CYP2C19 Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description cytochrome P450, family 2, subfamily C, polypeptide 19|This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1557)
External Link https://ncbi.nlm.nih.gov/gene/1557
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Genes

499 genes differentially expressed following the CYP2C19 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 0.0217586
MAP7 microtubule-associated protein 7 0.016977
IFI27 interferon, alpha-inducible protein 27 0.016852
CD59 CD59 molecule, complement regulatory protein 0.0149822
BAMBI BMP and activin membrane-bound inhibitor 0.0144432
S100A8 S100 calcium binding protein A8 0.0142082
HOPX HOP homeobox 0.0137492
SELL selectin L 0.0136971
TACSTD2 tumor-associated calcium signal transducer 2 0.0130251
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 0.0130038
TSC22D1 TSC22 domain family, member 1 0.0124487
CXCL13 chemokine (C-X-C motif) ligand 13 0.0124365
S100A9 S100 calcium binding protein A9 0.0124217
FXYD3 FXYD domain containing ion transport regulator 3 0.0124183
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) 0.0119817
STOM stomatin 0.0118415
IL32 interleukin 32 0.0116893
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.011619
LTF lactotransferrin 0.0115598
CXCL10 chemokine (C-X-C motif) ligand 10 0.0115132
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 0.0114026
GJA1 gap junction protein, alpha 1, 43kDa 0.0113269
SH3YL1 SH3 and SYLF domain containing 1 0.0109384
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0108747
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.0108177
IFIH1 interferon induced with helicase C domain 1 0.0107697
AQP1 aquaporin 1 (Colton blood group) 0.0106542
CTSS cathepsin S 0.0105812
PI3 peptidase inhibitor 3, skin-derived 0.0105663
ADAMDEC1 ADAM-like, decysin 1 0.010508
IFI44L interferon-induced protein 44-like 0.0105066
COG7 component of oligomeric golgi complex 7 0.0104786
SAT1 spermidine/spermine N1-acetyltransferase 1 0.0103716
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 0.0101589
TRIM22 tripartite motif containing 22 0.0100137
AQP3 aquaporin 3 (Gill blood group) 0.00995338
GPR171 G protein-coupled receptor 171 0.00989017
HIST1H2AC histone cluster 1, H2ac 0.00984486
TM4SF1 transmembrane 4 L six family member 1 0.00982351
AMACR alpha-methylacyl-CoA racemase 0.00981988
TPD52L1 tumor protein D52-like 1 0.00976491
GUCY1A3 guanylate cyclase 1, soluble, alpha 3 0.00975732
IL2RG interleukin 2 receptor, gamma 0.00975499
LY75 lymphocyte antigen 75 0.0097419
ISG20 interferon stimulated exonuclease gene 20kDa 0.00973759
TARP TCR gamma alternate reading frame protein 0.00970158
SFRP1 secreted frizzled-related protein 1 0.00963678
GABARAPL2 GABA(A) receptor-associated protein-like 2 0.00961384
CXCL14 chemokine (C-X-C motif) ligand 14 0.00957409
C1ORF54 chromosome 1 open reading frame 54 0.00957283
S100A7 S100 calcium binding protein A7 0.00956194
ATF3 activating transcription factor 3 0.0095351
JCHAIN joining chain of multimeric IgA and IgM 0.00941848
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28 0.00939379
IL7R interleukin 7 receptor 0.00938359
IFI6 interferon, alpha-inducible protein 6 0.00930477
BCL2A1 BCL2-related protein A1 0.00928098
TFEC transcription factor EC 0.00927921
LAMP3 lysosomal-associated membrane protein 3 0.00927908
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.00927602
AZGP1 alpha-2-glycoprotein 1, zinc-binding 0.00923539
FGF13 fibroblast growth factor 13 0.00921672
CST7 cystatin F (leukocystatin) 0.00913143
GIMAP4 GTPase, IMAP family member 4 0.00912839
MT1G metallothionein 1G 0.00912232
ABLIM1 actin binding LIM protein 1 0.00910943
