| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cabozantinib (S-malate) perturbation in C-33 A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Cabozantinib (S-malate)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TENM3 | teneurin transmembrane protein 3 | 0.252944 |
| RAD51B | RAD51 paralog B | 0.187279 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.108281 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0941212 |
| TOX | thymocyte selection-associated high mobility group box | 0.0915815 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.086728 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | 0.0843262 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0838982 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0815915 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0783399 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0773912 |
| COL5A2 | collagen, type V, alpha 2 | 0.0765375 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | 0.0717606 |
| ZNF608 | zinc finger protein 608 | 0.071554 |
| NPAS3 | neuronal PAS domain protein 3 | 0.0689809 |
| CADM2 | cell adhesion molecule 2 | 0.0680926 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0620121 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0586565 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0575735 |
| GRID2 | glutamate receptor, ionotropic, delta 2 | 0.0571044 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0570826 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0565873 |
| SETD5 | SET domain containing 5 | 0.0564896 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0555086 |
| FOXO3 | forkhead box O3 | 0.0551807 |
| FMNL2 | formin-like 2 | 0.0549675 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0547875 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0547393 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0529094 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | 0.0526091 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0521931 |
| ACTG1 | actin gamma 1 | 0.0514861 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0505813 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0497886 |
| ATP11A | ATPase, class VI, type 11A | 0.049388 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0468593 |
| ZNF638 | zinc finger protein 638 | 0.0463311 |
| CABIN1 | calcineurin binding protein 1 | 0.0461355 |
| VMP1 | vacuole membrane protein 1 | 0.045936 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0457461 |
| OGA | O-GlcNAcase | 0.0452521 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.045064 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0448807 |
| NUP58 | nucleoporin 58 | 0.0432347 |
| PARD3 | par-3 family cell polarity regulator | 0.0425975 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0420535 |
| RBM33 | RNA binding motif protein 33 | 0.0418813 |
| PGK1 | phosphoglycerate kinase 1 | 0.0408802 |
| ADAR | adenosine deaminase, RNA-specific | 0.0407346 |
| HHIP | hedgehog interacting protein | 0.0405958 |
| JMJD1C | jumonji domain containing 1C | 0.0405375 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0396159 |
| SRSF4 | serine/arginine-rich splicing factor 4 | 0.0395322 |
| TPD52 | tumor protein D52 | 0.0393808 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0380908 |
| ATP9A | ATPase, class II, type 9A | 0.0375807 |
| H1-0 | H1.0 linker histone | 0.0373721 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0373226 |
| CCNY | cyclin Y | 0.03727 |
| DOCK3 | dedicator of cytokinesis 3 | 0.0370817 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0366134 |
| EFNA5 | ephrin-A5 | 0.0360107 |
| SON | SON DNA binding protein | 0.0356826 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0355562 |
| AUTS2 | autism susceptibility candidate 2 | 0.0348609 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0346907 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.0343637 |
| APP | amyloid beta (A4) precursor protein | 0.0343478 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0339292 |
| TPM3 | tropomyosin 3 | 0.0339186 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0338285 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0337985 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | 0.0330733 |
| DIDO1 | death inducer-obliterator 1 | 0.0328201 |
| SET | SET nuclear proto-oncogene | 0.0326252 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0322586 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0322578 |
| CEP250 | centrosomal protein 250kDa | 0.0321421 |
| PRICKLE1 | prickle homolog 1 (Drosophila) | 0.0321149 |
| PTK2 | protein tyrosine kinase 2 | 0.0319184 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0317725 |
| SMYD3 | SET and MYND domain containing 3 | 0.0309325 |
| NEBL | nebulette | 0.0309043 |
| ALDH7A1 | aldehyde dehydrogenase 7 family, member A1 | 0.0305959 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0305166 |
| CELF2 | CUGBP, Elav-like family member 2 | 0.0304331 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0299629 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.0298752 |
| YEATS2 | YEATS domain containing 2 | 0.0297715 |
| FAT1 | FAT atypical cadherin 1 | 0.0294677 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0293828 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0292196 |
| PRRC2B | proline-rich coiled-coil 2B | 0.029141 |
| YBX1 | Y box binding protein 1 | 0.0289662 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0289367 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.028919 |
| FAM168A | family with sequence similarity 168, member A | 0.0287133 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.028459 |
