| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | cytochrome P450, family 1, subfamily A, polypeptide 2|This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1544) |
| External Link | https://ncbi.nlm.nih.gov/gene/1544 |
| Similar Terms | |
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498 genes differentially expressed following the CYP1A2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TNNT1 | troponin T type 1 (skeletal, slow) | 0.0183903 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0176997 |
| HSPB8 | heat shock 22kDa protein 8 | 0.0173259 |
| H1-2 | H1.2 linker histone, cluster member | 0.0158151 |
| GPX3 | glutathione peroxidase 3 | 0.0154453 |
| TSPAN13 | tetraspanin 13 | 0.0151996 |
| JCHAIN | joining chain of multimeric IgA and IgM | 0.0147233 |
| MAGEA3 | melanoma antigen family A3 | 0.0144958 |
| PLXNB2 | plexin B2 | 0.0141338 |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 | 0.0136082 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | 0.0135728 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 0.0134928 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | 0.0133702 |
| PLIN2 | perilipin 2 | 0.0133312 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0133085 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 0.0131418 |
| HHEX | hematopoietically expressed homeobox | 0.0130707 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0128573 |
| ACTA1 | actin, alpha 1, skeletal muscle | 0.0127543 |
| CXCL11 | chemokine (C-X-C motif) ligand 11 | 0.0126974 |
| NPY1R | neuropeptide Y receptor Y1 | 0.0126065 |
| SST | somatostatin | 0.0125841 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0125593 |
| ATF3 | activating transcription factor 3 | 0.0123847 |
| NPTX2 | neuronal pentraxin II | 0.0123288 |
| FABP4 | fatty acid binding protein 4, adipocyte | 0.0121853 |
| DES | desmin | 0.0120126 |
| KLHL41 | kelch-like family member 41 | 0.0120114 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | 0.011925 |
| RTN2 | reticulon 2 | 0.0118802 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | 0.0117887 |
| CPE | carboxypeptidase E | 0.0117765 |
| LYZ | lysozyme | 0.0115744 |
| RARRES2 | retinoic acid receptor responder (tazarotene induced) 2 | 0.0115739 |
| CA2 | carbonic anhydrase II | 0.0114841 |
| ENPEP | glutamyl aminopeptidase (aminopeptidase A) | 0.0110486 |
| KRT18 | keratin 18, type I | 0.011018 |
| SMPDL3A | sphingomyelin phosphodiesterase, acid-like 3A | 0.0109416 |
| FILIP1L | filamin A interacting protein 1-like | 0.0109226 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | 0.0109182 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0108634 |
| CCNG2 | cyclin G2 | 0.0108044 |
| CLGN | calmegin | 0.010777 |
| ACTC1 | actin, alpha, cardiac muscle 1 | 0.0107682 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | 0.0107637 |
| ARG2 | arginase 2 | 0.0107506 |
| ZFPM2 | zinc finger protein, FOG family member 2 | 0.0107376 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | 0.0105549 |
| MYL2 | myosin, light chain 2, regulatory, cardiac, slow | 0.0105449 |
| CD36 | CD36 molecule (thrombospondin receptor) | 0.0105412 |
| MB | myoglobin | 0.0104773 |
| CKM | creatine kinase, muscle | 0.0104422 |
| MIR22HG | MIR22 host gene | 0.0103976 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0103594 |
| TAX1BP3 | Tax1 (human T-cell leukemia virus type I) binding protein 3 | 0.010331 |
| TNNC2 | troponin C type 2 (fast) | 0.0103147 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0102724 |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 | 0.0101557 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 | 0.0101374 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0101161 |