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 0.00910218
F2RL1 coagulation factor II (thrombin) receptor-like 1 0.00904736
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 0.00901675
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.00888232
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 0.00886154
SP110 SP110 nuclear body protein 0.00886055
ZFP36L2 ZFP36 ring finger protein-like 2 0.00881277
C10ORF10 chromosome 10 open reading frame 10 0.00880676
LXN latexin 0.00877891
ACE2 angiotensin I converting enzyme 2 0.0087738
PLSCR1 phospholipid scramblase 1 0.00873454
RSAD2 radical S-adenosyl methionine domain containing 2 0.00873054
COG5 component of oligomeric golgi complex 5 0.0087253
KLRB1 killer cell lectin-like receptor subfamily B, member 1 0.00871183
SRGN serglycin 0.00867643
AREG amphiregulin 0.00864174
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 0.00860733
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.00857279
SPRR3 small proline-rich protein 3 0.00855057
CHPT1 choline phosphotransferase 1 0.00853925
ANXA1 annexin A1 0.00850823
C1ORF115 chromosome 1 open reading frame 115 0.00846191
KRT14 keratin 14, type I 0.00843883
TARBP1 TAR (HIV-1) RNA binding protein 1 0.00843845
CRYBG1 crystallin beta-gamma domain containing 1 0.00842274
GPM6B glycoprotein M6B 0.00842205
TSPAN13 tetraspanin 13 0.00831375
NME4 NME/NM23 nucleoside diphosphate kinase 4 0.00827597
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 0.00826466
MRTFB myocardin related transcription factor B 0.00826075
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 0.00822272
UBE2L6 ubiquitin-conjugating enzyme E2L 6 0.00820131
SPRR1B small proline-rich protein 1B 0.00816173
ATP5PD ATP synthase peripheral stalk subunit d 0.00814525
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D 0.00813701
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) 0.0081267
ITK IL2-inducible T-cell kinase 0.0081132
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.00810588
CFDP1 craniofacial development protein 1 0.00806191
HBB hemoglobin, beta 0.00803602
S100A10 S100 calcium binding protein A10 0.00802485
CD69 CD69 molecule 0.00801723
FGFR3 fibroblast growth factor receptor 3 0.00799992
MYO1C myosin IC 0.0079803
CCL5 chemokine (C-C motif) ligand 5 0.00795632
IRF7 interferon regulatory factor 7 0.0079416
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.00792125
GSTO1 glutathione S-transferase omega 1 0.00786939
NIBAN1 niban apoptosis regulator 1 0.00786523
BFAR bifunctional apoptosis regulator 0.00785836
MT1X metallothionein 1X 0.00784762
HSBP1 heat shock factor binding protein 1 0.00783253
BDH2 3-hydroxybutyrate dehydrogenase, type 2 0.0078091
HMOX2 heme oxygenase 2 0.00779624
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.00776089
AGTR1 angiotensin II receptor, type 1 0.00775704
NRN1 neuritin 1 0.00774417
DAXX death-domain associated protein 0.00771704
MVP major vault protein 0.00770889
MREG melanoregulin 0.0076989
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent 0.00757568
CLDN8 claudin 8 0.00757549
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 0.00757459
OPN3 opsin 3 0.00756867
COMT catechol-O-methyltransferase 0.0075634
PHF11 PHD finger protein 11 0.00755584
CXCL11 chemokine (C-X-C motif) ligand 11 0.00753747
MGST3 microsomal glutathione S-transferase 3 0.00753182
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 0.00752445
AVPI1 arginine vasopressin-induced 1 0.00752419
OPTN optineurin 0.00752259
ADD3 adducin 3 (gamma) 0.00750931
BTN3A2 butyrophilin, subfamily 3, member A2 0.00750552
BIRC3 baculoviral IAP repeat containing 3 0.00749428
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.00749167
