| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | cytochrome P450, family 3, subfamily A, polypeptide 4|This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011] (NCBI Entrez Gene Database, 1576) |
| External Link | https://ncbi.nlm.nih.gov/gene/1576 |
| Similar Terms | |
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499 genes differentially expressed following the CYP3A4 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CSTA | cystatin A (stefin A) | 0.0178019 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0174219 |
| S100A8 | S100 calcium binding protein A8 | 0.0170364 |
| MT1X | metallothionein 1X | 0.0158333 |
| KRT5 | keratin 5, type II | 0.0155134 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.0150285 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0148534 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 | 0.0142802 |
| AQP1 | aquaporin 1 (Colton blood group) | 0.0141059 |
| MT1G | metallothionein 1G | 0.0135677 |
| MGP | matrix Gla protein | 0.0134583 |
| CRYBG1 | crystallin beta-gamma domain containing 1 | 0.013357 |
| ADIRF | adipogenesis regulatory factor | 0.0131408 |
| MT2A | metallothionein 2A | 0.0130308 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.01291 |
| S100A2 | S100 calcium binding protein A2 | 0.0127617 |
| KRT14 | keratin 14, type I | 0.0124734 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0124477 |
| KRT6A | keratin 6A, type II | 0.012275 |
| MT1H | metallothionein 1H | 0.0122238 |
| MT1HL1 | metallothionein 1H-like 1 | 0.0121436 |
| SLPI | secretory leukocyte peptidase inhibitor | 0.0119656 |
| MT1F | metallothionein 1F | 0.0118863 |
| MT1E | metallothionein 1E | 0.0116438 |
| ANXA1 | annexin A1 | 0.0114952 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | 0.011394 |
| COG7 | component of oligomeric golgi complex 7 | 0.0112466 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | 0.0111711 |
| CADM1 | cell adhesion molecule 1 | 0.0110165 |
| CLU | clusterin | 0.0109775 |
| GPM6B | glycoprotein M6B | 0.01088 |
| STOM | stomatin | 0.0108633 |
| CD9 | CD9 molecule | 0.0106461 |
| SPRR1B | small proline-rich protein 1B | 0.0106305 |
| KRT17 | keratin 17, type I | 0.0105253 |
| VWF | von Willebrand factor | 0.0105116 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | 0.0104249 |
| SPARCL1 | SPARC-like 1 (hevin) | 0.0102337 |
| PI3 | peptidase inhibitor 3, skin-derived | 0.0101736 |
| KRT6B | keratin 6B, type II | 0.00999574 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0098916 |
| A2M | alpha-2-macroglobulin | 0.00977262 |
| FUCA1 | fucosidase, alpha-L- 1, tissue | 0.00951108 |
| MALL | mal, T-cell differentiation protein-like | 0.00931404 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | 0.00920921 |
| RBM34 | RNA binding motif protein 34 | 0.00916791 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.00916158 |
| LAMP3 | lysosomal-associated membrane protein 3 | 0.00909741 |
| KYNU | kynureninase | 0.0090817 |
| THBD | thrombomodulin | 0.00900259 |
| HIST1H2AC | histone cluster 1, H2ac | 0.00889245 |
| SPRR3 | small proline-rich protein 3 | 0.0088826 |
| MXRA7 | matrix-remodelling associated 7 | 0.00886694 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.00886569 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | 0.0088357 |
| S100A9 | S100 calcium binding protein A9 | 0.00880134 |
| CETN2 | centrin, EF-hand protein, 2 | 0.00875077 |
| FN1 | fibronectin 1 | 0.00869006 |
| GLUL | glutamate-ammonia ligase | 0.00846384 |
| S100A7 | S100 calcium binding protein A7 | 0.00841202 |
| TRIM22 | tripartite motif containing 22 | 0.00839028 |
