Cabozantinib (S-malate)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cabozantinib (S-malate) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cabozantinib (S-malate)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.105238
CSF1 colony stimulating factor 1 (macrophage) 0.103126
EIF1 eukaryotic translation initiation factor 1 0.0943434
DENND2B DENN domain containing 2B 0.0859422
SMAD3 SMAD family member 3 0.0847564
PBX1 pre-B-cell leukemia homeobox 1 0.0813933
MYH9 myosin, heavy chain 9, non-muscle 0.0800362
G0S2 G0/G1 switch 2 0.0766561
NAMPT nicotinamide phosphoribosyltransferase 0.0754062
ICAM1 intercellular adhesion molecule 1 0.0711124
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0688777
RPS6 ribosomal protein S6 0.0688248
RPL23 ribosomal protein L23 0.0666887
TPT1 tumor protein, translationally-controlled 1 0.0636717
FAM13A family with sequence similarity 13, member A 0.0632776
HLA-B major histocompatibility complex, class I, B 0.062378
TRIO trio Rho guanine nucleotide exchange factor 0.0610183
IRS2 insulin receptor substrate 2 0.0587978
RPS20 ribosomal protein S20 0.0575396
CP ceruloplasmin (ferroxidase) 0.055916
RPL28 ribosomal protein L28 0.0548338
NRIP1 nuclear receptor interacting protein 1 0.0502496
RPL26 ribosomal protein L26 0.0488288
FTH1 ferritin, heavy polypeptide 1 0.0484648
ANKRD11 ankyrin repeat domain 11 0.0458659
RPS8 ribosomal protein S8 0.0447722
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0441271
RUNX1 runt-related transcription factor 1 0.0424516
KYNU kynureninase 0.0418049
CA12 carbonic anhydrase XII 0.0417869
ANKRD33B ankyrin repeat domain 33B 0.0417119
APP amyloid beta (A4) precursor protein 0.0415864
RPL34 ribosomal protein L34 0.0406272
PDLIM5 PDZ and LIM domain 5 0.0400203
RPL35A ribosomal protein L35a 0.0396476
FNDC3B fibronectin type III domain containing 3B 0.0393611
RPS4X ribosomal protein S4, X-linked 0.0387161
SOD2 superoxide dismutase 2, mitochondrial 0.038692
NFE2L1 nuclear factor, erythroid 2-like 1 0.0386397
MBNL2 muscleblind-like splicing regulator 2 0.0373195
NFIA nuclear factor I/A 0.0361738
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0360631
DAPK1 death-associated protein kinase 1 0.0360234
NDRG1 N-myc downstream regulated 1 0.0358528
ARRDC3 arrestin domain containing 3 0.0349904
NAP1L1 nucleosome assembly protein 1-like 1 0.0346972
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0343858
LOC112694756 uncharaterized LOC112694756 0.034276
ANKRD10 ankyrin repeat domain 10 0.034108
ETV6 ets variant 6 0.0336001
RPL19 ribosomal protein L19 0.0322965
NFIB nuclear factor I/B 0.0322118
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0321791
ARHGAP26 Rho GTPase activating protein 26 0.031927
RPLP2 ribosomal protein, large, P2 0.0313358
DENND4C DENN/MADD domain containing 4C 0.031165
PML promyelocytic leukemia 0.0311432
RPLP1 ribosomal protein, large, P1 0.0311415
SHB Src homology 2 domain containing adaptor protein B 0.0310706
SQSTM1 sequestosome 1 0.0308064
SRRM2 serine/arginine repetitive matrix 2 0.0307526
RPL12 ribosomal protein L12 0.0306895
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.030625
RPL11 ribosomal protein L11 0.0305039
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0299381
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0297828
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0297421
FLNA filamin A, alpha 0.0294746
NACA nascent polypeptide-associated complex alpha subunit 0.0292294
ACTG1 actin gamma 1 0.0292138
RPS19 ribosomal protein S19 0.0291349
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0289361
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0288762
RNF213 ring finger protein 213 0.0288168
TNRC6A trinucleotide repeat containing 6A 0.0287417
RBM33 RNA binding motif protein 33 0.0285261
PLPP3 phospholipid phosphatase 3 0.028461
HSPA8 heat shock 70kDa protein 8 0.0283289
RPL37 ribosomal protein L37 0.0282253
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0281736
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0280867
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0279166
RPL13A ribosomal protein L13a 0.0278946
DNM2 dynamin 2 0.0278168
GDA guanine deaminase 0.0276158
ADM adrenomedullin 0.0274845
BIRC3 baculoviral IAP repeat containing 3 0.0273856
HOMER2 homer scaffolding protein 2 0.0272606
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0270247
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0266928
AFF1 AF4/FMR2 family, member 1 0.0266865
HLA-C major histocompatibility complex, class I, C 0.026627
FOXP1 forkhead box P1 0.026415
RPS12 ribosomal protein S12 0.0263927
USP3 ubiquitin specific peptidase 3 0.0261299
EIF4H eukaryotic translation initiation factor 4H 0.0261099
SEPTIN9 septin 9 0.0260167
DSCAM Down syndrome cell adhesion molecule 0.0259556
AOPEP aminopeptidase O (putative) 0.025893
HELZ helicase with zinc finger 0.0258348

decreased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 -0.163005
IGFBP3 insulin-like growth factor binding protein 3 -0.158023