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.00748285
XIC X chromosome inactivation center 0.00744629
STAT1 signal transducer and activator of transcription 1, 91kDa 0.00743949
CSRP2 cysteine and glycine-rich protein 2 0.00743418
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 0.0074309
UQCRC2 ubiquinol-cytochrome c reductase core protein II 0.00742861
NR1H3 nuclear receptor subfamily 1, group H, member 3 0.00741946
WASHC4 WASH complex subunit 4 0.00741869
IL6ST interleukin 6 signal transducer 0.00741135
MRPL40 mitochondrial ribosomal protein L40 0.00740693
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 0.00740611
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.00739872
GIMAP6 GTPase, IMAP family member 6 0.00738695
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 0.00736125
TLE4 transducin-like enhancer of split 4 0.0073516
IFITM1 interferon induced transmembrane protein 1 0.00734093
MPHOSPH8 M-phase phosphoprotein 8 0.00733581
FKBP11 FK506 binding protein 11, 19 kDa 0.00731825
ALCAM activated leukocyte cell adhesion molecule 0.00731589
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.00725161
TMEM59 transmembrane protein 59 0.00723827
TRIM38 tripartite motif containing 38 0.00721373
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 0.00718496
UXT ubiquitously-expressed, prefoldin-like chaperone 0.00718448
IRF6 interferon regulatory factor 6 0.00717593
QPCT glutaminyl-peptide cyclotransferase 0.00717173
CA2 carbonic anhydrase II 0.00716127
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 0.00715881
SCRG1 stimulator of chondrogenesis 1 0.00714426
HEXB hexosaminidase B (beta polypeptide) 0.00710545
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.00707964
ERG v-ets avian erythroblastosis virus E26 oncogene homolog 0.0070795
UGP2 UDP-glucose pyrophosphorylase 2 0.00707582
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 0.0070758
KRT5 keratin 5, type II 0.00707386
C8ORF4 chromosome 8 open reading frame 4 0.00706363
HILPDA hypoxia inducible lipid droplet-associated 0.00706017
AKAP7 A kinase (PRKA) anchor protein 7 0.00704816
USP18 ubiquitin specific peptidase 18 0.00704405
DNASE1L3 deoxyribonuclease I-like 3 0.00703588
HACD1 3-hydroxyacyl-CoA dehydratase 1 0.00701718
UGT2A3 UDP glucuronosyltransferase 2 family, polypeptide A3 0.00699585
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.0069958
FUCA1 fucosidase, alpha-L- 1, tissue 0.0069924
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.00696057
SMAGP small cell adhesion glycoprotein 0.00695996
MT1HL1 metallothionein 1H-like 1 0.00694107
APOL2 apolipoprotein L, 2 0.00694076
SOX9 SRY (sex determining region Y)-box 9 0.00693227
PROM1 prominin 1 0.00693091
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 0.00691184
KRT17 keratin 17, type I 0.00689871
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.00689763
ERAP2 endoplasmic reticulum aminopeptidase 2 0.00688922
MT1M metallothionein 1M 0.00688314
MT1E metallothionein 1E 0.00688231
CLCA2 chloride channel accessory 2 0.00687815
HSPA2 heat shock 70kDa protein 2 0.00687218
RTP4 receptor (chemosensory) transporter protein 4 0.00686798
GRB7 growth factor receptor-bound protein 7 0.00682178
APOD apolipoprotein D 0.00679106
NPY1R neuropeptide Y receptor Y1 0.00679064
CCDC28A coiled-coil domain containing 28A 0.00678039
GLIPR1 GLI pathogenesis-related 1 0.00677859
KRT6A keratin 6A, type II 0.00677304
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 0.00674163
TPST2 tyrosylprotein sulfotransferase 2 0.00672875
MALL mal, T-cell differentiation protein-like 0.00672582
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.00671708
