| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | cytochrome P450, family 2, subfamily A, polypeptide 6|This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1548) |
| External Link | https://ncbi.nlm.nih.gov/gene/1548 |
| Similar Terms | |
| Downloads & Tools |
498 genes differentially expressed following the CYP2A6 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MAL | mal, T-cell differentiation protein | 0.010812 |
| RGS10 | regulator of G-protein signaling 10 | 0.0104053 |
| PITX3 | paired-like homeodomain 3 | 0.00988059 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.00983126 |
| AK4 | adenylate kinase 4 | 0.00980006 |
| ACAT2 | acetyl-CoA acetyltransferase 2 | 0.00970939 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.00939494 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.00933631 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | 0.00922316 |
| ANXA1 | annexin A1 | 0.00918827 |
| EIF5A | eukaryotic translation initiation factor 5A | 0.00905315 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 0.0088621 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.00853417 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.00835104 |
| TUBA1A | tubulin, alpha 1a | 0.00822585 |
| SELL | selectin L | 0.00815843 |
| SRPX | sushi-repeat containing protein, X-linked | 0.00799604 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.00767895 |
| GCA | grancalcin, EF-hand calcium binding protein | 0.00760557 |
| MDFIC | MyoD family inhibitor domain containing | 0.00755866 |
| TYRP1 | tyrosinase-related protein 1 | 0.00742978 |
| GNAS | GNAS complex locus | 0.00727588 |
| THBS1 | thrombospondin 1 | 0.00722968 |
| IFI44 | interferon-induced protein 44 | 0.00721847 |
| TUBB2A | tubulin, beta 2A class IIa | 0.00711368 |
| ZIC1 | Zic family member 1 | 0.00709854 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | 0.00702352 |
| BID | BH3 interacting domain death agonist | 0.00699621 |
| TXNDC9 | thioredoxin domain containing 9 | 0.00699436 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | 0.0069228 |
| ADD3 | adducin 3 (gamma) | 0.00684327 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | 0.00681163 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 0.00675825 |
| GGH | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) | 0.00673563 |
| PLPBP | pyridoxal phosphate binding protein | 0.00666355 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | 0.00664246 |
| THBS2 | thrombospondin 2 | 0.00662714 |
| S100A8 | S100 calcium binding protein A8 | 0.00659409 |
| ABLIM1 | actin binding LIM protein 1 | 0.00657245 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | 0.00657234 |
| IFI44L | interferon-induced protein 44-like | 0.006567 |
| LCN2 | lipocalin 2 | 0.00654071 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.00642227 |
| BAMBI | BMP and activin membrane-bound inhibitor | 0.00641598 |
| RGS4 | regulator of G-protein signaling 4 | 0.00639441 |
| MOXD1 | monooxygenase, DBH-like 1 | 0.0063808 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.00635957 |
| BEX4 | brain expressed, X-linked 4 | 0.00629773 |
| SSR3 | signal sequence receptor, gamma (translocon-associated protein gamma) | 0.00629425 |
| FAM171A1 | family with sequence similarity 171, member A1 | 0.00626847 |
| PADI2 | peptidyl arginine deiminase, type II | 0.00623956 |
| MPO | myeloperoxidase | 0.00622183 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.00617261 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | 0.0061682 |
| SMYD2 | SET and MYND domain containing 2 | 0.00611482 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 0.00607101 |
| FABP7 | fatty acid binding protein 7, brain | 0.00598158 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.00597388 |
