| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | cytochrome P450, family 2, subfamily B, polypeptide 6|This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1555) |
| External Link | https://ncbi.nlm.nih.gov/gene/1555 |
| Similar Terms | |
| Downloads & Tools |
499 genes differentially expressed following the CYP2B6 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.0181962 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | 0.0175428 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 0.0174646 |
| NIBAN1 | niban apoptosis regulator 1 | 0.0132475 |
| CCND1 | cyclin D1 | 0.0123125 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.0123008 |
| TUBA1A | tubulin, alpha 1a | 0.0111413 |
| AQP3 | aquaporin 3 (Gill blood group) | 0.0106825 |
| NGFRAP1 | nerve growth factor receptor (TNFRSF16) associated protein 1 | 0.0105654 |
| KRT5 | keratin 5, type II | 0.0100034 |
| S100A8 | S100 calcium binding protein A8 | 0.00994217 |
| GNAS | GNAS complex locus | 0.0098019 |
| S100A2 | S100 calcium binding protein A2 | 0.00966076 |
| GSTM3 | glutathione S-transferase mu 3 (brain) | 0.00948254 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.00926806 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.0092026 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.00915881 |
| PRKACB | protein kinase, cAMP-dependent, catalytic, beta | 0.0087627 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.00874922 |
| AK4 | adenylate kinase 4 | 0.00848582 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | 0.00843657 |
| KRT1 | keratin 1, type II | 0.00826452 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.00824808 |
| TMEM45A | transmembrane protein 45A | 0.00820371 |
| TYRP1 | tyrosinase-related protein 1 | 0.00816287 |
| CD52 | CD52 molecule | 0.0081393 |
| WDR7 | WD repeat domain 7 | 0.00810059 |
| PRAME | preferentially expressed antigen in melanoma | 0.008082 |
| IFI44 | interferon-induced protein 44 | 0.00800256 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.00796506 |
| CADM1 | cell adhesion molecule 1 | 0.0079533 |
| GGH | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) | 0.00792106 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | 0.00789936 |
| LPAR6 | lysophosphatidic acid receptor 6 | 0.00789248 |
| IL1RN | interleukin 1 receptor antagonist | 0.00787843 |
| DEFA4 | defensin, alpha 4, corticostatin | 0.0078757 |
| CLEC2B | C-type lectin domain family 2, member B | 0.00787256 |
| MSMO1 | methylsterol monooxygenase 1 | 0.00782463 |
| GCA | grancalcin, EF-hand calcium binding protein | 0.00782265 |
| TUBA4A | tubulin, alpha 4a | 0.00769603 |
| RNF167 | ring finger protein 167 | 0.00766179 |
| SFTPC | surfactant protein C | 0.00763836 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.00758136 |
| PKP1 | plakophilin 1 | 0.00757253 |
| NRGN | neurogranin (protein kinase C substrate, RC3) | 0.00755899 |
| SPTSSA | serine palmitoyltransferase, small subunit A | 0.00752102 |
| CEP70 | centrosomal protein 70kDa | 0.0074926 |
| CEACAM8 | carcinoembryonic antigen-related cell adhesion molecule 8 | 0.0074925 |
| FOXC1 | forkhead box C1 | 0.00748512 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.00747782 |
| SFTPA2 | surfactant protein A2 | 0.00744552 |
| LAMP3 | lysosomal-associated membrane protein 3 | 0.00735291 |
| CD59 | CD59 molecule, complement regulatory protein | 0.00733587 |
| SCGB1A1 | secretoglobin, family 1A, member 1 (uteroglobin) | 0.00715528 |
| ACP3 | acid phosphatase 3 | 0.00713688 |
| FST | follistatin | 0.00713328 |
| TMSB15A | thymosin beta 15a | 0.00708518 |
| CRELD2 | cysteine-rich with EGF-like domains 2 | 0.00702027 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | 0.00700952 |