ETHE1 ethylmalonic encephalopathy 1 0.00671431
TMPRSS2 transmembrane protease, serine 2 0.00671067
VAMP8 vesicle-associated membrane protein 8 0.00670861
PON2 paraoxonase 2 0.00670653
ECM1 extracellular matrix protein 1 0.00669124
RBM34 RNA binding motif protein 34 0.00667902
TMEM140 transmembrane protein 140 0.00666603
RBKS ribokinase 0.00666202
CD48 CD48 molecule 0.00665572
ACP5 acid phosphatase 5, tartrate resistant 0.00664026
DEFA4 defensin, alpha 4, corticostatin 0.0066295
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.00662734
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.00661957
CPA3 carboxypeptidase A3 (mast cell) 0.00661713
ANXA3 annexin A3 0.00661699
ELOB elongin B 0.00660991
TBC1D4 TBC1 domain family, member 4 0.0066094
EIF2D eukaryotic translation initiation factor 2D 0.00660711
VCAM1 vascular cell adhesion molecule 1 0.00660475
ZNF267 zinc finger protein 267 0.00659716
PRR15L proline rich 15-like 0.00659663
NMT2 N-myristoyltransferase 2 0.00659366
GLUD2 glutamate dehydrogenase 2 0.00658966
TJP2 tight junction protein 2 0.00657659
MIA melanoma inhibitory activity 0.00657361
RPP40 ribonuclease P/MRP 40kDa subunit 0.00656355
DDIT4 DNA-damage-inducible transcript 4 0.00653681
FGFR4 fibroblast growth factor receptor 4 0.00650596
ATG5 autophagy related 5 0.0065041
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 0.00649975
EPCAM epithelial cell adhesion molecule 0.00649945
PRKCQ protein kinase C, theta 0.00649058
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 0.00648272
A2M alpha-2-macroglobulin 0.00648178
HIST1H2BD histone cluster 1, H2bd 0.00648103
NNMT nicotinamide N-methyltransferase 0.00645093
CRYL1 crystallin, lambda 1 0.00642818
LCMT1 leucine carboxyl methyltransferase 1 0.00642018
CNIH1 cornichon family AMPA receptor auxiliary protein 1 0.00641401
LGALS2 lectin, galactoside-binding, soluble, 2 0.00641271

decreased expression

Symbol Name Standardized Value
TXLNA taxilin alpha -0.0167941
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.0144166
ASS1 argininosuccinate synthase 1 -0.0123869
RTN2 reticulon 2 -0.0120248
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -0.0118398
LPCAT1 lysophosphatidylcholine acyltransferase 1 -0.0112975
MXRA5 matrix-remodelling associated 5 -0.011081
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) -0.0109423
INSR insulin receptor -0.0107529
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) -0.0106614
KRT19 keratin 19, type I -0.0104838
COL16A1 collagen, type XVI, alpha 1 -0.0102391
TENT4A terminal nucleotidyltransferase 4A -0.0100571
C9ORF3 chromosome 9 open reading frame 3 -0.010045
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 -0.00989135
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.00942944
KDM5D lysine (K)-specific demethylase 5D -0.00941786
PCP4 Purkinje cell protein 4 -0.00930428
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.00929402
RTN3 reticulon 3 -0.00923923
FST follistatin -0.00921789
CALCA calcitonin-related polypeptide alpha -0.00918791
ZFPM2 zinc finger protein, FOG family member 2 -0.00915306
DEGS1 delta(4)-desaturase, sphingolipid 1 -0.00909616
HNRNPM heterogeneous nuclear ribonucleoprotein M -0.00899804
NLGN4X neuroligin 4, X-linked -0.00892595
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 -0.00873988
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.00865468
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.00849564
STC1 stanniocalcin 1 -0.00846259
COL9A2 collagen, type IX, alpha 2 -0.00844302
THBS4 thrombospondin 4 -0.00840783
FEN1 flap structure-specific endonuclease 1 -0.00840396
PEG3 paternally expressed 3 -0.0084038
ELN elastin -0.00831984
HOXD1 homeobox D1 -0.00829215
