| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cabozantinib (S-malate) perturbation in CFPAC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Cabozantinib (S-malate)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.140408 |
| SMAD3 | SMAD family member 3 | 0.126373 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.101497 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0937094 |
| RPL23 | ribosomal protein L23 | 0.0888673 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0792344 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0744038 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0733703 |
| HLA-B | major histocompatibility complex, class I, B | 0.0732124 |
| HLA-C | major histocompatibility complex, class I, C | 0.0715839 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0708858 |
| NRG3 | neuregulin 3 | 0.0673536 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.064778 |
| APP | amyloid beta (A4) precursor protein | 0.0607434 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0592796 |
| HLA-A | major histocompatibility complex, class I, A | 0.0575107 |
| TOP1 | topoisomerase (DNA) I | 0.0557897 |
| ZNF292 | zinc finger protein 292 | 0.0551515 |
| RNF213 | ring finger protein 213 | 0.0543973 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0526745 |
| JAK1 | Janus kinase 1 | 0.0523753 |
| RAD51B | RAD51 paralog B | 0.0500395 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.049388 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.0483572 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0481335 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0465471 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0464931 |
| RPL4 | ribosomal protein L4 | 0.0456349 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0446412 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0442744 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0442627 |
| TMSB4X | thymosin beta 4, X-linked | 0.0436001 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0434617 |
| RPL11 | ribosomal protein L11 | 0.0432076 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0431681 |
| TMEM51 | transmembrane protein 51 | 0.0429181 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0428804 |
| ACTG1 | actin gamma 1 | 0.0426252 |
| USP3 | ubiquitin specific peptidase 3 | 0.0425454 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0425187 |
| NRP1 | neuropilin 1 | 0.0423219 |
| HPCAL1 | hippocalcin-like 1 | 0.0423149 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0423029 |
| MEF2A | myocyte enhancer factor 2A | 0.0419363 |
| EFNA5 | ephrin-A5 | 0.0418575 |
| CCNY | cyclin Y | 0.0416816 |
| APOL2 | apolipoprotein L, 2 | 0.0416009 |
| B2M | beta-2-microglobulin | 0.0409242 |
| FAM13A | family with sequence similarity 13, member A | 0.0406074 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0405263 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0399051 |
| PGK1 | phosphoglycerate kinase 1 | 0.039887 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0394727 |
| HELZ | helicase with zinc finger | 0.0389862 |
| OGA | O-GlcNAcase | 0.0389628 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0388761 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0383579 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0378373 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.037733 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0372696 |
| CLMN | calmin (calponin-like, transmembrane) | 0.0367962 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0367345 |
| TGM2 | transglutaminase 2 | 0.0366749 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0363992 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0363249 |
| PHF3 | PHD finger protein 3 | 0.0353896 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0353894 |
| IRAK3 | interleukin-1 receptor-associated kinase 3 | 0.0353044 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0350328 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0347505 |
| RPL19 | ribosomal protein L19 | 0.0345587 |
| RPL35A | ribosomal protein L35a | 0.0345316 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0344781 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0337971 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.0337106 |
| CD47 | CD47 molecule | 0.0336366 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0336164 |
| KIAA1217 | KIAA1217 | 0.033451 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0333471 |
| DDX52 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 | 0.0333195 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0330052 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | 0.0327898 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0326302 |
| CDC73 | cell division cycle 73 | 0.0324852 |
| RPS6 | ribosomal protein S6 | 0.0324018 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0323947 |
| ADAR | adenosine deaminase, RNA-specific | 0.0322943 |
| PTMA | prothymosin, alpha | 0.0321941 |
| RAP2B | RAP2B, member of RAS oncogene family | 0.0321148 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0318453 |
| PLAU | plasminogen activator, urokinase | 0.0314775 |
| RNF149 | ring finger protein 149 | 0.0313911 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0313132 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0312706 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0309517 |
| ITGB8 | integrin, beta 8 | 0.0309258 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0305997 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0304836 |
