| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cabozantinib (S-malate) perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Cabozantinib (S-malate)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.207551 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.119904 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.106118 |
| FBN1 | fibrillin 1 | 0.0901292 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0840408 |
| PODXL | podocalyxin-like | 0.0778943 |
| SQSTM1 | sequestosome 1 | 0.0773996 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.067185 |
| AUTS2 | autism susceptibility candidate 2 | 0.0647526 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.059804 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0571231 |
| NAV2 | neuron navigator 2 | 0.0564596 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0561833 |
| CD109 | CD109 molecule | 0.0558643 |
| CSTB | cystatin B (stefin B) | 0.0549479 |
| MEIS2 | Meis homeobox 2 | 0.0526926 |
| GPC6 | glypican 6 | 0.0519975 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0514842 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0512218 |
| MSI2 | musashi RNA-binding protein 2 | 0.050439 |
| UBC | ubiquitin C | 0.0502638 |
| ADM | adrenomedullin | 0.049662 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0492248 |
| GOLGA4 | golgin A4 | 0.0474488 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.047339 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0470861 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0454037 |
| FNIP1 | folliculin interacting protein 1 | 0.0443527 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0441196 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.044096 |
| OGA | O-GlcNAcase | 0.0439024 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.043353 |
| PRELID2 | PRELI domain containing 2 | 0.0424824 |
| SETD5 | SET domain containing 5 | 0.0414256 |
| OPTN | optineurin | 0.0408173 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0408058 |
| LOXL2 | lysyl oxidase-like 2 | 0.0398237 |
| RUNX1 | runt-related transcription factor 1 | 0.0395712 |
| C1D | C1D nuclear receptor corepressor | 0.039327 |
| HELZ | helicase with zinc finger | 0.038143 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0379214 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0378634 |
| RND3 | Rho family GTPase 3 | 0.0375949 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0371428 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0363626 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0358696 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0351552 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0350914 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0337754 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.033525 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0333665 |
| COPA | coatomer protein complex, subunit alpha | 0.0331686 |
| DST | dystonin | 0.0331659 |
| APP | amyloid beta (A4) precursor protein | 0.0329299 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0327065 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0326318 |
| FLNA | filamin A, alpha | 0.0324297 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0323419 |
| MMP12 | matrix metallopeptidase 12 | 0.031843 |
| WDFY1 | WD repeat and FYVE domain containing 1 | 0.0316891 |
| ADAR | adenosine deaminase, RNA-specific | 0.0311425 |
| SEPTIN9 | septin 9 | 0.0311328 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | 0.0309423 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0297978 |
| SFTPA2 | surfactant protein A2 | 0.0297469 |
| PML | promyelocytic leukemia | 0.0293434 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0287476 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0286524 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0285798 |
| ATP13A3 | ATPase type 13A3 | 0.0283757 |
| BBX | bobby sox homolog (Drosophila) | 0.028372 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.028139 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0279522 |
| B2M | beta-2-microglobulin | 0.0278016 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0276873 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0276811 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0274706 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0274227 |
| PHF21A | PHD finger protein 21A | 0.0269775 |
| INSIG2 | insulin induced gene 2 | 0.026623 |
| INSIG1 | insulin induced gene 1 | 0.026475 |
| IRF1 | interferon regulatory factor 1 | 0.0263429 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0262609 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0261863 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0261652 |
| GOLGA2 | golgin A2 | 0.0261223 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0260867 |
| SUCNR1 | succinate receptor 1 | 0.0260147 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 0.0259824 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0258782 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0253645 |
| AHNAK | AHNAK nucleoprotein | 0.0252648 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0251754 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.025156 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.0248481 |
| FAM13A | family with sequence similarity 13, member A | 0.0247679 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.02455 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0244723 |
| CLU | clusterin | 0.0242478 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0239926 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.221224 |