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase -0.00827888
NVL nuclear VCP-like -0.00818124
SLC38A1 solute carrier family 38, member 1 -0.00815719
SRSF6 serine/arginine-rich splicing factor 6 -0.00814286
PAN2 PAN2 poly(A) specific ribonuclease subunit -0.00808742
KRT7 keratin 7, type II -0.00806775
SLIT2 slit homolog 2 (Drosophila) -0.00805905
RXRA retinoid X receptor, alpha -0.00799566
TBL1X transducin (beta)-like 1X-linked -0.00799196
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.00798485
COL11A1 collagen, type XI, alpha 1 -0.00798169
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A -0.00794296
PNN pinin, desmosome associated protein -0.0079054
ACTC1 actin, alpha, cardiac muscle 1 -0.00788769
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 -0.00788061
PWWP3A PWWP domain containing 3A, DNA repair factor -0.00786551
INPP5A inositol polyphosphate-5-phosphatase, 40kDa -0.00786394
PTN pleiotrophin -0.00780267
AEBP1 AE binding protein 1 -0.0077889
ANGPTL2 angiopoietin-like 2 -0.00775796
MB myoglobin -0.00774777
FLNC filamin C, gamma -0.00757186
DACT1 dishevelled-binding antagonist of beta-catenin 1 -0.00753749
SCG5 secretogranin V -0.00753018
KIF1A kinesin family member 1A -0.00750894
HIP1 huntingtin interacting protein 1 -0.00748742
CHD7 chromodomain helicase DNA binding protein 7 -0.00747822
CDC20 cell division cycle 20 -0.00747302
AKAP8L A kinase (PRKA) anchor protein 8-like -0.00747118
CTSZ cathepsin Z -0.00746271
CERK ceramide kinase -0.00745363
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B -0.00745322
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide -0.00743884
OLFM1 olfactomedin 1 -0.00743621
ARID4A AT rich interactive domain 4A (RBP1-like) -0.00741698
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.00739905
GOLGA8A golgin A8 family, member A -0.00739663
MAB21L1 mab-21-like 1 (C. elegans) -0.00738814
CHGB chromogranin B -0.00738142
ZNF423 zinc finger protein 423 -0.007358
PTP4A3 protein tyrosine phosphatase type IVA, member 3 -0.0073432
NUAK1 NUAK family, SNF1-like kinase, 1 -0.00732239
MXRA8 matrix-remodelling associated 8 -0.00730156
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 -0.00729966
MEST mesoderm specific transcript -0.0072899
KIAA0232 KIAA0232 -0.00728926
MMP1 matrix metallopeptidase 1 -0.00727466
ANKRD11 ankyrin repeat domain 11 -0.00727077
ADGRG2 adhesion G protein-coupled receptor G2 -0.00725965
LOXL1 lysyl oxidase-like 1 -0.00724481
CCNL2 cyclin L2 -0.00723257
FRZB frizzled-related protein -0.00723155
NID2 nidogen 2 (osteonidogen) -0.00713868
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.00712795
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.00710923
PDLIM3 PDZ and LIM domain 3 -0.0070958
IRAK1 interleukin-1 receptor-associated kinase 1 -0.00708483
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 -0.00707602
SPRY4 sprouty homolog 4 (Drosophila) -0.00706251
CREB1 cAMP responsive element binding protein 1 -0.00705197
COL1A2 collagen, type I, alpha 2 -0.00702479
TNNT1 troponin T type 1 (skeletal, slow) -0.00700202
KCTD14 potassium channel tetramerization domain containing 14 -0.00699093
CLCN4 chloride channel, voltage-sensitive 4 -0.00697939
MATN2 matrilin 2 -0.00695802
IRS1 insulin receptor substrate 1 -0.00695372
TMPRSS4 transmembrane protease, serine 4 -0.00692764
CHKA choline kinase alpha -0.00691814
ZNF331 zinc finger protein 331 -0.00685255
NREP neuronal regeneration related protein -0.00684186
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 -0.00683646
BEX1 brain expressed, X-linked 1 -0.00680745
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -0.00676751
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) -0.00676034