| FRZB | frizzled-related protein | 0.0100824 |
| TBC1D9 | TBC1 domain family, member 9 (with GRAM domain) | 0.0100567 |
| MYOT | myotilin | 0.0100321 |
| TGFB1 | transforming growth factor, beta 1 | 0.0100283 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.00994183 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.00990354 |
| MAGEA12 | melanoma antigen family A12 | 0.00989585 |
| MYH2 | myosin, heavy chain 2, skeletal muscle, adult | 0.0098351 |
| UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) | 0.00981499 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | 0.00980349 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.00977599 |
| ALOX5 | arachidonate 5-lipoxygenase | 0.00977456 |
| G0S2 | G0/G1 switch 2 | 0.00975402 |
| CRYAB | crystallin, alpha B | 0.0097279 |
| PLN | phospholamban | 0.00971234 |
| CPB1 | carboxypeptidase B1 (tissue) | 0.00963101 |
| FGFR2 | fibroblast growth factor receptor 2 | 0.00958742 |
| KRT8 | keratin 8, type II | 0.00958371 |
| CDC34 | cell division cycle 34 | 0.00955349 |
| PSCA | prostate stem cell antigen | 0.00953797 |
| ELF4 | E74-like factor 4 (ets domain transcription factor) | 0.00950274 |
| NIT1 | nitrilase 1 | 0.009398 |
| NNMT | nicotinamide N-methyltransferase | 0.00939785 |
| FHL1 | four and a half LIM domains 1 | 0.00939357 |
| TTN | titin | 0.00933598 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | 0.00932168 |
| MYL1 | myosin, light chain 1, alkali; skeletal, fast | 0.00929908 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | 0.00924327 |
| ORC1 | origin recognition complex, subunit 1 | 0.00920531 |
| GCH1 | GTP cyclohydrolase 1 | 0.00919653 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | 0.00913426 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 0.00910764 |
| WT1 | Wilms tumor 1 | 0.00905468 |
| TNNC1 | troponin C type 1 (slow) | 0.00904549 |
| HTATIP2 | HIV-1 Tat interactive protein 2, 30kDa | 0.00904377 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 0.00904311 |
| MGLL | monoglyceride lipase | 0.00899121 |
| BLVRB | biliverdin reductase B | 0.008984 |
| MAP7 | microtubule-associated protein 7 | 0.00897175 |
| TCTA | T-cell leukemia translocation altered | 0.00894564 |
| RBM47 | RNA binding motif protein 47 | 0.00887825 |
| TNNI2 | troponin I type 2 (skeletal, fast) | 0.00885714 |
| RND3 | Rho family GTPase 3 | 0.00884305 |
| HIST1H2BD | histone cluster 1, H2bd | 0.00883324 |
| ENO3 | enolase 3 (beta, muscle) | 0.00883323 |
| CFD | complement factor D (adipsin) | 0.00879337 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.00878077 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 | 0.00876246 |
| ADIRF | adipogenesis regulatory factor | 0.00874798 |
| MN1 | meningioma (disrupted in balanced translocation) 1 | 0.00872666 |
| CCND1 | cyclin D1 | 0.00871399 |
| IL32 | interleukin 32 | 0.00868699 |
| FGF13 | fibroblast growth factor 13 | 0.00868643 |
| TMEM176B | transmembrane protein 176B | 0.00862648 |
| PDE2A | phosphodiesterase 2A, cGMP-stimulated | 0.0085717 |
| DSE | dermatan sulfate epimerase | 0.00851174 |
| HBB | hemoglobin, beta | 0.00849707 |
| SOWAHC | sosondowah ankyrin repeat domain family member C | 0.00842537 |
| SLN | sarcolipin | 0.00841068 |
| RBM38 | RNA binding motif protein 38 | 0.00840919 |
| SLC38A2 | solute carrier family 38, member 2 | 0.00840455 |
| CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | 0.00840384 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.00840185 |
| TENT4A | terminal nucleotidyltransferase 4A | 0.00837323 |
| RAP1GAP2 | RAP1 GTPase activating protein 2 | 0.00836618 |