| FZD6 | frizzled class receptor 6 | 0.00828282 |
| CX3CL1 | chemokine (C-X3-C motif) ligand 1 | 0.0082552 |
| TRIM29 | tripartite motif containing 29 | 0.00823916 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | 0.00823155 |
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | 0.00822344 |
| CD59 | CD59 molecule, complement regulatory protein | 0.00822111 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.00820926 |
| CTSB | cathepsin B | 0.0081456 |
| MET | MET proto-oncogene, receptor tyrosine kinase | 0.00812171 |
| C1QB | complement component 1, q subcomponent, B chain | 0.00811861 |
| KRT13 | keratin 13, type I | 0.00811144 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.00797217 |
| CXADR | coxsackie virus and adenovirus receptor | 0.00796068 |
| LAMC2 | laminin, gamma 2 | 0.00794086 |
| CTSC | cathepsin C | 0.00791478 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | 0.00789938 |
| NFIB | nuclear factor I/B | 0.00789117 |
| IQCG | IQ motif containing G | 0.00788493 |
| RGS10 | regulator of G-protein signaling 10 | 0.00786387 |
| AREG | amphiregulin | 0.00786348 |
| IL6ST | interleukin 6 signal transducer | 0.00786249 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.00784724 |
| NEBL | nebulette | 0.00780954 |
| ZBED2 | zinc finger, BED-type containing 2 | 0.00779682 |
| RGCC | regulator of cell cycle | 0.00777743 |
| LXN | latexin | 0.00775952 |
| PERP | PERP, TP53 apoptosis effector | 0.00774813 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.00774295 |
| LYZ | lysozyme | 0.00770665 |
| FAM107A | family with sequence similarity 107, member A | 0.00766216 |
| EFHC1 | EF-hand domain (C-terminal) containing 1 | 0.00761961 |
| SH3YL1 | SH3 and SYLF domain containing 1 | 0.00761952 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.00761588 |
| TPM2 | tropomyosin 2 (beta) | 0.00758127 |
| TSC22D1 | TSC22 domain family, member 1 | 0.00755281 |
| C1QA | complement component 1, q subcomponent, A chain | 0.00751936 |
| KRT15 | keratin 15, type I | 0.00750179 |
| CLMN | calmin (calponin-like, transmembrane) | 0.00742497 |
| KLHL24 | kelch-like family member 24 | 0.00740695 |
| PLSCR1 | phospholipid scramblase 1 | 0.00734511 |
| BCL2A1 | BCL2-related protein A1 | 0.0073317 |
| LIPT1 | lipoyltransferase 1 | 0.00732437 |
| TAPBP | TAP binding protein (tapasin) | 0.00732388 |
| NRN1 | neuritin 1 | 0.00729783 |
| ACKR1 | atypical chemokine receptor 1 (Duffy blood group) | 0.00726684 |
| COPS7A | COP9 signalosome subunit 7A | 0.00722384 |
| STON1 | stonin 1 | 0.00721999 |
| RHOB | ras homolog family member B | 0.00720186 |
| MRTFB | myocardin related transcription factor B | 0.0071921 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.00718889 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.00718071 |
| SRGN | serglycin | 0.00716881 |
| ABI1 | abl-interactor 1 | 0.00713299 |
| GSTO1 | glutathione S-transferase omega 1 | 0.00711827 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0071026 |
| CMAHP | cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene | 0.00708045 |
| C1RL | complement component 1, r subcomponent-like | 0.00705434 |
| C3 | complement component 3 | 0.00705292 |
| PALLD | palladin, cytoskeletal associated protein | 0.00704943 |
| CCN2 | cellular communication network factor 2 | 0.00703209 |
| AQP3 | aquaporin 3 (Gill blood group) | 0.00701503 |
| RGS1 | regulator of G-protein signaling 1 | 0.00701049 |
| ITGB4 | integrin, beta 4 | 0.00699825 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 0.00697121 |
| SFRP1 | secreted frizzled-related protein 1 | 0.00696263 |
| CEL | carboxyl ester lipase | 0.00694415 |