CRABP2 cellular retinoic acid binding protein 2 -0.00674919
RAPSN receptor-associated protein of the synapse -0.00674913
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) -0.00674527
CNPY3 canopy FGF signaling regulator 3 -0.00674081
PRDX2 peroxiredoxin 2 -0.00672089
SYNE3 spectrin repeat containing, nuclear envelope family member 3 -0.00669505
FKBP9 FK506 binding protein 9, 63 kDa -0.00666319
TRIP13 thyroid hormone receptor interactor 13 -0.00663866
CRYBG3 beta-gamma crystallin domain containing 3 -0.00662771
TARDBP TAR DNA binding protein -0.00662108
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1 -0.00662102
FNBP1 formin binding protein 1 -0.00660175
L1CAM L1 cell adhesion molecule -0.00654902
FADS1 fatty acid desaturase 1 -0.00653841
LIMCH1 LIM and calponin homology domains 1 -0.00653042
TCERG1 transcription elongation regulator 1 -0.00650386
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.00649716
FAM168B family with sequence similarity 168, member B -0.00644968
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic -0.00643802
LMNB2 lamin B2 -0.00643328
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.00643115
PTBP1 polypyrimidine tract binding protein 1 -0.00642067
TGFB3 transforming growth factor, beta 3 -0.0064111
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase -0.00640724
RECQL RecQ helicase-like -0.00638349
SCRIB scribbled planar cell polarity protein -0.00637667
NSD2 nuclear receptor binding SET domain protein 2 -0.0063745
NEFH neurofilament, heavy polypeptide -0.00636197
MRPL12 mitochondrial ribosomal protein L12 -0.00635785
MFAP4 microfibrillar-associated protein 4 -0.00635687
NMU neuromedin U -0.00634907
MCM7 minichromosome maintenance complex component 7 -0.00634642
SRF serum response factor (c-fos serum response element-binding transcription factor) -0.00633085
GAS1 growth arrest-specific 1 -0.00633032
EIF1AY eukaryotic translation initiation factor 1A, Y-linked -0.00632899
HMGB2 high mobility group box 2 -0.00631891
GSE1 Gse1 coiled-coil protein -0.0063139
NUP50 nucleoporin 50kDa -0.00630034
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 -0.00627289
TOR4A torsin family 4, member A -0.00627057
MLPH melanophilin -0.00626763
STEAP3 STEAP family member 3, metalloreductase -0.00626416
PCGF3 polycomb group ring finger 3 -0.00625
FRS2 fibroblast growth factor receptor substrate 2 -0.00624494
KLF13 Kruppel-like factor 13 -0.00623179
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B -0.00622281
HAS2 hyaluronan synthase 2 -0.00621867
NXN nucleoredoxin -0.00620964
AURKB aurora kinase B -0.00619429
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 -0.00619044
CBX6 chromobox homolog 6 -0.00618371
COL6A1 collagen, type VI, alpha 1 -0.00618169
TRMT5 tRNA methyltransferase 5 -0.00615671
LETM1 leucine zipper-EF-hand containing transmembrane protein 1 -0.0061276
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha -0.00612647
COMP cartilage oligomeric matrix protein -0.00612453
HDAC1 histone deacetylase 1 -0.00611374
CBX5 chromobox homolog 5 -0.00610856
BCAT2 branched chain amino-acid transaminase 2, mitochondrial -0.00610285
AMOTL2 angiomotin like 2 -0.00609993
SQLE squalene epoxidase -0.00606825
STS steroid sulfatase (microsomal), isozyme S -0.00605841
RAMP1 receptor (G protein-coupled) activity modifying protein 1 -0.00605558
CSK c-src tyrosine kinase -0.00605344
TLN1 talin 1 -0.00603819
MAP1B microtubule-associated protein 1B -0.00603272
OSR2 odd-skipped related transciption factor 2 -0.0060283
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.00602145
SEPTIN10 septin 10 -0.00601061
HRASLS HRAS-like suppressor -0.00600633
DGCR8 DGCR8 microprocessor complex subunit -0.00600142
