| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cabozantinib (S-malate) perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Cabozantinib (S-malate)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MBNL2 | muscleblind-like splicing regulator 2 | 0.206332 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.155447 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.104076 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0985083 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.0865698 |
| HLA-B | major histocompatibility complex, class I, B | 0.0780415 |
| PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | 0.0767345 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0749179 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0725365 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0712753 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.068043 |
| AHI1 | Abelson helper integration site 1 | 0.0653814 |
| RNF43 | ring finger protein 43 | 0.0620623 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0615767 |
| TRERF1 | transcriptional regulating factor 1 | 0.0594492 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0592543 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.0588096 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0587277 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0540844 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0540102 |
| CANX | calnexin | 0.0534228 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0530355 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0520119 |
| OARD1 | O-acyl-ADP-ribose deacylase 1 | 0.0513805 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0513057 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0510265 |
| RUNX1 | runt-related transcription factor 1 | 0.049048 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0489106 |
| AOPEP | aminopeptidase O (putative) | 0.0487964 |
| ATXN1 | ataxin 1 | 0.0469434 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0465532 |
| OGA | O-GlcNAcase | 0.0463951 |
| SERINC5 | serine incorporator 5 | 0.0454288 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0450811 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0437957 |
| MPHOSPH8 | M-phase phosphoprotein 8 | 0.0432224 |
| FNIP1 | folliculin interacting protein 1 | 0.0432121 |
| NEBL | nebulette | 0.0424946 |
| RBM26 | RNA binding motif protein 26 | 0.0413065 |
| RPS6 | ribosomal protein S6 | 0.0406507 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0387291 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.0386639 |
| ZC3H13 | zinc finger CCCH-type containing 13 | 0.0377257 |
| B2M | beta-2-microglobulin | 0.0373841 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0373806 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0370346 |
| CALR | calreticulin | 0.0365294 |
| SFTPA2 | surfactant protein A2 | 0.0357673 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | 0.0356959 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0354923 |
| HLA-A | major histocompatibility complex, class I, A | 0.0352726 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0347422 |
| RNF149 | ring finger protein 149 | 0.034587 |
| PRELID2 | PRELI domain containing 2 | 0.0345633 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0337007 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0333405 |
| MLPH | melanophilin | 0.0331922 |
| SBF2 | SET binding factor 2 | 0.0330774 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0329918 |
| HBS1L | HBS1-like translational GTPase | 0.0329726 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0329677 |
| GOLGA4 | golgin A4 | 0.0327913 |
| BICRAL | BICRA like chromatin remodeling complex associated protein | 0.0326045 |
| SMYD3 | SET and MYND domain containing 3 | 0.0325729 |
| HDLBP | high density lipoprotein binding protein | 0.0314713 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 0.0313115 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.031182 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0309967 |
| PTEN | phosphatase and tensin homolog | 0.0307755 |
| RNF145 | ring finger protein 145 | 0.0305216 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0303474 |
| CHD6 | chromodomain helicase DNA binding protein 6 | 0.0302721 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0301233 |
| DENND4C | DENN/MADD domain containing 4C | 0.03008 |
| CMIP | c-Maf inducing protein | 0.0300007 |
| ZNF638 | zinc finger protein 638 | 0.0299206 |
| UBL3 | ubiquitin-like 3 | 0.0296762 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.029525 |
| AHNAK | AHNAK nucleoprotein | 0.0295178 |
| USP3 | ubiquitin specific peptidase 3 | 0.0294194 |
| GRAMD2B | GRAM domain containing 2B | 0.0289205 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0289087 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0289004 |
| RAD51B | RAD51 paralog B | 0.0287927 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0287045 |
| EPB41 | erythrocyte membrane protein band 4.1 | 0.0286492 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0286167 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0284159 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 | 0.0282646 |
| SPATA13 | spermatogenesis associated 13 | 0.0280589 |
| ARHGEF10L | Rho guanine nucleotide exchange factor (GEF) 10-like | 0.028015 |
| HELZ | helicase with zinc finger | 0.0279929 |
| PHF3 | PHD finger protein 3 | 0.0279466 |
| GSE1 | Gse1 coiled-coil protein | 0.0278595 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0277947 |
| NCKAP5 | NCK-associated protein 5 | 0.0276008 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0275609 |
