CYP2B6 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description cytochrome P450, family 2, subfamily B, polypeptide 6|This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1555)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GNF2_CYP2B6
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Genes

49 co-expressed genes for CYP2B6 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
AGXT alanine-glyoxylate aminotransferase
ANG angiogenin, ribonuclease, RNase A family, 5
APCS amyloid P component, serum
APOC1 apolipoprotein C-I
APOC4 apolipoprotein C-IV
ASL argininosuccinate lyase
C4BPA complement component 4 binding protein, alpha
C8G complement component 8, gamma polypeptide
CES1 carboxylesterase 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DCXR dicarbonyl/L-xylulose reductase
F12 coagulation factor XII (Hageman factor)
F2 coagulation factor II (thrombin)
FBP1 fructose-1,6-bisphosphatase 1
FCN3 ficolin (collagen/fibrinogen domain containing) 3
GCHFR GTP cyclohydrolase I feedback regulator
HAMP hepcidin antimicrobial peptide
HGFAC HGF activator
HPD 4-hydroxyphenylpyruvate dioxygenase
HPN hepsin
HPX hemopexin
HRG histidine-rich glycoprotein
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IGFALS insulin-like growth factor binding protein, acid labile subunit
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4
LCAT lecithin-cholesterol acyltransferase
MAT1A methionine adenosyltransferase I, alpha
NNMT nicotinamide N-methyltransferase
ORM1 orosomucoid 1
ORM2 orosomucoid 2
PROC protein C (inactivator of coagulation factors Va and VIIIa)
RDH16 retinol dehydrogenase 16 (all-trans)
SAA4 serum amyloid A4, constitutive
SDS serine dehydratase
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
TAT tyrosine aminotransferase
TST thiosulfate sulfurtransferase (rhodanese)
UPB1 ureidopropionase, beta