| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cabozantinib (S-malate) perturbation in HEC-1-A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Cabozantinib (S-malate)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0839341 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0696961 |
| APP | amyloid beta (A4) precursor protein | 0.0690377 |
| SMAD3 | SMAD family member 3 | 0.0679002 |
| ZNF292 | zinc finger protein 292 | 0.065258 |
| RNF145 | ring finger protein 145 | 0.0607886 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.059067 |
| RHEX | regulator of hemoglobinization and erythroid cell expansion | 0.0582903 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0577695 |
| TRIM2 | tripartite motif containing 2 | 0.0529586 |
| ZNF148 | zinc finger protein 148 | 0.0524161 |
| MATR3 | matrin 3 | 0.0518947 |
| HELZ | helicase with zinc finger | 0.0497174 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.049395 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0481618 |
| AFDN | afadin, adherens junction formation factor | 0.0428367 |
| TFG | TRK-fused gene | 0.0423465 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0419753 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0415415 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0403553 |
| PCBP2 | poly(rC) binding protein 2 | 0.0401009 |
| SETD5 | SET domain containing 5 | 0.0399609 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0399493 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0397473 |
| GOLGA4 | golgin A4 | 0.0382446 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0377865 |
| FNBP1L | formin binding protein 1-like | 0.0374341 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0369691 |
| DNM2 | dynamin 2 | 0.036504 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0361662 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0361314 |
| SLMAP | sarcolemma associated protein | 0.0357042 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0356987 |
| ITGB8 | integrin, beta 8 | 0.0355437 |
| CCNL1 | cyclin L1 | 0.0355325 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0355054 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0348179 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0348077 |
| RBM33 | RNA binding motif protein 33 | 0.0340976 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0340564 |
| MSI2 | musashi RNA-binding protein 2 | 0.0337157 |
| CDC73 | cell division cycle 73 | 0.0335574 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0332691 |
| CTBP2 | C-terminal binding protein 2 | 0.0328205 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0326214 |
| CDC42BPB | CDC42 binding protein kinase beta (DMPK-like) | 0.0326041 |
| IRS2 | insulin receptor substrate 2 | 0.0325557 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0325014 |
| USP24 | ubiquitin specific peptidase 24 | 0.0325005 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0322234 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0322052 |
| FAM168A | family with sequence similarity 168, member A | 0.0320573 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0318424 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0314787 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0308942 |
| ORC4 | origin recognition complex, subunit 4 | 0.0303632 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0303221 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0301612 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0300507 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0298443 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0297677 |
| NCKAP1 | NCK-associated protein 1 | 0.0296865 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0294465 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0292336 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | 0.0290212 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0290084 |
| CCNT2 | cyclin T2 | 0.0288858 |
| RPL13A | ribosomal protein L13a | 0.028875 |
| SPOPL | speckle-type POZ protein-like | 0.0288204 |
| COPA | coatomer protein complex, subunit alpha | 0.0287233 |
| DIAPH1 | diaphanous-related formin 1 | 0.0286358 |
| WDR43 | WD repeat domain 43 | 0.0284821 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0281836 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0281266 |
| USP3 | ubiquitin specific peptidase 3 | 0.0279146 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.027829 |
| VEGFA | vascular endothelial growth factor A | 0.0277881 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | 0.027574 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0274899 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0271497 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.026953 |
| RPL21 | ribosomal protein L21 | 0.0268633 |
| FTO | fat mass and obesity associated | 0.0267547 |
| MEF2A | myocyte enhancer factor 2A | 0.0261903 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0261832 |
| WDFY3 | WD repeat and FYVE domain containing 3 | 0.0261763 |
| FIGN | fidgetin | 0.0261707 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0259661 |
| FLNA | filamin A, alpha | 0.0258426 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0257583 |
| MED13L | mediator complex subunit 13-like | 0.0257212 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0256726 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0255316 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0255106 |
| RNF213 | ring finger protein 213 | 0.0253392 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0251761 |
| DPP4 | dipeptidyl-peptidase 4 | 0.025015 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0250099 |