| GOLGB1 | golgin B1 | 0.0274407 |
| H1-0 | H1.0 linker histone | 0.0272619 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.0271426 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VCL | vinculin | -0.129785 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.125667 |
| STS | steroid sulfatase (microsomal), isozyme S | -0.125009 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.124621 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.108759 |
| ANXA2 | annexin A2 | -0.104942 |
| INTS6 | integrator complex subunit 6 | -0.0992359 |
| LMO7 | LIM domain 7 | -0.0950883 |
| RIGI | RNA sensor RIG-I | -0.0934076 |
| RNF213 | ring finger protein 213 | -0.090012 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0872348 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | -0.0867405 |
| AREG | amphiregulin | -0.0863412 |
| SP100 | SP100 nuclear antigen | -0.0848474 |
| EGR1 | early growth response 1 | -0.0815959 |
| MX1 | MX dynamin-like GTPase 1 | -0.0813053 |
| MX2 | MX dynamin-like GTPase 2 | -0.0760132 |
| TJP1 | tight junction protein 1 | -0.0706763 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0693611 |
| ERBIN | erbb2 interacting protein | -0.0654624 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0635606 |
| EZR | ezrin | -0.063089 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0624906 |
| PLSCR2 | phospholipid scramblase 2 | -0.0621262 |
| LYZ | lysozyme | -0.0615817 |
| RAB7A | RAB7A, member RAS oncogene family | -0.061009 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.057253 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0571195 |
| MYO1E | myosin IE | -0.0562067 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0561843 |
| VMP1 | vacuole membrane protein 1 | -0.0559514 |
| PLSCR1 | phospholipid scramblase 1 | -0.0554312 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.054093 |
| EFNB2 | ephrin-B2 | -0.0537245 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0505112 |
| SMAD3 | SMAD family member 3 | -0.0488306 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0487416 |
| TM4SF19 | transmembrane 4 L six family member 19 | -0.0483794 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0478872 |
| NPSR1 | neuropeptide S receptor 1 | -0.0463778 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0452966 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.045194 |
| PKM | pyruvate kinase, muscle | -0.0448428 |
| LAMA4 | laminin, alpha 4 | -0.0442954 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0440665 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.043701 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.0429101 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0414204 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0412128 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0399011 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0388473 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0386987 |
| PRKCA | protein kinase C, alpha | -0.0386391 |
| LCN2 | lipocalin 2 | -0.0372331 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0371118 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0365501 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0364993 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0356193 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0355536 |
| TNS4 | tensin 4 | -0.0353843 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0347257 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | -0.0334698 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0331001 |
| UBAP2 | ubiquitin associated protein 2 | -0.0330276 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0327826 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0327203 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0325889 |
| DIAPH1 | diaphanous-related formin 1 | -0.0325597 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0318625 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0317732 |
| PMP22 | peripheral myelin protein 22 | -0.0317006 |
| BCL2L1 | BCL2-like 1 | -0.0314888 |
| POU2F2 | POU class 2 homeobox 2 | -0.031011 |
| PERP | PERP, TP53 apoptosis effector | -0.0310095 |
| MCL1 | myeloid cell leukemia 1 | -0.0309898 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0308415 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0305983 |
| ASPH | aspartate beta-hydroxylase | -0.0298917 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0298718 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0296493 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0291392 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0288035 |
| SETX | senataxin | -0.0286455 |
| ETV6 | ets variant 6 | -0.0285613 |
| LIMA1 | LIM domain and actin binding 1 | -0.0278353 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0276579 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0276526 |
| FBXO39 | F-box protein 39 | -0.0276237 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0275171 |
| POTEF | POTE ankyrin domain family, member F | -0.0274708 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0271823 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0263478 |
| LRRC8A | leucine rich repeat containing 8 family, member A | -0.0260776 |
| NABP1 | nucleic acid binding protein 1 | -0.0259393 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0254296 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0248495 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0244272 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0242219 |
| PARD3 | par-3 family cell polarity regulator | -0.0241968 |
| CCNL1 | cyclin L1 | -0.0238259 |