RHOBTB3 Rho-related BTB domain containing 3 -0.00599499
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.00599489
MEN1 multiple endocrine neoplasia I -0.00598146
NBPF10 neuroblastoma breakpoint family, member 10 -0.00596699
FZD2 frizzled class receptor 2 -0.00595893
NINJ2 ninjurin 2 -0.00594152
GTPBP3 GTP binding protein 3 (mitochondrial) -0.00589814
AKAP8 A kinase (PRKA) anchor protein 8 -0.00589781
DACH1 dachshund family transcription factor 1 -0.00587701
CFD complement factor D (adipsin) -0.00587527
MFAP2 microfibrillar-associated protein 2 -0.00587031
LARP1 La ribonucleoprotein domain family, member 1 -0.00586464
MBOAT7 membrane bound O-acyltransferase domain containing 7 -0.0058612
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 -0.00584759
TRIO trio Rho guanine nucleotide exchange factor -0.00584096
ZNF211 zinc finger protein 211 -0.00583663
TAGLN transgelin -0.00582312
PIMREG PICALM interacting mitotic regulator -0.00582101
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0058132
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) -0.00580549
TARS1 threonyl-tRNA synthetase 1 -0.00580195
INPPL1 inositol polyphosphate phosphatase-like 1 -0.00578283
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -0.00578267
SETBP1 SET binding protein 1 -0.00576879
ESR1 estrogen receptor 1 -0.00576852
SLC43A3 solute carrier family 43, member 3 -0.00572453
NAA40 N(alpha)-acetyltransferase 40, NatD catalytic subunit -0.00571885
FZD10 frizzled class receptor 10 -0.00571272
TTN titin -0.00570783
ZC2HC1A zinc finger, C2HC-type containing 1A -0.00570409
HNRNPR heterogeneous nuclear ribonucleoprotein R -0.00570393
SFPQ splicing factor proline/glutamine-rich -0.00569159
ADCY1 adenylate cyclase 1 (brain) -0.00568148
FAM120A family with sequence similarity 120A -0.00567393
MECOM MDS1 and EVI1 complex locus -0.00566604
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5 -0.00565928
IGFBP1 insulin-like growth factor binding protein 1 -0.00564964
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor -0.0056492
RGS16 regulator of G-protein signaling 16 -0.00564339
ADGRL2 adhesion G protein-coupled receptor L2 -0.00562978
TFRC transferrin receptor -0.00562086
NCOA3 nuclear receptor coactivator 3 -0.00561835
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.00561529
STON1 stonin 1 -0.00561141
CTBP1 C-terminal binding protein 1 -0.00560887
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -0.00560786
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) -0.00559966
PTGIS prostaglandin I2 (prostacyclin) synthase -0.00558528
DLG5 discs, large homolog 5 (Drosophila) -0.00558357
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing -0.00558274
HAMP hepcidin antimicrobial peptide -0.00557742
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) -0.00557551
ATP2A3 ATPase, Ca++ transporting, ubiquitous -0.00556364
EIF3B eukaryotic translation initiation factor 3, subunit B -0.00556197
TUBB2B tubulin, beta 2B class IIb -0.00555663
NCOA6 nuclear receptor coactivator 6 -0.00554609
WASHC5 WASH complex subunit 5 -0.00553577
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 -0.00553421
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon -0.00552135
H2AFV H2A histone family, member V -0.00550388
LAMP5 lysosomal-associated membrane protein family, member 5 -0.00549445
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 -0.00548811
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.00548206
TYMS thymidylate synthetase -0.00547979
NCOR2 nuclear receptor corepressor 2 -0.00547519
LAMA5 laminin, alpha 5 -0.00544687
PER3 period circadian clock 3 -0.00544444
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 -0.00543554