| SOSTDC1 | sclerostin domain containing 1 | 0.00699751 |
| GLO1 | glyoxalase I | 0.00681917 |
| MXI1 | MAX interactor 1, dimerization protein | 0.00681378 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0068099 |
| SFTPD | surfactant protein D | 0.00673386 |
| LAPTM4B | lysosomal protein transmembrane 4 beta | 0.00673304 |
| NETO2 | neuropilin (NRP) and tolloid (TLL)-like 2 | 0.00670811 |
| ASF1A | anti-silencing function 1A histone chaperone | 0.0067027 |
| DCK | deoxycytidine kinase | 0.00669114 |
| BCHE | butyrylcholinesterase | 0.00666963 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.00662921 |
| FCGR2B | Fc fragment of IgG, low affinity IIb, receptor (CD32) | 0.00661806 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.00661569 |
| ARG1 | arginase 1 | 0.00659702 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.00658332 |
| CTSS | cathepsin S | 0.00653139 |
| CHIT1 | chitinase 1 (chitotriosidase) | 0.00651957 |
| CD36 | CD36 molecule (thrombospondin receptor) | 0.00650623 |
| CYTL1 | cytokine-like 1 | 0.00649103 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.00645116 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | 0.00645093 |
| FCN1 | ficolin (collagen/fibrinogen domain containing) 1 | 0.00642809 |
| MMP9 | matrix metallopeptidase 9 | 0.00641952 |
| GPR65 | G protein-coupled receptor 65 | 0.00641155 |
| THEMIS2 | thymocyte selection associated family member 2 | 0.00637517 |
| IFI44L | interferon-induced protein 44-like | 0.00636319 |
| BBX | bobby sox homolog (Drosophila) | 0.00635834 |
| ARRB2 | arrestin, beta 2 | 0.0063305 |
| PTPRO | protein tyrosine phosphatase, receptor type, O | 0.00631175 |
| PHF20 | PHD finger protein 20 | 0.00631077 |
| GRB7 | growth factor receptor-bound protein 7 | 0.00627384 |
| KRT10 | keratin 10, type I | 0.00625632 |
| GANAB | glucosidase, alpha; neutral AB | 0.00622835 |
| MT1HL1 | metallothionein 1H-like 1 | 0.00619841 |
| CXADR | coxsackie virus and adenovirus receptor | 0.00618057 |
| SLC47A1 | solute carrier family 47 (multidrug and toxin extrusion), member 1 | 0.00617869 |
| CTBS | chitobiase, di-N-acetyl- | 0.00617162 |
| RPRD1A | regulation of nuclear pre-mRNA domain containing 1A | 0.00615895 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | 0.00614648 |
| DSG1 | desmoglein 1 | 0.00603235 |
| ALOX5 | arachidonate 5-lipoxygenase | 0.00602214 |
| BPI | bactericidal/permeability-increasing protein | 0.00601541 |
| NMU | neuromedin U | 0.00600239 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | 0.00600144 |
| MYH10 | myosin, heavy chain 10, non-muscle | 0.00597793 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | 0.00595217 |
| ST6GALNAC5 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 | 0.00594228 |
| SOAT1 | sterol O-acyltransferase 1 | 0.0059319 |
| PRSS21 | protease, serine, 21 (testisin) | 0.00592752 |
| NVL | nuclear VCP-like | 0.00591425 |
| PLA2G12A | phospholipase A2, group XIIA | 0.00590851 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | 0.00587892 |
| FABP7 | fatty acid binding protein 7, brain | 0.00586263 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.00584074 |
| CKAP4 | cytoskeleton-associated protein 4 | 0.00582898 |
| TARP | TCR gamma alternate reading frame protein | 0.00582602 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 0.00581826 |
| LOR | loricrin | 0.00580171 |
| HBD | hemoglobin, delta | 0.00580102 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.00578815 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 0.00578245 |
| TRIM14 | tripartite motif containing 14 | 0.00577971 |
| ZNF184 | zinc finger protein 184 | 0.00577825 |
| SCRG1 | stimulator of chondrogenesis 1 | 0.0057498 |
| RCN2 | reticulocalbin 2, EF-hand calcium binding domain | 0.00574289 |