| LXN | latexin | 0.00596202 |
| CRELD2 | cysteine-rich with EGF-like domains 2 | 0.0059396 |
| AK5 | adenylate kinase 5 | 0.00592757 |
| PNMA8A | PNMA family member 8A | 0.00590508 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.00588391 |
| BMP4 | bone morphogenetic protein 4 | 0.00584721 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.00584587 |
| PPBP | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) | 0.0058284 |
| ASCL1 | achaete-scute family bHLH transcription factor 1 | 0.00582248 |
| C1QBP | complement component 1, q subcomponent binding protein | 0.00581592 |
| TREM1 | triggering receptor expressed on myeloid cells 1 | 0.00581061 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 0.0057854 |
| BCL2A1 | BCL2-related protein A1 | 0.00577058 |
| HAL | histidine ammonia-lyase | 0.00575205 |
| PTPRO | protein tyrosine phosphatase, receptor type, O | 0.0057424 |
| C6ORF48 | chromosome 6 open reading frame 48 | 0.00573936 |
| GRB7 | growth factor receptor-bound protein 7 | 0.00571263 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.00570859 |
| ME2 | malic enzyme 2, NAD(+)-dependent, mitochondrial | 0.00567776 |
| ELOVL2 | ELOVL fatty acid elongase 2 | 0.00567664 |
| RPP40 | ribonuclease P/MRP 40kDa subunit | 0.00567304 |
| KRCC1 | lysine-rich coiled-coil 1 | 0.00567226 |
| S100A7 | S100 calcium binding protein A7 | 0.00566567 |
| PRKAR2B | protein kinase, cAMP-dependent, regulatory, type II, beta | 0.00566341 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 0.00565705 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.00564386 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | 0.0056236 |
| SPTSSA | serine palmitoyltransferase, small subunit A | 0.00560228 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.00559085 |
| SRPX2 | sushi-repeat containing protein, X-linked 2 | 0.00555452 |
| TRIM22 | tripartite motif containing 22 | 0.00555293 |
| NIBAN1 | niban apoptosis regulator 1 | 0.00554229 |
| ACTA2 | actin, alpha 2, smooth muscle, aorta | 0.00553083 |
| TNFSF4 | tumor necrosis factor (ligand) superfamily, member 4 | 0.00552032 |
| TFRC | transferrin receptor | 0.00549982 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.00549149 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | 0.00544435 |
| ATP5F1C | ATP synthase F1 subunit gamma | 0.00543019 |
| MSMO1 | methylsterol monooxygenase 1 | 0.00541571 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 0.00540008 |
| GSTO1 | glutathione S-transferase omega 1 | 0.00539243 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 0.00538903 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | 0.00537449 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.00534674 |
| PAH | phenylalanine hydroxylase | 0.00534165 |
| PHGDH | phosphoglycerate dehydrogenase | 0.00534002 |
| MPDZ | multiple PDZ domain protein | 0.005337 |
| NSG1 | neuron specific gene family member 1 | 0.00533252 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | 0.00532715 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.00531805 |
| PRKCA | protein kinase C, alpha | 0.00531762 |
| ESD | esterase D | 0.00531426 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.00530391 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.00529466 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.00527985 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.0052724 |
| FGF1 | fibroblast growth factor 1 (acidic) | 0.0052596 |
| TSPYL5 | TSPY-like 5 | 0.00524876 |
| CTSS | cathepsin S | 0.00521447 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.00520731 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.00518179 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | 0.00518114 |