| PPL | periplakin | 0.00693097 |
| BTG3 | BTG family, member 3 | 0.00691532 |
| CLEC2B | C-type lectin domain family 2, member B | 0.00685936 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.00683996 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.00683341 |
| CRIPT | cysteine-rich PDZ-binding protein | 0.00682741 |
| VSIG4 | V-set and immunoglobulin domain containing 4 | 0.00681738 |
| PIGP | phosphatidylinositol glycan anchor biosynthesis, class P | 0.00681495 |
| CHPT1 | choline phosphotransferase 1 | 0.00681055 |
| CTSS | cathepsin S | 0.00678355 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.00677603 |
| IQCK | IQ motif containing K | 0.00677565 |
| H1-2 | H1.2 linker histone, cluster member | 0.00677551 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.00676699 |
| FOXG1 | forkhead box G1 | 0.00675812 |
| CD93 | CD93 molecule | 0.00675607 |
| DCUN1D1 | DCN1, defective in cullin neddylation 1, domain containing 1 | 0.00672457 |
| ACP5 | acid phosphatase 5, tartrate resistant | 0.00669495 |
| FGF13 | fibroblast growth factor 13 | 0.00669398 |
| IGFBP4 | insulin-like growth factor binding protein 4 | 0.00669158 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.00668734 |
| IL2RG | interleukin 2 receptor, gamma | 0.00667231 |
| PEX2 | peroxisomal biogenesis factor 2 | 0.00665328 |
| BID | BH3 interacting domain death agonist | 0.00662726 |
| ETHE1 | ethylmalonic encephalopathy 1 | 0.00661904 |
| SCGB1A1 | secretoglobin, family 1A, member 1 (uteroglobin) | 0.006617 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | 0.0066068 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0065876 |
| PLTP | phospholipid transfer protein | 0.00657806 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.00656305 |
| EAPP | E2F-associated phosphoprotein | 0.00655825 |
| ERGIC3 | ERGIC and golgi 3 | 0.00654893 |
| SELE | selectin E | 0.006545 |
| EMP1 | epithelial membrane protein 1 | 0.00652497 |
| FGFBP1 | fibroblast growth factor binding protein 1 | 0.00651231 |
| MLF1 | myeloid leukemia factor 1 | 0.00647756 |
| SIRT3 | sirtuin 3 | 0.006472 |
| ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) | 0.00645816 |
| SP100 | SP100 nuclear antigen | 0.00645781 |
| GTF2H5 | general transcription factor IIH, polypeptide 5 | 0.00644909 |
| CLCA2 | chloride channel accessory 2 | 0.00641258 |
| MYO1C | myosin IC | 0.00639183 |
| IL1B | interleukin 1, beta | 0.00638858 |
| MAL | mal, T-cell differentiation protein | 0.00636252 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.00635133 |
| PON2 | paraoxonase 2 | 0.00635028 |
| GNPTAB | N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits | 0.00631895 |
| RMND1 | required for meiotic nuclear division 1 homolog (S. cerevisiae) | 0.00631878 |
| BMERB1 | bMERB domain containing 1 | 0.00631643 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | 0.00631499 |
| GLUD1 | glutamate dehydrogenase 1 | 0.00630843 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.00628319 |
| TMEM106B | transmembrane protein 106B | 0.0062682 |
| PFN2 | profilin 2 | 0.00626407 |
| KRT18 | keratin 18, type I | 0.00624557 |
| FEZ2 | fasciculation and elongation protein zeta 2 (zygin II) | 0.00624283 |
| PLVAP | plasmalemma vesicle associated protein | 0.00622568 |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 | 0.00621108 |
| NME4 | NME/NM23 nucleoside diphosphate kinase 4 | 0.00620109 |
| GLUD2 | glutamate dehydrogenase 2 | 0.00619154 |
| EFHD1 | EF-hand domain family, member D1 | 0.00616486 |
| PHF11 | PHD finger protein 11 | 0.00615321 |
| MRPL40 | mitochondrial ribosomal protein L40 | 0.00614652 |
