CYP2D6 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description cytochrome P450, family 2, subfamily D, polypeptide 6|This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] (NCBI Entrez Gene Database, 1565)
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Genes

355 genes differentially expressed following the CYP2D6 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase) 2.4509
CDH26 cadherin 26 2.4509
RUNX3 runt-related transcription factor 3 2.4509
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B 2.4509
LEP leptin 2.4509
ERVW-1 endogenous retrovirus group W, member 1 2.4509
YIPF7 Yip1 domain family, member 7 2.4509
CCDC121 coiled-coil domain containing 121 2.4509
FGD2 FYVE, RhoGEF and PH domain containing 2 2.4509
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 2.4509
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 2.4509
PDE7B phosphodiesterase 7B 2.4509
DRD3 dopamine receptor D3 2.4509
DNASE1L2 deoxyribonuclease I-like 2 2.4509
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.4509
GPR149 G protein-coupled receptor 149 2.4509
FNDC8 fibronectin type III domain containing 8 2.4509
UPK1A uroplakin 1A 2.4509
RORC RAR-related orphan receptor C 2.4509
GOLGA8R golgin A8 family, member R 2.4509
FABP12 fatty acid binding protein 12 2.4509
GOLGA8N golgin A8 family, member N 2.4509
TEX46 testis expressed 46 2.4509
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 2.4509
SPAAR small regulatory polypeptide of amino acid response 2.4509
COLEC10 collectin sub-family member 10 (C-type lectin) 2.38298
OR4F17 olfactory receptor, family 4, subfamily F, member 17 2.38298
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 2.38298
ANKRD22 ankyrin repeat domain 22 2.38298
ZNF285 zinc finger protein 285 2.38298
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 2.38298
PRB4 proline-rich protein BstNI subfamily 4 2.38298
COL20A1 collagen, type XX, alpha 1 2.38298
OR2A25 olfactory receptor, family 2, subfamily A, member 25 2.38298
RPL41 ribosomal protein L41 2.38298
HHEX hematopoietically expressed homeobox 2.38298
POMC proopiomelanocortin 2.38298
MYO7B myosin VIIB 2.38298
SRSF3 serine/arginine-rich splicing factor 3 2.38298
NAPSA napsin A aspartic peptidase 2.38298
CD300LG CD300 molecule-like family member g 2.38298
NKX2-2 NK2 homeobox 2 2.38298
SCGB3A1 secretoglobin, family 3A, member 1 2.38298
AKR1C4 aldo-keto reductase family 1, member C4 2.38298
SSTR3 somatostatin receptor 3 2.38298
C19ORF67 chromosome 19 open reading frame 67 2.38298
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 2.38298
KAT7 K(lysine) acetyltransferase 7 2.38298
TRAT1 T cell receptor associated transmembrane adaptor 1 2.38298
NRROS negative regulator of reactive oxygen species 2.38298
GNAT3 guanine nucleotide binding protein, alpha transducing 3 2.38298
TDRD9 tudor domain containing 9 2.38298
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.38298
GNG13 guanine nucleotide binding protein (G protein), gamma 13 2.38298
SSTR5 somatostatin receptor 5 2.38298
KMT2B lysine (K)-specific methyltransferase 2B 2.38298
ARMC6 armadillo repeat containing 6 2.38298
NXF2 nuclear RNA export factor 2 2.38298
GFRA3 GDNF family receptor alpha 3 2.38298
SCGB2B2 secretoglobin, family 2B, member 2 2.38298
CRISP2 cysteine-rich secretory protein 2 2.38298
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 2.38298
DSG3 desmoglein 3 2.38298
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit 2.38298
EPHX4 epoxide hydrolase 4 2.38298
C6ORF58 chromosome 6 open reading frame 58 2.38298
CEP295NL CEP295 N-terminal like 2.38298
