| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cabozantinib (S-malate) perturbation in H4 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Cabozantinib (S-malate)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SMAD3 | SMAD family member 3 | 0.0828961 |
| COL6A3 | collagen, type VI, alpha 3 | 0.074302 |
| KYNU | kynureninase | 0.0670995 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0659521 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0637 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0547858 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0537457 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0530114 |
| GOLGB1 | golgin B1 | 0.0517587 |
| TXNIP | thioredoxin interacting protein | 0.0495574 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0488411 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0484133 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0453502 |
| MSN | moesin | 0.0438176 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0432141 |
| PHF14 | PHD finger protein 14 | 0.0424591 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0424267 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.042075 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0419049 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0418708 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0414844 |
| METTL15 | methyltransferase like 15 | 0.0411062 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0407073 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0404898 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0403178 |
| ATM | ATM serine/threonine kinase | 0.0402815 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0400582 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0398129 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0377354 |
| TNRC18 | trinucleotide repeat containing 18 | 0.0372204 |
| ZNF841 | zinc finger protein 841 | 0.0370963 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0360897 |
| UMAD1 | UBAP1-MVB12-associated (UMA) domain containing 1 | 0.0359196 |
| VMP1 | vacuole membrane protein 1 | 0.0350832 |
| SCFD2 | sec1 family domain containing 2 | 0.0343881 |
| RARS1 | arginyl-tRNA synthetase 1 | 0.0343673 |
| NAV2 | neuron navigator 2 | 0.0340641 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0335678 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0333114 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0330921 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0330665 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0330036 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0327326 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0325017 |
| TPM3 | tropomyosin 3 | 0.0321361 |
| PGK1 | phosphoglycerate kinase 1 | 0.0317164 |
| ALPK1 | alpha-kinase 1 | 0.0314075 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0311131 |
| FAM114A1 | family with sequence similarity 114, member A1 | 0.0310571 |
| GOSR2 | golgi SNAP receptor complex member 2 | 0.0310189 |
| SETD5 | SET domain containing 5 | 0.0306805 |
| OGA | O-GlcNAcase | 0.0305833 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0300824 |
| COPA | coatomer protein complex, subunit alpha | 0.0297147 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0292832 |
| SBF2 | SET binding factor 2 | 0.0291781 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0288977 |
| ZNF292 | zinc finger protein 292 | 0.028867 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.028771 |
| MAGED1 | melanoma antigen family D1 | 0.0287655 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0283249 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.027798 |
| ZNF395 | zinc finger protein 395 | 0.027402 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0273191 |
| CALN1 | calneuron 1 | 0.0270476 |
| ZNF148 | zinc finger protein 148 | 0.0269653 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.026962 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0268599 |
| TP53BP1 | tumor protein p53 binding protein 1 | 0.0265355 |
| PPIP5K2 | diphosphoinositol pentakisphosphate kinase 2 | 0.0265094 |
| ATXN1 | ataxin 1 | 0.0264893 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0263096 |
| ZNF160 | zinc finger protein 160 | 0.0261204 |
| GOLGA2 | golgin A2 | 0.0258504 |
| FOXJ3 | forkhead box J3 | 0.0257129 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.0257015 |
| FAM219A | family with sequence similarity 219, member A | 0.02564 |
| CDK19 | cyclin-dependent kinase 19 | 0.0254939 |
| PHF3 | PHD finger protein 3 | 0.0253328 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0252363 |
| CLTC | clathrin, heavy chain (Hc) | 0.0251786 |
| NF1 | neurofibromin 1 | 0.0251119 |
| NUDCD3 | NudC domain containing 3 | 0.024854 |
| USO1 | USO1 vesicle transport factor | 0.0247567 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0247234 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0241735 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0236601 |
| KMT2A | lysine (K)-specific methyltransferase 2A | 0.0232987 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0231967 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | 0.0230514 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0230513 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | 0.023044 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0230187 |
| SPG7 | spastic paraplegia 7 (pure and complicated autosomal recessive) | 0.0229976 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0224996 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0224794 |
