3.68224
ALOX15B arachidonate 15-lipoxygenase, type B 3.68224
SIGLEC15 sialic acid binding Ig-like lectin 15 3.68224
MMP13 matrix metallopeptidase 13 3.68224
DUOXA1 dual oxidase maturation factor 1 3.68224
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 3.68224
PRR15L proline rich 15-like 3.68224
PYY peptide YY 3.68224
MMP11 matrix metallopeptidase 11 3.68224
PCDH20 protocadherin 20 3.68224
LMX1A LIM homeobox transcription factor 1, alpha 3.68224
TGM4 transglutaminase 4 3.68224
OR52N4 olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene) 3.68224
VMO1 vitelline membrane outer layer 1 homolog (chicken) 3.68224
LRRN4 leucine rich repeat neuronal 4 3.68224
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 3.68224
IRAK1BP1 interleukin-1 receptor-associated kinase 1 binding protein 1 3.68224
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 3.68224
GPR68 G protein-coupled receptor 68 3.68224
ACKR2 atypical chemokine receptor 2 3.68224
PENK proenkephalin 3.68224
CARD9 caspase recruitment domain family, member 9 3.68224
PPP1R3G protein phosphatase 1, regulatory subunit 3G 3.68224
POTEI POTE ankyrin domain family, member I 3.68224
DNAH8 dynein, axonemal, heavy chain 8 3.68224
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 3.68224
GLT6D1 glycosyltransferase 6 domain containing 1 3.68224
IL33 interleukin 33 3.68224
RERGL RERG/RAS-like 3.68224
PLA1A phospholipase A1 member A 3.68224
FARSB phenylalanyl-tRNA synthetase, beta subunit 3.66506
STK32A serine/threonine kinase 32A 3.59423
AKAP3 A kinase (PRKA) anchor protein 3 3.57525
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 3.57525
CREG2 cellular repressor of E1A-stimulated genes 2 3.57525
SIM2 single-minded family bHLH transcription factor 2 3.57525
CERS4 ceramide synthase 4 3.54703
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 3.30195
MVP major vault protein 3.22926
MTMR12 myotubularin related protein 12 3.21299
MDFIC MyoD family inhibitor domain containing 3.20684
DHFR2 dihydrofolate reductase 2 3.20495
XKR7 XK, Kell blood group complex subunit-related family, member 7 3.03687
SEC14L6 SEC14-like 6 (S. cerevisiae) 3.03687
DACT3 dishevelled-binding antagonist of beta-catenin 3 2.9548
MTDH metadherin 2.95424
CORO1B coronin, actin binding protein, 1B 2.91737
SLC41A1 solute carrier family 41 (magnesium transporter), member 1 2.902
PPIL3 peptidylprolyl isomerase (cyclophilin)-like 3 2.7652
OSCAR osteoclast associated, immunoglobulin-like receptor 2.67334
ZNF141 zinc finger protein 141 2.61146
PAK5 p21 (RAC1) activated kinase 5 2.57904
QPRT quinolinate phosphoribosyltransferase 2.56885
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2.53404
REM2 RAS (RAD and GEM)-like GTP binding 2 2.50134
TECTA tectorin alpha 2.50134
NECAB2 N-terminal EF-hand calcium binding protein 2 2.50134
ANKRD63 ankyrin repeat domain 63 2.50134
CCDC183 coiled-coil domain containing 183 2.50134
TET3 tet methylcytosine dioxygenase 3 2.50134
ZSCAN22 zinc finger and SCAN domain containing 22 2.50134
TMEM213 transmembrane protein 213 2.50134
CPT2 carnitine palmitoyltransferase 2 2.50134
CLIC2 chloride intracellular channel 2 2.50134
HDGFL2 HDGF like 2 2.45853
GPSM1 G-protein signaling modulator 1 2.40489
KLF13 Kruppel-like factor 13 2.39977
TSHZ1 teashirt zinc finger homeobox 1 2.39977
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 2.38317
RNPS1 RNA binding protein S1, serine-rich domain 2.37487
IGF2R insulin-like growth factor 2 receptor 2.35659
PHEX phosphate regulating endopeptidase homolog, X-linked 2.35
WNT8B wingless-type MMTV integration site family, member 8B 2.34536