COL15A1 collagen, type XV, alpha 1 2.38298
COXFA4L3 cytochrome c oxidase associated subunit FA4L3 2.38298
AVPR1A arginine vasopressin receptor 1A 2.38298
SPI1 Spi-1 proto-oncogene 2.38298
PDF peptide deformylase (mitochondrial) 2.38298
PLCZ1 phospholipase C, zeta 1 2.38298
C20ORF202 chromosome 20 open reading frame 202 2.38298
VDAC3 voltage-dependent anion channel 3 2.38298
VASP vasodilator-stimulated phosphoprotein 2.38298
ASB9 ankyrin repeat and SOCS box containing 9 2.38298
TTR transthyretin 2.38298
C10ORF53 chromosome 10 open reading frame 53 2.38298
KYAT1 kynurenine aminotransferase 1 2.38298
CCDC9B coiled-coil domain containing 9B 2.38298
ALPG alkaline phosphatase, germ cell 2.38298
SPATA31F3 SPATA31 subfamily F member 3 2.38298
SPMIP7 sperm microtubule inner protein 7 2.38298
ZC3H11C zinc finger CCCH-type containing 11C 2.38298
SPEGNB SPEG neighbor 2.38298
LITAFD LITAF domain containing 2.38298
DEFB109B defensin beta 109B 2.38298
H4C15 H4 clustered histone 15 2.38298
DNAAF6 dynein axonemal assembly factor 6 2.38298
BNIP5 BCL2 interacting protein 5 2.38298
MINAR2 membrane integral NOTCH2 associated receptor 2 2.38298
TSPAN1 tetraspanin 1 2.38298
CNOT11 CCR4-NOT transcription complex, subunit 11 2.38298
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 2.38298
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 2.38298
SH3TC2 SH3 domain and tetratricopeptide repeats 2 2.38298
SLC9D1 solute carrier family 9 member D1 2.38298
MIA melanoma inhibitory activity 2.38298
MYH13 myosin, heavy chain 13, skeletal muscle 2.38298
AWAT1 acyl-CoA wax alcohol acyltransferase 1 2.38298
LIX1 Lix1 homolog (chicken) 2.38298
C3ORF80 chromosome 3 open reading frame 80 2.38298
DAO D-amino-acid oxidase 2.38298
TEX101 testis expressed 101 2.38298
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.38298
CFAP45 cilia and flagella associated protein 45 2.38298
CCR8 chemokine (C-C motif) receptor 8 2.38298
GATA3 GATA binding protein 3 2.38298
OR7D2 olfactory receptor, family 7, subfamily D, member 2 2.38298
CSAG2 CSAG family, member 2 2.38298
LTB lymphotoxin beta (TNF superfamily, member 3) 2.38298
PCDHGC4 protocadherin gamma subfamily C, 4 2.38298
ASZ1 ankyrin repeat, SAM and basic leucine zipper domain containing 1 2.38298
TAS1R1 taste receptor, type 1, member 1 2.38298
STARD6 StAR-related lipid transfer (START) domain containing 6 2.38298
ALG10B ALG10B, alpha-1,2-glucosyltransferase 2.38298
GSC goosecoid homeobox 2.38298
PTPRC protein tyrosine phosphatase, receptor type, C 2.38298
DMTN dematin actin binding protein 2.38298
IFI44 interferon-induced protein 44 2.38298
RTBDN retbindin 2.38298
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.38298
KIAA1328 KIAA1328 2.38298
TDRD15 tudor domain containing 15 2.38298
CDH19 cadherin 19, type 2 2.38298
BAHCC1 BAH domain and coiled-coil containing 1 2.38298
LMOD2 leiomodin 2 (cardiac) 2.38298
MUC13 mucin 13, cell surface associated 2.38298
CSTA cystatin A (stefin A) 2.38298
BRDT bromodomain, testis-specific 2.38298
LCN6 lipocalin 6 2.38298
TOPAZ1 testis and ovary specific PAZ domain containing 1 2.38298
SMYD1 SET and MYND domain containing 1 2.38298
PLA2G4E phospholipase A2, group IVE 2.38298
LRRC32 leucine rich repeat containing 32 2.38298
PYHIN1 pyrin and HIN domain family, member 1 2.38298
MBOAT4 membrane bound O-acyltransferase domain containing 4 2.38298
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 2.38298
KRT3 keratin 3, type II 2.38298
KCNK9 potassium channel, two pore domain subfamily K, member 9 2.38298
VWA3B von Willebrand factor A domain containing 3B 2.38298
IL19 interleukin 19 2.38298
