| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cabozantinib (S-malate) perturbation in HCT15 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Cabozantinib (S-malate)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.163499 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0832605 |
| RAD51B | RAD51 paralog B | 0.0738481 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0726228 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0707691 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0673343 |
| OGA | O-GlcNAcase | 0.0618463 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0602828 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0590005 |
| GOLGA4 | golgin A4 | 0.0554278 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0550892 |
| PRELID2 | PRELI domain containing 2 | 0.0549977 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0537331 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.053679 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0534375 |
| ZNF638 | zinc finger protein 638 | 0.0503695 |
| PGK1 | phosphoglycerate kinase 1 | 0.0447485 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | 0.0440054 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0430362 |
| CANX | calnexin | 0.0430023 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0423762 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0421229 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0421009 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0415006 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0412759 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0404118 |
| HELZ | helicase with zinc finger | 0.0396563 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.039404 |
| ATXN1 | ataxin 1 | 0.0383096 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0382756 |
| PCBP2 | poly(rC) binding protein 2 | 0.0381386 |
| RPS6 | ribosomal protein S6 | 0.038106 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0380357 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0379366 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0375701 |
| EXOC4 | exocyst complex component 4 | 0.0372554 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0372211 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0365765 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0365131 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0349235 |
| SETD5 | SET domain containing 5 | 0.0345662 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0345453 |
| METTL15 | methyltransferase like 15 | 0.0344178 |
| PHF3 | PHD finger protein 3 | 0.0342903 |
| RBM33 | RNA binding motif protein 33 | 0.0342093 |
| ZNF292 | zinc finger protein 292 | 0.0341858 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0340053 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0333574 |
| CTBP2 | C-terminal binding protein 2 | 0.0331041 |
| MAP4 | microtubule-associated protein 4 | 0.0328215 |
| NEBL | nebulette | 0.0327173 |
| RPL23 | ribosomal protein L23 | 0.0317482 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0316832 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0313978 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0311797 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0311319 |
| RPL4 | ribosomal protein L4 | 0.031118 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.030456 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0304524 |
| FNBP4 | formin binding protein 4 | 0.0303851 |
| ESRP1 | epithelial splicing regulatory protein 1 | 0.0303475 |
| EPB41 | erythrocyte membrane protein band 4.1 | 0.0299874 |
| RPL11 | ribosomal protein L11 | 0.0299658 |
| TMF1 | TATA element modulatory factor 1 | 0.0294108 |
| EXOC6B | exocyst complex component 6B | 0.0293627 |
| KIAA1217 | KIAA1217 | 0.0293498 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0292184 |
| TNRC6B | trinucleotide repeat containing 6B | 0.029007 |
| HDLBP | high density lipoprotein binding protein | 0.0288567 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0284922 |
| GANAB | glucosidase, alpha; neutral AB | 0.0278755 |
| EP300 | E1A binding protein p300 | 0.0278078 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0277343 |
| HOXB3 | homeobox B3 | 0.0276037 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 0.0269309 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0268298 |
| RARS1 | arginyl-tRNA synthetase 1 | 0.0265662 |
| BBX | bobby sox homolog (Drosophila) | 0.0265601 |
| B2M | beta-2-microglobulin | 0.0264865 |
| HYOU1 | hypoxia up-regulated 1 | 0.0263906 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0263083 |
| MATR3 | matrin 3 | 0.0262601 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0261098 |
| NUCB2 | nucleobindin 2 | 0.026068 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0258375 |
| ZNF148 | zinc finger protein 148 | 0.0257275 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0256496 |
| DNHD1 | dynein heavy chain domain 1 | 0.025638 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0255562 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0254411 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0254326 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0253815 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0253776 |
| CPEB3 | cytoplasmic polyadenylation element binding protein 3 | 0.0251763 |
| ACBD6 | acyl-CoA binding domain containing 6 | 0.0251454 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0251018 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0250552 |