GPR162 G protein-coupled receptor 162 2.34536
ZFP1 ZFP1 zinc finger protein 2.3417
USF3 upstream transcription factor family member 3 2.33593
GLCCI1 glucocorticoid induced 1 2.30781
SIRAL2 SIR2 antiphage like 2 2.2834
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.26551
SGSM3 small G protein signaling modulator 3 2.24297
DDHD2 DDHD domain containing 2 2.24297
ABLIM1 actin binding LIM protein 1 2.23383
PCDH7 protocadherin 7 2.21101
SPIDR scaffolding protein involved in DNA repair 2.20695
APTX aprataxin 2.19953
SSPN sarcospan 2.18402
CMTM4 CKLF-like MARVEL transmembrane domain containing 4 2.15165
KLKB1 kallikrein B, plasma (Fletcher factor) 1 2.14732
TRAPPC12 trafficking protein particle complex 12 2.14479
LRRIQ1 leucine-rich repeats and IQ motif containing 1 2.14251
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 2.11072
TALDO1 transaldolase 1 2.11072
CNN3 calponin 3, acidic 2.11072
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 2.10848
PPP4R2 protein phosphatase 4, regulatory subunit 2 2.10037
FAT3 FAT atypical cadherin 3 2.10037
HDAC2 histone deacetylase 2 2.09684
NXPE3 neurexophilin and PC-esterase domain family, member 3 2.08408
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 2.08301
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 2.07851
KIZ kizuna centrosomal protein 2.07851
C6ORF132 chromosome 6 open reading frame 132 2.07313
BRD2 bromodomain containing 2 2.0669
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 2.05951
GGPS1 geranylgeranyl diphosphate synthase 1 2.05951
MFAP2 microfibrillar-associated protein 2 2.05951
NMI N-myc (and STAT) interactor 2.05837
KLHL15 kelch-like family member 15 2.04729
MID2 midline 2 2.02663
ACSM3 acyl-CoA synthetase medium-chain family member 3 2.02441
CCDC175 coiled-coil domain containing 175 2.00099

decreased expression

Symbol Name Standardized Value
CPHXL cytoplasmic polyadenylated homeobox like -3.68224
C17ORF100 chromosome 17 open reading frame 100 -3.68224
PSORS1C1 psoriasis susceptibility 1 candidate 1 -3.68224
SUN3 Sad1 and UNC84 domain containing 3 -3.68224
KANK4 KN motif and ankyrin repeat domains 4 -3.68224
ECM1 extracellular matrix protein 1 -3.68224
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 -3.68224
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 -3.68224
LRRC43 leucine rich repeat containing 43 -3.68224
GFI1B growth factor independent 1B transcription repressor -3.68224
CTF1 cardiotrophin 1 -3.68224
GAGE10 G antigen 10 -3.68224
GREM2 gremlin 2, DAN family BMP antagonist -3.68224
WNK4 WNK lysine deficient protein kinase 4 -3.68224
ALPK2 alpha-kinase 2 -3.68224
DYNLRB2 dynein, light chain, roadblock-type 2 -3.68224
TAS1R1 taste receptor, type 1, member 1 -3.68224
TLR7 toll-like receptor 7 -3.68224
PANX2 pannexin 2 -3.68224
IRF9 interferon regulatory factor 9 -3.68224
SPMIP8 sperm microtubule inner protein 8 -3.68224
SFXN3 sideroflexin 3 -3.68224
CXCL5 chemokine (C-X-C motif) ligand 5 -3.68224
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -3.68224
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -3.68224
CPLX1 complexin 1 -3.68224
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -3.68224
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) -3.68224
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 -3.68224
TPTE2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 -3.68224
NT5DC4 5'-nucleotidase domain containing 4 -3.68224
WFDC3 WAP four-disulfide core domain 3 -3.68224
LRRIQ3 leucine-rich repeats and IQ motif containing 3 -3.68224
ISL2 ISL LIM homeobox 2 -3.68224
OPTC opticin -3.68224