| PHF21A | PHD finger protein 21A | 0.0284482 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0284041 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.139291 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0828805 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0630503 |
| GNAS | GNAS complex locus | -0.0456236 |
| RPLP1 | ribosomal protein, large, P1 | -0.0427556 |
| TMSB10 | thymosin beta 10 | -0.0427029 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0383465 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0359537 |
| RPS24 | ribosomal protein S24 | -0.035678 |
| RPL30 | ribosomal protein L30 | -0.0346115 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0338688 |
| HMGB1 | high mobility group box 1 | -0.0313044 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0309125 |
| RPL38 | ribosomal protein L38 | -0.0302473 |
| ENO1 | enolase 1, (alpha) | -0.0287575 |
| VIM | vimentin | -0.0282178 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0278569 |
| MT2A | metallothionein 2A | -0.0277772 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0277114 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0257917 |
| RPLP2 | ribosomal protein, large, P2 | -0.0255863 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0252686 |
| RPL5 | ribosomal protein L5 | -0.0237659 |
| RPL37A | ribosomal protein L37a | -0.0237635 |
| CLOCK | clock circadian regulator | -0.0222881 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -0.0222121 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.0220075 |
| RPS17 | ribosomal protein S17 | -0.0215244 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0213858 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.021175 |
| TXNRD1 | thioredoxin reductase 1 | -0.0207931 |
| CCDC47 | coiled-coil domain containing 47 | -0.0206047 |
| RPS21 | ribosomal protein S21 | -0.020357 |
| RPL9 | ribosomal protein L9 | -0.0201971 |
| RPL31 | ribosomal protein L31 | -0.0199517 |
| RPL12 | ribosomal protein L12 | -0.0199041 |
| RPS8 | ribosomal protein S8 | -0.0194081 |
| RPL35A | ribosomal protein L35a | -0.019371 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0193352 |
| RPS19 | ribosomal protein S19 | -0.0191129 |
| RPL36A | ribosomal protein L36a | -0.0184936 |
| USP34 | ubiquitin specific peptidase 34 | -0.0183438 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0182376 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0180747 |
| RHOB | ras homolog family member B | -0.017994 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0175215 |
| HMGA1 | high mobility group AT-hook 1 | -0.0174023 |
| CENPE | centromere protein E, 312kDa | -0.0169639 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.0168576 |
| RACK1 | receptor for activated C kinase 1 | -0.0167057 |
| RPS29 | ribosomal protein S29 | -0.0165344 |
| EMP1 | epithelial membrane protein 1 | -0.0160455 |
| SRSF2 | serine/arginine-rich splicing factor 2 | -0.015972 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0159075 |
| TIA1 | TIA1 cytotoxic granule-associated RNA binding protein | -0.0158341 |
| RPS25 | ribosomal protein S25 | -0.0157905 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.015778 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0157756 |
| RPLP0 | ribosomal protein, large, P0 | -0.0157345 |
| CCDC138 | coiled-coil domain containing 138 | -0.0156388 |
| KLF6 | Kruppel-like factor 6 | -0.0155491 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0155191 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0155101 |
| RPL34 | ribosomal protein L34 | -0.0154679 |
| RAN | RAN, member RAS oncogene family | -0.0153236 |
| CANX | calnexin | -0.0150758 |
| SMC3 | structural maintenance of chromosomes 3 | -0.0147902 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0145797 |
| RPS27A | ribosomal protein S27a | -0.0144587 |
| RPS13 | ribosomal protein S13 | -0.0144131 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.01428 |
| MKI67 | marker of proliferation Ki-67 | -0.0142017 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0139822 |
| VMA21 | VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) | -0.0139371 |
| CCAR1 | cell division cycle and apoptosis regulator 1 | -0.0139197 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0137843 |
| RPS2 | ribosomal protein S2 | -0.0137068 |
| DNM1L | dynamin 1-like | -0.0135593 |
| AEBP2 | AE binding protein 2 | -0.013505 |
| SRP14 | signal recognition particle 14kDa (homologous Alu RNA binding protein) | -0.0133416 |
| PTMA | prothymosin, alpha | -0.0133206 |
| TUT4 | terminal uridylyl transferase 4 | -0.0132923 |
| CENPF | centromere protein F, 350/400kDa | -0.0132794 |
| S100A10 | S100 calcium binding protein A10 | -0.0131998 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0131658 |
| CEP350 | centrosomal protein 350kDa | -0.0131296 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0130909 |
| ADAM32 | ADAM metallopeptidase domain 32 | -0.0130619 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0129773 |
| DIAPH3 | diaphanous-related formin 3 | -0.0128632 |
| RPL36 | ribosomal protein L36 | -0.0128253 |
| NUP107 | nucleoporin 107kDa | -0.012769 |
| SNX14 | sorting nexin 14 | -0.0127493 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | -0.0126174 |
| SLC25A3 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 | -0.0125783 |
| TRNAU1AP | tRNA selenocysteine 1 associated protein 1 | -0.012473 |
| SRSF9 | serine/arginine-rich splicing factor 9 | -0.0123334 |
| RERG | RAS-like, estrogen-regulated, growth inhibitor | -0.0123116 |
| HDAC2 | histone deacetylase 2 | -0.012229 |
| RPS5 | ribosomal protein S5 | -0.0119726 |