| MYO1C | myosin IC | 0.00516412 |
| NPHS2 | nephrosis 2, idiopathic, steroid-resistant (podocin) | 0.00513923 |
| FZD6 | frizzled class receptor 6 | 0.00513558 |
| CCNG1 | cyclin G1 | 0.00510668 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.00509582 |
| CSTA | cystatin A (stefin A) | 0.00507168 |
| SYT11 | synaptotagmin XI | 0.00505325 |
| FAR2 | fatty acyl CoA reductase 2 | 0.00504631 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | 0.00504246 |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | 0.00503291 |
| AP1S1 | adaptor-related protein complex 1, sigma 1 subunit | 0.00501423 |
| SLC2A10 | solute carrier family 2 (facilitated glucose transporter), member 10 | 0.00501137 |
| NRGN | neurogranin (protein kinase C substrate, RC3) | 0.00500436 |
| MT1HL1 | metallothionein 1H-like 1 | 0.00499981 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | 0.0049561 |
| UMOD | uromodulin | 0.00494068 |
| PSMA5 | proteasome (prosome, macropain) subunit, alpha type, 5 | 0.00493055 |
| PPA1 | pyrophosphatase (inorganic) 1 | 0.00489067 |
| MAT2B | methionine adenosyltransferase II, beta | 0.00488338 |
| GOLGA7 | golgin A7 | 0.0048795 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.00487113 |
| FST | follistatin | 0.00486549 |
| TMEM110 | transmembrane protein 110 | 0.00484806 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | 0.00483225 |
| SAMHD1 | SAM domain and HD domain 1 | 0.00480484 |
| ARG1 | arginase 1 | 0.0048038 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | 0.00479064 |
| NVL | nuclear VCP-like | 0.00478477 |
| AP1S2 | adaptor-related protein complex 1, sigma 2 subunit | 0.00478204 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | 0.00476829 |
| C3ORF14 | chromosome 3 open reading frame 14 | 0.00476519 |
| PRR7 | proline rich 7 (synaptic) | 0.0047454 |
| ALB | albumin | 0.0047439 |
| ASH2L | ash2 (absent, small, or homeotic)-like (Drosophila) | 0.00473898 |
| B3GNT2 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 | 0.00473704 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.00472959 |
| NUDT21 | nudix (nucleoside diphosphate linked moiety X)-type motif 21 | 0.00471854 |
| BAG2 | BCL2-associated athanogene 2 | 0.00470701 |
| HIGD1A | HIG1 hypoxia inducible domain family, member 1A | 0.00469891 |
| DAZAP2 | DAZ associated protein 2 | 0.00469571 |
| RPRD1A | regulation of nuclear pre-mRNA domain containing 1A | 0.00469408 |
| COMMD8 | COMM domain containing 8 | 0.00469233 |
| MREG | melanoregulin | 0.0046903 |
| NGFRAP1 | nerve growth factor receptor (TNFRSF16) associated protein 1 | 0.00467218 |
| SLC15A2 | solute carrier family 15 (oligopeptide transporter), member 2 | 0.00466981 |
| FYB1 | FYN binding protein 1 | 0.00466909 |
| LSM2 | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.00466323 |
| TAGLN3 | transgelin 3 | 0.00466016 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0046431 |
| SP110 | SP110 nuclear body protein | 0.00463341 |
| MT1X | metallothionein 1X | 0.00461732 |
| GOLT1B | golgi transport 1B | 0.0046091 |
| DAXX | death-domain associated protein | 0.00460456 |
| SLC35A5 | solute carrier family 35, member A5 | 0.00459979 |
| CFI | complement factor I | 0.00458451 |
| TUBB6 | tubulin, beta 6 class V | 0.00456966 |
| ASRGL1 | asparaginase like 1 | 0.00456951 |
| CYCS | cytochrome c, somatic | 0.00456208 |
| LPPR4 | lipid phosphate phosphatase-related protein type 4 | 0.0045542 |
| PLP1 | proteolipid protein 1 | 0.00454306 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.00454034 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.00454029 |
| THYN1 | thymocyte nuclear protein 1 | 0.00453477 |