| DENND4A | DENN/MADD domain containing 4A | 0.0304537 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0303927 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.152202 |
| LAMB3 | laminin, beta 3 | -0.149352 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.136819 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.136507 |
| NDRG1 | N-myc downstream regulated 1 | -0.130092 |
| KRT19 | keratin 19, type I | -0.0831928 |
| EZR | ezrin | -0.0763011 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0750143 |
| LAMA4 | laminin, alpha 4 | -0.0710637 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.07059 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0681216 |
| LMO7 | LIM domain 7 | -0.0667881 |
| MMP7 | matrix metallopeptidase 7 | -0.0663024 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0635563 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0629599 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0624632 |
| PKM | pyruvate kinase, muscle | -0.0602448 |
| RASAL2 | RAS protein activator like 2 | -0.0600522 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0586127 |
| RAB7A | RAB7A, member RAS oncogene family | -0.054595 |
| MT1X | metallothionein 1X | -0.0540502 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0535729 |
| POTEF | POTE ankyrin domain family, member F | -0.052582 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0512874 |
| FLNB | filamin B, beta | -0.0501205 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0487135 |
| DTNA | dystrobrevin, alpha | -0.0475088 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0465923 |
| MAP1B | microtubule-associated protein 1B | -0.0459732 |
| SNAPC1 | small nuclear RNA activating complex, polypeptide 1, 43kDa | -0.0451888 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.045122 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0450471 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0450239 |
| RIOK3 | RIO kinase 3 | -0.0443629 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0431772 |
| ENO1 | enolase 1, (alpha) | -0.0431257 |
| LDHA | lactate dehydrogenase A | -0.0425981 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0423245 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0422052 |
| TPM4 | tropomyosin 4 | -0.0414963 |
| PLAT | plasminogen activator, tissue | -0.0403695 |
| UBC | ubiquitin C | -0.0398347 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0387116 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0384206 |
| FOSL1 | FOS-like antigen 1 | -0.0381274 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.037859 |
| DST | dystonin | -0.0366552 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0365869 |
| HMGA1 | high mobility group AT-hook 1 | -0.0364152 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0363446 |
| LAMC2 | laminin, gamma 2 | -0.0361431 |
| RCOR1 | REST corepressor 1 | -0.0360729 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.034747 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0339779 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0338324 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0337206 |
| DSPP | dentin sialophosphoprotein | -0.0323202 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0323099 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0319045 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0317554 |
| JUP | junction plakoglobin | -0.0314352 |
| NABP1 | nucleic acid binding protein 1 | -0.0309119 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0303711 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0301992 |
| EGR1 | early growth response 1 | -0.0298813 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0297885 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0295714 |
| EHBP1 | EH domain binding protein 1 | -0.0290106 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0289652 |
| HMGA2 | high mobility group AT-hook 2 | -0.0287335 |
| ANXA1 | annexin A1 | -0.0286921 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0283703 |
| HDAC9 | histone deacetylase 9 | -0.0282722 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0282714 |
| AREG | amphiregulin | -0.0272549 |
| S100A6 | S100 calcium binding protein A6 | -0.0272274 |
| SGMS2 | sphingomyelin synthase 2 | -0.0266611 |
| FNIP1 | folliculin interacting protein 1 | -0.0265301 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0264176 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0258983 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0256396 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0254006 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0253459 |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | -0.0253434 |
| FRYL | FRY-like | -0.0251899 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | -0.0249714 |
| STC2 | stanniocalcin 2 | -0.0248245 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0247882 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0247773 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0247569 |
| OSMR | oncostatin M receptor | -0.0245879 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0245403 |
| SPAG9 | sperm associated antigen 9 | -0.0241726 |
| ITGA6 | integrin, alpha 6 | -0.0241387 |
| ANXA3 | annexin A3 | -0.0238336 |
| SVIL | supervillin | -0.0238265 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0233899 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0233288 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0232153 |
| S100A11 | S100 calcium binding protein A11 | -0.0230642 |