KISS1 KiSS-1 metastasis-suppressor 2.38298
NCR3 natural cytotoxicity triggering receptor 3 2.38298
MOBP myelin-associated oligodendrocyte basic protein 2.38298
LGALS12 lectin, galactoside-binding, soluble, 12 2.38298
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 2.38298
CNGB1 cyclic nucleotide gated channel beta 1 2.38298
TEX29 testis expressed 29 2.38298
EVI2A ecotropic viral integration site 2A 2.38298
GOLGA8M golgin A8 family, member M 2.38298
MZB1 marginal zone B and B1 cell-specific protein 2.38298
PRSS33 protease, serine, 33 2.38298
DLX5 distal-less homeobox 5 2.38298
CRHBP corticotropin releasing hormone binding protein 2.38298
KLK15 kallikrein-related peptidase 15 2.38298
KLK5 kallikrein-related peptidase 5 2.38298
ASTL astacin-like metallo-endopeptidase (M12 family) 2.38298
HK3 hexokinase 3 (white cell) 2.38298
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 2.38298
SLCO2B1 solute carrier organic anion transporter family, member 2B1 2.38298
VSTM1 V-set and transmembrane domain containing 1 2.38298
TF transferrin 2.38298
DMRT1 doublesex and mab-3 related transcription factor 1 2.38298
PHOX2A paired-like homeobox 2a 2.38298
TMIGD3 transmembrane and immunoglobulin domain containing 3 2.38298
GNRHR gonadotropin-releasing hormone receptor 2.38298
PODN podocan 2.38298
NFE2 nuclear factor, erythroid 2 2.38298
AREG amphiregulin 2.38298
IRX4 iroquois homeobox 4 2.38298
LPA lipoprotein, Lp(a) 2.38298
SPATA5L1 spermatogenesis associated 5-like 1 2.38298
MYOZ2 myozenin 2 2.38298
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21 2.38298
TAS2R46 taste receptor, type 2, member 46 2.38298
BTBD16 BTB (POZ) domain containing 16 2.38298
ACSM2B acyl-CoA synthetase medium-chain family member 2B 2.38298
VSX1 visual system homeobox 1 2.38298
TAS2R19 taste receptor, type 2, member 19 2.38298
CORO6 coronin 6 2.38298
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 2.38298
EVPL envoplakin 2.38298
STEAP4 STEAP family member 4 2.38298
TMEM132C transmembrane protein 132C 2.38298
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 2.38298
TPRX1 tetra-peptide repeat homeobox 1 2.38298
AMDHD1 amidohydrolase domain containing 1 2.38298
ADRA1B adrenoceptor alpha 1B 2.38298
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 2.38298
DBX2 developing brain homeobox 2 2.38298
SLC51B solute carrier family 51, beta subunit 2.38298
OR56B1 olfactory receptor, family 56, subfamily B, member 1 2.38298
TRPM2 transient receptor potential cation channel, subfamily M, member 2 2.38298
LAMP3 lysosomal-associated membrane protein 3 2.38298
SUN3 Sad1 and UNC84 domain containing 3 2.38298
OR5V1 olfactory receptor, family 5, subfamily V, member 1 2.38298
SLITRK2 SLIT and NTRK-like family, member 2 2.38298
SLITRK6 SLIT and NTRK-like family, member 6 2.38298
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 2.38298
ACKR2 atypical chemokine receptor 2 2.38298
ASB12 ankyrin repeat and SOCS box containing 12 2.37334
PCSK5 proprotein convertase subtilisin/kexin type 5 2.36995
SYNJ2 synaptojanin 2 2.25483
TMC2 transmembrane channel-like 2 2.25483
AAGAB alpha- and gamma-adaptin binding protein 2.25483
EFCAB9 EF-hand calcium binding domain 9 2.25483
PPP4R2 protein phosphatase 4, regulatory subunit 2 2.2519
FGD1 FYVE, RhoGEF and PH domain containing 1 2.24096
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 2.22716
DNAAF9 dynein axonemal assembly factor 9 2.22608
AHI1 Abelson helper integration site 1 2.22125
NELFA negative elongation factor complex member A 2.18864
POLH polymerase (DNA directed), eta 2.188
