Cabozantinib (S-malate)_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cabozantinib (S-malate) perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cabozantinib (S-malate)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EIF1 eukaryotic translation initiation factor 1 0.106934
TENM3 teneurin transmembrane protein 3 0.106328
SRRM2 serine/arginine repetitive matrix 2 0.0963901
MGAT4C MGAT4 family, member C 0.0954837
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0930653
ZBTB20 zinc finger and BTB domain containing 20 0.0926629
ACTG1 actin gamma 1 0.0889673
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0724453
TMSB10 thymosin beta 10 0.0713368
CNRIP1 cannabinoid receptor interacting protein 1 0.0712173
RPL23 ribosomal protein L23 0.0695849
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0691732
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0689184
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0640898
NLGN1 neuroligin 1 0.0635637
HDAC9 histone deacetylase 9 0.0610871
NACA nascent polypeptide-associated complex alpha subunit 0.0605431
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 0.0601548
BCAS3 breast carcinoma amplified sequence 3 0.0571115
MED13L mediator complex subunit 13-like 0.0560873
CALR calreticulin 0.054285
HSPA8 heat shock 70kDa protein 8 0.051344
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0500404
RPL11 ribosomal protein L11 0.0495107
PCBP2 poly(rC) binding protein 2 0.0494086
CDK6 cyclin-dependent kinase 6 0.0486813
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.0483319
EPHA6 EPH receptor A6 0.0482541
SYT1 synaptotagmin I 0.0474118
PTMA prothymosin, alpha 0.047095
PUM2 pumilio RNA-binding family member 2 0.046967
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.045755
RPL19 ribosomal protein L19 0.0454
GASK1B golgi associated kinase 1B 0.0446884
NEBL nebulette 0.0446448
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0437505
RPS19 ribosomal protein S19 0.0432933
RPS8 ribosomal protein S8 0.0430869
MMP12 matrix metallopeptidase 12 0.0429959
NCAPD2 non-SMC condensin I complex, subunit D2 0.0420871
MPG N-methylpurine-DNA glycosylase 0.0418661
PHF3 PHD finger protein 3 0.0416579
H1-0 H1.0 linker histone 0.041404
ATP11A ATPase, class VI, type 11A 0.0410884
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.040428
PDIA6 protein disulfide isomerase family A, member 6 0.0401172
ARHGAP12 Rho GTPase activating protein 12 0.0394328
ANKRD11 ankyrin repeat domain 11 0.0392937
RPL28 ribosomal protein L28 0.0389873
RPL13A ribosomal protein L13a 0.0386087
SETD5 SET domain containing 5 0.0380751
RPL34 ribosomal protein L34 0.0379675
BRD2 bromodomain containing 2 0.0377776
RPS20 ribosomal protein S20 0.0370953
RPL4 ribosomal protein L4 0.0360751
PDGFC platelet derived growth factor C 0.0339888
RPS3 ribosomal protein S3 0.0338576
RAD51B RAD51 paralog B 0.033583
NRXN3 neurexin 3 0.0331998
EEF2 eukaryotic translation elongation factor 2 0.0328596
NEK7 NIMA-related kinase 7 0.0323913
ZFAND3 zinc finger, AN1-type domain 3 0.0323445
RPL12 ribosomal protein L12 0.0322496
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0318248
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.0310987
EIF4B eukaryotic translation initiation factor 4B 0.0310084
CXADR coxsackie virus and adenovirus receptor 0.0309857
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0309618
SLC38A2 solute carrier family 38, member 2 0.0309081
ANKRD12 ankyrin repeat domain 12 0.0304124
CEP112 centrosomal protein 112kDa 0.0303345
PRRC2C proline-rich coiled-coil 2C 0.0302566
TTC3 tetratricopeptide repeat domain 3 0.030102
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.030057
ZDHHC2 zinc finger, DHHC-type containing 2 0.0300473
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0299503
RPS6 ribosomal protein S6 0.0299046
RPLP2 ribosomal protein, large, P2 0.0296275
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0295805
PRRC2A proline-rich coiled-coil 2A 0.0295632
NCOR1 nuclear receptor corepressor 1 0.0290613
GOLGA4 golgin A4 0.029047
LOC112694756 uncharaterized LOC112694756 0.0289262
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0288692
ASTN2 astrotactin 2 0.0287831
ERO1B endoplasmic reticulum oxidoreductase 1 beta 0.0287709
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0287578
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.028749
RPL35A ribosomal protein L35a 0.0285536
TNRC6A trinucleotide repeat containing 6A 0.028348
KLHL24 kelch-like family member 24 0.0283264
CAMKMT calmodulin-lysine N-methyltransferase 0.0282737
SMYD3 SET and MYND domain containing 3 0.0282314
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0282007
LARP1 La ribonucleoprotein domain family, member 1 0.0281398
PARD3 par-3 family cell polarity regulator 0.0281026
CPOX coproporphyrinogen oxidase 0.028026
HDLBP high density lipoprotein binding protein 0.0280241
DDB2 damage-specific DNA binding protein 2, 48kDa 0.027973
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) 0.0277398