| BTG2 | BTG family, member 2 | 0.00834327 |
| ABHD3 | abhydrolase domain containing 3 | 0.00834181 |
| NXN | nucleoredoxin | 0.00833827 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.00832277 |
| PLAAT3 | phospholipase A and acyltransferase 3 | 0.00828494 |
| ACADVL | acyl-CoA dehydrogenase, very long chain | 0.00827509 |
| WDR45 | WD repeat domain 45 | 0.00827358 |
| S100P | S100 calcium binding protein P | 0.00826547 |
| MAP3K7CL | MAP3K7 C-terminal like | 0.00822684 |
| BCAP31 | B-cell receptor-associated protein 31 | 0.00819344 |
| KRT7 | keratin 7, type II | 0.00816131 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.00814182 |
| RRAD | Ras-related associated with diabetes | 0.00809714 |
| DUSP5 | dual specificity phosphatase 5 | 0.00807527 |
| ARL14 | ADP-ribosylation factor-like 14 | 0.00806939 |
| CCL19 | chemokine (C-C motif) ligand 19 | 0.00805485 |
| GSTA1 | glutathione S-transferase alpha 1 | 0.00804843 |
| EVI2A | ecotropic viral integration site 2A | 0.00802241 |
| CILP | cartilage intermediate layer protein, nucleotide pyrophosphohydrolase | 0.00801397 |
| L1CAM | L1 cell adhesion molecule | 0.0079926 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.00797031 |
| ZNF91 | zinc finger protein 91 | 0.00790511 |
| COQ8A | coenzyme Q8A | 0.00789507 |
| GUCY1A3 | guanylate cyclase 1, soluble, alpha 3 | 0.0078934 |
| PIEZO1 | piezo-type mechanosensitive ion channel component 1 | 0.00785542 |
| FZD5 | frizzled class receptor 5 | 0.00783323 |
| SCAND1 | SCAN domain containing 1 | 0.00779274 |
| LAMA5 | laminin, alpha 5 | 0.00777746 |
| IER5 | immediate early response 5 | 0.00776702 |
| MS4A4A | membrane-spanning 4-domains, subfamily A, member 4A | 0.00775628 |
| C2CD2 | C2 calcium-dependent domain containing 2 | 0.00773724 |
| TNNI1 | troponin I type 1 (skeletal, slow) | 0.00772157 |
| PDZK1IP1 | PDZK1 interacting protein 1 | 0.00771454 |
| NMU | neuromedin U | 0.0077056 |
| WTAP | Wilms tumor 1 associated protein | 0.00768546 |
| SMPX | small muscle protein, X-linked | 0.00766135 |
| BLNK | B-cell linker | 0.00762399 |
| CRISPLD2 | cysteine-rich secretory protein LCCL domain containing 2 | 0.00760981 |
| PDGFC | platelet derived growth factor C | 0.00759709 |
| CCL8 | chemokine (C-C motif) ligand 8 | 0.0075919 |
| AMOTL2 | angiomotin like 2 | 0.00757895 |
| APOA1 | apolipoprotein A-I | 0.00756053 |
| BAD | BCL2-associated agonist of cell death | 0.00755533 |
| GALNT3 | polypeptide N-acetylgalactosaminyltransferase 3 | 0.00754453 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | 0.00752722 |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B | 0.00752556 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.00751983 |
| SNAP29 | synaptosomal-associated protein, 29kDa | 0.00751818 |
| TMEM70 | transmembrane protein 70 | 0.00750225 |
| CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | 0.00748333 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 0.00748264 |
| RRAGA | Ras-related GTP binding A | 0.00747986 |
| FABP6 | fatty acid binding protein 6, ileal | 0.00747858 |
| TSPAN12 | tetraspanin 12 | 0.00746573 |
| RAI2 | retinoic acid induced 2 | 0.00746529 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) | 0.00745407 |
| SULT1A1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 | 0.00744522 |
| CASP8 | caspase 8, apoptosis-related cysteine peptidase | 0.00741824 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | 0.00741225 |
| CLIC2 | chloride intracellular channel 2 | 0.00738547 |
| TFF2 | trefoil factor 2 | 0.00735536 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | 0.00734547 |
| AADAC | arylacetamide deacetylase | 0.00733901 |