IPP intracisternal A particle-promoted polypeptide 2.17667
PPARG peroxisome proliferator-activated receptor gamma 2.16799
SPTBN2 spectrin, beta, non-erythrocytic 2 2.1574
CFAP44 cilia and flagella associated protein 44 2.15041
FAM91A1 family with sequence similarity 91, member A1 2.13068
SDCCAG8 serologically defined colon cancer antigen 8 2.09217
TM4SF18 transmembrane 4 L six family member 18 2.08699
GMIP GEM interacting protein 2.07345
KCTD15 potassium channel tetramerization domain containing 15 2.06644
BMS1 BMS1 ribosome biogenesis factor 2.05384
LCORL ligand dependent nuclear receptor corepressor-like 2.04056
PLSCR1 phospholipid scramblase 1 2.0399
ZMAT1 zinc finger, matrin-type 1 2.0399
INTS6L integrator complex subunit 6 like 2.03227
CEP57 centrosomal protein 57kDa 2.0306
MORC3 MORC family CW-type zinc finger 3 2.02541
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 2.02309
ARHGAP17 Rho GTPase activating protein 17 2.00842
PCBP4 poly(rC) binding protein 4 2.00543
CSKMT citrate synthase lysine methyltransferase 2.00504

decreased expression

Symbol Name Standardized Value
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.4509
TM6SF2 transmembrane 6 superfamily member 2 -2.4509
ABTB1 ankyrin repeat and BTB (POZ) domain containing 1 -2.4509
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 -2.4509
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -2.4509
ARMCX6 armadillo repeat containing, X-linked 6 -2.4509
NHLH1 nescient helix loop helix 1 -2.4509
IRX3 iroquois homeobox 3 -2.4509
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein -2.38466
TMEM79 transmembrane protein 79 -2.38298
CRIP1 cysteine-rich protein 1 (intestinal) -2.38298
MUC6 mucin 6, oligomeric mucus/gel-forming -2.38298
DLL4 delta-like 4 (Drosophila) -2.38298
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -2.38298
SACK1D scaffolding CK1 anchoring protein D -2.38298
FAM167B family with sequence similarity 167, member B -2.38298
ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif, 15 -2.38298
DPEP1 dipeptidase 1 (renal) -2.38298
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 -2.38298
SCARB1 scavenger receptor class B, member 1 -2.38298
ARRDC3 arrestin domain containing 3 -2.38298
UBP1 upstream binding protein 1 (LBP-1a) -2.38298
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) -2.38298
GPR162 G protein-coupled receptor 162 -2.38298
TUBB1 tubulin, beta 1 class VI -2.38298
DIO3 deiodinase, iodothyronine, type III -2.38298
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -2.38298
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 -2.38298
CCR9 chemokine (C-C motif) receptor 9 -2.38298
PGLYRP1 peptidoglycan recognition protein 1 -2.38298
SPAG4 sperm associated antigen 4 -2.38298
STMN3 stathmin-like 3 -2.38298
ALX1 ALX homeobox 1 -2.38298
CD2AP CD2-associated protein -2.38298
CPS1 carbamoyl-phosphate synthase 1, mitochondrial -2.38298
ATRN attractin -2.38298
NYNRIN NYN domain and retroviral integrase containing -2.38298
MIS18BP1 MIS18 binding protein 1 -2.38298
IL11RA interleukin 11 receptor, alpha -2.38298
KLHL34 kelch-like family member 34 -2.38298
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 -2.38298
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 -2.38298
LY6K lymphocyte antigen 6 complex, locus K -2.38298
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -2.38298
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) -2.38298
C1QTNF7 C1q and tumor necrosis factor related protein 7 -2.38298
NRDC nardilysin convertase -2.38298
SPON2 spondin 2, extracellular matrix protein -2.38298
SLTM SAFB-like, transcription modulator -2.38298