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.132929
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.10186
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0954641
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0827056
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0800598
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0632598
RASAL2 RAS protein activator like 2 -0.0627506
JMJD1C jumonji domain containing 1C -0.0569921
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0516334
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.046991
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0451552
RAB7A RAB7A, member RAS oncogene family -0.0450637
AREG amphiregulin -0.0442678
RTN4 reticulon 4 -0.041573
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0414015
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0396003
ERBIN erbb2 interacting protein -0.0386858
EGR1 early growth response 1 -0.0370607
GJA1 gap junction protein, alpha 1, 43kDa -0.0363531
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0361489
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0359796
TXNRD1 thioredoxin reductase 1 -0.0359677
CLDN1 claudin 1 -0.035298
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0343994
EZR ezrin -0.0330857
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0330752
TM4SF1 transmembrane 4 L six family member 1 -0.0320757
TMEM41B transmembrane protein 41B -0.031919
MARCHF4 membrane associated ring-CH-type finger 4 -0.0311673
ASPH aspartate beta-hydroxylase -0.0306513
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0304384
ZNF804A zinc finger protein 804A -0.0298917
EHBP1 EH domain binding protein 1 -0.0290657
MYL12B myosin, light chain 12B, regulatory -0.0287775
NAV3 neuron navigator 3 -0.0283936
LDHA lactate dehydrogenase A -0.028
NHSL1 NHS-like 1 -0.0275827
CSNK1A1 casein kinase 1, alpha 1 -0.0275389
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0270512
MTAP methylthioadenosine phosphorylase -0.0256892
CCND1 cyclin D1 -0.0244669
GCG glucagon -0.0239436
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0236677
VDAC1 voltage-dependent anion channel 1 -0.0234536
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0231317
VCL vinculin -0.0230029
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0225044
ANKRD17 ankyrin repeat domain 17 -0.0215638
HMGA1 high mobility group AT-hook 1 -0.0212741
BIRC3 baculoviral IAP repeat containing 3 -0.0212249
VMP1 vacuole membrane protein 1 -0.0209193
KLF6 Kruppel-like factor 6 -0.0208903
FTL ferritin, light polypeptide -0.0208355
POTEF POTE ankyrin domain family, member F -0.0207244
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0205604
PKM pyruvate kinase, muscle -0.0198644
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -0.0197286
CCDC47 coiled-coil domain containing 47 -0.0196432
HMGA2 high mobility group AT-hook 2 -0.0195884
YBX3 Y box binding protein 3 -0.0195839
IPO7 importin 7 -0.0193873
PRIM2 primase, DNA, polypeptide 2 (58kDa) -0.0192145
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0190654
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0190343
PRDX1 peroxiredoxin 1 -0.0190113
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit -0.0189252
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.018881
BLZF1 basic leucine zipper nuclear factor 1 -0.018657
NABP1 nucleic acid binding protein 1 -0.0184875
UBXN4 UBX domain protein 4 -0.0184504
SMC4 structural maintenance of chromosomes 4 -0.0184227
CHD4 chromodomain helicase DNA binding protein 4 -0.0184152
ARL5B ADP-ribosylation factor-like 5B -0.0178982
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0178757
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0178344
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G -0.0174969
CCT8 chaperonin containing TCP1, subunit 8 (theta) -0.0171289
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0167829
TMEM123 transmembrane protein 123 -0.016769
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0167456
GTPBP4 GTP binding protein 4 -0.016398
ANXA1 annexin A1 -0.0162672
MKI67 marker of proliferation Ki-67 -0.0161454
BCHE butyrylcholinesterase -0.0155927
DLC1 DLC1 Rho GTPase activating protein -0.0155154
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0153616
KPNB1 karyopherin (importin) beta 1 -0.0151987
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0151424
RAI14 retinoic acid induced 14 -0.015142
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0151047
BIRC2 baculoviral IAP repeat containing 2 -0.0150881
TUBA1B tubulin, alpha 1b -0.0148927
RCOR1 REST corepressor 1 -0.0148573
ZFAND6 zinc finger, AN1-type domain 6 -0.0147112
PARD6B par-6 family cell polarity regulator beta -0.0146991
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0146747
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0146249
TPM4 tropomyosin 4 -0.0145793
RPL7L1 ribosomal protein L7-like 1 -0.0144791
NSUN6 NOP2/Sun domain family, member 6 -0.0143235