| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cabozantinib (S-malate) perturbation in AsPC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Cabozantinib (S-malate)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMTK2 | lemur tyrosine kinase 2 | 0.138312 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.134269 |
| PLEC | plectin | 0.124147 |
| SMAD3 | SMAD family member 3 | 0.110523 |
| PTMA | prothymosin, alpha | 0.101756 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0953906 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0885152 |
| SQSTM1 | sequestosome 1 | 0.0833845 |
| ACTG1 | actin gamma 1 | 0.0778329 |
| TMSB10 | thymosin beta 10 | 0.0774381 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0734674 |
| FNDC3B | fibronectin type III domain containing 3B | 0.072945 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0726776 |
| PRELID2 | PRELI domain containing 2 | 0.0720799 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0714634 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0698872 |
| KRT18 | keratin 18, type I | 0.0687943 |
| KRT8 | keratin 8, type II | 0.0641715 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0620594 |
| PGK1 | phosphoglycerate kinase 1 | 0.0573727 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0570029 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0564147 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0561694 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0542918 |
| ITGB8 | integrin, beta 8 | 0.0536722 |
| OGA | O-GlcNAcase | 0.0530299 |
| EGFR | epidermal growth factor receptor | 0.0529584 |
| EZR | ezrin | 0.052358 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0523544 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0521991 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0519429 |
| TUFT1 | tuftelin 1 | 0.0512909 |
| VCAN | versican | 0.05116 |
| PLA2R1 | phospholipase A2 receptor 1, 180kDa | 0.0510097 |
| LMO7 | LIM domain 7 | 0.0509062 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0504836 |
| PTK2 | protein tyrosine kinase 2 | 0.0502315 |
| ANXA11 | annexin A11 | 0.0494361 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0492087 |
| AHNAK | AHNAK nucleoprotein | 0.0489727 |
| B2M | beta-2-microglobulin | 0.0487409 |
| ARPC1A | actin related protein 2/3 complex, subunit 1A, 41kDa | 0.048214 |
| RBM39 | RNA binding motif protein 39 | 0.0478618 |
| H1-0 | H1.0 linker histone | 0.0474219 |
| TRRAP | transformation/transcription domain-associated protein | 0.0471025 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0468644 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0460197 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0453491 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0451907 |
| DST | dystonin | 0.0451223 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0450626 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0443003 |
| RPL11 | ribosomal protein L11 | 0.0436025 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0435276 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.043389 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0422956 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0418645 |
| MED13L | mediator complex subunit 13-like | 0.0413469 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.041019 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0401354 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0393649 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0390642 |
| PON2 | paraoxonase 2 | 0.039036 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0389865 |
| JMJD1C | jumonji domain containing 1C | 0.0386244 |
| RNF145 | ring finger protein 145 | 0.038282 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0381679 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0380742 |
| RPL8 | ribosomal protein L8 | 0.0376093 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0369344 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0366245 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0360629 |
| SLTM | SAFB-like, transcription modulator | 0.0359853 |
| RPS3 | ribosomal protein S3 | 0.0353597 |
| TOP1 | topoisomerase (DNA) I | 0.0352274 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0352144 |
| RPL35A | ribosomal protein L35a | 0.0351387 |
| CPNE8 | copine VIII | 0.0349047 |
| FHL2 | four and a half LIM domains 2 | 0.0347445 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0343212 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0342047 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0341911 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.034125 |
| OPTN | optineurin | 0.0340129 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.0339578 |
| DIAPH1 | diaphanous-related formin 1 | 0.033808 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0333966 |
| LY6E | lymphocyte antigen 6 complex, locus E | 0.0332526 |
| RNF213 | ring finger protein 213 | 0.0328612 |
| TMSB4X | thymosin beta 4, X-linked | 0.0327822 |
| NCOA2 | nuclear receptor coactivator 2 | 0.0326804 |
| RBM33 | RNA binding motif protein 33 | 0.0326695 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0325908 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0323419 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0323123 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0322656 |
| RPL26 | ribosomal protein L26 | 0.0322435 |
| RPS20 | ribosomal protein S20 | 0.0321098 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.0319816 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0318515 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | -0.14185 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.11761 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.0925041 |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | -0.0833138 |
