| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cabozantinib (S-malate) perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Cabozantinib (S-malate)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LPIN1 | lipin 1 | 0.140275 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0736551 |
| TRIB2 | tribbles pseudokinase 2 | 0.0718035 |
| UNC5C | unc-5 homolog C (C. elegans) | 0.0685738 |
| SYT1 | synaptotagmin I | 0.0670369 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0643798 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0634063 |
| MSI2 | musashi RNA-binding protein 2 | 0.0613681 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0603835 |
| DPH6 | diphthamine biosynthesis 6 | 0.0585077 |
| RPL4 | ribosomal protein L4 | 0.0582384 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0560401 |
| NRG1 | neuregulin 1 | 0.055928 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0534486 |
| ACTG1 | actin gamma 1 | 0.0527178 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | 0.0479459 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0471364 |
| SEPTIN9 | septin 9 | 0.0466029 |
| RPS6 | ribosomal protein S6 | 0.0448653 |
| C1ORF21 | chromosome 1 open reading frame 21 | 0.0439903 |
| HELZ | helicase with zinc finger | 0.0432899 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | 0.0429689 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0427882 |
| APP | amyloid beta (A4) precursor protein | 0.0420464 |
| PRKCA | protein kinase C, alpha | 0.0416574 |
| FAM13A | family with sequence similarity 13, member A | 0.0415534 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0413902 |
| MEIS2 | Meis homeobox 2 | 0.041285 |
| PTK2 | protein tyrosine kinase 2 | 0.0400889 |
| DNMBP | dynamin binding protein | 0.0396905 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.038473 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.037939 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0371384 |
| RBM20 | RNA binding motif protein 20 | 0.0370229 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0369619 |
| MYCN | v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog | 0.0363463 |
| FRMD4A | FERM domain containing 4A | 0.0362185 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0360389 |
| NRP1 | neuropilin 1 | 0.0357358 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0352693 |
| CCND1 | cyclin D1 | 0.0352039 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.034937 |
| GATA3 | GATA binding protein 3 | 0.0347898 |
| RAD51B | RAD51 paralog B | 0.0347595 |
| ATRNL1 | attractin-like 1 | 0.0346751 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0342829 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0341199 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0336868 |
| TLK2 | tousled-like kinase 2 | 0.0319313 |
| RUNX1 | runt-related transcription factor 1 | 0.0317193 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0317064 |
| PLCB4 | phospholipase C, beta 4 | 0.0311517 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0305899 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | 0.0305557 |
| AUTS2 | autism susceptibility candidate 2 | 0.0304661 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0302272 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0300314 |
| ANGPT1 | angiopoietin 1 | 0.0299485 |
| FOXP1 | forkhead box P1 | 0.0296058 |
| PRKCE | protein kinase C, epsilon | 0.0295994 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0295763 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0293945 |
| CCNY | cyclin Y | 0.029316 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0288538 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0285812 |
| MEF2A | myocyte enhancer factor 2A | 0.0284571 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0282341 |
| PDZRN3 | PDZ domain containing ring finger 3 | 0.0281824 |
| MYO6 | myosin VI | 0.0281732 |
| NEK7 | NIMA-related kinase 7 | 0.0280949 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0280843 |
| CTBP2 | C-terminal binding protein 2 | 0.0280646 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0278934 |
| ANXA2 | annexin A2 | 0.0275056 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0271858 |
| RPL26 | ribosomal protein L26 | 0.0268696 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.026748 |
| XPO1 | exportin 1 | 0.0267096 |
| XRN2 | 5'-3' exoribonuclease 2 | 0.0265348 |
| TRPA1 | transient receptor potential cation channel, subfamily A, member 1 | 0.026407 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0259681 |
| EXOC4 | exocyst complex component 4 | 0.0259081 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0257185 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0256594 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0256481 |
| SMAD3 | SMAD family member 3 | 0.0252659 |
| TIAL1 | TIA1 cytotoxic granule-associated RNA binding protein-like 1 | 0.0251644 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0249968 |
| ASPH | aspartate beta-hydroxylase | 0.0249576 |
| MKI67 | marker of proliferation Ki-67 | 0.0248294 |
| CENPF | centromere protein F, 350/400kDa | 0.0247524 |
| PRKD1 | protein kinase D1 | 0.0246907 |
| FKBP1A | FK506 binding protein 1A, 12kDa | 0.0244387 |
| FUS | FUS RNA binding protein | 0.0244021 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0242692 |
| RUNX1T1 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | 0.0241054 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0240421 |
| KCTD3 | potassium channel tetramerization domain containing 3 | 0.0234209 |
| PGK1 | phosphoglycerate kinase 1 | 0.0233229 |
| RBM33 | RNA binding motif protein 33 | 0.0233051 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.200812 |