| ADO | 2-aminoethanethiol (cysteamine) dioxygenase | 0.00573279 |
| MMP8 | matrix metallopeptidase 8 | 0.00572318 |
| CAMP | cathelicidin antimicrobial peptide | 0.00571869 |
| CYP27A1 | cytochrome P450, family 27, subfamily A, polypeptide 1 | 0.00571733 |
| ERGIC2 | ERGIC and golgi 2 | 0.00570871 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.00567312 |
| TIPRL | TOR signaling pathway regulator | 0.00566415 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.00565436 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | 0.00565146 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.00564257 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.00563575 |
| CCDC47 | coiled-coil domain containing 47 | 0.00563362 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | 0.00563356 |
| GALNT1 | polypeptide N-acetylgalactosaminyltransferase 1 | 0.00560186 |
| NFIB | nuclear factor I/B | 0.00559341 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.00558466 |
| HTRA1 | HtrA serine peptidase 1 | 0.00557944 |
| ACTN1 | actinin, alpha 1 | 0.00557477 |
| NCF2 | neutrophil cytosolic factor 2 | 0.00557128 |
| BCL2A1 | BCL2-related protein A1 | 0.00556417 |
| RAPSN | receptor-associated protein of the synapse | 0.00556351 |
| PCP4 | Purkinje cell protein 4 | 0.00553592 |
| PDSS2 | prenyl (decaprenyl) diphosphate synthase, subunit 2 | 0.00551527 |
| TSPAN12 | tetraspanin 12 | 0.00550683 |
| KLRB1 | killer cell lectin-like receptor subfamily B, member 1 | 0.00550172 |
| IL1RAP | interleukin 1 receptor accessory protein | 0.00549994 |
| KIAA0100 | KIAA0100 | 0.00549465 |
| ADORA2B | adenosine A2b receptor | 0.00548629 |
| NSG1 | neuron specific gene family member 1 | 0.00548449 |
| CLEC5A | C-type lectin domain family 5, member A | 0.00548308 |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.00545784 |
| CRYM | crystallin, mu | 0.00545576 |
| GPM6A | glycoprotein M6A | 0.00545432 |
| CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | 0.00544436 |
| NREP | neuronal regeneration related protein | 0.00543629 |
| AMACR | alpha-methylacyl-CoA racemase | 0.00542954 |
| TCEAL1 | transcription elongation factor A (SII)-like 1 | 0.00540748 |
| SAMHD1 | SAM domain and HD domain 1 | 0.00539998 |
| SPRR1B | small proline-rich protein 1B | 0.00537733 |
| HAUS3 | HAUS augmin-like complex, subunit 3 | 0.00537297 |
| KRT23 | keratin 23, type I | 0.00537109 |
| HBB | hemoglobin, beta | 0.00536646 |
| F2R | coagulation factor II (thrombin) receptor | 0.0053648 |
| H2AZ1 | H2A.Z variant histone 1 | 0.00536367 |
| IFITM2 | interferon induced transmembrane protein 2 | 0.0053629 |
| LMO3 | LIM domain only 3 (rhombotin-like 2) | 0.00536279 |
| HEY1 | hes-related family bHLH transcription factor with YRPW motif 1 | 0.00536235 |
| MPO | myeloperoxidase | 0.00533661 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.00531156 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.00530596 |
| ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 | 0.00529245 |
| SLC15A2 | solute carrier family 15 (oligopeptide transporter), member 2 | 0.00528024 |
| HSDL2 | hydroxysteroid dehydrogenase like 2 | 0.00527934 |
| HK3 | hexokinase 3 (white cell) | 0.00527869 |
| RAB14 | RAB14, member RAS oncogene family | 0.00526741 |
| MSR1 | macrophage scavenger receptor 1 | 0.0052479 |
| TMEM100 | transmembrane protein 100 | 0.00524602 |
| FCER1A | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide | 0.00524434 |
| RNASE6 | ribonuclease, RNase A family, k6 | 0.00524349 |
| ACP2 | acid phosphatase 2, lysosomal | 0.00524111 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0052317 |
| ZNF395 | zinc finger protein 395 | 0.00520932 |