| DSTN | destrin (actin depolymerizing factor) | 0.00614419 |
| TGIF1 | TGFB-induced factor homeobox 1 | 0.00614297 |
| PKP1 | plakophilin 1 | 0.00613828 |
| MPZL2 | myelin protein zero-like 2 | 0.00613142 |
| BDH2 | 3-hydroxybutyrate dehydrogenase, type 2 | 0.00611112 |
| ADAMDEC1 | ADAM-like, decysin 1 | 0.00610966 |
| JCHAIN | joining chain of multimeric IgA and IgM | 0.00609899 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.00607977 |
| HSBP1 | heat shock factor binding protein 1 | 0.00607731 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.00605942 |
| MTIF2 | mitochondrial translational initiation factor 2 | 0.00605854 |
| TRIM16 | tripartite motif containing 16 | 0.00605585 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.00604348 |
| CD96 | CD96 molecule | 0.00603625 |
| PEX11B | peroxisomal biogenesis factor 11 beta | 0.00603 |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 | 0.00602677 |
| CAV2 | caveolin 2 | 0.00602375 |
| AHR | aryl hydrocarbon receptor | 0.00600003 |
| CD44 | CD44 molecule (Indian blood group) | 0.00597869 |
| FAM162A | family with sequence similarity 162, member A | 0.0059715 |
| BBOX1 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 | 0.00595845 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.00592821 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.00592278 |
| PDE2A | phosphodiesterase 2A, cGMP-stimulated | 0.00591678 |
| VAMP5 | vesicle-associated membrane protein 5 | 0.00591242 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.00589538 |
| MT1M | metallothionein 1M | 0.00589174 |
| LAMA3 | laminin, alpha 3 | 0.00588406 |
| LTF | lactotransferrin | 0.00587883 |
| MMD | monocyte to macrophage differentiation-associated | 0.00587851 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.00587826 |
| CLDN8 | claudin 8 | 0.00587738 |
| CCDC28A | coiled-coil domain containing 28A | 0.00587087 |
| UBFD1 | ubiquitin family domain containing 1 | 0.00586985 |
| GPR171 | G protein-coupled receptor 171 | 0.00586101 |
| EAF2 | ELL associated factor 2 | 0.00585968 |
| LPAR6 | lysophosphatidic acid receptor 6 | 0.0058525 |
| LMO3 | LIM domain only 3 (rhombotin-like 2) | 0.00584624 |
| ANOS1 | anosmin 1 | 0.0058462 |
| GNAS | GNAS complex locus | 0.00584037 |
| PDE8B | phosphodiesterase 8B | 0.00583718 |
| GIMAP6 | GTPase, IMAP family member 6 | 0.00583641 |
| PROM1 | prominin 1 | 0.00583319 |
| JAG1 | jagged 1 | 0.00583182 |
| ATG5 | autophagy related 5 | 0.00582354 |
| SDC4 | syndecan 4 | 0.0058205 |
| YPEL5 | yippee-like 5 (Drosophila) | 0.00580568 |
| ZNF185 | zinc finger protein 185 (LIM domain) | 0.00579864 |
| SPP1 | secreted phosphoprotein 1 | 0.00579682 |
| SLC15A2 | solute carrier family 15 (oligopeptide transporter), member 2 | 0.00578706 |
| TMEM50B | transmembrane protein 50B | 0.00578571 |
| SPCS1 | signal peptidase complex subunit 1 homolog (S. cerevisiae) | 0.00578149 |
| AMZ2 | archaelysin family metallopeptidase 2 | 0.00577946 |
| CEP57 | centrosomal protein 57kDa | 0.00575611 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 0.00575165 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.00574367 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.00574079 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.00573662 |
| SCEL | sciellin | 0.00573277 |
| TSPAN13 | tetraspanin 13 | 0.00572505 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RTN2 | reticulon 2 | -0.0174946 |
| ADO | 2-aminoethanethiol (cysteamine) dioxygenase | -0.0150071 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.0148698 |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 | -0.0142986 |
