| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cabozantinib (S-malate) perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Cabozantinib (S-malate)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SRCIN1 | SRC kinase signaling inhibitor 1 | 0.165544 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.150562 |
| ACACA | acetyl-CoA carboxylase alpha | 0.139218 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.117329 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | 0.109334 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.0949915 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0859965 |
| FASN | fatty acid synthase | 0.0844455 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0712647 |
| CEP250 | centrosomal protein 250kDa | 0.0673779 |
| NFIA | nuclear factor I/A | 0.0670562 |
| ENAH | enabled homolog (Drosophila) | 0.0636823 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.062625 |
| PRLR | prolactin receptor | 0.0625097 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0605992 |
| EHMT1 | euchromatic histone-lysine N-methyltransferase 1 | 0.0586571 |
| IL1RAPL2 | interleukin 1 receptor accessory protein-like 2 | 0.0571142 |
| MSI2 | musashi RNA-binding protein 2 | 0.0565036 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 0.0559754 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0554058 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0553749 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0523848 |
| TC2N | tandem C2 domains, nuclear | 0.0517786 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0515874 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0511632 |
| VAV3 | vav 3 guanine nucleotide exchange factor | 0.0508668 |
| GSE1 | Gse1 coiled-coil protein | 0.0496659 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0494038 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0472932 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0461818 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0452903 |
| PTK2 | protein tyrosine kinase 2 | 0.0449343 |
| PSMD3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | 0.0448817 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0446365 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0441373 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0437674 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0437257 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0434596 |
| KAZN | kazrin, periplakin interacting protein | 0.0433957 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | 0.0430322 |
| HS6ST2 | heparan sulfate 6-O-sulfotransferase 2 | 0.042507 |
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | 0.0420331 |
| GRHL2 | grainyhead-like 2 (Drosophila) | 0.0419906 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0419099 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0415419 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0413067 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0404303 |
| RBM47 | RNA binding motif protein 47 | 0.0393388 |
| ASPH | aspartate beta-hydroxylase | 0.0392649 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0391707 |
| NCOA6 | nuclear receptor coactivator 6 | 0.0391677 |
| RABGAP1 | RAB GTPase activating protein 1 | 0.0382787 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0375494 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0374015 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0370609 |
| KIF1A | kinesin family member 1A | 0.0367443 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0367009 |
| YPEL2 | yippee-like 2 (Drosophila) | 0.035798 |
| CDK5RAP2 | CDK5 regulatory subunit associated protein 2 | 0.0353172 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0347169 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0345059 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0342977 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | 0.0342341 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0334418 |
| SEPTIN11 | septin 11 | 0.0334156 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0333797 |
| CADPS2 | Ca++-dependent secretion activator 2 | 0.0332858 |
| ARHGEF38 | Rho guanine nucleotide exchange factor (GEF) 38 | 0.0324594 |
| LASP1 | LIM and SH3 protein 1 | 0.0322309 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.032226 |
| TTC6 | tetratricopeptide repeat domain 6 | 0.0321501 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0318845 |
| SET | SET nuclear proto-oncogene | 0.0313282 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0312429 |
| NF1 | neurofibromin 1 | 0.0308425 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0306739 |
| ANKRD30A | ankyrin repeat domain 30A | 0.0306017 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0300444 |
| STARD3 | StAR-related lipid transfer (START) domain containing 3 | 0.0300411 |
| MLPH | melanophilin | 0.0297278 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0293134 |
| DENND1A | DENN/MADD domain containing 1A | 0.0292376 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0291013 |
| DUSP16 | dual specificity phosphatase 16 | 0.0290519 |
| STX16 | syntaxin 16 | 0.02877 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0287276 |
| MACROD2 | MACRO domain containing 2 | 0.028317 |
| EXOC4 | exocyst complex component 4 | 0.0280511 |
| EFNA1 | ephrin-A1 | 0.0278967 |
| TPCN1 | two pore segment channel 1 | 0.0274561 |
| MED24 | mediator complex subunit 24 | 0.0274242 |
| FADS2 | fatty acid desaturase 2 | 0.0271704 |
| SHROOM3 | shroom family member 3 | 0.0271492 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.027119 |
| SEC16A | SEC16 homolog A (S. cerevisiae) | 0.0270924 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0264362 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.0264352 |