| YME1L1 | YME1-like 1 ATPase | 0.00516667 |
| MEIS2 | Meis homeobox 2 | 0.00515967 |
| PIGK | phosphatidylinositol glycan anchor biosynthesis, class K | 0.00515611 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.00515598 |
| SIKE1 | suppressor of IKBKE 1 | 0.00514945 |
| BANK1 | B-cell scaffold protein with ankyrin repeats 1 | 0.0051295 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.00512608 |
| DEK | DEK proto-oncogene | 0.00512258 |
| TM6SF1 | transmembrane 6 superfamily member 1 | 0.00510401 |
| SFTPB | surfactant protein B | 0.00510223 |
| PPBP | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) | 0.00509924 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.00509779 |
| MMP7 | matrix metallopeptidase 7 | 0.00509147 |
| AQP4 | aquaporin 4 | 0.00507989 |
| HOMER3 | homer scaffolding protein 3 | 0.0050625 |
| PLBD1 | phospholipase B domain containing 1 | 0.00504718 |
| CA2 | carbonic anhydrase II | 0.00504469 |
| POLE3 | polymerase (DNA directed), epsilon 3, accessory subunit | 0.00504461 |
| CRBN | cereblon | 0.00503688 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 0.0050364 |
| LYVE1 | lymphatic vessel endothelial hyaluronan receptor 1 | 0.00501309 |
| SPCS3 | signal peptidase complex subunit 3 homolog (S. cerevisiae) | 0.00501036 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0050093 |
| STRAP | serine/threonine kinase receptor associated protein | 0.00500922 |
| OTULINL | OTU deubiquitinase with linear linkage specificity like | 0.0049983 |
| CRABP1 | cellular retinoic acid binding protein 1 | 0.00498763 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.00498244 |
| IL10RA | interleukin 10 receptor, alpha | 0.00495994 |
| S100A9 | S100 calcium binding protein A9 | 0.00495483 |
| OSBPL11 | oxysterol binding protein-like 11 | 0.00495037 |
| SRP9 | signal recognition particle 9kDa | 0.00493929 |
| ITM2B | integral membrane protein 2B | 0.00492367 |
| ACAT2 | acetyl-CoA acetyltransferase 2 | 0.00491313 |
| CLEC7A | C-type lectin domain family 7, member A | 0.0049114 |
| RNF5 | ring finger protein 5, E3 ubiquitin protein ligase | 0.00489026 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | 0.00488261 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.00488105 |
| CASP1 | caspase 1, apoptosis-related cysteine peptidase | 0.00485057 |
| CDC7 | cell division cycle 7 | 0.00483384 |
| TNC | tenascin C | 0.00483144 |
| IFT57 | intraflagellar transport 57 | 0.00483023 |
| MPDZ | multiple PDZ domain protein | 0.00482975 |
| ASH2L | ash2 (absent, small, or homeotic)-like (Drosophila) | 0.00482558 |
| C5AR1 | complement component 5a receptor 1 | 0.00481713 |
| FEZ1 | fasciculation and elongation protein zeta 1 (zygin I) | 0.00480064 |
| ACP5 | acid phosphatase 5, tartrate resistant | 0.00479854 |
| MAP9 | microtubule-associated protein 9 | 0.00479838 |
| ALDH6A1 | aldehyde dehydrogenase 6 family, member A1 | 0.00479365 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.00479306 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.00477684 |
| CYBB | cytochrome b-245, beta polypeptide | 0.00476684 |
| FGR | FGR proto-oncogene, Src family tyrosine kinase | 0.00475184 |
| TSFM | Ts translation elongation factor, mitochondrial | 0.00474866 |
| CNR1 | cannabinoid receptor 1 (brain) | 0.0047304 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.00473032 |
| SPIN1 | spindlin 1 | 0.00471032 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.00470785 |
| ITGAM | integrin, alpha M (complement component 3 receptor 3 subunit) | 0.00470652 |
| GNPTAB | N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits | 0.00470156 |
| NME5 | NME/NM23 family member 5 | 0.00469687 |
| RPN2 | ribophorin II | 0.00468478 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 0.00468265 |