| PF4 | platelet factor 4 | 0.00452362 |
| GSTM3 | glutathione S-transferase mu 3 (brain) | 0.00450598 |
| EMP2 | epithelial membrane protein 2 | 0.00449645 |
| CEL | carboxyl ester lipase | 0.00447414 |
| LSM1 | LSM1, U6 small nuclear RNA associated | 0.004471 |
| MME | membrane metallo-endopeptidase | 0.00446736 |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 | 0.00446597 |
| PEG3 | paternally expressed 3 | 0.00446471 |
| SLC12A1 | solute carrier family 12 (sodium/potassium/chloride transporter), member 1 | 0.00444364 |
| PLSCR1 | phospholipid scramblase 1 | 0.00440681 |
| PSME1 | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) | 0.00440066 |
| ERAP2 | endoplasmic reticulum aminopeptidase 2 | 0.00438797 |
| PRDX3 | peroxiredoxin 3 | 0.00438106 |
| MICA | MHC class I polypeptide-related sequence A | 0.00437469 |
| ADK | adenosine kinase | 0.00437106 |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | 0.00436244 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.00435306 |
| ATP6V1H | ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H | 0.00434907 |
| TXN | thioredoxin | 0.00434688 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.00434565 |
| CLDN8 | claudin 8 | 0.00434466 |
| POPDC3 | popeye domain containing 3 | 0.00434242 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | 0.00433981 |
| RSL24D1 | ribosomal L24 domain containing 1 | 0.00433923 |
| IL1R1 | interleukin 1 receptor, type I | 0.00432283 |
| AZIN1 | antizyme inhibitor 1 | 0.00432002 |
| BCAS2 | breast carcinoma amplified sequence 2 | 0.00431508 |
| RANBP9 | RAN binding protein 9 | 0.00430563 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 0.00430523 |
| RAB29 | RAB29, member RAS oncogene family | 0.00430203 |
| CNIH3 | cornichon family AMPA receptor auxiliary protein 3 | 0.00429786 |
| DEFB1 | defensin, beta 1 | 0.00429079 |
| ADM | adrenomedullin | 0.00427237 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | 0.00427 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | 0.00426232 |
| SKP1 | S-phase kinase-associated protein 1 | 0.00425982 |
| DPYD | dihydropyrimidine dehydrogenase | 0.00425914 |
| PDCD10 | programmed cell death 10 | 0.00425519 |
| HSBP1 | heat shock factor binding protein 1 | 0.00425518 |
| PLEKHF2 | pleckstrin homology domain containing, family F (with FYVE domain) member 2 | 0.00424529 |
| MYH10 | myosin, heavy chain 10, non-muscle | 0.00422621 |
| RNASE2 | ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) | 0.0042243 |
| MRPL39 | mitochondrial ribosomal protein L39 | 0.00421388 |
| ERLIN2 | ER lipid raft associated 2 | 0.00421316 |
| PMP2 | peripheral myelin protein 2 | 0.00421209 |
| MX1 | MX dynamin-like GTPase 1 | 0.00420565 |
| NME5 | NME/NM23 family member 5 | 0.00420549 |
| PRKCQ | protein kinase C, theta | 0.00420505 |
| DCXR | dicarbonyl/L-xylulose reductase | 0.0042016 |
| SLC25A46 | solute carrier family 25, member 46 | 0.00420145 |
| ASF1A | anti-silencing function 1A histone chaperone | 0.00419259 |
| PSMD6 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 | 0.00419256 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | 0.00419174 |
| MBD2 | methyl-CpG binding domain protein 2 | 0.0041788 |
| PCYOX1L | prenylcysteine oxidase 1 like | 0.00417315 |
| VCAN | versican | 0.00416894 |
| GSDME | gasdermin E | 0.00416855 |
| PSAT1 | phosphoserine aminotransferase 1 | 0.00416755 |
| FZD3 | frizzled class receptor 3 | 0.00416391 |
| DHTKD1 | dehydrogenase E1 and transketolase domain containing 1 | 0.00416314 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | 0.00416019 |
| CLTB | clathrin, light chain B | 0.00415171 |
| PCSK1N | proprotein convertase subtilisin/kexin type 1 inhibitor | 0.00414061 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.00413166 |