| GOLGB1 | golgin B1 | 0.0250499 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0250084 |
| YARS1 | tyrosyl-tRNA synthetase 1 | 0.0249097 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FAT1 | FAT atypical cadherin 1 | -0.19081 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.154006 |
| EZR | ezrin | -0.137224 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.134526 |
| AHNAK | AHNAK nucleoprotein | -0.125002 |
| PTMA | prothymosin, alpha | -0.0951778 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0942291 |
| TPM4 | tropomyosin 4 | -0.0827853 |
| PKM | pyruvate kinase, muscle | -0.0776876 |
| ARF4 | ADP-ribosylation factor 4 | -0.0719086 |
| MKI67 | marker of proliferation Ki-67 | -0.0695024 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0694622 |
| EGR1 | early growth response 1 | -0.0687771 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0682671 |
| MCL1 | myeloid cell leukemia 1 | -0.0659463 |
| TMSB10 | thymosin beta 10 | -0.0654947 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0638366 |
| KRT18 | keratin 18, type I | -0.0610122 |
| NDRG1 | N-myc downstream regulated 1 | -0.0607433 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0577043 |
| TXNRD1 | thioredoxin reductase 1 | -0.0574335 |
| POTEF | POTE ankyrin domain family, member F | -0.0559436 |
| LDHA | lactate dehydrogenase A | -0.0552871 |
| ENO1 | enolase 1, (alpha) | -0.0549779 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0525394 |
| VCL | vinculin | -0.0502523 |
| KRT19 | keratin 19, type I | -0.045469 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0419882 |
| JUN | jun proto-oncogene | -0.0414698 |
| S100A10 | S100 calcium binding protein A10 | -0.0413131 |
| FRMD5 | FERM domain containing 5 | -0.0409073 |
| ANXA2 | annexin A2 | -0.0402452 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0392723 |
| KLF6 | Kruppel-like factor 6 | -0.0390641 |
| CCND1 | cyclin D1 | -0.0374139 |
| HMGA1 | high mobility group AT-hook 1 | -0.0365666 |
| KRT8 | keratin 8, type II | -0.036523 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0360925 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0357102 |
| MT2A | metallothionein 2A | -0.0343256 |
| RHOA | ras homolog family member A | -0.0324887 |
| EGFR | epidermal growth factor receptor | -0.0324383 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0321568 |
| TUBA1B | tubulin, alpha 1b | -0.0319969 |
| VMP1 | vacuole membrane protein 1 | -0.0319705 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.0318188 |
| SDC4 | syndecan 4 | -0.0314037 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0307837 |
| CDCP1 | CUB domain containing protein 1 | -0.0305725 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0304429 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0298503 |
| ACTN4 | actinin, alpha 4 | -0.0295051 |
| SERINC5 | serine incorporator 5 | -0.0292581 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0286695 |
| NUP50 | nucleoporin 50kDa | -0.0283057 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0281298 |
| TUBB | tubulin, beta class I | -0.0278602 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0271167 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.027084 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0262597 |
| LSR | lipolysis stimulated lipoprotein receptor | -0.025989 |
| HMGB2 | high mobility group box 2 | -0.0258175 |
| BCL2L1 | BCL2-like 1 | -0.0257499 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.02502 |
| CADPS | Ca++-dependent secretion activator | -0.0246628 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0245335 |
| ASPH | aspartate beta-hydroxylase | -0.0244367 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0244171 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0242676 |
| ACTG1 | actin gamma 1 | -0.0242111 |
| HMGA2 | high mobility group AT-hook 2 | -0.0241107 |
| NT5DC3 | 5'-nucleotidase domain containing 3 | -0.0238565 |
| CENPF | centromere protein F, 350/400kDa | -0.0237615 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0233208 |
| S100A6 | S100 calcium binding protein A6 | -0.0232387 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0231318 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0230155 |
| ECT2 | epithelial cell transforming 2 | -0.0226748 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0220952 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0220063 |
| ITGB4 | integrin, beta 4 | -0.0220023 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0217986 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0217443 |
| RCOR1 | REST corepressor 1 | -0.0215772 |
| EHBP1 | EH domain binding protein 1 | -0.0215601 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0213786 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0205905 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0205651 |
| DIAPH3 | diaphanous-related formin 3 | -0.0204825 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0203884 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0203183 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0202852 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.020149 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0200952 |
| DUSP5 | dual specificity phosphatase 5 | -0.0197493 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0196913 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0194357 |
| IER2 | immediate early response 2 | -0.0193282 |
| LMNA | lamin A/C | -0.0191932 |
| ITPKC | inositol-trisphosphate 3-kinase C | -0.0188878 |