| SLFN12 | schlafen family member 12 | 0.00468084 |
| DBT | dihydrolipoamide branched chain transacylase E2 | 0.00467766 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -0.0189761 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0181571 |
| S100P | S100 calcium binding protein P | -0.0144873 |
| KRT19 | keratin 19, type I | -0.0136789 |
| AGR2 | anterior gradient 2 | -0.0132722 |
| STC1 | stanniocalcin 1 | -0.0132455 |
| TCTA | T-cell leukemia translocation altered | -0.0131654 |
| RGS5 | regulator of G-protein signaling 5 | -0.0125694 |
| TFF1 | trefoil factor 1 | -0.0125428 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0125043 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0124532 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.0122573 |
| NID2 | nidogen 2 (osteonidogen) | -0.0121568 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | -0.0120067 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | -0.0118364 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0115336 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 | -0.0114192 |
| MMP1 | matrix metallopeptidase 1 | -0.0112255 |
| EPCAM | epithelial cell adhesion molecule | -0.0112085 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -0.0108966 |
| KRT18 | keratin 18, type I | -0.0107041 |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | -0.0105702 |
| TIMM17B | translocase of inner mitochondrial membrane 17 homolog B (yeast) | -0.0105055 |
| HSPB1 | heat shock 27kDa protein 1 | -0.010274 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | -0.0102644 |
| HSPA1A | heat shock 70kDa protein 1A | -0.0100865 |
| TFF3 | trefoil factor 3 (intestinal) | -0.00998686 |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 | -0.00986572 |
| AEBP1 | AE binding protein 1 | -0.00985024 |
| BIK | BCL2-interacting killer (apoptosis-inducing) | -0.00976482 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.00921847 |
| COL6A2 | collagen, type VI, alpha 2 | -0.00919384 |
| C1S | complement component 1, s subcomponent | -0.00908366 |
| INSR | insulin receptor | -0.00907685 |
| APOA2 | apolipoprotein A-II | -0.00889531 |
| AREG | amphiregulin | -0.00873317 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | -0.00870127 |
| GPX2 | glutathione peroxidase 2 | -0.00865909 |
| RALB | v-ral simian leukemia viral oncogene homolog B | -0.00860059 |
| CRIP1 | cysteine-rich protein 1 (intestinal) | -0.00825191 |
| IGFBP6 | insulin-like growth factor binding protein 6 | -0.00816522 |
| PSCA | prostate stem cell antigen | -0.00813681 |
| COL15A1 | collagen, type XV, alpha 1 | -0.00812641 |
| ADIRF | adipogenesis regulatory factor | -0.00811656 |
| PPFIBP2 | PTPRF interacting protein, binding protein 2 (liprin beta 2) | -0.00809299 |
| CRISPLD2 | cysteine-rich secretory protein LCCL domain containing 2 | -0.00803124 |
| ASS1 | argininosuccinate synthase 1 | -0.00793117 |
| MAGEA3 | melanoma antigen family A3 | -0.00792756 |
| TNS3 | tensin 3 | -0.00792406 |
| XIC | X chromosome inactivation center | -0.00782965 |
| SERPING1 | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | -0.00778218 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.00773982 |
| OFD1 | oral-facial-digital syndrome 1 | -0.00772016 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.00771622 |
| DIPK1A | divergent protein kinase domain 1A | -0.00770595 |
| UBA1 | ubiquitin-like modifier activating enzyme 1 | -0.00765572 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | -0.00762683 |
| HEPH | hephaestin | -0.00762066 |
| FGB | fibrinogen beta chain | -0.00761074 |
| C3 | complement component 3 | -0.00754134 |
| MMP3 | matrix metallopeptidase 3 | -0.00745915 |