| PLAT | plasminogen activator, tissue | -0.167113 |
| MT2A | metallothionein 2A | -0.151246 |
| TMSB10 | thymosin beta 10 | -0.141503 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.132222 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.113428 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0920369 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0779209 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0702088 |
| S100A10 | S100 calcium binding protein A10 | -0.0587257 |
| LOX | lysyl oxidase | -0.0585902 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0545869 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0528546 |
| CD44 | CD44 molecule (Indian blood group) | -0.0470547 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0455975 |
| S100A6 | S100 calcium binding protein A6 | -0.0443234 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.041985 |
| NAV1 | neuron navigator 1 | -0.0417336 |
| MYADM | myeloid-associated differentiation marker | -0.0407616 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0404699 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0385481 |
| MT1X | metallothionein 1X | -0.0373405 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0368522 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0361435 |
| PTMA | prothymosin, alpha | -0.0360859 |
| CAVIN1 | caveolae associated protein 1 | -0.0349141 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0334342 |
| GLIS3 | GLIS family zinc finger 3 | -0.0328794 |
| PRSS23 | protease, serine, 23 | -0.0325338 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0322442 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0312249 |
| MAP1B | microtubule-associated protein 1B | -0.0294139 |
| COL3A1 | collagen, type III, alpha 1 | -0.0291002 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0287106 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0285773 |
| LMNA | lamin A/C | -0.027778 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0273237 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0269323 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0268429 |
| POTEF | POTE ankyrin domain family, member F | -0.024976 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0245927 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0242796 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0237188 |
| S100A4 | S100 calcium binding protein A4 | -0.0236871 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0236213 |
| TPM4 | tropomyosin 4 | -0.0236044 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0230729 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0225599 |
| RRBP1 | ribosome binding protein 1 | -0.0220721 |
| ASPH | aspartate beta-hydroxylase | -0.0220478 |
| FN1 | fibronectin 1 | -0.02192 |
| NDRG1 | N-myc downstream regulated 1 | -0.0218155 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.021787 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.02172 |
| CCND1 | cyclin D1 | -0.021717 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0213968 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.021323 |
| PKM | pyruvate kinase, muscle | -0.021096 |
| CALR | calreticulin | -0.0210572 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0208945 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.020592 |
| SEPTIN7 | septin 7 | -0.0201728 |
| RPLP1 | ribosomal protein, large, P1 | -0.0199662 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | -0.019888 |
| DGKG | diacylglycerol kinase, gamma 90kDa | -0.0198401 |
| NPR2 | natriuretic peptide receptor 2 | -0.0196901 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.019541 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0191949 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0186582 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.018561 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0185493 |
| TUBA1B | tubulin, alpha 1b | -0.0183325 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0183316 |
| STC1 | stanniocalcin 1 | -0.0183007 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0181233 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0180549 |
| S100A11 | S100 calcium binding protein A11 | -0.0177185 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0176297 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0175994 |
| RAI1 | retinoic acid induced 1 | -0.0175384 |
| RASAL2 | RAS protein activator like 2 | -0.0171887 |
| SDC4 | syndecan 4 | -0.0171748 |
| VCL | vinculin | -0.0169636 |
| EXT1 | exostosin glycosyltransferase 1 | -0.016947 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0168292 |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | -0.0168151 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0164934 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.016318 |
| SP3 | Sp3 transcription factor | -0.0162239 |
| ZNF217 | zinc finger protein 217 | -0.016215 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0160495 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0158183 |
| OSMR | oncostatin M receptor | -0.0156872 |
| MYDGF | myeloid-derived growth factor | -0.0156101 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0155505 |
| FEZ2 | fasciculation and elongation protein zeta 2 (zygin II) | -0.0152478 |
| DIAPH3 | diaphanous-related formin 3 | -0.0151934 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0151737 |
| PFN1 | profilin 1 | -0.0147733 |
| SERPINB6 | serpin peptidase inhibitor, clade B (ovalbumin), member 6 | -0.014735 |
