CXCR4 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description chemokine (C-X-C motif) receptor 4|This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7852)
External Link http://www.ncbi.nlm.nih.gov/gene/7852
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Genes

73 interacting proteins for CXCR4 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ADRBK1 adrenergic, beta, receptor kinase 1
ADRBK2 adrenergic, beta, receptor kinase 2
ARR3 arrestin 3, retinal (X-arrestin)
ARRB2 arrestin, beta 2
ATP13A2 ATPase type 13A2
BCAR1 breast cancer anti-estrogen resistance 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD164 CD164 molecule, sialomucin
CD4 CD4 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC42 cell division cycle 42
CTSG cathepsin G
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CXCR5 chemokine (C-X-C motif) receptor 5
DBN1 drebrin 1
DNM1 dynamin 1
DPP4 dipeptidyl-peptidase 4
ELANE elastase, neutrophil expressed
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNG2 guanine nucleotide binding protein (G protein), gamma 2
GRK6 G protein-coupled receptor kinase 6
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HLA-C major histocompatibility complex, class I, C
HSPA8 heat shock 70kDa protein 8
ITCH itchy E3 ubiquitin protein ligase
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JAK3 Janus kinase 3
LCK LCK proto-oncogene, Src family tyrosine kinase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYH9 myosin, heavy chain 9, non-muscle
P4HB prolyl 4-hydroxylase, beta polypeptide
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PRKCD protein kinase C, delta
PTK2 protein tyrosine kinase 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
PXN paxillin
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RALB v-ral simian leukemia viral oncogene homolog B
S1PR3 sphingosine-1-phosphate receptor 3
SDC4 syndecan 4
SOCS1 suppressor of cytokine signaling 1
SOCS3 suppressor of cytokine signaling 3
SSH1 slingshot protein phosphatase 1
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
SUMO4 small ubiquitin-like modifier 4
TLR2 toll-like receptor 2
UBC ubiquitin C
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
VAV1 vav 1 guanine nucleotide exchange factor