| COL1A1 | collagen, type I, alpha 1 | -0.0074323 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | -0.00740164 |
| ISLR | immunoglobulin superfamily containing leucine-rich repeat | -0.00739916 |
| PLAAT3 | phospholipase A and acyltransferase 3 | -0.00733595 |
| POU2AF1 | POU class 2 associating factor 1 | -0.00731758 |
| TMEM135 | transmembrane protein 135 | -0.00730592 |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | -0.00729469 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.00723276 |
| RBM47 | RNA binding motif protein 47 | -0.00708733 |
| STX1A | syntaxin 1A (brain) | -0.00702803 |
| ARL14 | ADP-ribosylation factor-like 14 | -0.00698018 |
| CYBA | cytochrome b-245, alpha polypeptide | -0.00695611 |
| KRT7 | keratin 7, type II | -0.00693296 |
| FBLN1 | fibulin 1 | -0.00693181 |
| ITGB4 | integrin, beta 4 | -0.0068981 |
| PPAP2A | phosphatidic acid phosphatase type 2A | -0.00689533 |
| TXLNA | taxilin alpha | -0.00687865 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | -0.00683792 |
| MYRF | myelin regulatory factor | -0.00681946 |
| FHL2 | four and a half LIM domains 2 | -0.00681163 |
| SLC25A6 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 | -0.00677809 |
| RHOB | ras homolog family member B | -0.00675803 |
| DCN | decorin | -0.00674667 |
| MXRA5 | matrix-remodelling associated 5 | -0.00673473 |
| ANXA10 | annexin A10 | -0.00671864 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.00669927 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.00667798 |
| CD38 | CD38 molecule | -0.00662974 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.00662575 |
| GAS6 | growth arrest-specific 6 | -0.00660405 |
| PERP | PERP, TP53 apoptosis effector | -0.00658938 |
| WDR45 | WD repeat domain 45 | -0.00657621 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.00654702 |
| FA2H | fatty acid 2-hydroxylase | -0.00654662 |
| KLK6 | kallikrein-related peptidase 6 | -0.00652657 |
| ASPN | asporin | -0.00652568 |
| CCL19 | chemokine (C-C motif) ligand 19 | -0.00652471 |
| UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) | -0.0065071 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.00646698 |
| IL6 | interleukin 6 | -0.00646315 |
| RND3 | Rho family GTPase 3 | -0.00645138 |
| PER2 | period circadian clock 2 | -0.00642303 |
| GSTP1 | glutathione S-transferase pi 1 | -0.00638494 |
| RARRES3 | retinoic acid receptor responder (tazarotene induced) 3 | -0.00638333 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.00637889 |
| DUSP5 | dual specificity phosphatase 5 | -0.00637487 |
| AIM2 | absent in melanoma 2 | -0.0063693 |
| DACT1 | dishevelled-binding antagonist of beta-catenin 1 | -0.00636049 |
| IER5 | immediate early response 5 | -0.00632399 |
| STEAP3 | STEAP family member 3, metalloreductase | -0.00632052 |
| SH3BP4 | SH3-domain binding protein 4 | -0.00630017 |
| CCN2 | cellular communication network factor 2 | -0.00626498 |
| STC2 | stanniocalcin 2 | -0.00624452 |
| MLXIP | MLX interacting protein | -0.00623668 |
| COL6A3 | collagen, type VI, alpha 3 | -0.00623443 |
| MAGEA12 | melanoma antigen family A12 | -0.00620319 |
| LGALS4 | lectin, galactoside-binding, soluble, 4 | -0.00619203 |
| FGF13 | fibroblast growth factor 13 | -0.00618815 |
| MYO5C | myosin VC | -0.00617727 |
| NADSYN1 | NAD synthetase 1 | -0.00616928 |
| LDB2 | LIM domain binding 2 | -0.00615158 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | -0.00614785 |
| HEBP2 | heme binding protein 2 | -0.00613943 |
| RGS16 | regulator of G-protein signaling 16 | -0.00613697 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | -0.00612185 |
| SVEP1 | sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 | -0.00611333 |
| MYO15B | myosin XVB | -0.00610785 |