AMN amnion associated transmembrane protein -3.68224
LYG2 lysozyme G-like 2 -3.68224
FAM222A family with sequence similarity 222, member A -3.68224
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) -3.68224
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 -3.68224
DST dystonin -3.55218
PMPCA peptidase (mitochondrial processing) alpha -3.20937
COX4I1 cytochrome c oxidase subunit IV isoform 1 -3.17899
DUSP14 dual specificity phosphatase 14 -3.10304
RAP2B RAP2B, member of RAS oncogene family -2.99624
FOXI3 forkhead box I3 -2.9258
SBK2 SH3 domain binding kinase family, member 2 -2.9258
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) -2.83637
ZNF24 zinc finger protein 24 -2.80454
ZNF256 zinc finger protein 256 -2.76783
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 -2.76464
MST1R macrophage stimulating 1 receptor -2.76464
SMOC1 SPARC related modular calcium binding 1 -2.76464
ADCY10 adenylate cyclase 10 (soluble) -2.76464
FAM167B family with sequence similarity 167, member B -2.76464
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) -2.76464
ASB2 ankyrin repeat and SOCS box containing 2 -2.76464
DISP2 dispatched homolog 2 (Drosophila) -2.76464
OXSM 3-oxoacyl-ACP synthase, mitochondrial -2.7222
MBNL1 muscleblind-like splicing regulator 1 -2.7222
AIG1 androgen-induced 1 -2.64206
BMPER BMP binding endothelial regulator -2.56642
SLIT1 slit homolog 1 (Drosophila) -2.51146
MT1F metallothionein 1F -2.50134
PILRA paired immunoglobin-like type 2 receptor alpha -2.46038
C4ORF51 chromosome 4 open reading frame 51 -2.44592
FSTL3 follistatin-like 3 (secreted glycoprotein) -2.44592
CSRNP1 cysteine-serine-rich nuclear protein 1 -2.42648
FST follistatin -2.37225
CDA cytidine deaminase -2.36669
TMEM258 transmembrane protein 258 -2.34874
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) -2.3478
RAD54L2 RAD54-like 2 (S. cerevisiae) -2.3417
FNDC5 fibronectin type III domain containing 5 -2.33232
S100A10 S100 calcium binding protein A10 -2.31444
PVALEF parvalbumin like EF-hand containing -2.31399
PON3 paraoxonase 3 -2.31399
LBP lipopolysaccharide binding protein -2.31399
TRPA1 transient receptor potential cation channel, subfamily A, member 1 -2.31399
AGTPBP1 ATP/GTP binding protein 1 -2.30781
CNTLN centlein, centrosomal protein -2.30781
FICD FIC domain containing -2.30781
YIPF4 Yip1 domain family, member 4 -2.30781
TEDC1 tubulin epsilon and delta complex 1 -2.30781
EMC6 ER membrane protein complex subunit 6 -2.30781
SMIM18 small integral membrane protein 18 -2.30781
ATP8B4 ATPase, class I, type 8B, member 4 -2.30781
PARD6B par-6 family cell polarity regulator beta -2.29122
GLTP glycolipid transfer protein -2.29122
PTPRM protein tyrosine phosphatase, receptor type, M -2.2834
MAOA monoamine oxidase A -2.27698
MED8 mediator complex subunit 8 -2.27698
CMSS1 cms1 ribosomal small subunit homolog (yeast) -2.24297
EDF1 endothelial differentiation-related factor 1 -2.2426
TRAF1 TNF receptor-associated factor 1 -2.20418
CLK2 CDC-like kinase 2 -2.19953
AKAP17A A kinase (PRKA) anchor protein 17A -2.15165
ZNF146 zinc finger protein 146 -2.13621
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -2.09824
CAAP1 caspase activity and apoptosis inhibitor 1 -2.09617
DPY19L3 dpy-19-like 3 (C. elegans) -2.09065
PTPRE protein tyrosine phosphatase, receptor type, E -2.08537
PA2G4 proliferation-associated 2G4, 38kDa -2.08408
RECQL5 RecQ protein-like 5 -2.07851
FASTKD5 FAST kinase domains 5 -2.04364
PUS1 pseudouridylate synthase 1 -2.03565
EAF1 ELL associated factor 1 -2.02708
SLC25A46 solute carrier family 25, member 46 -2.01599
RYBP RING1 and YY1 binding protein -2.00099