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.133792
FRMD4A FERM domain containing 4A -0.127542
VIM vimentin -0.124644
RAI14 retinoic acid induced 14 -0.117542
ASPH aspartate beta-hydroxylase -0.11558
MAP1B microtubule-associated protein 1B -0.0898903
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0834419
POTEF POTE ankyrin domain family, member F -0.0747017
TXNRD1 thioredoxin reductase 1 -0.0731474
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0725207
ZFP36L1 ZFP36 ring finger protein-like 1 -0.071072
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0632087
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0595326
CALU calumenin -0.0502797
TPM4 tropomyosin 4 -0.0432128
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.042251
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0419941
SCFD2 sec1 family domain containing 2 -0.0418535
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0418522
RRBP1 ribosome binding protein 1 -0.0413052
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0396193
VMP1 vacuole membrane protein 1 -0.0384921
DIAPH3 diaphanous-related formin 3 -0.0376745
RND3 Rho family GTPase 3 -0.0376344
BLZF1 basic leucine zipper nuclear factor 1 -0.0372493
MYADM myeloid-associated differentiation marker -0.0371496
CD44 CD44 molecule (Indian blood group) -0.0370653
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0369631
PLK2 polo-like kinase 2 -0.035077
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0346987
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0342814
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0342719
FN1 fibronectin 1 -0.0325568
EHBP1 EH domain binding protein 1 -0.0323111
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0318578
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0315354
PFN1 profilin 1 -0.031403
TUBA1B tubulin, alpha 1b -0.0310521
BIRC6 baculoviral IAP repeat containing 6 -0.030487
CDCP1 CUB domain containing protein 1 -0.0299649
TLN1 talin 1 -0.0296596
TRAM1 translocation associated membrane protein 1 -0.0295196
CBX3 chromobox homolog 3 -0.0294192
TTC3 tetratricopeptide repeat domain 3 -0.0289866
ATP13A3 ATPase type 13A3 -0.0288145
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0279822
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0278889
CREB5 cAMP responsive element binding protein 5 -0.0275856
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0274937
DGKD diacylglycerol kinase, delta 130kDa -0.027465
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 -0.0272795
ERLEC1 endoplasmic reticulum lectin 1 -0.0267835
EXT1 exostosin glycosyltransferase 1 -0.026691
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.026622
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0264803
CD82 CD82 molecule -0.0261973
GDF15 growth differentiation factor 15 -0.0258523
EIF5B eukaryotic translation initiation factor 5B -0.0258066
JUN jun proto-oncogene -0.0253689
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0253376
CCL2 chemokine (C-C motif) ligand 2 -0.0252784
TGFB2 transforming growth factor, beta 2 -0.0250031
VDAC1 voltage-dependent anion channel 1 -0.0249128
LTN1 listerin E3 ubiquitin protein ligase 1 -0.0246873
ARL4C ADP-ribosylation factor-like 4C -0.0246388
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0245054
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) -0.0243765
SEC31A SEC31 homolog A (S. cerevisiae) -0.0243207
CLMP CXADR-like membrane protein -0.0239023
MTDH metadherin -0.0237149
RRM2 ribonucleotide reductase M2 -0.0236825
USP34 ubiquitin specific peptidase 34 -0.0236741
SLC31A1 solute carrier family 31 (copper transporter), member 1 -0.0231734
NUP98 nucleoporin 98kDa -0.0231135
EML4 echinoderm microtubule associated protein like 4 -0.0229911
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0228975
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0228765
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -0.0226573
PKM pyruvate kinase, muscle -0.0226335
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0225741
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -0.0225416
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0223721
NOLC1 nucleolar and coiled-body phosphoprotein 1 -0.0223233
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0218419
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -0.0218116
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0216094
NUDCD1 NudC domain containing 1 -0.0213557
EVI5 ecotropic viral integration site 5 -0.0211362
MORF4L2 mortality factor 4 like 2 -0.0211023
LMAN1 lectin, mannose-binding, 1 -0.0210639
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 -0.021003
SPAG9 sperm associated antigen 9 -0.0208104
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0208074
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0207952
KPNB1 karyopherin (importin) beta 1 -0.020629
ADAM10 ADAM metallopeptidase domain 10 -0.0203138
TFPI2 tissue factor pathway inhibitor 2 -0.0200581
TOR1AIP2 torsin A interacting protein 2 -0.0199346