| GPC3 | glypican 3 | 0.0041225 |
| AOX1 | aldehyde oxidase 1 | 0.00412096 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | 0.00411842 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MAP7 | microtubule-associated protein 7 | -0.0124295 |
| C1QA | complement component 1, q subcomponent, A chain | -0.011037 |
| MAGEA3 | melanoma antigen family A3 | -0.0108764 |
| EGR1 | early growth response 1 | -0.0101309 |
| C1QB | complement component 1, q subcomponent, B chain | -0.0100555 |
| CCND1 | cyclin D1 | -0.0099464 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | -0.00988249 |
| CCL19 | chemokine (C-C motif) ligand 19 | -0.00967764 |
| TIMM17B | translocase of inner mitochondrial membrane 17 homolog B (yeast) | -0.00909462 |
| NNMT | nicotinamide N-methyltransferase | -0.00899052 |
| GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | -0.00890585 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | -0.00888896 |
| AKAP8 | A kinase (PRKA) anchor protein 8 | -0.00869538 |
| GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | -0.00863249 |
| KRT14 | keratin 14, type I | -0.00833905 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.00786316 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | -0.00784179 |
| IDO1 | indoleamine 2,3-dioxygenase 1 | -0.00778418 |
| MAGEA12 | melanoma antigen family A12 | -0.00769727 |
| EFNB2 | ephrin-B2 | -0.00763925 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.00732097 |
| ACTC1 | actin, alpha, cardiac muscle 1 | -0.00727314 |
| CPB1 | carboxypeptidase B1 (tissue) | -0.00726437 |
| PGGHG | protein-glucosylgalactosylhydroxylysine glucosidase | -0.00722558 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | -0.00710823 |
| AGR2 | anterior gradient 2 | -0.00703724 |
| KRT16 | keratin 16, type I | -0.00703199 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0069457 |
| MTCL1 | microtubule crosslinking factor 1 | -0.00689786 |
| TPSAB1 | tryptase alpha/beta 1 | -0.00683587 |
| PDGFD | platelet derived growth factor D | -0.0068037 |
| TCTA | T-cell leukemia translocation altered | -0.00666072 |
| KRT18 | keratin 18, type I | -0.00659683 |
| TNS3 | tensin 3 | -0.00657684 |
| PLXND1 | plexin D1 | -0.00654553 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.00654146 |
| FRZB | frizzled-related protein | -0.00650907 |
| JCHAIN | joining chain of multimeric IgA and IgM | -0.00644619 |
| RGS5 | regulator of G-protein signaling 5 | -0.00641534 |
| TSPAN13 | tetraspanin 13 | -0.00639388 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.00633632 |
| LPCAT1 | lysophosphatidylcholine acyltransferase 1 | -0.00633445 |
| SIK1 | salt-inducible kinase 1 | -0.00633246 |
| PLVAP | plasmalemma vesicle associated protein | -0.00630555 |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | -0.00629683 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.00622656 |
| STK26 | serine/threonine protein kinase 26 | -0.00619983 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.00616339 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0061558 |
| HSPB8 | heat shock 22kDa protein 8 | -0.00614067 |
| BMP2 | bone morphogenetic protein 2 | -0.00605804 |
| PRKCZ | protein kinase C, zeta | -0.00605104 |
| GALC | galactosylceramidase | -0.00603418 |
| KRT17 | keratin 17, type I | -0.00603216 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | -0.00601345 |
| SKIV2L | superkiller viralicidic activity 2-like (S. cerevisiae) | -0.00593975 |
| HIC2 | hypermethylated in cancer 2 | -0.00590224 |
| SLC25A6 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 | -0.00588827 |
| WDR13 | WD repeat domain 13 | -0.00588094 |