| WASHC4 | WASH complex subunit 4 | -0.013874 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | -0.0135568 |
| GAS1 | growth arrest-specific 1 | -0.0129286 |
| TNNT1 | troponin T type 1 (skeletal, slow) | -0.0111737 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 | -0.0109248 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | -0.0108079 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | -0.0102635 |
| PRDX2 | peroxiredoxin 2 | -0.00978612 |
| PFKM | phosphofructokinase, muscle | -0.00973007 |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | -0.00948506 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | -0.00934354 |
| HAL | histidine ammonia-lyase | -0.00928869 |
| DLK1 | delta-like 1 homolog (Drosophila) | -0.00927315 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | -0.00922013 |
| MYBPC2 | myosin binding protein C, fast type | -0.00918811 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.00915331 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | -0.0091025 |
| TFF3 | trefoil factor 3 (intestinal) | -0.00908838 |
| WT1 | Wilms tumor 1 | -0.00896625 |
| SCG5 | secretogranin V | -0.00881532 |
| PTP4A3 | protein tyrosine phosphatase type IVA, member 3 | -0.00873342 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.00871555 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | -0.00858488 |
| ACTC1 | actin, alpha, cardiac muscle 1 | -0.00850643 |
| SFRP4 | secreted frizzled-related protein 4 | -0.00840036 |
| MB | myoglobin | -0.00838585 |
| CILP | cartilage intermediate layer protein, nucleotide pyrophosphohydrolase | -0.00828069 |
| LRRC15 | leucine rich repeat containing 15 | -0.00818009 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.00805182 |
| NEFH | neurofilament, heavy polypeptide | -0.00795217 |
| CGA | glycoprotein hormones, alpha polypeptide | -0.00792231 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.00790566 |
| CALCA | calcitonin-related polypeptide alpha | -0.00789357 |
| PTN | pleiotrophin | -0.0078329 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.00778817 |
| CKM | creatine kinase, muscle | -0.00774147 |
| TBL1X | transducin (beta)-like 1X-linked | -0.00772981 |
| PLCXD1 | phosphatidylinositol-specific phospholipase C, X domain containing 1 | -0.00760674 |
| FLNC | filamin C, gamma | -0.00746701 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | -0.00741168 |
| TTN | titin | -0.0074063 |
| TSPAN8 | tetraspanin 8 | -0.0074058 |
| ADGRG2 | adhesion G protein-coupled receptor G2 | -0.00738763 |
| LMNB2 | lamin B2 | -0.00733072 |
| STUB1 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | -0.00729879 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.00727668 |
| FHOD3 | formin homology 2 domain containing 3 | -0.00724381 |
| KCNE4 | potassium channel, voltage gated subfamily E regulatory beta subunit 4 | -0.00719815 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | -0.00717141 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -0.00709287 |
| ANXA6 | annexin A6 | -0.00701459 |
| TIMM17B | translocase of inner mitochondrial membrane 17 homolog B (yeast) | -0.00700158 |
| RXRA | retinoid X receptor, alpha | -0.00699515 |
| HTR3A | 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic | -0.00694833 |
| REC8 | REC8 meiotic recombination protein | -0.00693101 |
| RTN3 | reticulon 3 | -0.00691466 |
| PXDN | peroxidasin | -0.00690632 |
| FZD2 | frizzled class receptor 2 | -0.00688204 |
| COL10A1 | collagen, type X, alpha 1 | -0.00686026 |
| DCN | decorin | -0.00684719 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.00684668 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | -0.00684479 |
| GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | -0.00683634 |
| TNNC2 | troponin C type 2 (fast) | -0.00681808 |
| CPS1 | carbamoyl-phosphate synthase 1, mitochondrial | -0.00677437 |
| ACTA1 | actin, alpha 1, skeletal muscle | -0.00672158 |
| PDZK1IP1 | PDZK1 interacting protein 1 | -0.00672046 |
| CTH | cystathionine gamma-lyase | -0.00671591 |
| TENM3 | teneurin transmembrane protein 3 | -0.00668228 |
| GSTT1 | glutathione S-transferase theta 1 | -0.00666934 |
| NAV3 | neuron navigator 3 | -0.00662304 |
| PEG3 | paternally expressed 3 | -0.00659824 |
| CRISPLD2 | cysteine-rich secretory protein LCCL domain containing 2 | -0.00658808 |
| TENT4A | terminal nucleotidyltransferase 4A | -0.00658337 |
| BCHE | butyrylcholinesterase | -0.006582 |
| KLHL41 | kelch-like family member 41 | -0.00655843 |
| EGR2 | early growth response 2 | -0.00649762 |
| COL3A1 | collagen, type III, alpha 1 | -0.0064569 |
| YBX3 | Y box binding protein 3 | -0.00642736 |
| UBE2M | ubiquitin-conjugating enzyme E2M | -0.00642344 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | -0.00642189 |
| MLPH | melanophilin | -0.00641615 |
| CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | -0.006415 |
| MYLPF | myosin light chain, phosphorylatable, fast skeletal muscle | -0.00639364 |
| SHOX2 | short stature homeobox 2 | -0.00638752 |
| STX3 | syntaxin 3 | -0.00632599 |
| NID2 | nidogen 2 (osteonidogen) | -0.00631339 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.00630686 |
| SPON2 | spondin 2, extracellular matrix protein | -0.00624496 |
| TXLNA | taxilin alpha | -0.00623888 |
| IRX5 | iroquois homeobox 5 | -0.0062278 |
| BCAT2 | branched chain amino-acid transaminase 2, mitochondrial | -0.00620942 |
| MGLL | monoglyceride lipase | -0.00619336 |
| IRS2 | insulin receptor substrate 2 | -0.00618331 |
| MYL1 | myosin, light chain 1, alkali; skeletal, fast | -0.00618278 |
| MMP1 | matrix metallopeptidase 1 | -0.00615475 |
| PDLIM5 | PDZ and LIM domain 5 | -0.00614696 |
| SLC25A6 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 | -0.00614533 |
| ACADVL | acyl-CoA dehydrogenase, very long chain | -0.00611934 |
| NES | nestin | -0.00611659 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.00609139 |
| CRISP3 | cysteine-rich secretory protein 3 | -0.00606596 |
| RET | ret proto-oncogene | -0.00606 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | -0.00605371 |
| CHST2 | carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 | -0.00604776 |
| SHMT2 | serine hydroxymethyltransferase 2 (mitochondrial) | -0.0060462 |
| HS3ST1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 | -0.00604284 |
| TM7SF2 | transmembrane 7 superfamily member 2 | -0.00603183 |
| TK1 | thymidine kinase 1, soluble | -0.0059702 |
| APLP1 | amyloid beta (A4) precursor-like protein 1 | -0.00596589 |
| TTC38 | tetratricopeptide repeat domain 38 | -0.00593868 |
| KCNN2 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 | -0.00588545 |
| IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 | -0.00588362 |
| HOMER3 | homer scaffolding protein 3 | -0.00586063 |
| E2F2 | E2F transcription factor 2 | -0.0058551 |
| EPHX2 | epoxide hydrolase 2, cytoplasmic | -0.00585231 |
| APOA1 | apolipoprotein A-I | -0.00584158 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.00583451 |
| DACT1 | dishevelled-binding antagonist of beta-catenin 1 | -0.00583124 |
| NVL | nuclear VCP-like | -0.00578802 |
| PDZK1 | PDZ domain containing 1 | -0.00577589 |
| SOX11 | SRY (sex determining region Y)-box 11 | -0.00577428 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.00576971 |
