| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cabozantinib (S-malate) perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Cabozantinib (S-malate)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SMAD3 | SMAD family member 3 | 0.14421 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.130191 |
| KYNU | kynureninase | 0.121782 |
| ACTG1 | actin gamma 1 | 0.115026 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0928074 |
| PDE10A | phosphodiesterase 10A | 0.084038 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0631685 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0564772 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0564198 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.055591 |
| RPL23 | ribosomal protein L23 | 0.0537987 |
| RPS6 | ribosomal protein S6 | 0.0533088 |
| NAV2 | neuron navigator 2 | 0.0528366 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0525703 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0523693 |
| SMYD3 | SET and MYND domain containing 3 | 0.0493513 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0492119 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.049135 |
| FNDC3B | fibronectin type III domain containing 3B | 0.048703 |
| TGM2 | transglutaminase 2 | 0.048293 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0450558 |
| PLEC | plectin | 0.0439455 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.043582 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0434368 |
| RNF145 | ring finger protein 145 | 0.0434052 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0426883 |
| RPL4 | ribosomal protein L4 | 0.0420468 |
| RPL26 | ribosomal protein L26 | 0.0417269 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0398771 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0384688 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0378498 |
| FLNA | filamin A, alpha | 0.0376966 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0374717 |
| KRT7 | keratin 7, type II | 0.0373724 |
| ASPH | aspartate beta-hydroxylase | 0.0357697 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0357032 |
| HSPA8 | heat shock 70kDa protein 8 | 0.035488 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0354617 |
| SEPTIN9 | septin 9 | 0.0345979 |
| ETNK1 | ethanolamine kinase 1 | 0.0344342 |
| RPL13A | ribosomal protein L13a | 0.0341913 |
| PCBP2 | poly(rC) binding protein 2 | 0.0336873 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0325145 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0318099 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0317485 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0314854 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0308061 |
| RPL11 | ribosomal protein L11 | 0.0306099 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0303995 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0297358 |
| KIRREL3 | kin of IRRE like 3 (Drosophila) | 0.0296243 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0289706 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.028702 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0283735 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0278473 |
| INTS6 | integrator complex subunit 6 | 0.0277943 |
| ST6GAL2 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 | 0.0277555 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0273434 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0272344 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0268856 |
| GPRIN3 | GPRIN family member 3 | 0.0268646 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0266421 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0265856 |
| RPL19 | ribosomal protein L19 | 0.0265575 |
| RPL28 | ribosomal protein L28 | 0.0265068 |
| GRAMD1A | GRAM domain containing 1A | 0.0263897 |
| FAT1 | FAT atypical cadherin 1 | 0.0261145 |
| SQSTM1 | sequestosome 1 | 0.0255597 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0254072 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0254055 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0252653 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0251591 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0251286 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0250524 |
| RPS16 | ribosomal protein S16 | 0.0247892 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0246349 |
| RPS20 | ribosomal protein S20 | 0.0244851 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0244355 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0244246 |
| ANTXR1 | anthrax toxin receptor 1 | 0.0242763 |
| BPTF | bromodomain PHD finger transcription factor | 0.0242045 |
| CA8 | carbonic anhydrase VIII | 0.0242038 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0240287 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.023986 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0228629 |
| BCL2L1 | BCL2-like 1 | 0.0228509 |
| PCM1 | pericentriolar material 1 | 0.0224842 |
| TMEM245 | transmembrane protein 245 | 0.0222511 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0221887 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0220548 |
| PDZD8 | PDZ domain containing 8 | 0.0219604 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0215168 |
| ACLY | ATP citrate lyase | 0.0214727 |
| RBM33 | RNA binding motif protein 33 | 0.021425 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0213713 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | 0.0211288 |
| AADAC | arylacetamide deacetylase | 0.0211047 |
| KRT8 | keratin 8, type II | 0.020907 |
| LAMA5 | laminin, alpha 5 | 0.0208529 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0208466 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.33342 |
| NDRG1 | N-myc downstream regulated 1 | -0.156565 |
| EFNA5 | ephrin-A5 | -0.127282 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.119365 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.112917 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.103431 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0973224 |
| VIM | vimentin | -0.0720042 |
| TMSB10 | thymosin beta 10 | -0.0713836 |
| STC1 | stanniocalcin 1 | -0.0622642 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0610864 |
| EHBP1 | EH domain binding protein 1 | -0.0560306 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0538246 |
| TXNRD1 | thioredoxin reductase 1 | -0.053531 |
| RRBP1 | ribosome binding protein 1 | -0.0532603 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0518707 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0508139 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0496354 |
| MT1X | metallothionein 1X | -0.0492981 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0474689 |
| MAP1B | microtubule-associated protein 1B | -0.0469839 |
| RIN2 | Ras and Rab interactor 2 | -0.0461073 |
| LDHA | lactate dehydrogenase A | -0.0457299 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0455183 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.043818 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0435258 |
| RIGI | RNA sensor RIG-I | -0.0422746 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0417737 |
| CANX | calnexin | -0.0416784 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0410905 |
| MT2A | metallothionein 2A | -0.0409441 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0409028 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0401162 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0401125 |
| ATG7 | autophagy related 7 | -0.039808 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0393241 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0385242 |
| CLTC | clathrin, heavy chain (Hc) | -0.0383833 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0373972 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0370276 |
| CALU | calumenin | -0.0369496 |
| RAI14 | retinoic acid induced 14 | -0.0369015 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0368254 |
| GOLGA4 | golgin A4 | -0.0360181 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0358685 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0355682 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0348282 |
| LAMB3 | laminin, beta 3 | -0.0344694 |
| S100A6 | S100 calcium binding protein A6 | -0.0339188 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0333498 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0328984 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0326572 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0324629 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0323748 |
| NGLY1 | N-glycanase 1 | -0.0323117 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0316197 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0315772 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0314419 |
| ANXA2 | annexin A2 | -0.0306367 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0305151 |
| CA12 | carbonic anhydrase XII | -0.0302897 |
| SBF2 | SET binding factor 2 | -0.030234 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0295131 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | -0.029105 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.028833 |
| OSMR | oncostatin M receptor | -0.0288054 |
| TPM4 | tropomyosin 4 | -0.0287143 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0286988 |
| GOSR1 | golgi SNAP receptor complex member 1 | -0.0286741 |
| SRP54 | signal recognition particle 54kDa | -0.0285605 |
| FA2H | fatty acid 2-hydroxylase | -0.0284203 |
| BMERB1 | bMERB domain containing 1 | -0.0281803 |
| COPA | coatomer protein complex, subunit alpha | -0.0279991 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | -0.027922 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.027896 |
| LOXL2 | lysyl oxidase-like 2 | -0.0277115 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0276683 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0276211 |
| SEC24A | SEC24 family member A | -0.027361 |
| GOLGB1 | golgin B1 | -0.0272239 |
| HDLBP | high density lipoprotein binding protein | -0.0268914 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0267626 |
| WASF2 | WAS protein family, member 2 | -0.0257864 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0257833 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0256076 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0254234 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0253203 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0252391 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0251519 |
| CLINT1 | clathrin interactor 1 | -0.0249337 |
| EGFR | epidermal growth factor receptor | -0.0246814 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0245037 |
| COL5A2 | collagen, type V, alpha 2 | -0.0244494 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.0243058 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0242802 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.02407 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0238758 |
| CDCP1 | CUB domain containing protein 1 | -0.0233251 |
| CCDC88A | coiled-coil domain containing 88A | -0.0232074 |
| FAM13A | family with sequence similarity 13, member A | -0.0230354 |