| RIN2 | Ras and Rab interactor 2 | 0.00733189 |
| PDLIM3 | PDZ and LIM domain 3 | 0.0073236 |
| KRT19 | keratin 19, type I | 0.00732204 |
| MYLPF | myosin light chain, phosphorylatable, fast skeletal muscle | 0.00731159 |
| ZBED2 | zinc finger, BED-type containing 2 | 0.00730768 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 0.00729955 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 | 0.00729806 |
| TMPRSS4 | transmembrane protease, serine 4 | 0.00729777 |
| AHSP | alpha hemoglobin stabilizing protein | 0.00729576 |
| VNN1 | vanin 1 | 0.00729221 |
| RNF103 | ring finger protein 103 | 0.00728778 |
| C3 | complement component 3 | 0.00728677 |
| C7 | complement component 7 | 0.00724871 |
| PCP4 | Purkinje cell protein 4 | 0.00724341 |
| PTGER3 | prostaglandin E receptor 3 (subtype EP3) | 0.00723425 |
| DNAJC12 | DnaJ (Hsp40) homolog, subfamily C, member 12 | 0.00722823 |
| CCL2 | chemokine (C-C motif) ligand 2 | 0.0072281 |
| PLVAP | plasmalemma vesicle associated protein | 0.00722281 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.00721659 |
| GREM1 | gremlin 1, DAN family BMP antagonist | 0.00721196 |
| RAB9A | RAB9A, member RAS oncogene family | 0.00721025 |
| MS4A6A | membrane-spanning 4-domains, subfamily A, member 6A | 0.00719308 |
| LGALS2 | lectin, galactoside-binding, soluble, 2 | 0.00718766 |
| PTP4A3 | protein tyrosine phosphatase type IVA, member 3 | 0.00717396 |
| TMSB15A | thymosin beta 15a | 0.00714889 |
| POU2AF1 | POU class 2 associating factor 1 | 0.00713146 |
| REG1A | regenerating islet-derived 1 alpha | 0.00712543 |
| GRK5 | G protein-coupled receptor kinase 5 | 0.00710928 |
| REEP1 | receptor accessory protein 1 | 0.00710123 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.00707342 |
| SNAP23 | synaptosomal-associated protein, 23kDa | 0.00705052 |
| MFAP4 | microfibrillar-associated protein 4 | 0.00704485 |
| KCNK3 | potassium channel, two pore domain subfamily K, member 3 | 0.00703845 |
| BMP2 | bone morphogenetic protein 2 | 0.00700681 |
| TST | thiosulfate sulfurtransferase (rhodanese) | 0.00698264 |
| CCNE1 | cyclin E1 | 0.00697571 |
| CLEC2B | C-type lectin domain family 2, member B | 0.00696253 |
| IL10RA | interleukin 10 receptor, alpha | 0.00694195 |
| ITIH5 | inter-alpha-trypsin inhibitor heavy chain family, member 5 | 0.00692482 |
| ASS1 | argininosuccinate synthase 1 | 0.00689722 |
| MAGEA1 | melanoma antigen family A1 | 0.00688625 |
| MOSPD1 | motile sperm domain containing 1 | 0.00684736 |
| CDIPT | CDP-diacylglycerol--inositol 3-phosphatidyltransferase | 0.0068102 |
| HSPB3 | heat shock 27kDa protein 3 | 0.00681013 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.00680281 |
| SLC3A1 | solute carrier family 3 (amino acid transporter heavy chain), member 1 | 0.00679745 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.00678509 |
| ADIPOQ | adiponectin, C1Q and collagen domain containing | 0.00678028 |
| ANXA4 | annexin A4 | 0.00678027 |
| HIST1H2AC | histone cluster 1, H2ac | 0.00677218 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.00674955 |
| PMM2 | phosphomannomutase 2 | 0.00674848 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.00674154 |
| ALAS2 | 5'-aminolevulinate synthase 2 | 0.0067294 |
| GALC | galactosylceramidase | 0.00672398 |
| HIC2 | hypermethylated in cancer 2 | 0.00671217 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.00671093 |
| ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 | 0.00671066 |
| CAV2 | caveolin 2 | 0.00670829 |
| PROCR | protein C receptor, endothelial | 0.0066904 |
| GALE | UDP-galactose-4-epimerase | 0.0066842 |
| Symbol | Name | Standardized Value |