| UBE2S | ubiquitin-conjugating enzyme E2S | -0.00576903 |
| EPHB3 | EPH receptor B3 | -0.00575071 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.00574965 |
| NLGN4X | neuroligin 4, X-linked | -0.00574825 |
| HNMT | histamine N-methyltransferase | -0.00571659 |
| TNNI1 | troponin I type 1 (skeletal, slow) | -0.00569775 |
| PDLIM3 | PDZ and LIM domain 3 | -0.00569764 |
| ITGA4 | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | -0.00569617 |
| MBOAT7 | membrane bound O-acyltransferase domain containing 7 | -0.00568812 |
| IPW | imprinted in Prader-Willi syndrome (non-protein coding) | -0.00567649 |
| GSE1 | Gse1 coiled-coil protein | -0.00566363 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | -0.0056551 |
| NREP | neuronal regeneration related protein | -0.00565141 |
| MYL2 | myosin, light chain 2, regulatory, cardiac, slow | -0.00564564 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.00563293 |
| PRUNE2 | prune homolog 2 (Drosophila) | -0.00562787 |
| MFAP2 | microfibrillar-associated protein 2 | -0.00562618 |
| ELANE | elastase, neutrophil expressed | -0.00560642 |
| APOB | apolipoprotein B | -0.0056031 |
| YARS1 | tyrosyl-tRNA synthetase 1 | -0.00557711 |
| CLC | Charcot-Leyden crystal galectin | -0.00557464 |
| S100A12 | S100 calcium binding protein A12 | -0.00556435 |
| DACH1 | dachshund family transcription factor 1 | -0.00555511 |
| TARS1 | threonyl-tRNA synthetase 1 | -0.00551625 |
| KLF13 | Kruppel-like factor 13 | -0.0055086 |
| PSG5 | pregnancy specific beta-1-glycoprotein 5 | -0.00549985 |
| DNMT3A | DNA (cytosine-5-)-methyltransferase 3 alpha | -0.00549487 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | -0.00548514 |
| ASCL1 | achaete-scute family bHLH transcription factor 1 | -0.00548403 |
| CAMK2B | calcium/calmodulin-dependent protein kinase II beta | -0.0054564 |
| PWWP3A | PWWP domain containing 3A, DNA repair factor | -0.00545569 |
| CCNL2 | cyclin L2 | -0.00545159 |
| FEN1 | flap structure-specific endonuclease 1 | -0.00544635 |
| ZWINT | ZW10 interacting kinetochore protein | -0.00543977 |
| RUFY3 | RUN and FYVE domain containing 3 | -0.00542966 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | -0.00542846 |
| FST | follistatin | -0.00542783 |
| HSPB8 | heat shock 22kDa protein 8 | -0.0054254 |
| CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | -0.00542103 |
| BIN1 | bridging integrator 1 | -0.00541761 |
| CUX1 | cut-like homeobox 1 | -0.00540856 |
| CDC20 | cell division cycle 20 | -0.00540097 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.00539842 |
| COL4A5 | collagen, type IV, alpha 5 | -0.00539405 |
| ACO2 | aconitase 2, mitochondrial | -0.00539143 |
| SPRY2 | sprouty homolog 2 (Drosophila) | -0.00539061 |
| PLK2 | polo-like kinase 2 | -0.00538879 |
| STS | steroid sulfatase (microsomal), isozyme S | -0.00538624 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | -0.00538526 |
| CLCN4 | chloride channel, voltage-sensitive 4 | -0.0053778 |
| GAS2 | growth arrest-specific 2 | -0.00537383 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.00536475 |
| NCAM1 | neural cell adhesion molecule 1 | -0.00534149 |
| CHFR | checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase | -0.00532798 |
| COL16A1 | collagen, type XVI, alpha 1 | -0.00530594 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | -0.00530375 |
| CAMKK2 | calcium/calmodulin-dependent protein kinase kinase 2, beta | -0.00528648 |
| PCDH9 | protocadherin 9 | -0.00528464 |
| COL5A1 | collagen, type V, alpha 1 | -0.00528195 |
| STK26 | serine/threonine protein kinase 26 | -0.0052583 |