| KCTD3 | potassium channel tetramerization domain containing 3 | 0.0248679 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0247602 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ASPH | aspartate beta-hydroxylase | -0.189065 |
| MT2A | metallothionein 2A | -0.185215 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.169624 |
| CCND1 | cyclin D1 | -0.110586 |
| LAMB3 | laminin, beta 3 | -0.101198 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0981727 |
| TPM4 | tropomyosin 4 | -0.0971741 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.090942 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0863788 |
| CD44 | CD44 molecule (Indian blood group) | -0.0855832 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0850979 |
| TMSB10 | thymosin beta 10 | -0.0831615 |
| ENO1 | enolase 1, (alpha) | -0.0722329 |
| LAMC2 | laminin, gamma 2 | -0.0690367 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0650768 |
| FTL | ferritin, light polypeptide | -0.0614458 |
| CDCP1 | CUB domain containing protein 1 | -0.0613779 |
| HMGA2 | high mobility group AT-hook 2 | -0.0613193 |
| S100A10 | S100 calcium binding protein A10 | -0.0602062 |
| LDHA | lactate dehydrogenase A | -0.0589577 |
| TXNRD1 | thioredoxin reductase 1 | -0.0569564 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0547303 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0540652 |
| MKI67 | marker of proliferation Ki-67 | -0.0531682 |
| RPL31 | ribosomal protein L31 | -0.050755 |
| RPL35A | ribosomal protein L35a | -0.050664 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0490454 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0487245 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0478176 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0477457 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0464808 |
| ITGA6 | integrin, alpha 6 | -0.0454845 |
| RPS24 | ribosomal protein S24 | -0.0454551 |
| PTMA | prothymosin, alpha | -0.0453075 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0443306 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0428915 |
| RPLP1 | ribosomal protein, large, P1 | -0.0417498 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0417495 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0410668 |
| DIAPH3 | diaphanous-related formin 3 | -0.0407153 |
| LAMA4 | laminin, alpha 4 | -0.0406882 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0390907 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0385354 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0375297 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0365671 |
| S100A6 | S100 calcium binding protein A6 | -0.0362715 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0359898 |
| RPLP0 | ribosomal protein, large, P0 | -0.0356251 |
| HMGB1 | high mobility group box 1 | -0.0354866 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0349893 |
| RPS27A | ribosomal protein S27a | -0.0348712 |
| HMGA1 | high mobility group AT-hook 1 | -0.0345273 |
| RPL12 | ribosomal protein L12 | -0.0341056 |
| ATXN1 | ataxin 1 | -0.0339964 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0328081 |
| TUBA1B | tubulin, alpha 1b | -0.0326194 |
| NDRG1 | N-myc downstream regulated 1 | -0.0321849 |
| AHNAK | AHNAK nucleoprotein | -0.0320182 |
| IER3 | immediate early response 3 | -0.0315866 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0312706 |
| VCL | vinculin | -0.0311512 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.030345 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0301409 |
| RPL32 | ribosomal protein L32 | -0.0300745 |
| PRELID2 | PRELI domain containing 2 | -0.0291754 |
| SEPTIN7 | septin 7 | -0.0290716 |
| RPS8 | ribosomal protein S8 | -0.0290578 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0287699 |
| MT1X | metallothionein 1X | -0.0286142 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0275412 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0269605 |
| RPL34 | ribosomal protein L34 | -0.026844 |
| RPL19 | ribosomal protein L19 | -0.026683 |
| RRBP1 | ribosome binding protein 1 | -0.0265555 |
| PKM | pyruvate kinase, muscle | -0.0265522 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.0265506 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0264078 |
| EGR1 | early growth response 1 | -0.0262779 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0259743 |
| ANKLE2 | ankyrin repeat and LEM domain containing 2 | -0.0259375 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0259252 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.025646 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0251168 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0250562 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0250028 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0249316 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0247854 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0247594 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.02437 |
| KLF6 | Kruppel-like factor 6 | -0.0243641 |
| RPL9 | ribosomal protein L9 | -0.0243461 |
| SEC61G | Sec61 gamma subunit | -0.0241004 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0240951 |
| ENOSF1 | enolase superfamily member 1 | -0.0239773 |
| MSANTD3 | Myb/SANT-like DNA-binding domain containing 3 | -0.0239591 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0238346 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0237739 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0237409 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0235305 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0235042 |