| MUC17 | mucin 17, cell surface associated | -0.0770765 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0748232 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0637593 |
| POTEF | POTE ankyrin domain family, member F | -0.0593607 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | -0.0584003 |
| FLNB | filamin B, beta | -0.0582064 |
| VIM | vimentin | -0.0560117 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0551445 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0536672 |
| KLK10 | kallikrein-related peptidase 10 | -0.0476929 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0471896 |
| ITGA6 | integrin, alpha 6 | -0.0463081 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0454081 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0446816 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0439721 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0381551 |
| TXNRD1 | thioredoxin reductase 1 | -0.038077 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0373216 |
| FERMT1 | fermitin family member 1 | -0.0354572 |
| RASAL2 | RAS protein activator like 2 | -0.0348444 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0348346 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0343945 |
| CLMP | CXADR-like membrane protein | -0.0313411 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | -0.029594 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0293655 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0291034 |
| ARF4 | ADP-ribosylation factor 4 | -0.0288957 |
| LAMC2 | laminin, gamma 2 | -0.0287419 |
| TPM4 | tropomyosin 4 | -0.0280316 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0280189 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0273866 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0268203 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0251322 |
| PARD3 | par-3 family cell polarity regulator | -0.0244477 |
| MSN | moesin | -0.0233278 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | -0.0231156 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0230703 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0228877 |
| S100A11 | S100 calcium binding protein A11 | -0.0224339 |
| LAMA4 | laminin, alpha 4 | -0.022191 |
| NPSR1 | neuropeptide S receptor 1 | -0.0218295 |
| RTN4 | reticulon 4 | -0.0214349 |
| PARD6B | par-6 family cell polarity regulator beta | -0.0210883 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.020564 |
| CD44 | CD44 molecule (Indian blood group) | -0.0205604 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0202797 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0201358 |
| PLEK2 | pleckstrin 2 | -0.0200202 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0199938 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.019782 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0192064 |
| RAB7A | RAB7A, member RAS oncogene family | -0.019156 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0189322 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0187105 |
| OSMR | oncostatin M receptor | -0.0183419 |
| TUBA1B | tubulin, alpha 1b | -0.0183115 |
| HMGA2 | high mobility group AT-hook 2 | -0.0181522 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0181447 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | -0.017662 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0169672 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0168021 |
| BMP6 | bone morphogenetic protein 6 | -0.0166597 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0165972 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0163324 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0163309 |
| PERP | PERP, TP53 apoptosis effector | -0.0163294 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0161816 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0160249 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0160015 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0159045 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0158147 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0157344 |
| TXNIP | thioredoxin interacting protein | -0.0155761 |
| ENO1 | enolase 1, (alpha) | -0.0155672 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | -0.0152355 |
| WDR45B | WD repeat domain 45B | -0.0150032 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | -0.0149109 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.0148818 |
| TGFA | transforming growth factor, alpha | -0.0148128 |
| DSC3 | desmocollin 3 | -0.0145487 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0144984 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0144804 |
| ATG16L1 | autophagy related 16-like 1 (S. cerevisiae) | -0.0142801 |
| MCL1 | myeloid cell leukemia 1 | -0.0142397 |
| GORASP2 | golgi reassembly stacking protein 2, 55kDa | -0.0141924 |
| CALU | calumenin | -0.0141172 |
| TMEM165 | transmembrane protein 165 | -0.0139049 |
| CCDC88A | coiled-coil domain containing 88A | -0.0138016 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0135491 |
| DENND2C | DENN/MADD domain containing 2C | -0.0134889 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0132799 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0132171 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0132062 |
| MXD1 | MAX dimerization protein 1 | -0.0130509 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0130057 |
| IL6ST | interleukin 6 signal transducer | -0.0129678 |