| RHOB | ras homolog family member B | -0.00584336 |
| AIM2 | absent in melanoma 2 | -0.00581292 |
| INSR | insulin receptor | -0.00575972 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | -0.00575123 |
| RBM47 | RNA binding motif protein 47 | -0.00574454 |
| NDNF | neuron-derived neurotrophic factor | -0.00572575 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.00571387 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0057118 |
| GZMB | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | -0.00569185 |
| KANK2 | KN motif and ankyrin repeat domains 2 | -0.00566203 |
| IGHMBP2 | immunoglobulin mu binding protein 2 | -0.00565861 |
| TFF3 | trefoil factor 3 (intestinal) | -0.00563413 |
| RAB8A | RAB8A, member RAS oncogene family | -0.00559564 |
| SMAD7 | SMAD family member 7 | -0.00557734 |
| MRPL12 | mitochondrial ribosomal protein L12 | -0.0055757 |
| GRIA2 | glutamate receptor, ionotropic, AMPA 2 | -0.00554942 |
| CDIPT | CDP-diacylglycerol--inositol 3-phosphatidyltransferase | -0.00553759 |
| MID1 | midline 1 | -0.00552517 |
| DUSP5 | dual specificity phosphatase 5 | -0.00551128 |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 | -0.00550229 |
| ADIRF | adipogenesis regulatory factor | -0.00549546 |
| COL4A3 | collagen, type IV, alpha 3 (Goodpasture antigen) | -0.0054941 |
| VCAM1 | vascular cell adhesion molecule 1 | -0.00549178 |
| GPX3 | glutathione peroxidase 3 | -0.00545904 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | -0.00545737 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.00542684 |
| CDK5RAP3 | CDK5 regulatory subunit associated protein 3 | -0.00541615 |
| TAGLN | transgelin | -0.00539997 |
| RIN2 | Ras and Rab interactor 2 | -0.00539955 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -0.00539807 |
| CP | ceruloplasmin (ferroxidase) | -0.0053762 |
| AKAP8L | A kinase (PRKA) anchor protein 8-like | -0.00536769 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | -0.00534644 |
| MAGEA1 | melanoma antigen family A1 | -0.00534379 |
| WDR45 | WD repeat domain 45 | -0.0053205 |
| POU2AF1 | POU class 2 associating factor 1 | -0.00531887 |
| MICAL1 | microtubule associated monooxygenase, calponin and LIM domain containing 1 | -0.00528594 |
| TYMP | thymidine phosphorylase | -0.00528201 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.0052738 |
| PPAP2A | phosphatidic acid phosphatase type 2A | -0.00527272 |
| NUMA1 | nuclear mitotic apparatus protein 1 | -0.00527174 |
| FUCA1 | fucosidase, alpha-L- 1, tissue | -0.00526292 |
| STAB1 | stabilin 1 | -0.00525883 |
| ARGLU1 | arginine and glutamate rich 1 | -0.00525725 |
| NKG7 | natural killer cell granule protein 7 | -0.00523478 |
| CCN2 | cellular communication network factor 2 | -0.00522464 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -0.00521646 |
| MET | MET proto-oncogene, receptor tyrosine kinase | -0.00520734 |
| MEST | mesoderm specific transcript | -0.00519924 |
| KDR | kinase insert domain receptor | -0.00519794 |
| SCGN | secretagogin, EF-hand calcium binding protein | -0.00519113 |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 | -0.00519112 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.00518941 |
| TIMM13 | translocase of inner mitochondrial membrane 13 homolog (yeast) | -0.00517713 |
| MMP1 | matrix metallopeptidase 1 | -0.00515065 |
| TTN | titin | -0.0051118 |
| TSPAN12 | tetraspanin 12 | -0.00504511 |
| SPATA20 | spermatogenesis associated 20 | -0.00504204 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | -0.00503949 |
| BCAP31 | B-cell receptor-associated protein 31 | -0.00503558 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | -0.00503013 |
| EPHA2 | EPH receptor A2 | -0.00500466 |
| KAZN | kazrin, periplakin interacting protein | -0.0049972 |