| DYNLL1 | dynein, light chain, LC8-type 1 | -0.00610716 |
| PNN | pinin, desmosome associated protein | -0.00609028 |
| MFAP5 | microfibrillar associated protein 5 | -0.00608938 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.00608371 |
| MCF2L | MCF.2 cell line derived transforming sequence-like | -0.00607629 |
| GOLGA8A | golgin A8 family, member A | -0.0060615 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | -0.00604705 |
| KRT20 | keratin 20, type I | -0.00604103 |
| COL6A1 | collagen, type VI, alpha 1 | -0.00603873 |
| CEL | carboxyl ester lipase | -0.00600164 |
| ACTA2 | actin, alpha 2, smooth muscle, aorta | -0.00598966 |
| CHGB | chromogranin B | -0.00598032 |
| MXRA8 | matrix-remodelling associated 8 | -0.00596477 |
| TMEM243 | transmembrane protein 243, mitochondrial | -0.00595345 |
| PLVAP | plasmalemma vesicle associated protein | -0.00592086 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.00589892 |
| CLEC11A | C-type lectin domain family 11, member A | -0.00587292 |
| ALDH2 | aldehyde dehydrogenase 2 family (mitochondrial) | -0.00586906 |
| SCD5 | stearoyl-CoA desaturase 5 | -0.00583502 |
| ANKRD10 | ankyrin repeat domain 10 | -0.00581842 |
| APOA1 | apolipoprotein A-I | -0.00579932 |
| BTF3P11 | basic transcription factor 3 pseudogene 11 | -0.00576916 |
| FAM50A | family with sequence similarity 50, member A | -0.00576517 |
| TFF2 | trefoil factor 2 | -0.00575603 |
| LAMA2 | laminin, alpha 2 | -0.00574226 |
| POSTN | periostin, osteoblast specific factor | -0.00572269 |
| MZB1 | marginal zone B and B1 cell-specific protein | -0.00571399 |
| TTR | transthyretin | -0.00571294 |
| DOCK9 | dedicator of cytokinesis 9 | -0.00570602 |
| VAMP1 | vesicle-associated membrane protein 1 (synaptobrevin 1) | -0.00567515 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | -0.00566891 |
| SASH1 | SAM and SH3 domain containing 1 | -0.00566474 |
| ALB | albumin | -0.00565878 |
| C10ORF10 | chromosome 10 open reading frame 10 | -0.00565364 |
| UGT2B28 | UDP glucuronosyltransferase 2 family, polypeptide B28 | -0.00565324 |
| APOB | apolipoprotein B | -0.00565162 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | -0.00563671 |
| TP53I3 | tumor protein p53 inducible protein 3 | -0.00563631 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | -0.00563315 |
| SYNE3 | spectrin repeat containing, nuclear envelope family member 3 | -0.0056238 |
| REG1A | regenerating islet-derived 1 alpha | -0.00561815 |
| SPATA20 | spermatogenesis associated 20 | -0.00560991 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.00560835 |
| EGR1 | early growth response 1 | -0.00560087 |
| RUNX1T1 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | -0.00559862 |
| GRIA2 | glutamate receptor, ionotropic, AMPA 2 | -0.00556204 |
| RAB9A | RAB9A, member RAS oncogene family | -0.00555581 |
| PAMR1 | peptidase domain containing associated with muscle regeneration 1 | -0.00555154 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | -0.00554971 |
| PDGFRL | platelet-derived growth factor receptor-like | -0.0055483 |
| PLPP2 | phospholipid phosphatase 2 | -0.00552473 |
| RBM25 | RNA binding motif protein 25 | -0.00551891 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | -0.00550177 |
| LUM | lumican | -0.00549087 |
| GABRE | gamma-aminobutyric acid (GABA) A receptor, epsilon | -0.00547892 |
| GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | -0.0054709 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.00546876 |
| ADAMTS5 | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | -0.00545839 |
| VILL | villin-like | -0.00545761 |
| UCKL1 | uridine-cytidine kinase 1-like 1 | -0.00545421 |
| TIMM13 | translocase of inner mitochondrial membrane 13 homolog (yeast) | -0.00542816 |