|---|---|---|
| KRT5 | keratin 5, type II | -0.0193833 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0168804 |
| AUTS2 | autism susceptibility candidate 2 | -0.0161573 |
| TYRP1 | tyrosinase-related protein 1 | -0.0131492 |
| PITX3 | paired-like homeodomain 3 | -0.0127449 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0122484 |
| KRT14 | keratin 14, type I | -0.0121643 |
| TNC | tenascin C | -0.0114515 |
| GPM6B | glycoprotein M6B | -0.0114509 |
| RGS4 | regulator of G-protein signaling 4 | -0.0114285 |
| ALOX5AP | arachidonate 5-lipoxygenase-activating protein | -0.0111561 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | -0.011105 |
| TP63 | tumor protein p63 | -0.0109717 |
| ZIC1 | Zic family member 1 | -0.0109458 |
| SPRY2 | sprouty homolog 2 (Drosophila) | -0.0109398 |
| MMP12 | matrix metallopeptidase 12 | -0.0109031 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | -0.0108349 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | -0.0106981 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0106662 |
| COPS7A | COP9 signalosome subunit 7A | -0.0106161 |
| KRT6A | keratin 6A, type II | -0.0105688 |
| FGF1 | fibroblast growth factor 1 (acidic) | -0.0105668 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0105381 |
| S100A2 | S100 calcium binding protein A2 | -0.010497 |
| SPRR1B | small proline-rich protein 1B | -0.0104909 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0104213 |
| PCDH9 | protocadherin 9 | -0.0103573 |
| S100B | S100 calcium binding protein B | -0.0103486 |
| IL2RG | interleukin 2 receptor, gamma | -0.0100645 |
| MOXD1 | monooxygenase, DBH-like 1 | -0.00995106 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0099462 |
| SFN | stratifin | -0.00991722 |
| TRIB2 | tribbles pseudokinase 2 | -0.00990497 |
| FABP7 | fatty acid binding protein 7, brain | -0.00981983 |
| PRKCA | protein kinase C, alpha | -0.00978723 |
| RBBP4 | retinoblastoma binding protein 4 | -0.00960051 |
| TXLNA | taxilin alpha | -0.00958334 |
| PTCH1 | patched 1 | -0.00958086 |
| ACTA2 | actin, alpha 2, smooth muscle, aorta | -0.009461 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | -0.00943854 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.00924398 |
| FAM171A1 | family with sequence similarity 171, member A1 | -0.00921764 |
| PMP2 | peripheral myelin protein 2 | -0.00920484 |
| ATP1A1 | ATPase, Na+/K+ transporting, alpha 1 polypeptide | -0.00919474 |
| ACP6 | acid phosphatase 6, lysophosphatidic | -0.00918239 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | -0.00917743 |
| MAP2K6 | mitogen-activated protein kinase kinase 6 | -0.00917643 |
| FCGBP | Fc fragment of IgG binding protein | -0.00904938 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.00902917 |
| SLA | Src-like-adaptor | -0.00897626 |
| CSTA | cystatin A (stefin A) | -0.00896148 |
| DPYD | dihydropyrimidine dehydrogenase | -0.00895775 |
| PEBP1 | phosphatidylethanolamine binding protein 1 | -0.00895732 |
| SPINK5 | serine peptidase inhibitor, Kazal type 5 | -0.00893219 |
| TREM1 | triggering receptor expressed on myeloid cells 1 | -0.00892929 |
| ASCL1 | achaete-scute family bHLH transcription factor 1 | -0.00887387 |
| TRIM29 | tripartite motif containing 29 | -0.00876641 |
| ATP6V0E2 | ATPase, H+ transporting V0 subunit e2 | -0.00874913 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | -0.00874824 |
| SELL | selectin L | -0.00873588 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | -0.00861136 |
| HAL | histidine ammonia-lyase | -0.00854449 |
| BPIFA1 | BPI fold containing family A, member 1 | -0.00854367 |
| WDR7 | WD repeat domain 7 | -0.00851821 |