| ADGRF5 | adhesion G protein-coupled receptor F5 | -0.00499462 |
| LPAR2 | lysophosphatidic acid receptor 2 | -0.00499069 |
| ACADVL | acyl-CoA dehydrogenase, very long chain | -0.00496267 |
| DKFZP586I1420 | uncharacterized protein DKFZp586I1420 | -0.00494884 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | -0.00490722 |
| SFN | stratifin | -0.00488153 |
| IER2 | immediate early response 2 | -0.0048746 |
| RRBP1 | ribosome binding protein 1 | -0.00487042 |
| CD14 | CD14 molecule | -0.00486166 |
| AMOTL2 | angiomotin like 2 | -0.00485604 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.00485056 |
| HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 | -0.00484972 |
| HOPX | HOP homeobox | -0.00484778 |
| RGS13 | regulator of G-protein signaling 13 | -0.00484568 |
| SULT1C2 | sulfotransferase family, cytosolic, 1C, member 2 | -0.00483833 |
| IRAK1 | interleukin-1 receptor-associated kinase 1 | -0.004833 |
| EML3 | echinoderm microtubule associated protein like 3 | -0.00482058 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.00481647 |
| UPF3A | UPF3 regulator of nonsense transcripts homolog A (yeast) | -0.00481571 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.00480247 |
| NXN | nucleoredoxin | -0.00480074 |
| NDUFA4L2 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 | -0.00479448 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.00478999 |
| IL32 | interleukin 32 | -0.00478618 |
| GSTP1 | glutathione S-transferase pi 1 | -0.00476812 |
| STK25 | serine/threonine kinase 25 | -0.00476538 |
| VWF | von Willebrand factor | -0.00476315 |
| LAMA5 | laminin, alpha 5 | -0.00475221 |
| ACTA1 | actin, alpha 1, skeletal muscle | -0.00475017 |
| BCL2L1 | BCL2-like 1 | -0.0047496 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | -0.00474128 |
| RNF19B | ring finger protein 19B | -0.00474009 |
| DCLK1 | doublecortin-like kinase 1 | -0.00472769 |
| ELF4 | E74-like factor 4 (ets domain transcription factor) | -0.004726 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | -0.00468547 |
| GZMH | granzyme H (cathepsin G-like 2, protein h-CCPX) | -0.00467877 |
| SPARCL1 | SPARC-like 1 (hevin) | -0.00467648 |
| PAEP | progestagen-associated endometrial protein | -0.00467482 |
| PROCR | protein C receptor, endothelial | -0.00466129 |
| CDC34 | cell division cycle 34 | -0.00465866 |
| PTP4A3 | protein tyrosine phosphatase type IVA, member 3 | -0.00465617 |
| GABRE | gamma-aminobutyric acid (GABA) A receptor, epsilon | -0.00464636 |
| STK32B | serine/threonine kinase 32B | -0.00463595 |
| MAGEB2 | melanoma antigen family B2 | -0.00462611 |
| CKM | creatine kinase, muscle | -0.00461613 |
| ABHD17A | abhydrolase domain containing 17A | -0.00460507 |
| EVA1B | eva-1 homolog B (C. elegans) | -0.00460039 |
| FGFR3 | fibroblast growth factor receptor 3 | -0.00459088 |
| CPA3 | carboxypeptidase A3 (mast cell) | -0.00459064 |
| PDLIM5 | PDZ and LIM domain 5 | -0.00458925 |
| SASH1 | SAM and SH3 domain containing 1 | -0.00458117 |
| MAGEA4 | melanoma antigen family A4 | -0.00456783 |
| EXOC3 | exocyst complex component 3 | -0.00456758 |
| SERPING1 | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | -0.00456707 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | -0.0045346 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.00452664 |
| HEXIM1 | hexamethylene bis-acetamide inducible 1 | -0.00452418 |
| MALL | mal, T-cell differentiation protein-like | -0.0045231 |
| RASIP1 | Ras interacting protein 1 | -0.00451659 |
| CCNA2 | cyclin A2 | -0.00449026 |
| EZR | ezrin | -0.00448938 |
| SSX1 | synovial sarcoma, X breakpoint 1 | -0.00448487 |
| C1S | complement component 1, s subcomponent | -0.00446748 |