| COX7A1 | cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) | -0.00540612 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | -0.00540452 |
| ADAP1 | ArfGAP with dual PH domains 1 | -0.00539879 |
| HSPB8 | heat shock 22kDa protein 8 | -0.00537115 |
| CP | ceruloplasmin (ferroxidase) | -0.00535869 |
| CHMP2A | charged multivesicular body protein 2A | -0.00535608 |
| H1-2 | H1.2 linker histone, cluster member | -0.00535313 |
| GRK5 | G protein-coupled receptor kinase 5 | -0.00533945 |
| IRS1 | insulin receptor substrate 1 | -0.0053282 |
| EFHD1 | EF-hand domain family, member D1 | -0.00531959 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | -0.0053174 |
| TCERG1 | transcription elongation regulator 1 | -0.00530453 |
| UPF3A | UPF3 regulator of nonsense transcripts homolog A (yeast) | -0.00529263 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | -0.00529171 |
| PFDN4 | prefoldin subunit 4 | -0.0052861 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | -0.00525899 |
| IL32 | interleukin 32 | -0.00525565 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | -0.0052415 |
| ARGLU1 | arginine and glutamate rich 1 | -0.00523988 |
| GOLGA8H | golgin A8 family, member H | -0.00522937 |
| NOTCH3 | notch 3 | -0.0052085 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.00520101 |
| ADCY1 | adenylate cyclase 1 (brain) | -0.00519963 |
| NMNAT2 | nicotinamide nucleotide adenylyltransferase 2 | -0.00519645 |
| CALCOCO2 | calcium binding and coiled-coil domain 2 | -0.00517668 |
| BEX1 | brain expressed, X-linked 1 | -0.00517435 |
| ATP5MF | ATP synthase membrane subunit f | -0.00517086 |
| DEPTOR | DEP domain containing MTOR-interacting protein | -0.00516962 |
| CPT1A | carnitine palmitoyltransferase 1A (liver) | -0.00515995 |
| TRRAP | transformation/transcription domain-associated protein | -0.00514318 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | -0.00514152 |
| AEN | apoptosis enhancing nuclease | -0.00513851 |
| UPF3B | UPF3 regulator of nonsense transcripts homolog B (yeast) | -0.00513759 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.00513441 |
| RPS27L | ribosomal protein S27-like | -0.00512704 |
| MICAL1 | microtubule associated monooxygenase, calponin and LIM domain containing 1 | -0.00511653 |
| REX1BD | required for excision 1-B domain containing | -0.00510866 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | -0.00510416 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | -0.00510151 |
| LRRC15 | leucine rich repeat containing 15 | -0.00509417 |
| RABAC1 | Rab acceptor 1 (prenylated) | -0.00509342 |
| OLFML3 | olfactomedin-like 3 | -0.00509333 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | -0.00509154 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | -0.00508519 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | -0.00508187 |
| FILIP1L | filamin A interacting protein 1-like | -0.00508042 |
| HTATIP2 | HIV-1 Tat interactive protein 2, 30kDa | -0.00507007 |
| OSR2 | odd-skipped related transciption factor 2 | -0.00505725 |
| PLK2 | polo-like kinase 2 | -0.00504246 |
| CES3 | carboxylesterase 3 | -0.00503139 |
| ZSCAN18 | zinc finger and SCAN domain containing 18 | -0.00501703 |
| MAP7 | microtubule-associated protein 7 | -0.00501655 |
| CHGA | chromogranin A | -0.0050143 |
| TAX1BP3 | Tax1 (human T-cell leukemia virus type I) binding protein 3 | -0.00500418 |
| RUFY2 | RUN and FYVE domain containing 2 | -0.00499405 |
| CDC34 | cell division cycle 34 | -0.00498503 |
| MCM7 | minichromosome maintenance complex component 7 | -0.00498219 |
| HOXC6 | homeobox C6 | -0.00498131 |
| CD248 | CD248 molecule, endosialin | -0.00496664 |
| GYG2 | glycogenin 2 | -0.00494671 |