| ADO | 2-aminoethanethiol (cysteamine) dioxygenase | -0.0085131 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.00848651 |
| LRRN3 | leucine rich repeat neuronal 3 | -0.00843212 |
| FOXC1 | forkhead box C1 | -0.00839444 |
| PNMA8A | PNMA family member 8A | -0.00838028 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | -0.00835302 |
| PCYOX1L | prenylcysteine oxidase 1 like | -0.00834392 |
| KRT15 | keratin 15, type I | -0.00831356 |
| FGFR3 | fibroblast growth factor receptor 3 | -0.00827657 |
| PI3 | peptidase inhibitor 3, skin-derived | -0.00827418 |
| NDRG2 | NDRG family member 2 | -0.008266 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -0.00825974 |
| PRPF4 | pre-mRNA processing factor 4 | -0.00821086 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | -0.00820399 |
| NOTCH3 | notch 3 | -0.0081882 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.00818754 |
| APOC2 | apolipoprotein C-II | -0.0081859 |
| CLNS1A | chloride channel, nucleotide-sensitive, 1A | -0.00817865 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.00817118 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | -0.00815842 |
| FAR2 | fatty acyl CoA reductase 2 | -0.00814066 |
| CDH3 | cadherin 3, type 1, P-cadherin (placental) | -0.0081222 |
| TUBB2A | tubulin, beta 2A class IIa | -0.00809627 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.00807989 |
| NRN1 | neuritin 1 | -0.00807756 |
| CAPN3 | calpain 3, (p94) | -0.00806566 |
| PADI2 | peptidyl arginine deiminase, type II | -0.00804881 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | -0.00803319 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.00799843 |
| AK5 | adenylate kinase 5 | -0.00789203 |
| GCA | grancalcin, EF-hand calcium binding protein | -0.00787656 |
| LPAR1 | lysophosphatidic acid receptor 1 | -0.00781914 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | -0.00780844 |
| S100A7 | S100 calcium binding protein A7 | -0.0077515 |
| PRKCQ | protein kinase C, theta | -0.00774489 |
| PHACTR1 | phosphatase and actin regulator 1 | -0.00767632 |
| SYT11 | synaptotagmin XI | -0.00767352 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | -0.00758503 |
| SPRR3 | small proline-rich protein 3 | -0.00757529 |
| CD1A | CD1a molecule | -0.00750993 |
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | -0.00750835 |
| SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | -0.0074861 |
| DHFR | dihydrofolate reductase | -0.00746427 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | -0.00745753 |
| CD3E | CD3e molecule, epsilon (CD3-TCR complex) | -0.00739759 |
| ADK | adenosine kinase | -0.00738264 |
| COL9A3 | collagen, type IX, alpha 3 | -0.00737275 |
| BCL2A1 | BCL2-related protein A1 | -0.00737064 |
| RPL36 | ribosomal protein L36 | -0.00736555 |
| CORO2B | coronin, actin binding protein, 2B | -0.00735711 |
| ENO1 | enolase 1, (alpha) | -0.00735555 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -0.00734343 |
| GPM6A | glycoprotein M6A | -0.00734134 |
| HIP1 | huntingtin interacting protein 1 | -0.00730341 |
| PKM | pyruvate kinase, muscle | -0.00728182 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | -0.00727293 |
| TCTN2 | tectonic family member 2 | -0.00726882 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.00725125 |
| MAB21L2 | mab-21-like 2 (C. elegans) | -0.00724349 |
| PLEKHB1 | pleckstrin homology domain containing, family B (evectins) member 1 | -0.00724136 |
| ADORA2B | adenosine A2b receptor | -0.00720492 |
| BHLHE41 | basic helix-loop-helix family, member e41 | -0.00720291 |
| PER2 | period circadian clock 2 | -0.00719416 |
| PTGES | prostaglandin E synthase | -0.00718787 |