| VCL | vinculin | -0.146505 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.144832 |
| LSAMP | limbic system-associated membrane protein | -0.144696 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | -0.138729 |
| VMP1 | vacuole membrane protein 1 | -0.102147 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.095406 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0892343 |
| EXT1 | exostosin glycosyltransferase 1 | -0.083658 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.068356 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0628354 |
| PLAT | plasminogen activator, tissue | -0.0523407 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0509882 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0509211 |
| FMN1 | formin 1 | -0.0504292 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0503581 |
| KLHL13 | kelch-like family member 13 | -0.048501 |
| STK38L | serine/threonine kinase 38 like | -0.0478594 |
| PCBP3 | poly(rC) binding protein 3 | -0.0446132 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0445061 |
| NREP | neuronal regeneration related protein | -0.0419365 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0418673 |
| EGR1 | early growth response 1 | -0.0410311 |
| PLPP1 | phospholipid phosphatase 1 | -0.0403199 |
| CRH | corticotropin releasing hormone | -0.0380482 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0368089 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.036402 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0359914 |
| SIK2 | salt-inducible kinase 2 | -0.0355331 |
| MCL1 | myeloid cell leukemia 1 | -0.0340667 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0323957 |
| ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | -0.0320087 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0319087 |
| GREM2 | gremlin 2, DAN family BMP antagonist | -0.0314712 |
| DTNA | dystrobrevin, alpha | -0.0310683 |
| GAB2 | GRB2-associated binding protein 2 | -0.0310309 |
| THBS1 | thrombospondin 1 | -0.0308134 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0305185 |
| VEGFA | vascular endothelial growth factor A | -0.0302998 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0299099 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.0296662 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0286535 |
| NDRG1 | N-myc downstream regulated 1 | -0.0285057 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | -0.0282278 |
| CCDC47 | coiled-coil domain containing 47 | -0.0277239 |
| POTEF | POTE ankyrin domain family, member F | -0.0270428 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0265336 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0264645 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0262521 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0261988 |
| GLCCI1 | glucocorticoid induced 1 | -0.0259318 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.025417 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0253575 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0253145 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0247825 |
| GOLGB1 | golgin B1 | -0.0246789 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0245375 |
| RAI14 | retinoic acid induced 14 | -0.0244148 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0243268 |
| RNF213 | ring finger protein 213 | -0.0242825 |
| FAM193A | family with sequence similarity 193, member A | -0.0242467 |
| SVIL | supervillin | -0.0239837 |
| BDKRB2 | bradykinin receptor B2 | -0.0239246 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0238567 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0237538 |
| TXNIP | thioredoxin interacting protein | -0.023013 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0226755 |
| RAB5A | RAB5A, member RAS oncogene family | -0.0225921 |
| CDON | cell adhesion associated, oncogene regulated | -0.0224183 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0223878 |
| HOOK3 | hook microtubule-tethering protein 3 | -0.0223053 |
| SETX | senataxin | -0.0221935 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0221734 |
| TPM1 | tropomyosin 1 (alpha) | -0.0220687 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0213283 |
| NAA15 | N(alpha)-acetyltransferase 15, NatA auxiliary subunit | -0.0212536 |
| LIMA1 | LIM domain and actin binding 1 | -0.0209863 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0209828 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0209411 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | -0.0208133 |
| CDK19 | cyclin-dependent kinase 19 | -0.020791 |
| RACK1 | receptor for activated C kinase 1 | -0.0206186 |
| INTS6 | integrator complex subunit 6 | -0.0206063 |
| FTL | ferritin, light polypeptide | -0.0205261 |
| DIS3 | DIS3 exosome endoribonuclease and 3'-5' exoribonuclease | -0.0204841 |
| PDE10A | phosphodiesterase 10A | -0.0203847 |
| STC1 | stanniocalcin 1 | -0.0203837 |
| ITGAV | integrin, alpha V | -0.0203432 |
| COG6 | component of oligomeric golgi complex 6 | -0.0203146 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0202145 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.0201735 |
| COPA | coatomer protein complex, subunit alpha | -0.0200751 |
| ARHGAP42 | Rho GTPase activating protein 42 | -0.0200261 |
| KLF6 | Kruppel-like factor 6 | -0.0200069 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | -0.0198289 |
| NUP160 | nucleoporin 160kDa | -0.0198053 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0197791 |
| DGKH | diacylglycerol kinase, eta | -0.0196933 |
| TMF1 | TATA element modulatory factor 1 | -0.0196751 |
| RHOB | ras homolog family member B | -0.0196254 |