| CDK12 | cyclin-dependent kinase 12 | 0.0263728 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0260955 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0259875 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.130755 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0985723 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0967277 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.086289 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0844978 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0801929 |
| NDRG1 | N-myc downstream regulated 1 | -0.0776758 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0758954 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0687916 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0684496 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0663183 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0622207 |
| DOCK5 | dedicator of cytokinesis 5 | -0.059355 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0565005 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0559771 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0548599 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0537768 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0528053 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0514461 |
| MCL1 | myeloid cell leukemia 1 | -0.0503933 |
| HLA-B | major histocompatibility complex, class I, B | -0.0501354 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0498734 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0492599 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0486887 |
| RPL19 | ribosomal protein L19 | -0.0479145 |
| TXNRD1 | thioredoxin reductase 1 | -0.0477044 |
| CDH15 | cadherin 15, type 1, M-cadherin (myotubule) | -0.0476548 |
| GRB7 | growth factor receptor-bound protein 7 | -0.0470219 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0453894 |
| LDHA | lactate dehydrogenase A | -0.0453695 |
| S100A9 | S100 calcium binding protein A9 | -0.045002 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0447972 |
| AREG | amphiregulin | -0.0441806 |
| S100A8 | S100 calcium binding protein A8 | -0.0435477 |
| EGFR | epidermal growth factor receptor | -0.0431335 |
| TMSB10 | thymosin beta 10 | -0.0427294 |
| ANXA2 | annexin A2 | -0.0425883 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0416226 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0409786 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0395386 |
| RAB7A | RAB7A, member RAS oncogene family | -0.039479 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0394525 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0391091 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0377743 |
| RAB22A | RAB22A, member RAS oncogene family | -0.0377245 |
| SMYD3 | SET and MYND domain containing 3 | -0.0375976 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0370456 |
| GLCCI1 | glucocorticoid induced 1 | -0.036409 |
| RASA2 | RAS p21 protein activator 2 | -0.0361117 |
| B2M | beta-2-microglobulin | -0.0357367 |
| CREB5 | cAMP responsive element binding protein 5 | -0.035497 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0351279 |
| PFDN4 | prefoldin subunit 4 | -0.0350543 |
| RPS19 | ribosomal protein S19 | -0.0349336 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.034261 |
| SYTL2 | synaptotagmin-like 2 | -0.0342057 |
| RPL12 | ribosomal protein L12 | -0.0340962 |
| CCND1 | cyclin D1 | -0.0340572 |
| SP100 | SP100 nuclear antigen | -0.0340474 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0340464 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0337952 |
| RPLP1 | ribosomal protein, large, P1 | -0.0333461 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0330784 |
| OSMR | oncostatin M receptor | -0.0328915 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | -0.0318952 |
| PLSCR1 | phospholipid scramblase 1 | -0.0311867 |
| STK17A | serine/threonine kinase 17a | -0.0311811 |
| S100A14 | S100 calcium binding protein A14 | -0.0310399 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0310072 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.031004 |
| S100A6 | S100 calcium binding protein A6 | -0.0308884 |
| ANXA5 | annexin A5 | -0.030454 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0300188 |
| NABP1 | nucleic acid binding protein 1 | -0.0298308 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0296419 |
| VCL | vinculin | -0.0294392 |
| RRBP1 | ribosome binding protein 1 | -0.0291426 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0285212 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0284381 |
| LMNA | lamin A/C | -0.0284296 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0278338 |
| PTMA | prothymosin, alpha | -0.0277144 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0274211 |
| TPM4 | tropomyosin 4 | -0.0273299 |
| TNIK | TRAF2 and NCK interacting kinase | -0.0272034 |
| S100P | S100 calcium binding protein P | -0.0271849 |
| LMO7 | LIM domain 7 | -0.0269455 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0266612 |
| SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | -0.0266244 |
| ANKRD36C | ankyrin repeat domain 36C | -0.0265174 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | -0.0262346 |
| MYO1D | myosin ID | -0.0260458 |
| KIAA1217 | KIAA1217 | -0.0254886 |
| CCNI | cyclin I | -0.0252244 |
| TMEM45B | transmembrane protein 45B | -0.0247071 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0246464 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0246311 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | -0.0246127 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0243883 |
| ACTG1 | actin gamma 1 | -0.024381 |