| NUDT21 | nudix (nucleoside diphosphate linked moiety X)-type motif 21 | -0.00715825 |
| HAS2 | hyaluronan synthase 2 | -0.00715298 |
| RCAN1 | regulator of calcineurin 1 | -0.00715023 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0071483 |
| NEBL | nebulette | -0.00714084 |
| PAMR1 | peptidase domain containing associated with muscle regeneration 1 | -0.00713923 |
| RAB25 | RAB25, member RAS oncogene family | -0.00711533 |
| LRP4 | low density lipoprotein receptor-related protein 4 | -0.00709565 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.00708547 |
| PCOLCE2 | procollagen C-endopeptidase enhancer 2 | -0.00707586 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.00702092 |
| KRT6B | keratin 6B, type II | -0.00701654 |
| CALML3 | calmodulin-like 3 | -0.00699891 |
| RRM1 | ribonucleotide reductase M1 | -0.00697681 |
| CHRNA3 | cholinergic receptor, nicotinic, alpha 3 (neuronal) | -0.00696563 |
| SRPX2 | sushi-repeat containing protein, X-linked 2 | -0.00695993 |
| A2M | alpha-2-macroglobulin | -0.00695278 |
| ATP5F1A | ATP synthase F1 subunit alpha | -0.0069382 |
| ME2 | malic enzyme 2, NAD(+)-dependent, mitochondrial | -0.00692404 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.00690942 |
| BPI | bactericidal/permeability-increasing protein | -0.00690749 |
| KCTD20 | potassium channel tetramerization domain containing 20 | -0.0068618 |
| OCRL | oculocerebrorenal syndrome of Lowe | -0.00685761 |
| LMNB1 | lamin B1 | -0.00683817 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | -0.00680463 |
| SOX9 | SRY (sex determining region Y)-box 9 | -0.00679232 |
| NGFRAP1 | nerve growth factor receptor (TNFRSF16) associated protein 1 | -0.00677959 |
| LOR | loricrin | -0.0067762 |
| STAT5B | signal transducer and activator of transcription 5B | -0.00676692 |
| SPRR1A | small proline-rich protein 1A | -0.00676338 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.00676104 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.00671856 |
| DMD | dystrophin | -0.00671366 |
| GAP43 | growth associated protein 43 | -0.00671033 |
| PABPC3 | poly(A) binding protein, cytoplasmic 3 | -0.00671029 |
| KAT7 | K(lysine) acetyltransferase 7 | -0.00669902 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.00668423 |
| PLAT | plasminogen activator, tissue | -0.00668294 |
| AK4 | adenylate kinase 4 | -0.00664281 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | -0.00664124 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.00664084 |
| STT3A | STT3A, subunit of the oligosaccharyltransferase complex (catalytic) | -0.00663121 |
| CLEC5A | C-type lectin domain family 5, member A | -0.00661802 |
| PPBP | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) | -0.00661636 |
| PLP1 | proteolipid protein 1 | -0.00655513 |
| FGR | FGR proto-oncogene, Src family tyrosine kinase | -0.00653967 |
| IRX5 | iroquois homeobox 5 | -0.00652773 |
| EMP1 | epithelial membrane protein 1 | -0.00652335 |
| PNMA2 | paraneoplastic Ma antigen 2 | -0.0065024 |
| VSNL1 | visinin-like 1 | -0.0064863 |
| SNRNP40 | small nuclear ribonucleoprotein 40kDa (U5) | -0.00647997 |
| GOT2 | glutamic-oxaloacetic transaminase 2, mitochondrial | -0.00645123 |
| CD2 | CD2 molecule | -0.00644909 |
| MTARC1 | mitochondrial amidoxime reducing component 1 | -0.00644444 |
| PAK1 | p21 protein (Cdc42/Rac)-activated kinase 1 | -0.00643712 |
| COG7 | component of oligomeric golgi complex 7 | -0.00643492 |
| TCAF1 | TRPM8 channel-associated factor 1 | -0.00643171 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.00641189 |