| DISC1 | disrupted in schizophrenia 1 | 0.0224576 |
| MBTD1 | mbt domain containing 1 | 0.0224558 |
| RNF216 | ring finger protein 216 | 0.0223614 |
| GOLGA4 | golgin A4 | 0.0223528 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.282805 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.207904 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.141059 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.126522 |
| FN1 | fibronectin 1 | -0.0903498 |
| VIM | vimentin | -0.0814152 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.081166 |
| TMSB10 | thymosin beta 10 | -0.0808601 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0745287 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0676229 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.067077 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0632522 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0622713 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0608675 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0521378 |
| DTNA | dystrobrevin, alpha | -0.0514037 |
| LDHA | lactate dehydrogenase A | -0.0507652 |
| ASPH | aspartate beta-hydroxylase | -0.0496562 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.049464 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0494332 |
| LOX | lysyl oxidase | -0.0467756 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0438062 |
| MT2A | metallothionein 2A | -0.0410534 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.040972 |
| FTL | ferritin, light polypeptide | -0.0396905 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0391367 |
| ENO1 | enolase 1, (alpha) | -0.0371525 |
| EGR1 | early growth response 1 | -0.0366826 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0353928 |
| PTMA | prothymosin, alpha | -0.0330195 |
| IGF2 | insulin-like growth factor 2 | -0.0327601 |
| GNAS | GNAS complex locus | -0.0326605 |
| CD44 | CD44 molecule (Indian blood group) | -0.032108 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0312296 |
| RPS8 | ribosomal protein S8 | -0.0310709 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0298174 |
| SPAG9 | sperm associated antigen 9 | -0.0293322 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0291518 |
| CCND1 | cyclin D1 | -0.0288513 |
| RPS24 | ribosomal protein S24 | -0.02872 |
| VDAC1 | voltage-dependent anion channel 1 | -0.02859 |
| S100A10 | S100 calcium binding protein A10 | -0.0282163 |
| ANXA2 | annexin A2 | -0.0275759 |
| NDRG1 | N-myc downstream regulated 1 | -0.0273806 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.027254 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.0269362 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0268837 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0268662 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0263336 |
| ACTG1 | actin gamma 1 | -0.0262994 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0261181 |
| SDC4 | syndecan 4 | -0.0255477 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0251026 |
| IER3 | immediate early response 3 | -0.0246894 |
| RPLP1 | ribosomal protein, large, P1 | -0.0244527 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.024191 |
| RPL35A | ribosomal protein L35a | -0.0234327 |
| ADM | adrenomedullin | -0.0232971 |
| CLMP | CXADR-like membrane protein | -0.0223037 |
| NRXN3 | neurexin 3 | -0.0219297 |
| RIGI | RNA sensor RIG-I | -0.0218736 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0214815 |
| HIP1 | huntingtin interacting protein 1 | -0.0214746 |
| NAV3 | neuron navigator 3 | -0.0213092 |
| POTEF | POTE ankyrin domain family, member F | -0.0209737 |
| RPL34 | ribosomal protein L34 | -0.0209505 |
| PTK2 | protein tyrosine kinase 2 | -0.0208402 |
| OXR1 | oxidation resistance 1 | -0.0206309 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0205051 |
| PRSS23 | protease, serine, 23 | -0.0204703 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0203386 |
| KCTD16 | potassium channel tetramerization domain containing 16 | -0.0193052 |
| CALD1 | caldesmon 1 | -0.0189878 |
| RPS25 | ribosomal protein S25 | -0.0189662 |
| S100A9 | S100 calcium binding protein A9 | -0.0187789 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0186678 |
| FAM162A | family with sequence similarity 162, member A | -0.0186011 |
| ZNF804A | zinc finger protein 804A | -0.0183852 |
| HS6ST3 | heparan sulfate 6-O-sulfotransferase 3 | -0.0183266 |
| PIAS2 | protein inhibitor of activated STAT, 2 | -0.0182967 |
| RAI1 | retinoic acid induced 1 | -0.018267 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0180369 |
| HMGA1 | high mobility group AT-hook 1 | -0.0176487 |
| INHBA | inhibin, beta A | -0.0173532 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0173277 |
| TMEM132B | transmembrane protein 132B | -0.0169307 |
| SMC4 | structural maintenance of chromosomes 4 | -0.016845 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0165628 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0164993 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.0164205 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0163893 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0162839 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0160546 |
| EMP1 | epithelial membrane protein 1 | -0.0160404 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0160371 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0157639 |
| FBXO11 | F-box protein 11 | -0.0157598 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0157212 |
| CLEC1B | C-type lectin domain family 1, member B | -0.0156919 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0156708 |