| COX8A | cytochrome c oxidase subunit VIIIA (ubiquitous) | -0.00525521 |
| SLC17A6 | solute carrier family 17 (vesicular glutamate transporter), member 6 | -0.00525047 |
| CDA | cytidine deaminase | -0.00523714 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | -0.00522265 |
| CD1E | CD1e molecule | -0.00522153 |
| NXF3 | nuclear RNA export factor 3 | -0.0052203 |
| LAT2 | linker for activation of T cells family, member 2 | -0.00521745 |
| CBS | cystathionine-beta-synthase | -0.00521665 |
| PDZD8 | PDZ domain containing 8 | -0.00521335 |
| CREB1 | cAMP responsive element binding protein 1 | -0.00520985 |
| ZNF91 | zinc finger protein 91 | -0.00520515 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | -0.00515762 |
| EGR3 | early growth response 3 | -0.00515374 |
| TUBB2B | tubulin, beta 2B class IIb | -0.00514913 |
| ABCA2 | ATP-binding cassette, sub-family A (ABC1), member 2 | -0.00514817 |
| KIAA1644 | KIAA1644 | -0.00514476 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.00512662 |
| CREB3L1 | cAMP responsive element binding protein 3-like 1 | -0.00511777 |
| CLEC11A | C-type lectin domain family 11, member A | -0.005099 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.00508622 |
| SGCD | sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) | -0.00508189 |
| CD22 | CD22 molecule | -0.00507044 |
| FA2H | fatty acid 2-hydroxylase | -0.00507018 |
| ANKRD11 | ankyrin repeat domain 11 | -0.00506453 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | -0.00504307 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | -0.00504005 |
| MBL2 | mannose-binding lectin (protein C) 2, soluble | -0.00503869 |
| CERK | ceramide kinase | -0.0050354 |
| CNTNAP2 | contactin associated protein-like 2 | -0.00502814 |
| ANK2 | ankyrin 2, neuronal | -0.0050256 |
| COL4A3 | collagen, type IV, alpha 3 (Goodpasture antigen) | -0.00502085 |
| KLC2 | kinesin light chain 2 | -0.00501037 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | -0.00500901 |
| DENND2A | DENN/MADD domain containing 2A | -0.0050044 |
| RECK | reversion-inducing-cysteine-rich protein with kazal motifs | -0.00499403 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | -0.00498559 |
| H2AX | H2A.X variant histone | -0.00498518 |
| FADS1 | fatty acid desaturase 1 | -0.00497953 |
| NQO2 | NAD(P)H dehydrogenase, quinone 2 | -0.00497346 |
| PXMP2 | peroxisomal membrane protein 2, 22kDa | -0.0049727 |
| MYRF | myelin regulatory factor | -0.00497145 |
| DSC1 | desmocollin 1 | -0.00496903 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.00496622 |
| SLN | sarcolipin | -0.00496305 |
| PPP1CC | protein phosphatase 1, catalytic subunit, gamma isozyme | -0.00495479 |
| ZBED1 | zinc finger, BED-type containing 1 | -0.00495184 |
| DGKZ | diacylglycerol kinase, zeta | -0.00494775 |
| AP1M2 | adaptor-related protein complex 1, mu 2 subunit | -0.00494537 |
| MEST | mesoderm specific transcript | -0.00493828 |
| FNBP1 | formin binding protein 1 | -0.00493242 |
| GLS | glutaminase | -0.0049313 |
| CCDC28B | coiled-coil domain containing 28B | -0.0049259 |
| NIT1 | nitrilase 1 | -0.00490772 |
| C4BPB | complement component 4 binding protein, beta | -0.00490481 |
| LYPD1 | LY6/PLAUR domain containing 1 | -0.00490414 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | -0.00490299 |
| HEPH | hephaestin | -0.00489408 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | -0.00489112 |
| ADAP1 | ArfGAP with dual PH domains 1 | -0.00488455 |
| SMPX | small muscle protein, X-linked | -0.00486505 |
| MINDY1 | MINDY lysine 48 deubiquitinase 1 | -0.00485563 |
| TMSB15A | thymosin beta 15a | -0.00485372 |