| DNAJC7 | DnaJ (Hsp40) homolog, subfamily C, member 7 | -0.00640701 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.00639445 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | -0.0063939 |
| BSPRY | B-box and SPRY domain containing | -0.0063854 |
| LHPP | phospholysine phosphohistidine inorganic pyrophosphate phosphatase | -0.00637893 |
| AQP9 | aquaporin 9 | -0.00636235 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.00634909 |
| LPPR4 | lipid phosphate phosphatase-related protein type 4 | -0.00633298 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.00632869 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -0.00630431 |
| BLM | Bloom syndrome, RecQ helicase-like | -0.00628856 |
| KRT2 | keratin 2, type II | -0.00628167 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.00628162 |
| NPM3 | nucleophosmin/nucleoplasmin 3 | -0.00625967 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.00625575 |
| LAPTM5 | lysosomal protein transmembrane 5 | -0.00625462 |
| NES | nestin | -0.00623595 |
| OGFOD1 | 2-oxoglutarate and iron-dependent oxygenase domain containing 1 | -0.00621615 |
| ETV5 | ets variant 5 | -0.00619378 |
| OPHN1 | oligophrenin 1 | -0.0061695 |
| CHEK1 | checkpoint kinase 1 | -0.00615967 |
| NPHS2 | nephrosis 2, idiopathic, steroid-resistant (podocin) | -0.00615574 |
| WIF1 | WNT inhibitory factor 1 | -0.00614948 |
| PTN | pleiotrophin | -0.00614713 |
| AQP4 | aquaporin 4 | -0.00612916 |
| ALDH9A1 | aldehyde dehydrogenase 9 family, member A1 | -0.00612287 |
| DYRK4 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 | -0.00612287 |
| SET | SET nuclear proto-oncogene | -0.00612146 |
| HAUS4 | HAUS augmin-like complex, subunit 4 | -0.00612144 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | -0.00610545 |
| SLC6A1 | solute carrier family 6 (neurotransmitter transporter), member 1 | -0.00610152 |
| CTPS1 | CTP synthase 1 | -0.0060993 |
| KIF20A | kinesin family member 20A | -0.00608015 |
| CTSZ | cathepsin Z | -0.00607745 |
| CLDN8 | claudin 8 | -0.00607572 |
| TFCP2L1 | transcription factor CP2-like 1 | -0.00607555 |
| LIG1 | ligase I, DNA, ATP-dependent | -0.00607059 |
| TUBB2B | tubulin, beta 2B class IIb | -0.00606314 |
| ACLY | ATP citrate lyase | -0.00605177 |
| KCNJ2 | potassium channel, inwardly rectifying subfamily J, member 2 | -0.00604721 |
| BATF3 | basic leucine zipper transcription factor, ATF-like 3 | -0.00603807 |
| GFAP | glial fibrillary acidic protein | -0.00603628 |
| PTDSS1 | phosphatidylserine synthase 1 | -0.00603547 |
| WFDC2 | WAP four-disulfide core domain 2 | -0.00603276 |
| KRT17 | keratin 17, type I | -0.00601931 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.00600807 |
| ELAVL1 | ELAV like RNA binding protein 1 | -0.00598626 |
| PLAUR | plasminogen activator, urokinase receptor | -0.00598582 |
| PZP | pregnancy-zone protein | -0.005983 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | -0.00596227 |
| KRT1 | keratin 1, type II | -0.00596132 |
| SCAMP1 | secretory carrier membrane protein 1 | -0.00595869 |
| PRAME | preferentially expressed antigen in melanoma | -0.00595723 |
| HOXC10 | homeobox C10 | -0.00595208 |
| ZFHX4 | zinc finger homeobox 4 | -0.00594246 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | -0.00592784 |
| CAMK2B | calcium/calmodulin-dependent protein kinase II beta | -0.0059241 |
| IFITM2 | interferon induced transmembrane protein 2 | -0.00591803 |
| BCL11A | B-cell CLL/lymphoma 11A (zinc finger protein) | -0.00591068 |
| SLC39A9 | solute carrier family 39, member 9 | -0.00589903 |
| PTPRA | protein tyrosine phosphatase, receptor type, A | -0.00589466 |
| SIRT3 | sirtuin 3 | -0.00589438 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.00588747 |