| PMP22 | peripheral myelin protein 22 | -0.00446429 |
| DYNLL1 | dynein, light chain, LC8-type 1 | -0.00445988 |
| DVL1 | dishevelled segment polarity protein 1 | -0.00445884 |
| TNNC2 | troponin C type 2 (fast) | -0.00445436 |
| CFTR | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) | -0.00445364 |
| SPAG9 | sperm associated antigen 9 | -0.00445107 |
| KLF2 | Kruppel-like factor 2 | -0.00443875 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 | -0.00443626 |
| IL18 | interleukin 18 | -0.00442789 |
| AEBP1 | AE binding protein 1 | -0.00442022 |
| PAX5 | paired box 5 | -0.00440657 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.00440182 |
| MN1 | meningioma (disrupted in balanced translocation) 1 | -0.00439818 |
| ILVBL | ilvB (bacterial acetolactate synthase)-like | -0.00438888 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | -0.0043851 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.00437319 |
| PILRB | paired immunoglobin-like type 2 receptor beta | -0.00436537 |
| RABEP2 | rabaptin, RAB GTPase binding effector protein 2 | -0.00436476 |
| CAVIN1 | caveolae associated protein 1 | -0.00436034 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.00433992 |
| ELN | elastin | -0.00433949 |
| U2AF2 | U2 small nuclear RNA auxiliary factor 2 | -0.00433723 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.00432363 |
| DGS2 | DiGeorge syndrome/velocardiofacial syndrome complex 2 | -0.00432013 |
| TMEM176B | transmembrane protein 176B | -0.00431103 |
| HELZ | helicase with zinc finger | -0.0043051 |
| CARD10 | caspase recruitment domain family, member 10 | -0.00429781 |
| KLHL41 | kelch-like family member 41 | -0.00429401 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) | -0.00427503 |
| PRF1 | perforin 1 (pore forming protein) | -0.00427435 |
| RBM6 | RNA binding motif protein 6 | -0.00427431 |
| MPRIP | myosin phosphatase Rho interacting protein | -0.00427223 |
| SCAF4 | SR-related CTD-associated factor 4 | -0.00427193 |
| ZNF83 | zinc finger protein 83 | -0.00426034 |
| CTSK | cathepsin K | -0.00425733 |
| ZNF91 | zinc finger protein 91 | -0.00425682 |
| KIF5B | kinesin family member 5B | -0.00425547 |
| SCAND1 | SCAN domain containing 1 | -0.00424256 |
| SIDT2 | SID1 transmembrane family, member 2 | -0.0042298 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.00422768 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -0.00422709 |
| PLXNB2 | plexin B2 | -0.00422403 |
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 | -0.00422279 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0042219 |
| FBXW12 | F-box and WD repeat domain containing 12 | -0.00421996 |
| UGT8 | UDP glycosyltransferase 8 | -0.00421084 |
| ARHGAP4 | Rho GTPase activating protein 4 | -0.00420996 |
| CCL4 | chemokine (C-C motif) ligand 4 | -0.00420747 |
| DROSHA | drosha, ribonuclease type III | -0.00420097 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.00419791 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | -0.00419586 |
| KRT7 | keratin 7, type II | -0.00418717 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.00418044 |
| MIOS | missing oocyte, meiosis regulator, homolog (Drosophila) | -0.00417781 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.00417624 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.00417462 |
| TTC17 | tetratricopeptide repeat domain 17 | -0.00417138 |
| ITGA8 | integrin, alpha 8 | -0.00416865 |
| NUCB1 | nucleobindin 1 | -0.00416486 |
| SEMA6A | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A | -0.00416076 |
| PPFIBP2 | PTPRF interacting protein, binding protein 2 (liprin beta 2) | -0.00415025 |
| NIT1 | nitrilase 1 | -0.00414812 |
| TXLNA | taxilin alpha | -0.00414772 |