SYNPO2 synaptopodin 2 -2.38298
DCPS decapping enzyme, scavenger -2.38298
MAML2 mastermind-like 2 (Drosophila) -2.38298
BEAN1 brain expressed, associated with NEDD4, 1 -2.38298
NGB neuroglobin -2.38298
FAM219B family with sequence similarity 219, member B -2.38298
RPA2 replication protein A2, 32kDa -2.38298
GGPS1 geranylgeranyl diphosphate synthase 1 -2.38298
FBXO43 F-box protein 43 -2.38298
FADD Fas (TNFRSF6)-associated via death domain -2.38298
UBE2G2 ubiquitin-conjugating enzyme E2G 2 -2.38298
SC5D sterol-C5-desaturase -2.38298
TMEM208 transmembrane protein 208 -2.38298
TMEM61 transmembrane protein 61 -2.38298
DGCR8 DGCR8 microprocessor complex subunit -2.38298
NLRP6 NLR family, pyrin domain containing 6 -2.38298
QRFP pyroglutamylated RFamide peptide -2.38298
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide -2.38298
AZU1 azurocidin 1 -2.38298
HSPD1 heat shock 60kDa protein 1 (chaperonin) -2.38298
DNAH2 dynein, axonemal, heavy chain 2 -2.38298
CD8B CD8b molecule -2.38298
POTEF POTE ankyrin domain family, member F -2.38298
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 -2.38298
LRRC24 leucine rich repeat containing 24 -2.38298
MEIS2 Meis homeobox 2 -2.38298
SLC25A29 solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 -2.35087
CIMAP3 ciliary microtubule associated protein 3 -2.34896
PXDNL peroxidasin-like -2.34048
PRMT1 protein arginine methyltransferase 1 -2.31266
WASL Wiskott-Aldrich syndrome-like -2.31033
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -2.30485
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) -2.2871
STK33 serine/threonine kinase 33 -2.28206
FAM13C family with sequence similarity 13, member C -2.28041
SPTSSA serine palmitoyltransferase, small subunit A -2.27303
ZNF267 zinc finger protein 267 -2.26772
NUDC nudC nuclear distribution protein -2.26772
ZNF160 zinc finger protein 160 -2.25204
ADO 2-aminoethanethiol (cysteamine) dioxygenase -2.22608
TK1 thymidine kinase 1, soluble -2.22608
CCDC12 coiled-coil domain containing 12 -2.22608
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 -2.22125
PDHX pyruvate dehydrogenase complex, component X -2.17833
COX18 COX18 cytochrome c oxidase assembly factor -2.17833
CFAP70 cilia and flagella associated protein 70 -2.17667
FLACC1 flagellum associated containing coiled-coil domains 1 -2.17667
NCAPD3 non-SMC condensin II complex, subunit D3 -2.17667
IL20RA interleukin 20 receptor, alpha -2.17667
SYNGAP1 synaptic Ras GTPase activating protein 1 -2.16526
TP53BP2 tumor protein p53 binding protein 2 -2.16526
TMEM144 transmembrane protein 144 -2.16358
MARCHF3 membrane associated ring-CH-type finger 3 -2.15886
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1) -2.15539
TARDBP TAR DNA binding protein -2.14789
SCAPER S-phase cyclin A-associated protein in the ER -2.14034
NKAIN1 Na+/K+ transporting ATPase interacting 1 -2.13253
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 -2.12079
RPL21 ribosomal protein L21 -2.11887
PTGES prostaglandin E synthase -2.11887
LDLRAD3 low density lipoprotein receptor class A domain containing 3 -2.11262
NXPH2 neurexophilin 2 -2.10062
SCAMP3 secretory carrier membrane protein 3 -2.10062
OTUD6B OTU domain containing 6B -2.09217
PLXDC2 plexin domain containing 2 -2.08029
HIBCH 3-hydroxyisobutyryl-CoA hydrolase -2.069
PHETA1 PH domain containing endocytic trafficking adaptor 1 -2.04194
TP53BP1 tumor protein p53 binding protein 1 -2.03848
ROR1 receptor tyrosine kinase-like orphan receptor 1 -2.03227
ZNF586 zinc finger protein 586 -2.02157
CDT1 chromatin licensing and DNA replication factor 1 -2.0086